LOCUS       NM_053313               1505 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus coagulation factor II (thrombin) receptor-like 2
            (F2rl2), mRNA.
ACCESSION   NM_053313 XM_579551
VERSION     NM_053313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Foley,J.H. and Conway,E.M.
  TITLE     Cross Talk Pathways Between Coagulation and Inflammation
  JOURNAL   Circ Res 118 (9), 1392-1408 (2016)
   PUBMED   27126649
  REMARK    Review article
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Jesmin,S., Gando,S., Zaedi,S. and Sakuraya,F.
  TITLE     Differential expression, time course and distribution of four PARs
            in rats with endotoxin-induced acute lung injury
  JOURNAL   Inflammation 30 (1-2), 14-27 (2007)
   PUBMED   17136598
  REMARK    GeneRIF: PAR 3 is regulated at the transcriptional level in a rat
            model of lipopolysaccharide induced acute lung injury and probably
            has a distinct role.
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Cappello,S., Attardo,A., Wu,X., Iwasato,T., Itohara,S.,
            Wilsch-Brauninger,M., Eilken,H.M., Rieger,M.A., Schroeder,T.T.,
            Huttner,W.B., Brakebusch,C. and Gotz,M.
  TITLE     The Rho-GTPase cdc42 regulates neural progenitor fate at the apical
            surface
  JOURNAL   Nat Neurosci 9 (9), 1099-1107 (2006)
   PUBMED   16892058
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Two forms of human Inscuteable-related protein that links Par3 to
            the Pins homologues LGN and AGS3
  JOURNAL   Biochem Biophys Res Commun 341 (4), 1001-1006 (2006)
   PUBMED   16458856
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Henrich-Noack,P., Riek-Burchardt,M., Baldauf,K., Reiser,G. and
            Reymann,K.G.
  TITLE     Focal ischemia induces expression of protease-activated receptor1
            (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the
            penumbra
  JOURNAL   Brain Res 1070 (1), 232-241 (2006)
   PUBMED   16403464
  REMARK    GeneRIF: PAR1 and PAR3 could be involved in thrombin-modulated
            initiation of post-ischemic inflammation and PAR4 may be associated
            with neuronal degeneration. (Protease-activated receptor 1, 3, 4)
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   Rohatgi,T., Henrich-Noack,P., Sedehizade,F., Goertler,M.,
            Wallesch,C.W., Reymann,K.G. and Reiser,G.
  TITLE     Transient focal ischemia in rat brain differentially regulates mRNA
            expression of protease-activated receptors 1 to 4
  JOURNAL   J Neurosci Res 75 (2), 273-279 (2004)
   PUBMED   14705148
  REMARK    GeneRIF: Involvement of the thrombin receptors PAR-1, PAR-3, and
            PAR-4 in the pathophysiology of brain ischemia was suggested by
            decreased mRNA levels observed for PAR-1, -2, and -3, whereas PAR-4
            levels were reduced only after 7 days
REFERENCE   7  (bases 1 to 1505)
  AUTHORS   Rohatgi,T., Sedehizade,F., Sabel,B.A. and Reiser,G.
  TITLE     Protease-activated receptor subtype expression in developing eye
            and adult retina of the rat after optic nerve crush
  JOURNAL   J Neurosci Res 73 (2), 246-254 (2003)
   PUBMED   12836167
  REMARK    GeneRIF: Par-3 mRNA is expressed in the developing rat eye and
            adult retina but shows a delayed upregulation after optic nerve
            crush compared to Par-1, Par-2, and Par-4.
REFERENCE   8  (bases 1 to 1505)
  AUTHORS   Riek-Burchardt,M., Striggow,F., Henrich-Noack,P., Reiser,G. and
            Reymann,K.G.
  TITLE     Increase of prothrombin-mRNA after global cerebral ischemia in
            rats, with constant expression of protease nexin-1 and
            protease-activated receptors
  JOURNAL   Neurosci Lett 329 (2), 181-184 (2002)
   PUBMED   12165407
  REMARK    GeneRIF: Expression of protease-activated receptor 3 does not
            change significantly in the hippocampus following severe ischemic
            insult.
REFERENCE   9  (bases 1 to 1505)
  AUTHORS   Thur,C. and Redaelli,C.
  TITLE     [The deltoid flap-plasty. Therapy of choice in large rotator cuff
            ruptures?]
  JOURNAL   Z Unfallchir Versicherungsmed 85 (4), 172-185 (1992)
   PUBMED   1299297
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF310076.1.
