LOCUS       NM_053808               1694 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus F2R like thrombin or trypsin receptor 3 (F2rl3),
            mRNA.
ACCESSION   NM_053808
VERSION     NM_053808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Fang,H., Yuan,Z., Zhu,Y., Tang,H., Pang,C., Li,J., Shi,J., Guo,W.
            and Zhang,S.
  TITLE     Blocking protease-activated receptor 4 alleviates liver injury
            induced by brain death
  JOURNAL   Biochem Biophys Res Commun 595, 47-53 (2022)
   PUBMED   35093640
  REMARK    GeneRIF: Blocking protease-activated receptor 4 alleviates liver
            injury induced by brain death.
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Foley,J.H. and Conway,E.M.
  TITLE     Cross Talk Pathways Between Coagulation and Inflammation
  JOURNAL   Circ Res 118 (9), 1392-1408 (2016)
   PUBMED   27126649
  REMARK    Review article
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Lekic,T., Klebe,D., McBride,D.W., Manaenko,A., Rolland,W.B.,
            Flores,J.J., Altay,O., Tang,J. and Zhang,J.H.
  TITLE     Protease-activated receptor 1 and 4 signal inhibition reduces
            preterm neonatal hemorrhagic brain injury
  JOURNAL   Stroke 46 (6), 1710-1713 (2015)
   PUBMED   25931468
  REMARK    GeneRIF: increased thrombin activity 6 to 24 hours after germinal
            matrix hemorrhage, and PAR-1, PAR-4, inhibition normalized
            cyclooxygenase-2, and mammalian target of rapamycin by 72 hours.
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Wang,Z., Chen,D., Zhang,Z., Zhang,R., An,S. and Yu,L.
  TITLE     Protease-activated receptor 4 activation increases the expression
            of calcitonin gene-related peptide mRNA and protein in dorsal root
            ganglion neurons
  JOURNAL   J Neurosci Res 91 (12), 1551-1562 (2013)
   PUBMED   24105611
  REMARK    GeneRIF: activation of PAR4 upregulates the expression of CGRP mRNA
            and protein levels in dorsal root ganglion neurons
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Vellani,V., Kinsey,A.M., Prandini,M., Hechtfischer,S.C., Reeh,P.,
            Magherini,P.C., Giacomoni,C. and McNaughton,P.A.
  TITLE     Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive
            neurones
  JOURNAL   Mol Pain 6, 61 (2010)
   PUBMED   20875131
  REMARK    GeneRIF: PAR1 and PAR4 are functionally expressed in large
            myelinated fibre neurons, and are also expressed in small
            nociceptors of the peptidergic subclass, where they are able to
            potentiate TRPV1 activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Grenegard,M., Vretenbrant-Oberg,K., Nylander,M., Desilets,S.,
            Lindstrom,E.G., Larsson,A., Ramstrom,I., Ramstrom,S. and
            Lindahl,T.L.
  TITLE     The ATP-gated P2X1 receptor plays a pivotal role in activation of
            aspirin-treated platelets by thrombin and epinephrine
  JOURNAL   J Biol Chem 283 (27), 18493-18504 (2008)
   PUBMED   18480058
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Jesmin,S., Gando,S., Zaedi,S. and Sakuraya,F.
  TITLE     Differential expression, time course and distribution of four PARs
            in rats with endotoxin-induced acute lung injury
  JOURNAL   Inflammation 30 (1-2), 14-27 (2007)
   PUBMED   17136598
  REMARK    GeneRIF: PAR 4 is regulated at the transcriptional level in a rat
            model of lipopolysaccharide induced acute lung injury and probably
            has a distinct role.
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Henrich-Noack,P., Riek-Burchardt,M., Baldauf,K., Reiser,G. and
            Reymann,K.G.
  TITLE     Focal ischemia induces expression of protease-activated receptor1
            (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the
            penumbra
  JOURNAL   Brain Res 1070 (1), 232-241 (2006)
   PUBMED   16403464
  REMARK    GeneRIF: PAR1 and PAR3 could be involved in thrombin-modulated
            initiation of post-ischemic inflammation and PAR4 may be associated
            with neuronal degeneration. (Protease-activated receptor 1, 3, 4)
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Wang,Y., Richter-Landsberg,C. and Reiser,G.
  TITLE     Expression of protease-activated receptors (PARs) in OLN-93
            oligodendroglial cells and mechanism of PAR-1-induced calcium
            signaling
  JOURNAL   Neuroscience 126 (1), 69-82 (2004)
   PUBMED   15145074
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Hoogerwerf,W.A., Hellmich,H.L., Micci,M.A., Winston,J.H., Zou,L.
            and Pasricha,P.J.
