LOCUS       NM_152846               1852 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus coagulation factor VII (F7), mRNA.
ACCESSION   NM_152846
VERSION     NM_152846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1852)
  AUTHORS   Sen,M.C., Turkyilmaz,Z., Sonmez,K., Karabulut,R., Kaya,Z.,
            Yenicesu,I., Gursel,T. and Basaklar,A.C.
  TITLE     The Effect of Carbon Dioxide Insufflation Applied at Different
            Pressures and Periods on Thrombotic Factors
  JOURNAL   Indian J Hematol Blood Transfus 32 (1), 87-91 (2016)
   PUBMED   26855512
REFERENCE   2  (bases 1 to 1852)
  AUTHORS   Hao,X., Cheng,X., Wang,Y., Yang,L., Xie,Y., Wang,M. and Jin,Y.
  TITLE     A novel gene insertion combined with a missense mutation causing
            factor VII deficiency in two unrelated Chinese families
  JOURNAL   Blood Coagul Fibrinolysis 26 (6), 687-690 (2015)
   PUBMED   26083983
REFERENCE   3  (bases 1 to 1852)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   4  (bases 1 to 1852)
  AUTHORS   Li,S., Ren,J., Xu,N., Zhang,J., Geng,Q., Cao,C., Lee,C., Song,J.,
            Li,J. and Chen,H.
  TITLE     MicroRNA-19b functions as potential anti-thrombotic protector in
            patients with unstable angina by targeting tissue factor
  JOURNAL   J Mol Cell Cardiol 75, 49-57 (2014)
   PUBMED   24998411
REFERENCE   5  (bases 1 to 1852)
  AUTHORS   Dong,F., Wang,C., Duan,J., Zhang,W., Xiang,D. and Li,M.
  TITLE     Puerarin attenuates ovalbumin-induced lung inflammation and
            hemostatic unbalance in rat asthma model
  JOURNAL   Evid Based Complement Alternat Med 2014, 726740 (2014)
   PUBMED   24523826
REFERENCE   6  (bases 1 to 1852)
  AUTHORS   Marchetti,G., Patracchini,P., Gemmati,D., DeRosa,V., Pinotti,M.,
            Rodorigo,G., Casonato,A., Girolami,A. and Bernardi,F.
  TITLE     Detection of two missense mutations and characterization of a
            repeat polymorphism in the factor VII gene (F7)
  JOURNAL   Hum Genet 89 (5), 497-502 (1992)
   PUBMED   1634227
REFERENCE   7  (bases 1 to 1852)
  AUTHORS   Soulban,G. and Labrecque,G.
  TITLE     Circadian rhythms of blood clotting time and coagulation factors
            II, VII, IX and X in rats
  JOURNAL   Life Sci 45 (25), 2485-2489 (1989)
   PUBMED   2607889
REFERENCE   8  (bases 1 to 1852)
  AUTHORS   Fuller,J.H., Keen,H., Jarrett,R.J., Omer,T., Meade,T.W.,
            Chakrabarti,R., North,W.R. and Stirling,Y.
  TITLE     Haemostatic variables associated with diabetes and its
            complications
  JOURNAL   Br Med J 2 (6196), 964-966 (1979)
   PUBMED   509177
REFERENCE   9  (bases 1 to 1852)
  AUTHORS   van Oosterom,A.T., Mattie,H., Hermens,W.T. and Veltkamp,J.J.
  TITLE     The influence of the thyroid function on the metabolic rate of
            prothrombin, factor VII, and factor X in the rat
  JOURNAL   Thromb Haemost 35 (3), 607-619 (1976)
   PUBMED   989968
REFERENCE   10 (bases 1 to 1852)
  AUTHORS   Kim,W.M., Merskey,C., Deming,Q.B., Adel,H.N., Wolinsky,H.,
            Clarkson,T.B. and Lofland,H.B.
