LOCUS       NM_001419051            7505 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus coagulation factor V (F5), mRNA.
ACCESSION   NM_001419051 XM_039090783
VERSION     NM_001419051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7505)
  AUTHORS   Ivancic,M.M., Anson,L.W., Pickhardt,P.J., Megna,B., Pooler,B.D.,
            Clipson,L., Reichelderfer,M., Sussman,M.R. and Dove,W.F.
  TITLE     Conserved serum protein biomarkers associated with growing early
            colorectal adenomas
  JOURNAL   Proc Natl Acad Sci U S A 116 (17), 8471-8480 (2019)
   PUBMED   30971492
REFERENCE   2  (bases 1 to 7505)
  AUTHORS   Guan,Z.Y., Yu,C.W., Song,T. and Gao,Y.
  TITLE     The relationship between the levels and function of endothelial
            progenitor cells and factor V Leiden and protein C deficiency in
            patients with primary Budd-Chiari syndrome
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (9), 2742-2750 (2018)
   PUBMED   29771426
REFERENCE   3  (bases 1 to 7505)
  AUTHORS   El Sebay,H.M., Safan,M.A., Daoud,A.A., Tayel,S.I., Nouh,M.A. and El
            Shafie,S.
  TITLE     Association of factor V Leiden, Janus kinase 2, prothrombin, and
            MTHFR mutations with primary Budd-Chiari syndrome in Egyptian
            patients
  JOURNAL   J Gastroenterol Hepatol 31 (1), 235-240 (2016)
   PUBMED   26238013
REFERENCE   4  (bases 1 to 7505)
  AUTHORS   Plompen,E.P., Darwish Murad,S., Hansen,B.E., Loth,D.W.,
            Schouten,J.N., Taimr,P., Hofman,A., Uitterlinden,A.G.,
            Stricker,B.H., Janssen,H.L. and Leebeek,F.W.
  TITLE     Prothrombotic genetic risk factors are associated with an increased
            risk of liver fibrosis in the general population: The Rotterdam
            Study
  JOURNAL   J Hepatol 63 (6), 1459-1465 (2015)
   PUBMED   26226452
REFERENCE   5  (bases 1 to 7505)
  AUTHORS   Sundquist,K., Wang,X., Svensson,P.J., Sundquist,J., Hedelius,A.,
            Larsson Lonn,S., Zoller,B. and Memon,A.A.
  TITLE     Plasminogen activator inhibitor-1 4G/5G polymorphism, factor V
            Leiden, prothrombin mutations and the risk of VTE recurrence
  JOURNAL   Thromb Haemost 114 (6), 1156-1164 (2015)
   PUBMED   26245493
REFERENCE   6  (bases 1 to 7505)
  AUTHORS   Pereira,L.M., Langley,P.G., Hayllar,K.M., Tredger,J.M. and
            Williams,R.
  TITLE     Coagulation factor V and VIII/V ratio as predictors of outcome in
            paracetamol induced fulminant hepatic failure: relation to other
            prognostic indicators
  JOURNAL   Gut 33 (1), 98-102 (1992)
   PUBMED   1740285
REFERENCE   7  (bases 1 to 7505)
  AUTHORS   Sinclair,S.B. and Levy,G.A.
  TITLE     Treatment of fulminant viral hepatic failure with prostaglandin E.
            A preliminary report
  JOURNAL   Dig Dis Sci 36 (6), 791-800 (1991)
   PUBMED   1903342
REFERENCE   8  (bases 1 to 7505)
  AUTHORS   Valla,D., Flejou,J.F., Lebrec,D., Bernuau,J., Rueff,B.,
            Salzmann,J.L. and Benhamou,J.P.
  TITLE     Portal hypertension and ascites in acute hepatitis: clinical,
            hemodynamic and histological correlations
  JOURNAL   Hepatology 10 (4), 482-487 (1989)
   PUBMED   2777210
REFERENCE   9  (bases 1 to 7505)
  AUTHORS   Mazzorana,M., Cornillon,B., Baffet,G., Hubert,N., Belleville,J.,
            Eloy,R. and Guguen-Guillouzo,C.
  TITLE     Biosynthesis of factor V by normal adult rat hepatocytes
  JOURNAL   Thromb Res 54 (6), 655-675 (1989)
   PUBMED   2675384
REFERENCE   10 (bases 1 to 7505)
  AUTHORS   Owen,C.A. Jr. and Bowie,E.J.
