LOCUS       NM_031540               2741 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus coagulation factor IX (F9), mRNA.
ACCESSION   NM_031540
VERSION     NM_031540.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2741)
  AUTHORS   Metzger,J.M., Tadin-Strapps,M., Thankappan,A., Strapps,W.R.,
            DiPietro,M., Leander,K., Zhang,Z., Shin,M.K., Levorse,J., Desai,K.,
            Xu,Y., Lai,K., Wu,W., Chen,Z., Cai,T.Q., Jochnowitz,N., Bentley,R.,
            Hoos,L., Zhou,Y., Sepp-Lorenzino,L., Seiffert,D. and Andre,P.
  TITLE     Titrating haemophilia B phenotypes using siRNA strategy: evidence
            that antithrombotic activity is separated from bleeding liability
  JOURNAL   Thromb Haemost 113 (6), 1300-1311 (2015)
   PUBMED   25790442
  REMARK    GeneRIF: Data provide substantial evidence of a participation of
            fIX in the mechanisms regulating thrombosis prior to those
            regulating primary haemostasis.
REFERENCE   2  (bases 1 to 2741)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   3  (bases 1 to 2741)
  AUTHORS   Mizurini,D.M., Francischetti,I.M., Andersen,J.F. and Monteiro,R.Q.
  TITLE     Nitrophorin 2, a factor IX(a)-directed anticoagulant, inhibits
            arterial thrombosis without impairing haemostasis
  JOURNAL   Thromb Haemost 104 (6), 1116-1123 (2010)
   PUBMED   20838739
  REMARK    GeneRIF: Nitrophorin 2, a factor IX(a)-directed anticoagulant, is a
            potent and long-lasting inhibitor of arterial thrombosis with minor
            effects on haemostasis.
REFERENCE   4  (bases 1 to 2741)
  AUTHORS   Zhang,L., Gu,D.S., DU,W.T., Liu,P.X., Lu,S.H. and Yang,R.C.
  TITLE     [Human coagulation factor IX gene therapy in murine hemophilia B by
            hydrodynamic delivery and site-specific genomic integration]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 31 (5), 294-299 (2010)
   PUBMED   21122306
REFERENCE   5  (bases 1 to 2741)
  AUTHORS   Verma,D., Moghimi,B., LoDuca,P.A., Singh,H.D., Hoffman,B.E.,
            Herzog,R.W. and Daniell,H.
  TITLE     Oral delivery of bioencapsulated coagulation factor IX prevents
            inhibitor formation and fatal anaphylaxis in hemophilia B mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (15), 7101-7106 (2010)
   PUBMED   20351275
REFERENCE   6  (bases 1 to 2741)
  AUTHORS   Reijnen,M.J., Sladek,F.M., Bertina,R.M. and Reitsma,P.H.
  TITLE     Disruption of a binding site for hepatocyte nuclear factor 4
            results in hemophilia B Leyden
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6300-6303 (1992)
   PUBMED   1631121
REFERENCE   7  (bases 1 to 2741)
  AUTHORS   Giannelli,F., Green,P.M., High,K.A., Sommer,S., Lillicrap,D.P.,
            Ludwig,M., Olek,K., Reitsma,P.H., Goossens,M., Yoshioka,A. et al.
  TITLE     Haemophilia B: database of point mutations and short additions and
            deletions--second edition
  JOURNAL   Nucleic Acids Res 19 Suppl (Suppl), 2193-2219 (1991)
   PUBMED   2041805
REFERENCE   8  (bases 1 to 2741)
  AUTHORS   Sarkar,G., Koeberl,D.D. and Sommer,S.S.
  TITLE     Direct sequencing of the activation peptide and the catalytic
            domain of the factor IX gene in six species
  JOURNAL   Genomics 6 (1), 133-143 (1990)
   PUBMED   2303254
REFERENCE   9  (bases 1 to 2741)
  AUTHORS   Suehiro,K., Kawabata,S., Miyata,T., Takeya,H., Takamatsu,J.,
            Ogata,K., Kamiya,T., Saito,H., Niho,Y. and Iwanaga,S.