  TITLE     Hyperlipidemia, hypercoagulability, and accelerated thrombosis:
            studies in congenitally hyperlipidemic rats and in rats and monkeys
            with induced hyperlipidemia
  JOURNAL   Blood 47 (2), 275-286 (1976)
   PUBMED   812575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 30, 2022 this sequence version replaced NM_152846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF532184.1, SRR26643286.42208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000016.1  83202655-83202738   c
            85-245              JAXUCZ010000016.1  83200116-83200276   c
            246-270             JAXUCZ010000016.1  83197439-83197463   c
            271-384             JAXUCZ010000016.1  83197249-83197362   c
            385-525             JAXUCZ010000016.1  83195583-83195723   c
            526-635             JAXUCZ010000016.1  83194423-83194532   c
            636-759             JAXUCZ010000016.1  83193862-83193985   c
            760-1852            JAXUCZ010000016.1  83191914-83193006   c
FEATURES             Location/Qualifiers
     source          1..1852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1852
                     /gene="F7"
                     /note="coagulation factor VII"
                     /db_xref="GeneID:260320"
                     /db_xref="RGD:628678"
     exon            1..84
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1352
                     /gene="F7"
                     /EC_number="3.4.21.21"
                     /note="serum prothrombin conversion accelerator"
                     /codon_start=1
                     /product="coagulation factor VII precursor"
                     /protein_id="NP_690059.1"
                     /db_xref="GeneID:260320"
                     /db_xref="RGD:628678"
                     /translation="MVPQTHGLLLLYFLLQLQGPLGAVVFITQEEAHGVLHRQRRANS
                     LLEELWSSSLERECNEERCSFEEAREIFKSPERTKQFWTIYSDGDQCASNPCQNGGTC
                     QDHLKSYVCFCPLDFEGRNCEKNKNEQLICANENGDCDQYCRDHVGTKRTCSCHEDYV
                     LQPDEVSCKPKVEYPCGRIPVVEKRNFSRPQGRIVGGYVCPKGECPWQAVLKFNEALL
                     CGAVLLDTRWIVTAAHCFDKFGKLVNITVVLGEHDFSEKEGTEQVRLVEQVIMPNKYT
                     RGRTDHDIALVRLHRPVTFTDYVVPLCLPERAFSENTLASIRFSRVSGWGQLLDRGAT
                     ALELMVIEVPRLMTQDCLEHAKHSANTPRITENMFCAGYMDGTKDACKGDSGGPHATH
                     YHGTWYLTGVVSWGEGCAAIGHIGVYTRVSQYIDWLVKYMDSKLRVGISRVSLL"
     exon            85..245
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            246..270
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            271..384
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            385..525
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            526..635
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            636..759
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1852
                     /gene="F7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtctcat catggttcca cagactcacg gactgctgct tctctacttt ctgctccagc
       61 tccagggacc cctaggggct gtggttttca taacccagga ggaagcacac ggtgtcctac
      121 acaggcaaag gcgtgccaac tcactcctag aggagctttg gtctagctcc ttggagaggg
      181 agtgcaatga agagcggtgc tcctttgagg aggcccgaga gatcttcaag agccctgaga
      241 gaaccaagca gttctggact atttacagcg atggcgacca gtgtgcctcg aatccatgtc
      301 agaacggggg tacctgccag gatcacctca agtcttatgt ctgcttctgc cccctagact
      361 ttgagggccg gaactgtgag aaaaacaaga atgagcagct gatctgtgca aatgaaaatg
      421 gtgactgtga ccagtactgc agggaccacg tagggaccaa gcgtacctgt agctgtcacg
      481 aggactacgt gctgcagcca gatgaggtgt cctgcaaacc aaaagttgag tacccatgcg
      541 ggagaatacc tgttgtagaa aaaagaaact tcagcagacc ccaaggccgg attgtgggag
      601 gctatgtgtg ccccaaaggg gagtgcccat ggcaggctgt gctgaaattc aatgaggcat
      661 tgctgtgtgg ggccgtcctg ctggacacca gatggatagt aactgcagcc cactgcttcg
      721 ataaattcgg gaaattggta aacatcacag tggtgttggg tgaacacgac ttcagtgaga
      781 aggaggggac tgagcaagta cggctggtgg aacaggtcat catgcccaac aagtacaccc
      841 gcggcaggac tgaccatgac atcgccctgg tccgccttca ccggcctgta accttcactg
      901 actacgtggt acctctgtgt ctgcctgaac gggccttctc cgagaacacc ctagccagca
      961 tccgcttctc gagggtcagc ggctggggcc agctactgga ccgtggtgcc acagctctgg
     1021 agctcatggt catcgaggtg ccccggctga tgacccagga ctgcctggag catgccaaac
     1081 acagtgctaa cacccccaga atcacggaga acatgttctg cgccggctac atggacggca
     1141 ccaaggacgc ctgcaagggt gacagtggag gcccacacgc cacccactac catggcactt
     1201 ggtatctgac aggtgtggtc agctgggggg agggctgtgc agctatcggc cacatcgggg
     1261 tgtacaccag ggtctcccag tacatagact ggctggtcaa atacatggac tccaagctcc
     1321 gggttgggat ttctcgagtc tccctactgt agctccttgg acagtccagc ctgtccaaga
     1381 cggaagccga ggcttgtgaa gctattttgt atcaaatcct atcgacttgc ctgctcttct
     1441 tttcctgagg gaggagaagg agctaaagaa gggtgaagaa ggcagaggaa gagatcaaac
     1501 gagaggggct gggagagggg aaacagaaag caggggaaga gtctgagtta gagactagca
     1561 agtcactcag agggtctggg cagtgcaacc acagacaggc agccagaagg gcagggtgtc
     1621 ctgagggaga cgaggctcag gccttgctcc tgtctccccc acagccacct cctgtctgca
     1681 caggttctgt ctgcagtgct acacagtagg tgtgttcaca tgcatgtagg acgtgtgaat
     1741 gtgagtgcgt gtgcgtgtgc ccatactaca cacgtcattc gtactattgt tccctttcgt
     1801 ctagtgcgag caccctgtct ttgtttccat taaatgagaa acacggtcgg ca
//