  TITLE     Rat coagulation factors V, VIII, XI, and XII: vitamin K dependent
  JOURNAL   Haemostasis 7 (4), 189-201 (1978)
   PUBMED   658784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 27, 2023 this sequence version replaced XM_039090783.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.29198.1,
                                           SRR26643284.16493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               JAXUCZ010000013.1  79046657-79046958
            303-391             JAXUCZ010000013.1  79049264-79049352
            392-514             JAXUCZ010000013.1  79057632-79057754
            515-727             JAXUCZ010000013.1  79066737-79066949
            728-871             JAXUCZ010000013.1  79068820-79068963
            872-1093            JAXUCZ010000013.1  79072544-79072765
            1094-1259           JAXUCZ010000013.1  79074891-79075056
            1260-1437           JAXUCZ010000013.1  79076047-79076224
            1438-1537           JAXUCZ010000013.1  79077779-79077878
            1538-1749           JAXUCZ010000013.1  79078186-79078397
            1750-1900           JAXUCZ010000013.1  79080286-79080436
            1901-2113           JAXUCZ010000013.1  79083049-79083261
            2114-4832           JAXUCZ010000013.1  79085359-79088077
            4833-5007           JAXUCZ010000013.1  79089012-79089186
            5008-5244           JAXUCZ010000013.1  79093731-79093967
            5245-5452           JAXUCZ010000013.1  79096706-79096913
            5453-5632           JAXUCZ010000013.1  79100707-79100886
            5633-5749           JAXUCZ010000013.1  79103132-79103248
            5750-5821           JAXUCZ010000013.1  79104090-79104161
            5822-5925           JAXUCZ010000013.1  79105154-79105257
            5926-6081           JAXUCZ010000013.1  79105672-79105827
            6082-6226           JAXUCZ010000013.1  79107996-79108140
            6227-6378           JAXUCZ010000013.1  79110953-79111104
            6379-6561           JAXUCZ010000013.1  79113885-79114067
            6562-7505           JAXUCZ010000013.1  79115304-79116247
FEATURES             Location/Qualifiers
     source          1..7505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..7505
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /note="coagulation factor V"
                     /db_xref="GeneID:304929"
                     /db_xref="RGD:1589758"
     exon            1..302
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..6708
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /note="coagulation factor V (proaccelerin, labile factor)"
                     /codon_start=1
                     /product="coagulation factor V"
                     /protein_id="NP_001405980.1"
                     /db_xref="GeneID:304929"
                     /db_xref="RGD:1589758"
                     /translation="MFLVCPRFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWN
                     YHPESADPSLNSIPSFKKIVYREYEPYFKKEKPRSSNSGLLGPTLYAEVGDTIKVHFR
                     NKADKPLSIHPQGIRYSKFSEGASYLDHTSPAERKDDAVAAGEEYTYEWFIGEDSGPT
                     PDDPPCLTHIYYSYENLTQDFNSGLIGPLLICKEGTLTEDGTQKMFDKQHVLLFAVFD
                     ESKSWSQSPALMYTVNGFVNRTMPDVTVCAYDHVSWHLIGMSSGPELFSIHFNGQVLE
                     QNQHKVSTVTLVSATSTTANMTMSPEGKWIVSSLIPKHYQAGMQAYIDIKNCPKKTRS
                     SKTLTREQRRHMKRWEYFIAAEEVIWNYAPVIPANMDKLYKSLHLDNFSNQIGKHYKK