  TITLE     Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by
            tryptophan and its activation by alpha-chymotrypsin and rat mast
            cell chymase
  JOURNAL   J Biol Chem 264 (35), 21257-21265 (1989)
   PUBMED   2592373
REFERENCE   10 (bases 1 to 2741)
  AUTHORS   Chen,S.H., Thompson,A.R., Zhang,M. and Scott,C.R.
  TITLE     Three point mutations in the factor IX genes of five hemophilia B
            patients. Identification strategy using localization by altered
            epitopes in their hemophilic proteins
  JOURNAL   J Clin Invest 84 (1), 113-118 (1989)
   PUBMED   2472424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1, FM036569.1 and M26247.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.48408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000021.1  143388642-143388677
            37-516              FM036569.1         1-480
            517-1362            M26247.1           1-846
            1363-2741           JAXUCZ010000021.1  143431765-143433143
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..2741
                     /gene="F9"
                     /note="coagulation factor IX"
                     /db_xref="GeneID:24946"
                     /db_xref="RGD:2589"
     CDS             1..1389
                     /gene="F9"
                     /EC_number="3.4.21.22"
                     /note="christmas factor; Coagulation factor IX (plasma
                     thromboplastic component, Christmas disease, hemophilia
                     B); coagulation factor 9"
                     /codon_start=1
                     /product="coagulation factor IX precursor"
                     /protein_id="NP_113728.1"
                     /db_xref="GeneID:24946"
                     /db_xref="RGD:2589"
                     /translation="MADAPGLIPIFLLGYLLSTECAVFLDRENATKILTRPKRYNSGK
                     LEEFVQGNLERECIEERCSFEEAREVFENTEKTTEFWKQYVDGDQCESNPCLNGGICK
                     DDINSYECWCQAGFEGRNCELDATCSIKNGRCKQFCKNSPDNKIICSCTEGYQLAEDQ
                     KSCEPAVPFPCGRVSVAYNSKKITRAETVFSNTDYGNSTELILDDITNSTILDNLTEN
                     SEPINDFTRVVGGENAKPGQIPWQVILNGEIEAFCGGAIINEKWIVTAAHCLKPGDKI
                     EVVAGEHNIDEKEDTEQRRNVIRTIPHHQYNATINKYSHDIALLELDKPLILNSYVTP
                     ICVANKEYTNIFLKFGSGYVSGWGKVFNKGRQASILQYLRVPLVDRATCLRSTKFSIY
                     NNMFCAGYREGGKDSCEGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSR
                     YVNWIKEKTKLT"
     exon            1..67
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            68..231
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            232..256
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            257..370
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            371..499
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            500..726
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            727..841
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
     exon            842..2741
                     /gene="F9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagacg ctccgggtct catccccatc ttccttctgg gctatctact cagcactgaa
       61 tgtgcagttt ttcttgatcg cgaaaatgcc accaaaattc ttacccgtcc aaagagatat
      121 aactcaggga aactggaaga gtttgttcag ggaaaccttg agagagagtg catagaagaa
