LOCUS       NM_001109323            1515 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coagulation factor VIII-associated 1 (F8a1),
            mRNA.
ACCESSION   NM_001109323 XM_001053469 XM_577058
VERSION     NM_001109323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Huang,Z.N. and Her,L.S.
  TITLE     The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome
            Activity
  JOURNAL   Mol Neurobiol 54 (9), 7382-7400 (2017)
   PUBMED   27815841
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Milman,P. and Woulfe,J.
  TITLE     Novel variant of neuronal intranuclear rodlet immunoreactive for 40
            kDa huntingtin associated protein and ubiquitin in the mouse brain
  JOURNAL   J Comp Neurol 521 (16), 3832-3846 (2013)
   PUBMED   23749422
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Pal,A., Severin,F., Lommer,B., Shevchenko,A. and Zerial,M.
  TITLE     Huntingtin-HAP40 complex is a novel Rab5 effector that regulates
            early endosome motility and is up-regulated in Huntington's disease
  JOURNAL   J Cell Biol 172 (4), 605-618 (2006)
   PUBMED   16476778
  REMARK    GeneRIF: We have identified Huntingtin (Htt)-associated protein 40
            (HAP40) as a novel effector of the small guanosine triphosphatase
            Rab5, a key regulator of endocytosis. HAP40 mediates the
            recruitment of Htt by Rab5 onto early endosomes.
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Peters,M.F. and Ross,C.A.
  TITLE     Isolation of a 40-kDa Huntingtin-associated protein
  JOURNAL   J Biol Chem 276 (5), 3188-3194 (2001)
   PUBMED   11035034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474110.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053469.1, XM_577058.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1515
                     /gene="F8a1"
                     /gene_synonym="F8a; Hap40; RGD1566014"
                     /note="coagulation factor VIII-associated 1"
                     /db_xref="GeneID:501661"
                     /db_xref="RGD:1566014"
     exon            1..1515
                     /gene="F8a1"
                     /gene_synonym="F8a; Hap40; RGD1566014"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1196
                     /gene="F8a1"
                     /gene_synonym="F8a; Hap40; RGD1566014"
                     /note="factor 8-associated gene A; factor VIII intron 22
                     protein; coagulation factor VIII-associated (intronic
                     transcript) 1; huntingtin-associated protein 40"
                     /codon_start=1
                     /product="40-kDa huntingtin-associated protein"
                     /protein_id="NP_001102793.1"
                     /db_xref="GeneID:501661"
                     /db_xref="RGD:1566014"
                     /translation="MAAGSASSLGGGSWPGSEAGDFLARYRQVSNKLKKRFLRKPNVA
                     EAGEQFAQLARELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQEC
                     DARQRLGCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRAVGQPAA
                     AAGHFQRAAQLHLPLMPLAALQALGDAASCQLLARDYTGALAVFTRMQRLAREHGGHP
                     VQQPELPQQLPSVPQPSLPGPQPRPVLGSTLPLPLPPDHAPGSVAQSPGTLGAFADVL
                     VRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDGHGQDSSGQLPEELFLLLQS
                     LVMAAHEKDTEGIKKLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV"
ORIGIN      
        1 cctcagccct ccctcaaccg gaagtaagcc agcgcggcta gccggtcaac atggcggcgg
       61 gctccgcgtc gtccctgggc ggaggctcct ggccaggctc tgaggctggg gacttcttgg
      121 cccgctaccg gcaggtgtcc aacaagctca agaagcgctt cttgcggaag ccgaacgtgg
      181 cggaggccgg ggagcagttc gcacagctgg cccgggagct gcgagctcaa gagtgcctgc
      241 cttatgccgc ctggtgccag ctggctgtgg cacgctgcca gcaggcgctc ttccatgggc
      301 ccggggaagc gctggccctt acagaggcgg cccgactttt cctgaggcag gagtgcgatg
      361 cgcgccaacg cctgggctgt cctgcggctt atggggagcc tttgcaggcg gccgccagcg
      421 cccttggcgc cgccgtgcgc ctgcaccttg agctgggcca gcccgccgct gctgccgcac
      481 tgtgcctaga actggctgcc gcccttcgcg ctgtgggcca gccagccgct gctgcaggtc
      541 actttcaacg tgctgcccag ctgcacctgc ccctgatgcc actggccgcg ctgcaggcac
      601 ttggtgatgc tgcctcctgc cagttgctgg cgcgcgacta cactggcgcc ctggcggttt
      661 ttacacgcat gcaacgcctg gcacgggagc atgggggcca cccggtacag caacccgagc
      721 tgccgcagca gctgccttct gtgcctcagc catctctgcc gggaccccag ccgagacctg
      781 tcttgggctc taccttgccc ctgccgctgc ccccggacca cgccccaggc tctgttgcgc
      841 agtcacctgg tacactcggt gccttcgctg acgttcttgt caggtgtgag gtgtcccgtg
      901 tattgttgct gctgctcctg caaccaccgc ctgccaagct gctgcctgag cacgcccaga
      961 ccctggagaa gtactcttgg gaggctttcg atggccatgg ccaggatagc agcggccagc
     1021 ttccagagga gctgtttttg ttattgcagt ccctggtcat ggctgcccac gaaaaggata
     1081 ctgaaggcat caagaagctg caggtggaga tgtggccact gctaactgct gagcagaacc
     1141 acctcctcca cctcgttctg caggaaacca tctctccctc gggacagggg gtctgataag
     1201 tcaccttcct aacaacttgc ttaatctttg gggacaggtg atgaaacacg tggtctagct
     1261 tctggttttt gcttctttgt tttgtttcat ttctattgtc actgtggtaa tttagctttg
     1321 tgtgcctacc tggttactta aattagtgcc ctccaattcc atccatattg cctcaaatgg
     1381 ggtaacttcg tccttaaggc tgaaggaaat tccactgtgt aatctgcttt ctttacgcat
     1441 tggtctgtag ttggataatg ttgattaatt ttcctggctg ttctaggtac agcttcaata
     1501 aacatggaag gacag
//