                     VIYREYKDETFTKRIENQSSRQSGILGPIIKAQVRDTLKIVFKNMASRPYSIYPHGVT
                     FSPYEDGVNSSSTSGSHTMIKPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVD
                     VTRDIASGLIGLLLICKSRSLDQRGIQRVADMEQEVVFAMFDENKSWYIEDNINKFCE
                     NPDEVKRDDPKFYESNIMNTINGYVPESISTLGFCFDDAVQWHFCSVGTHDDILTVHF
                     TGHSFIYGRRHEDTLTLFPMSGESVTVVMDNIGTWMLTTMSSNPRRRNLRLRFRDVKC
                     NRNDDDDEDSYEIYQPLEPTSMTTRKIHDSVENDFGIENEDDDYQYELASTLGIRSFR
                     KSLLNPKEDEFNLTALALENSSEFISLSTDGVVDSKSSRNLSKITNNNLNDSQRTLSG
                     SGATIAGILLGNLTGLGKNSVLNPSTEYHSSSYYENDMEDPQSNITVVYLLPLGAKGS
                     GSREQTKPKTIKTGRPHRMKHRFSWMKAPAGKTGRHSNPKNTSSRMKSEEDIPSDLLL
                     LKQKVASKLLNRQWHMASEKGSYEIIPANGENTDIDKLTNSPQNQNISTPWGASTSRI
                     NTTGKPSNLPTFSRFRHKSPHVRQEEESGDFKKRQLFIRTRKKKKNRKFALHSPLSPR
                     GFYHPRREDHPPLLDRRLLNHSLLLHKSNETALSTDLNQTSPPVSTDRSLPDYNQNPS
                     NDTEQMSSSLDLFQSVPPEEHSPTFPTQDPNQTHSTTDPSYRSSPPEPSQGIDYDLSH
                     EFYSDDISQTSFFPDQSQKSPLTSDDGQAIPSSDLNLFTISPELDQTIIYPDLDQLFL
                     SPDDIQKTSSQDLGQVTLSPDENQETSSQDLGQVTLSPNENQETSSQDLGQVTLSPDD
                     IQETSSQDLGQVTLSPDENQETSSPDLGQVPLTPDDNQKTSPDLGQVLLSLDDKQKTY
                     FLDPGQVPISSDQSWETSSTDLSLLTLSPKFGQTVISPDLDKMPLSSDNSQVTLSPDL
                     SLLTLSPDFNEIILSPDIDQVTLSPDLIQTSPALNHRHKTSSADPGQASYPPDSGQSS
                     PLPELNQTLPHPDLIHMQPPLLSPTPNDTSLSKTFNPLVVVGLSRVDGDDVEMIPSEE
                     LESIDEDYPEDDYVTYNDPYKTDTRANVNSSRNPDTIAAWYLRSFGGNKKFYYIAAEE
                     ISWDYSKFAPSEMDNEETDNTPKDTTYKKVVFRKYLDSTFTSRDPQGEYEEHLGILGP
                     VIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKNYEDDSPKWFQEDDAVQPNS
                     SYTYVWHATERAGPENPGSACRAWVYYSAVDVERDIHSGLIGPLLICRKGTLDRASNL
                     PLDMREFVLLFMVFDEKKSWYYEKSKGSWRIESPEAKNSHEFYAINGMIYNLPGLRMY
                     EQEWVRLYLLNMGGPQDIHVVHFHGQILLDNRTKQHHLGVWPLLPGSFKTLEMKASKP
                     GWWLLDTAVGENQIAGMQTPFLIIDKECKMPMGLSTGAISDSQIKASEYLTYWEPRLA
                     RLNNGGSYNAWSIEKSALDFPIKPWIQVDMEKEVVVTGIQTQGAKYYLKSCFTTEFQV
                     AYSSDRTNWQIFRGNSMKSVMSFAGNSDASTIKENRFDPPIVARYIRIHPTKSYNRPT
                     LRLELLGCEVNGCSTPLGLEDGRIQNKQITASSFKKSWWGSYWEPSLARLNAQGRVNA
                     WQAKANNNKQWLQIDLLKIKKVTAIVTQGCKSLSSEMYVKSYSILYSDQGVSWKPYRQ
                     KSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQSIALRLELFGCDIY"
     exon            303..391
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            392..514
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            515..727
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            728..871
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1093
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1259
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1437
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1537
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1749
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1900
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2113
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..4832
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            4833..5007
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5244
