LOCUS       NM_013057               1798 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus coagulation factor III, tissue factor (F3), mRNA.
ACCESSION   NM_013057
VERSION     NM_013057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Wu,D., Lin,Y., Yang,M., Li,H., Wang,W., Wu,Q., Chen,M., Shao,N. and
            Deng,C.
  TITLE     Tissue factor regulates autophagy in pulmonary artery endothelial
            cells from chronic thromboembolic pulmonary hypertension rats via
            the p38 MAPK-FoxO1 pathway
  JOURNAL   Respir Res 25 (1), 261 (2024)
   PUBMED   38943142
  REMARK    GeneRIF: Tissue factor regulates autophagy in pulmonary artery
            endothelial cells from chronic thromboembolic pulmonary
            hypertension rats via the p38 MAPK-FoxO1 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Jang,Y.J., Kim,H.K., Choi,B.C., Song,S.J., Park,J.I., Chun,S.Y. and
            Cho,M.K.
  TITLE     Expression of tissue factor and tissue factor pathway inhibitors
            during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome
  JOURNAL   Reprod Biol Endocrinol 19 (1), 52 (2021)
   PUBMED   33794911
  REMARK    GeneRIF: Expression of tissue factor and tissue factor pathway
            inhibitors during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Wan,S., Xiang,Y., Fang,W., Zheng,Y., Li,B., Hu,Y., Lang,C.,
            Huang,D., Sun,Q., Xiong,Y., Huang,X., Lv,J., Luo,Y., Shen,L.,
            Yang,H., Huang,G. and Yang,R.
  TITLE     Clinical features and treatment of COVID-19 patients in northeast
            Chongqing
  JOURNAL   J Med Virol 92 (7), 797-806 (2020)
   PUBMED   32198776
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Chen,F., Jiang,Y., Liu,S.L., Zou,L.H., Cao,Y. and Zhu,Y.M.
  TITLE     The expression changes and correlation analysis of high mobility
            group box-1 and tissue factor in the serum of rats with sepsis
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (4), 1634-1640 (2019)
   PUBMED   30840287
  REMARK    GeneRIF: expression levels of HMGB-1 and tissue factor (TF) of the
            rats with sepsis gradually increased with time, and the level of
            HMGB-1 was positively correlated with the level of TF
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Bauer,K.A., Conway,E.M., Bach,R., Konigsberg,W.H., Griffin,J.D. and
            Demetri,G.
  TITLE     Tissue factor gene expression in acute myeloblastic leukemia
  JOURNAL   Thromb Res 56 (3), 425-430 (1989)
   PUBMED   2617479
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Wilcox,J.N., Smith,K.M., Schwartz,S.M. and Gordon,D.
  TITLE     Localization of tissue factor in the normal vessel wall and in the
            atherosclerotic plaque
  JOURNAL   Proc Natl Acad Sci U S A 86 (8), 2839-2843 (1989)
   PUBMED   2704749
REFERENCE   8  (bases 1 to 1798)
  AUTHORS   Andoh,K., Kubota,T., Takada,M., Tanaka,H., Kobayashi,N. and
            Maekawa,T.
  TITLE     Tissue factor activity in leukemia cells. Special reference to
            disseminated intravascular coagulation
  JOURNAL   Cancer 59 (4), 748-754 (1987)
   PUBMED   3802033
REFERENCE   9  (bases 1 to 1798)
  AUTHORS   Guha,A., Bach,R., Konigsberg,W. and Nemerson,Y.
  TITLE     Affinity purification of human tissue factor: interaction of factor
            VII and tissue factor in detergent micelles
  JOURNAL   Proc Natl Acad Sci U S A 83 (2), 299-302 (1986)
   PUBMED   3455766
REFERENCE   10 (bases 1 to 1798)
  AUTHORS   Zacharski,L.R., Rosenstein,R., Cornwell,G.G. 3rd, Davis,W.M. and
            McIntyre,O.R.
  TITLE     Reduced tissue factor (thromboplastin) activity in von Willebrand's
            disease
  JOURNAL   Am J Med 57 (1), 102-107 (1974)
   PUBMED   4546024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081846.1.