      181 agatgcagtt ttgaagaagc acgagaagtt tttgaaaaca ctgaaaaaac tactgaattt
      241 tggaagcagt atgttgatgg agatcagtgt gaatcaaatc cttgcttaaa tggtggaata
      301 tgcaaggatg atattaattc ctatgaatgt tggtgccaag ctggatttga aggaaggaac
      361 tgtgaattag atgcaacatg tagcattaaa aatggcaggt gtaagcagtt ttgtaaaaac
      421 agccctgata acaagataat ttgttcctgc actgagggat accaacttgc agaagaccag
      481 aagtcctgtg aaccagcagt tccattccca tgtggaagag tttctgttgc ctacaattct
      541 aaaaagatca cccgtgctga gactgttttt tctaataccg actatggaaa ttccactgaa
      601 ttaatcctgg atgacatcac caacagcacc attcttgata acctcactga aaatagtgaa
      661 ccaattaatg acttcactcg agttgttggt ggagaaaatg cgaaaccagg tcaaatccct
      721 tggcaggtca ttctaaatgg tgaaattgag gcattctgtg gaggcgccat cattaatgaa
      781 aaatggattg taactgctgc ccactgtctt aaacctggtg ataaaattga ggttgttgct
      841 ggtgaacata atattgatga gaaggaagac acagaacaaa ggagaaatgt gattcgaact
      901 atccctcatc accagtacaa tgcaactatt aataagtata gtcatgacat tgccttgctg
      961 gaactggata aacctttaat actaaacagc tatgtaacac ctatctgtgt tgccaataag
     1021 gaatatacaa atatcttcct caagtttggt tctggttatg tgagtggctg ggggaaagtc
     1081 ttcaacaaag ggagacaggc ttccattctt cagtacctta gagttccact ggttgaccga
     1141 gccacatgcc ttaggtccac aaaattcagc atctataaca acatgttctg tgcaggttac
     1201 cgtgaaggag gcaaagattc atgtgaagga gatagtgggg gaccccatgt tactgaagta
     1261 gaagggacaa gtttcttaac tggcattatt agctggggtg aagaatgtgc aatgaaaggc
     1321 aaatatggaa tatatactaa ggtttccagg tatgtcaact ggattaagga aaaaacaaag
     1381 ctaacttaat gaaaaaccta attccaaagg caattcgctg ggattgaaca tggatgattc
     1441 ctttgcaaac tagtctttgc actgtttgct aaacttcaat acatatgctc tataaatact
     1501 gatttttctc tgtgcagggg acaagcccat gtaggatcta tattgtatta gattaagtag
     1561 gttagcaaat ataatcgcta aagaaatact ttagtaagag attaaccagt tctgcaagcc
     1621 cagtccttat taaaatttta aaattagaaa gtgtagctcc ccatgttgcc cataagacat
     1681 gatggttctt gatgtagaga tgtacccaat tctccctcct tggtatcagt tcatatttta
     1741 gatcttcctc acctctctca aatttattgg ttttctgtcc agaatcttta gctcgtttaa
     1801 ggccagaaga aagcaggaac aactgataca ttaaaactca tcaaaagcat gacttcctct
     1861 cttgattttc ccgaatcctg tatctttttc aactcccaat ccacaaatca ctgtcccgtc
     1921 catcattctc accctctagt tctccatcag ctttgaaaga ggaagaggtg tgagttccag
     1981 gacagtcagg agtacagaga aatcctgtct tgaaagaaaa aagaaagaga ggggcaggga
     2041 ggaaggaagg aaggaagaag gaaggaagga agaaggaagg agagaaagaa tgattaattt
     2101 agtcatattg gtatatatat ataaacacca ctaatcttac ttgtaacaac cacttatttc
     2161 tctgaagtaa atacctttac cttgatagat ttcaggctat taacataaag ttactggaaa
     2221 aggagttggg aaaacatatg caaaattact tttaaaactg tttcagccag ttttgaacct
     2281 cgaaccagct gagctttcta gaaacacttc aacggtttat cttcggcttt ctccagtgcc
     2341 aaccacccta agtcgtctct cacagcaggc cccaggatgc aagagtaaat ggcgaactga
     2401 attgcccagt tctggttttc tgctccccag tgaactgtgt tatcataatt aacattgtta
     2461 tgctgaattt tctagagggg tgctgaccac ctgacccatt tttcatctgt gatttgatga
     2521 actggcattt taatactttt ctggatcttt gtatgaactt gtttggaatt gacccagtca
     2581 cctcacactt aatgatgtat aaatcgtttg aaccccttgt cactgtcacc tgtccccacc
     2641 atacaatatc ctactttatt actgctgact ctattaatgt tccactactt actgcctctt
     2701 ttgtcttgca aaaagtatca ataaacatct atccaaattg c
//