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5452
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5453..5632
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5633..5749
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5750..5821
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5822..5925
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6081
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            6082..6226
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..6378
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            6379..6561
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
     exon            6562..7505
                     /gene="F5"
                     /gene_synonym="Ac2-120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgatac agccaccact ggggacaggg acactcactg cgcccaacag cttcttagtc
       61 ctccagggag tcaggacagc gcgcagcagg gacagagcac tgagcactgt cagccgtggc
      121 agcgcgcgcg gcaggacaag ggccatgttc ctagtctgcc cgcgcttctt cctcctggtg
      181 gttctgggca cccgatgggc gggctggggc agccaccagg cagaggccgc gcagctaagg
      241 cagttctatg tggctgctca aggcatcctc tggaactacc atcctgagtc cgcagatcca
      301 agtttgaatt ctataccttc cttcaagaaa attgtctaca gagagtatga gccatatttt
      361 aagaaagaaa agccacgatc tagcaactca ggacttctcg gaccaacttt atatgctgaa
      421 gttggcgaca ccatcaaggt tcactttaga aacaaagcag acaaacctct aagcatccac
      481 cctcaaggaa ttagatacag caaattttca gaaggggctt cttacctgga ccacacatcc
      541 ccggctgaga ggaaggacga tgctgtggct gctggagagg aatacaccta tgaatggttc
      601 atcggtgagg acagcgggcc cacacctgat gacccaccat gcctcaccca catctactac
      661 tcctatgaaa acctgaccca ggatttcaac tcaggcctga ttgggcctct gctcatctgc
      721 aaggaaggca ccctgactga ggatgggact cagaagatgt ttgacaagca acacgtgctt
      781 ctgtttgctg tatttgatga aagcaagagc tggagccagt caccagccct catgtacaca
      841 gtcaacggct ttgtgaatag gacaatgcca gatgtaacag tctgtgccta cgatcatgtc
      901 agctggcatc tgattgggat gagctcggga ccagaattgt tttctattca cttcaacggc
      961 caagtcctag agcagaacca acataaagtg tccaccgtga ctctggtcag tgcgacatct
     1021 acaactgcca acatgactat gagcccagaa ggaaaatgga ttgtttcttc tctcatccca
     1081 aagcattatc aagctgggat gcaggcttat attgacatta aaaactgccc aaagaaaacc
     1141 aggagctcca agacgctcac ccgagagcag cggcggcaca tgaagaggtg ggagtacttc
     1201 atcgccgcag aggaagtcat ttggaactac gcacctgtga tacccgcaaa catggacaaa
     1261 ctatacaagt ctctgcattt ggataacttc tcaaaccaaa ttggaaaaca ttacaagaaa
     1321 gtcatttaca gagaatataa agatgagacc ttcaccaaac gcatcgagaa tcaaagtagc
     1381 agacaaagcg ggattttggg ccctattatt aaagcccagg tcagggacac actcaagatc
     1441 gtgttcaaaa acatggccag ccgaccgtac agcatttacc cgcatggggt gaccttctct
     1501 ccttacgaag atggagtcaa ttcttcctcc acctcaggca gtcacaccat gatcaaacca
     1561 gttcaaccag gagaaacctt cacttacaaa tggaacattc tagagtttga cgaacccacg
     1621 gaaaatgacg cccagtgctt aacaaggcca tactacagtg atgtggatgt tacaagggac
     1681 attgcctctg gactgatagg gctccttcta atttgtaaga gcaggtccct ggaccagaga
     1741 ggcatacaga gggtagcaga catggagcag gaggtcgtgt ttgctatgtt tgatgagaac
     1801 aagagctggt acatcgagga caacatcaac aagttttgtg agaatcccga tgaggtgaag
     1861 cgtgatgacc ccaagtttta tgaatcaaac atcatgaaca ctatcaatgg gtacgtgcct
     1921 gagagcatat ccaccctagg attctgtttt gatgatgccg tacagtggca cttctgcagt
     1981 gtgggaactc atgatgacat tctgaccgtc cacttcactg ggcactcatt catctatggg
     2041 aggaggcacg aggacacctt gaccctgttc cccatgagtg gtgaatctgt gactgtcgtg