            
            On Sep 16, 2004 this sequence version replaced NM_013057.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081846.1, U07619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1798
                     /gene="F3"
                     /gene_synonym="TF"
                     /note="coagulation factor III, tissue factor"
                     /db_xref="GeneID:25584"
                     /db_xref="RGD:2587"
     exon            1..184
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..984
                     /gene="F3"
                     /gene_synonym="TF"
                     /note="tissue factor; coagulation factor 3; coagulation
                     factor III (thromboplastin, tissue factor)"
                     /codon_start=1
                     /product="tissue factor precursor"
                     /protein_id="NP_037189.2"
                     /db_xref="GeneID:25584"
                     /db_xref="RGD:2587"
                     /translation="MAIPMRPRLLAALAPTFLGFLLLQVAAGAGTPPGKAFNLTWIST
                     DFKTILEWQPKPTNYTYTVQISDRSRNWKYKCTGTTDTECDLTDEIVKDVNWTYEARV
                     LSVPWRNSTHGKETLFGTHGEEPPFTNARKFLPYRDTKIGQPVIQKYEQDGTKLKVTV
                     KDSFTLVRKNGTFLTLRQVFGNDLGYILTYRKDSSTGRKTNTTHTNEFLIDVEKGVSY
                     CFFVQAVIFSRKTNHKSPESITKCTEQWKSVLGETLIIVGAVVFLVTVFIILLTISLC
                     KRRKNRAGQKRKNTPSRLA"
     exon            185..293
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
     exon            294..511
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
     exon            512..690
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
     exon            691..850
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1769
                     /gene="F3"
                     /gene_synonym="TF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaccggtac ccatcactcg ctccgtctga tcgctcgtgt agcgtagcct ccgcgcctct
       61 gctgaagccc cgcgacctcg ccagcagccc ttggacatgg ctatccccat gcgcccgcgc
      121 ctcctagcgg ccctcgcgcc cacctttctc ggcttccttc tccttcaggt ggccgctggt
      181 gcaggcactc ctccagggaa agcgtttaat ttaacttgga tatcaactga tttcaagaca
      241 atcttggagt ggcaaccgaa acccaccaac tatacctaca ctgttcagat aagcgataga
      301 tctagaaact ggaaatacaa atgcactgga accacagaca ctgagtgtga cctcaccgac
      361 gagattgtga aggatgtgaa ctggacctat gaagcaaggg tcctatctgt cccatggagg
      421 aactcaactc atggaaagga aacactcttt ggaactcatg gggaggaacc gccatttaca
      481 aatgcccgga agtttttacc ttaccgagac acaaaaattg gacagccagt aattcagaag
      541 tatgaacaag acggtacgaa actgaaggtg actgtaaaag actcatttac attagtcaga
      601 aagaatggta cattcctcac tctgcggcaa gtttttggca atgacttggg ttatattctt
      661 acgtatcgga aagactcaag cacaggaagg aaaacaaaca ctacacatac caatgaattc
      721 ttgattgatg tggaaaaggg ggtaagctac tgcttcttcg tacaagccgt gattttctcc
      781 aggaaaacta accacaagag cccagaaagc atcaccaagt gcactgagca atggaagagt
      841 gtcctgggag aaacactcat cattgtggga gcagtggtgt tcctggtcac tgtctttatc
      901 atcctgctga ccatatctct gtgcaagcgc agaaagaaca gagcaggaca gaaaaggaag
      961 aacaccccgt cgcgcttggc atagacgagg aggctgacgc tgctgactgt cacactgccc
     1021 acacggcact gttaccgaga cctctgctgg gaactgtgga gtttgctcct agctcagaaa
     1081 gactcccttc atggcctgtc attccagcta atgctttgat tccaacacta gcatctgtca
     1141 ctttaggaca tactgaacgg tacaaattga tcaacactac agcacctttt gcacaaagct
     1201 taagattgtg tattctacac gcgggaagac actaggttgc ccaggcaaag ccagtggtca
     1261 gatgcctttc ctataacctg ggtgggcttt tggagaacct ttgaggagtg atgccatagg
     1321 ctctagaaca ggaaagtggg atttgggtgg acttttccaa cagttgtact ttcgtaaatc
     1381 ggtatttggg ttttgttttt ccttctacta ggtacttttg gaagttcaaa gtaactggca
     1441 aactgtcata tgttaaatgc aggatatttt tgcttgggac atccttgtga tttgtacttt
     1501 attacaactt agcactttaa ctgacaatga tggggattga acattggaca accaactcta
     1561 tttttataag actaccatac agaagaacta catatagttt tatgatctaa ggtacttaaa
     1621 gtgtttgtgg ttaacattgt gtatatttat atgagtttta aaggttttgt atatgggatt
     1681 ttctatttat atatctccta tttgtatata ttgagataat ttatttaata tacttttata
     1741 taaataaagg tgattgggaa ttgaggcgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
