LOCUS       NM_053897               2979 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus F2R like trypsin receptor 1 (F2rl1), mRNA.
ACCESSION   NM_053897
VERSION     NM_053897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Akasaka,R., Furukawa,A., Hayashi,Y., Hitomi,S., Koyama,R.,
            Oshima,E., Tamura,M., Yonemoto,M., Hojo,Y., Takahashi,R.,
            Shibuta,I., Iwata,K., Yonehara,Y. and Shinoda,M.
  TITLE     PAR2-dependent phosphorylation of TRPV4 at the trigeminal nerve
            terminals contributes to tongue cancer pain
  JOURNAL   J Oral Biosci 65 (4), 356-364 (2023)
   PUBMED   37838226
  REMARK    GeneRIF: PAR2-dependent phosphorylation of TRPV4 at the trigeminal
            nerve terminals contributes to tongue cancer pain.
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Gu,Q., Zhang,H., Li,J., He,T., Lei,Y. and Song,S.
  TITLE     Effects of PAR2 Gene Knockout on Visceral Sensitivity, Stress
            Behaviors, and Colonic Electrical Activities in Irritable Bowel
            Syndrome
  JOURNAL   Discov Med 35 (178), 805-814 (2023)
   PUBMED   37811618
  REMARK    GeneRIF: Effects of PAR2 Gene Knockout on Visceral Sensitivity,
            Stress Behaviors, and Colonic Electrical Activities in Irritable
            Bowel Syndrome.
REFERENCE   3  (bases 1 to 2979)
  AUTHORS   Shao,C. and Lu,L.
  TITLE     PAR2 Overexpression is Involved in the Occurrence of
            Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats
  JOURNAL   Fetal Pediatr Pathol 42 (3), 423-437 (2023)
   PUBMED   36657618
  REMARK    GeneRIF: PAR2 Overexpression is Involved in the Occurrence of
            Hyperoxygen-Induced Bronchopulmonary Dysplasia in Rats.
REFERENCE   4  (bases 1 to 2979)
  AUTHORS   Zhang,X., Lee,M.D., Buckley,C., Hollenberg,M.D., Wilson,C. and
            McCarron,J.G.
  TITLE     Endothelial PAR2 activation evokes resistance artery relaxation
  JOURNAL   J Cell Physiol 238 (4), 776-789 (2023)
   PUBMED   36791026
  REMARK    GeneRIF: Endothelial PAR2 activation evokes resistance artery
            relaxation.
REFERENCE   5  (bases 1 to 2979)
  AUTHORS   Tang,Y., Chen,Y., Yang,M., Zheng,Q., Li,Y. and Bao,Y.
  TITLE     Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting
            the activation of astrocytes and the ERK pathway
  JOURNAL   BMC Musculoskelet Disord 23 (1), 514 (2022)
   PUBMED   35637468
  REMARK    GeneRIF: Knockdown of PAR2 alleviates cancer-induced bone pain by
            inhibiting the activation of astrocytes and the ERK pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2979)
  AUTHORS   Kanke,T., Macfarlane,S.R., Seatter,M.J., Davenport,E., Paul,A.,
            McKenzie,R.C. and Plevin,R.
  TITLE     Proteinase-activated receptor-2-mediated activation of
            stress-activated protein kinases and inhibitory kappa B kinases in
            NCTC 2544 keratinocytes
  JOURNAL   J Biol Chem 276 (34), 31657-31666 (2001)
   PUBMED   11413129
REFERENCE   7  (bases 1 to 2979)
  AUTHORS   Sun,G., Stacey,M.A., Schmidt,M., Mori,L. and Mattoli,S.
  TITLE     Interaction of mite allergens Der p3 and Der p9 with
            protease-activated receptor-2 expressed by lung epithelial cells
  JOURNAL   J Immunol 167 (2), 1014-1021 (2001)
   PUBMED   11441110
REFERENCE   8  (bases 1 to 2979)
  AUTHORS   DeFea,K.A., Zalevsky,J., Thoma,M.S., Dery,O., Mullins,R.D. and
            Bunnett,N.W.
  TITLE     beta-arrestin-dependent endocytosis of proteinase-activated
            receptor 2 is required for intracellular targeting of activated
            ERK1/2
  JOURNAL   J Cell Biol 148 (6), 1267-1281 (2000)
   PUBMED   10725339
REFERENCE   9  (bases 1 to 2979)
  AUTHORS   Damiano,B.P., Cheung,W.M., Santulli,R.J., Fung-Leung,W.P., Ngo,K.,
            Ye,R.D., Darrow,A.L., Derian,C.K., de Garavilla,L. and
            Andrade-Gordon,P.
  TITLE     Cardiovascular responses mediated by protease-activated receptor-2
            (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice
            deficient in PAR-2 or PAR-1
  JOURNAL   J Pharmacol Exp Ther 288 (2), 671-678 (1999)
   PUBMED   9918574
REFERENCE   10 (bases 1 to 2979)
  AUTHORS   Saifeddine,M., al-Ani,B., Cheng,C.H., Wang,L. and Hollenberg,M.D.