     2101 atggataata ttggaacttg gatgttgacc accatgagtt ccaatccaag acgcagaaac
     2161 ctaagattga gattcaggga tgttaagtgt aaccggaatg atgatgacga tgaagactca
     2221 tatgagattt atcaacctct tgaacctaca tccatgacaa ctcggaaaat tcatgattct
     2281 gtggaaaatg actttggcat agaaaacgaa gatgatgatt accagtacga actggcgtca
     2341 acactaggaa ttaggtcatt cagaaagtca ttgttgaatc cgaaggaaga cgagttcaat
     2401 ctcactgctc tcgctctaga aaacagctct gaattcatat ctctaagcac agacggagtt
     2461 gttgactcaa aatcctcaag aaaccttagt aagatcacca ataataacct caacgactct
     2521 caaagaacac tttctggctc aggagccacc atagctggta tcctacttgg aaaccttact
     2581 ggcttaggta agaactccgt cctcaaccct tcaacagaat atcattccag ctcatattat
     2641 gaaaatgata tggaagaccc acagtcgaac atcacagtgg tatacctact tcctcttggt
     2701 gcaaaaggat cagggagtcg agaacagact aaacctaaaa caatcaagac aggaagaccc
     2761 cacaggatga agcacaggtt ctcctggatg aaagctccag ccggaaaaac tgggaggcat
     2821 tcaaatccaa agaatacttc ttccagaatg aagtctgagg aggacattcc tagtgatttg
     2881 ttactcttaa aacaaaaggt cgcatccaaa cttttgaaca gacagtggca tatggcttct
     2941 gaaaagggta gttatgaaat aataccagca aatggtgaaa acacagatat tgataagctg
     3001 acaaacagtc ctcaaaatca gaatatctca acgccttggg gagctagcac ctctcgcata
     3061 aacacgacag ggaagccaag taacctccca acattttcta gatttaggca taaatctcca
     3121 catgtaagac aggaggagga aagcggtgac tttaagaaaa gacagttgtt catcaggaca
     3181 cggaagaaga agaagaacag gaagtttgca ctacacagtc ctctgtctcc aaggggcttt
     3241 taccatccga gaagagaaga ccatcctcca cttttagata gaagactact caatcattca
     3301 ttactactcc acaaatccaa tgaaacagct ctttccacag atctgaatca gacctcccct
     3361 ccagtgagta ctgacaggtc acttcctgac tataatcaga acccttcaaa tgatactgag
     3421 cagatgagct cttctttaga cctttttcag tcagtgccac cagaggaaca ctctccaaca
     3481 tttcctaccc aagatcctaa tcaaacacac tctaccacag atcctagcta cagatcctct
     3541 cctccagagc ccagtcaagg gatcgattat gacctaagcc atgaatttta ttctgatgac
     3601 attagtcaaa catctttctt tccagaccaa agtcaaaagt cacctctcac ttcagatgat
     3661 ggccaagcaa tcccttcctc agacttaaat ctctttacca tctctccaga attggatcaa
     3721 acaattattt acccagacct ggatcagttg ttcctttctc cagatgacat ccagaagacc
     3781 tcctcccaag acctgggtca ggtgaccctt tctccagatg aaaaccaaga gacctcctcc
     3841 caagacctgg gtcaggtgac cctttctcca aatgaaaacc aagagacctc ctcccaagac
     3901 ctgggtcagg tgaccctttc tccagatgac atccaggaga cctcctccca agacctgggt
     3961 caggtgaccc tttctccaga tgaaaaccaa gagacctcct ccccagacct gggtcaggtg
     4021 ccccttaccc cagatgacaa ccagaagact tccccagacc taggtcaggt gctcctttct
     4081 ctagatgaca agcagaagac ttacttccta gacccaggtc aggtacccat ctcctcagac
     4141 caaagctggg agacctcctc cactgacctt agcctactga ctctctctcc gaaatttggt
     4201 cagacagtca tttccccaga cttggataag atgcccctct cttcagacaa cagtcaagtt
     4261 accctttccc cagacctcag cctcttgacc ctctcaccag attttaatga gataatacta
     4321 tccccagaca ttgatcaggt gaccctctct ccagacctca tccagacaag ccctgctctt
     4381 aatcacaggc acaaaacatc ctctgcagac cctggtcaag catcctaccc cccagattct
     4441 ggtcagtctt cacctcttcc agaactgaat cagactcttc ctcatccaga cctcattcac
     4501 atgcagcctc ctttactatc tcccacacct aatgacactt ctttgtcaaa gacatttaac
     4561 ccccttgttg tagtaggtct cagtagagtt gatggagacg atgttgagat gattccaagt
     4621 gaggagctag agagcattga cgaagattat cctgaggatg actatgtaac ctacaatgac
     4681 ccctacaaaa cagacaccag ggcaaatgtc aactcctcca gaaaccctga cactattgca
     4741 gcatggtatc tccgtagctt cggtgggaac aaaaaattct actatattgc tgctgaagaa