  TITLE     Molecular cloning of the rat proteinase-activated receptor 4 (PAR4)
  JOURNAL   BMC Mol Biol 3, 2 (2002)
   PUBMED   11886595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF269246.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF269246.2, AF310216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680431, SAMN06680452
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1694
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="F2R like thrombin or trypsin receptor 3"
                     /db_xref="GeneID:116498"
                     /db_xref="RGD:620872"
     CDS             1..1161
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /note="G-protein coupled receptor; coagulation factor II
                     (thrombin) receptor-like 3; protease-activated receptor 4;
                     PAR-4; thrombin receptor-like 3; coagulation factor II
                     receptor-like 3; F2R like thrombin/trypsin receptor 3"
                     /codon_start=1
                     /product="proteinase-activated receptor 4"
                     /protein_id="NP_446260.1"
                     /db_xref="GeneID:116498"
                     /db_xref="RGD:620872"
                     /translation="MLGFSISPAECQTPSIYDDVESTREGQEASLRPTVELNESKSPD
                     KPNPRGFPGKPCANNSDTLELPASSEALLLGWVPTRLVPAIYGLVVVVGLPANGLALW
                     VLATRVPRLPSTILLMNLAVADLLLALVLPPRLVYHLRGQRWPFGEAACRVATAALYG
                     HMYGSVLLLAAVSLDRYLALVHPLRARALRGQRLTTILCLVAWLSAATLVLPLTFHRQ
                     TFLLAGSDRMLCHDALPLAEQTSHWRPAFICLAVLGCFVPLLAMVLCYGATLRALAAN
                     GQRYSHAVRLTALVLFSAVAAFTPSNVLLVLHYSNPSPEAWGNLYGAYVPSLALSTLN
                     SCVDPFIYYYVSHEFREKVRAMLCRQLKASSSSQASREAGSRGTAICSSTLL"
     exon            1..82
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            83..1694
                     /gene="F2rl3"
                     /gene_synonym="PAR4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctcgggt tcagcatcag cccggcggaa tgccagacgc ccagcatcta cgacgatgta
       61 gagagtacca gggaaggcca agaagcctct ctgcgtccca cagtagaact taatgagtcg
      121 aagtccccag acaagcctaa tccacgaggc ttcccgggca agccctgtgc caacaacagt
      181 gacacgctgg agctcccagc cagctctgaa gcactgcttc tggggtgggt ccccacgagg
      241 ctggtacctg ccatctatgg gctagtggtg gtcgtggggc tgcctgccaa tgggctagcg
      301 ctgtgggtgc tggccacaag ggtcccacgc ttgccatcca ccattctgct catgaacctg
      361 gcagtggctg acttgctact ggccctggtg ctcccaccac gactggttta tcacctgcgt
      421 ggccagcgct ggccgtttgg ggaggctgcc tgccgggtgg ccacagctgc cctctatggc
      481 cacatgtatg gttcagtgtt gcttctggcc gcagtcagcc tggacagata cctggccctg
      541 gtgcatcctt tgcgggcccg ggcattgcgt ggtcaacgcc tcaccaccat actctgcttg
      601 gtggcctggc tctctgcagc cactctagtc ttgccactca cgtttcatcg gcagaccttc
      661 ctattggctg gctccgatcg catgctgtgt catgatgcgc tgccattggc ggagcagacc
      721 tcccattgga gaccggcctt catctgcctg gctgtcctgg gctgctttgt gccactgctg
      781 gccatggtcc tgtgctatgg ggccaccctt cgtgcactgg cagccaatgg tcagcggtac
      841 agccatgcag tgagactgac agccctggtc ctgttctcag cagtggccgc tttcacacct
      901 agcaatgtgc ttctggtgct gcactattca aacccaagcc ctgaggcctg gggcaatctc
      961 tatggagcct atgttcccag cctggcactc agcaccctta acagctgcgt agaccctttc
     1021 atctactact atgtgtccca cgagttcagg gagaaggtac gggctatgtt gtgtcgccag
     1081 ctgaaggcca gcagctcctc tcaggcctcc agggaggctg gaagccgagg gactgccatt
     1141 tgctcctcta cacttctgtg actgttagct gagttgggaa ggggacgttc agactcgact
     1201 ggatctcccc ttaaactgtc cctcctgaac cctcaggaca tgaccttatt tggatatgca
     1261 cttggcgcga ccttcattag tggagctgag gtccactgga aatgccctgg taaaaggcct
     1321 gggtaccata cacctgtcac cccagcacta gggaggtgga gaggaggatc agaagcccag
     1381 cattgtcttt gactatgtag tgacttcgaa gctaggctgg gctatgcgag agtccagagg
     1441 tggagaggta tcacgaggtc acgaggatgc tgagaaagca gaattgagcc tgtttcccac
     1501 tcagaggacc cagccccaga caccctgatt ttgtcattgt gcctcttaga acttcacact
     1561 gttgtgcttt gcatgtgtct gcacagcgta gatgtgtctt cacatgtata ttgtatgtgc
     1621 ctgtgggtac tcgaagaggc caaaggatga tgggtgtgta cctcaattcc ctctctacct
     1681 ttaaattttg taag
//