            
            On Jun 21, 2005 this sequence version replaced XM_579551.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF310076.1, FN804688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1505
                     /gene="F2rl2"
                     /gene_synonym="PAR3"
                     /note="coagulation factor II (thrombin) receptor-like 2"
                     /db_xref="GeneID:29636"
                     /db_xref="RGD:620871"
     exon            1..132
                     /gene="F2rl2"
                     /gene_synonym="PAR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1169
                     /gene="F2rl2"
                     /gene_synonym="PAR3"
                     /note="G-protein coupled receptor; proteinase-activated
                     receptor 3; PAR-3; thrombin receptor-like 2; coagulation
                     factor II receptor-like 2; protease-activated receptor 3"
                     /codon_start=1
                     /product="proteinase-activated receptor 3 precursor"
                     /protein_id="NP_445765.1"
                     /db_xref="GeneID:29636"
                     /db_xref="RGD:620871"
                     /translation="MEMKVLILVGVRLLFLPTTVCQSGMKHVSDNSALTAESFNGNEH
                     SFEEFPLSDIEGWTGATTTIKAKCPEESITTLHVNNATMGYLRSSLSTKVIPAIYILV
                     FVIGVPANIVTLWKLSSRTKSICLVIFHTNLAIADLLFCVTLPFKIAYHLNGNDWVFG
                     EVMCRVTTVAFYGNMYCAILILTCMGINRYLATVHPFTYRKLPKRNFTLLMCGVVWVM
                     VVLYMLPLAILKQEYHLVQPGITTCHDVHDTCESPLPFQFYYFVSLAFFGFLIPFVVS
                     VFCYTTLIHKLNAQDRKWLRYIKAVLLILVIFTICFAPTNIILIIHHANYYYSNTDSL
                     YFMYLIALCLGSLNSCLDPFLYFIMSKIVDQLTS"
     exon            133..1505
                     /gene="F2rl2"
                     /gene_synonym="PAR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggggaat ctaccctgtg tctctgcaca cttagtgaca tcccataacc gggtctcaag
       61 acatggagat gaaagtcctt atcttggttg gggttaggct gctgtttctg ccgaccactg
      121 tttgccaaag tggcatgaaa catgtttcag acaactcagc cttaactgct gagagtttta
      181 atggcaacga acattccttt gaagaattcc cactttctga catagagggc tggacaggag
      241 ccaccacaac tataaaagcg aagtgtcccg aagaaagcat tacaactctc catgtgaata
      301 atgctaccat gggatacctg agaagttcct taagtaccaa agtgatacct gccatctaca
      361 tcctggtgtt tgtgattggt gtaccagcga acatcgtgac cctgtggaaa ctctcctcaa
      421 ggaccaaatc catctgtctg gtcatctttc acaccaacct ggccatcgcg gatctccttt
      481 tctgtgtcac gctgccgttt aagatcgcct accatctcaa tgggaacgac tgggtctttg
      541 gcgaggtcat gtgccgggtc accacggtcg ctttctacgg caacatgtat tgtgctattc
      601 tcatcctcac ctgtatgggc atcaaccgct acctggccac ggtccatccc ttcacatacc
      661 gcaagctgcc caaacgcaac ttcactttgc tcatgtgtgg cgtggtgtgg gtcatggtgg
      721 tcttatatat gttgccgttg gccatcctca agcaggagta ccatcttgtc caaccaggga
      781 tcaccacctg ccacgacgtc cacgacacat gcgagtcccc gttgcccttc cagttctact
      841 acttcgtctc cttggccttc tttgggttcc ttatcccatt tgtggtcagt gtcttctgtt
      901 acacgactct catccacaag cttaacgcgc aggatcgcaa atggctgagg tacatcaagg
      961 cggttctcct catccttgtg attttcacca tctgctttgc ccccaccaac atcatactca
     1021 taattcacca cgccaactac tactacagca acactgatag cttgtacttt atgtatctca
     1081 tagctctctg cctgggcagc ctgaatagtt gcctagaccc attcctttat tttatcatgt
     1141 caaaaattgt agatcagctg acctcgtagt caacaatggc gagatcatct tggagaacaa
     1201 ggatagatat ctgggggaaa tgtatatgct tgggctgact tgtgcatggt accaacagct
     1261 caatttttaa tctttaattt taattttatg ttttttgagg cagggtgtca ctatgtagtc
     1321 ctggctggcc cggaattttc tatttttaga ctaggttggc ttgaactcat agagatctgc
     1381 ctgcttctgc ctcccatctg ctggggtcag ccagacctgg ccaccagctc catttttaag
     1441 ctccaatgaa atagtacttc acatatcaaa tgtaaaattg tggggattaa aaaaatactt
     1501 cacgt
//