     4801 atatcctggg attattcaaa atttgcacca agtgaaatgg acaatgaaga aacagacaac
     4861 actccaaagg acaccacata caagaaagtt gttttcagaa aataccttga tagtactttc
     4921 acaagccgtg atcctcaggg ggaatatgag gagcaccttg gcattcttgg ccctgtaata
     4981 cgtgctgaag tggatgatgt gatccaagtt cgatttaaaa atttagcatc cagaccatat
     5041 tctcttcatg cccatggact ttcctatgaa aagtcctcag agggaaagaa ttacgaagat
     5101 gactctccta aatggtttca ggaagatgat gctgtccagc ccaatagcag ttacacatat
     5161 gtatggcatg ccactgagcg cgcgggacca gagaaccccg gttctgcctg ccgggcttgg
     5221 gtctactatt ctgcagtgga tgtggagcga gacatccact caggcttgat cggccccctt
     5281 ctgatctgcc ggaaaggaac acttgacagg gcgagcaacc tgcctctgga catgagagag
     5341 tttgtcttgc tcttcatggt ctttgatgag aagaagagct ggtactatga aaagtccaaa
     5401 gggtcatgga gaattgaatc tccagaagcg aaaaattcgc acgagtttta cgcaattaat
     5461 gggatgattt acaacctgcc cggcctgaga atgtatgagc aagagtgggt gaggctgtac
     5521 ctgctgaaca tgggcggccc ccaagatatt cacgtggttc acttccatgg ccagatcctg
     5581 ctggataata ggaccaaaca gcaccactta ggggtctggc ccctcttgcc tggttcattt
     5641 aaaactcttg aaatgaaggc atccaagcct ggctggtggc tcctagacac agcggttgga
     5701 gaaaaccaga tagctggcat gcaaacacca ttccttatca tagacaaaga gtgcaagatg
     5761 ccaatgggtc taagtactgg tgccatatct gactcacaga tcaaggcttc agaatatctg
     5821 acttattggg agcccagatt agcacgatta aacaatggcg gctcatataa tgcttggagt
     5881 atagaaaaat ctgcattaga ttttcccatt aaaccttgga tccaggtgga catggagaag
     5941 gaagttgtag tcaccgggat acaaacccaa ggtgctaaat actacctcaa gtcttgcttt
     6001 accacggaat tccaagtggc ttacagctct gaccgaacca actggcagat cttcagaggg
     6061 aacagcatga aaagcgtgat gtcttttgct ggcaattcag atgcctctac gataaaagag
     6121 aatcgatttg acccacctat tgtggctaga tacattagga tacatcccac gaaatcctat
     6181 aacagaccca cccttcggtt ggagctgttg ggctgtgagg tgaacggatg ctccacacca
     6241 ctgggcctgg aagatggaag gatacaaaac aagcaaatta ctgcatcttc atttaaaaag
     6301 tcatggtggg gaagctactg ggagccttcc cttgcccgcc tgaatgccca gggccgagtg
     6361 aatgcctggc aagccaaggc aaacaacaac aagcagtggt tacaaattga tctgctcaaa
     6421 atcaagaagg taacggccat cgtaactcag ggttgcaagt ctctgtcctc tgagatgtat
     6481 gtgaagagct acagcatcct gtacagtgac cagggtgtct cctggaaacc ctaccggcag
     6541 aaatcctcca tggtggacaa gatttttgaa gggaatagca ataccaaagg gcatatgaag
     6601 aactttttca acccacctat tatttccaga tttatccgaa tcattcctaa aacatggaac
     6661 caaagtattg cacttcgcct ggaactcttc ggctgtgaca tttattagaa ttaaatacaa
     6721 aagaaaaaaa aaggaaaaga gaataaacac tgaagaaact ccttcaggct taagttattt
     6781 agagcaggca atatagtact ggtattttaa atgttaacaa actttctgct attttttcta
     6841 gttgagaata aagtttatat gagatgcttt tataatgttc ctttaccgct gccatcgaga
     6901 cagcggctat tatttttttc actgatttgg ttataaatgg gaaaatatta agacccggca
     6961 agactatgac tgtctttcac tctgattaaa gatattatat aatgtaatag ttagataatg
     7021 aaatgtgatt cactctggct cttttaaatc ctgtagacat tagtgaaaga gatattgctt
     7081 ttggaaactt ttcatgaacc cagaaaacct ttatttcttt atttttcttt taaaagcaaa
     7141 ctgtaatctg taaacaatgg aaacaaaaat agttgagttt tttttaatac tagggaaaaa
     7201 tatcttgttg taattaagca agaacttaaa atagccaggg ttgggctggc tgggtgggca
     7261 aaagtgcttg ctgccaaaac aaaacaacag caaacacaaa acaaaacaaa acaaagcaaa
     7321 acaaaacaaa acaaaacaaa acaaacaacc ctggacaacc tgagtcccag tcccaaaacc
     7381 cacggtgaaa ggagagaaca tattccagaa agcggccctc tgacttctgc atgcagctgt
     7441 ggcacatgcg tgcccccacg cccgtgtaca agctaaccgt aaataaaata tttttaaagc
     7501 ctgtc
//