  TITLE     Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and
            activity of receptor-derived peptides in gastric and vascular
            tissue
  JOURNAL   Br J Pharmacol 118 (3), 521-530 (1996)
   PUBMED   8762073
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053897.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099765.1, U61373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000002.1  28519780-28519954   c
            176-2979            JAXUCZ010000002.1  28507003-28509806   c
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2979
                     /gene="F2rl1"
                     /gene_synonym="Par-2; Par2"
                     /note="F2R like trypsin receptor 1"
                     /db_xref="GeneID:116677"
                     /db_xref="RGD:620866"
     exon            1..175
                     /gene="F2rl1"
                     /gene_synonym="Par-2; Par2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1281
                     /gene="F2rl1"
                     /gene_synonym="Par-2; Par2"
                     /note="proteinase-activated receptor 2; thrombin
                     receptor-like 1; coagulation factor II (thrombin)
                     receptor-like 1; coagulation factor II receptor-like 1;
                     Proteinase-activated receptor-2, G protein-coupled
                     receptor 11"
                     /codon_start=1
                     /product="proteinase-activated receptor 2 precursor"
                     /protein_id="NP_446349.1"
                     /db_xref="GeneID:116677"
                     /db_xref="RGD:620866"
                     /translation="MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDT
                     PPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFF
                     RTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMY
                     CSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYI
                     PALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDE
                     HSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLST
                     LNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTS
                     VKTSY"
     exon            176..2979
                     /gene="F2rl1"
                     /gene_synonym="Par-2; Par2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaaaggaa ggggacccgg tactccgagt ggggctcgga gtttcgaacc actggtggcg
       61 gattgcccgc ccgtcccacg tccggggatg cgaagtctca gcctggcgtg gctgctggga
      121 ggtatcaccc ttctggcggc ctcggcctcc tgcaaccgga ccgtgaatgc accgggaccc
      181 aacagtaaag ggagaagtct gattggcaga ttggacacgc cgcctcccat cactgggaaa
      241 ggggctccag ttgaaccagg cttttccgtt gatgaattct ctgcatccgt cctcaccggg
      301 aagctgacca ccgtctttct cccggtcatc tacatcattg tctttgtaat tggtttgccc
      361 agtaatggta tggccctctg ggtcttcttc ttccgaacga agaagaagca ccctgctgtg
      421 atttacatgg ccaacctggc cttggcagac ctcctctctg tcatctggtt ccccctgaag
      481 atctcctacc acctccatgg caacgactgg acctatgggg atgcgctctg caaggtgctc
      541 attggctttt tctacggcaa tatgtactgc tccatccttt tcatgacctg cctcagcgtg
      601 cagaggtact gggtgatcgt gaaccccatg ggacactcca ggaagagggc caacatcgct
      661 gttggcgtct ccctggccat ctggctcctg atttttctgg tcaccatccc tctgtacgtc
      721 atgaggcaga ccatctacat tccagccttg aacatcacca cctgtcacga cgtgctgccc
      781 gaggaggtcc tggtggggga catgttcagt tacttcctct ccctggccat tggagtcttt
      841 ctgttcccag ccctccttac tgcgtctgcc tacgtgctca tgatcaaaac gctccgttcc
      901 tccgccatgg acgagcactc ggagaagaaa aggcggaggg ctatccgcct catcatcacg
      961 gtgctgtcca tgtacttcat ctgcttcgct cccagcaacg tgctgctcgt cgtgcattat
     1021 ttcctcatca aaagccagag gcagagccac gtctacgccc tctacctcgt cgccctctgc
     1081 ctgtccaccc tcaacagctg catagacccc tttgtctact actttgtttc gaaagatttc
     1141 agggaccagg ccagaaacgc gctcctctgc cgaagcgtcc gcaccgtgaa acgcatgcag
     1201 atatcgctca cctccaacaa gttctccagg aaatccagct cttactcctc cagctcaacc
     1261 agtgttaaaa cctcctactg agctgggcct gaggatatgg agccagcttg atgatgatgc
     1321 tggtgatgat gatgatgatg atgatgatgg tgatgatgat gatgatgctg atgatgctga
     1381 tgatgctgat gatgatgatg tatgtgtgtg tatatgtgcg tgcatgcgtg tgtgtgtgtg
     1441 tgtgtgtgtg tgtgtgtgtg tgttagggat gcaccacaac gcacggggct gtcatttcct
     1501 atccaagttg ctagtctctg taccagtcac aagaatgatg gacgtcagcg tccgaaactg
     1561 aaggaaccga gaggaacatg ctttgcagaa gtgaggaagg aaattcgttg acctgcagag
     1621 aactacacct ggcaagaaag ttaagacccc cccgaaatgc tttcttgttc atctggagtc
     1681 cgtcatggct ttgtcaggat ctgagatcct tgtagagctt cagtccagct gataatgact
     1741 ctatagactt ggaagatgtg tctgcgaatg aggctcctgg ccggcattcc aactggttaa
     1801 cactgagctt gctggacgac aggattcaaa tggccacagt ggttccgttc tcgcatggtt
     1861 tcatcagaac tactggggat cttgttcaat gtgcaggtcc ctcagcctca gtgcccaggg
     1921 agctcggata cgagggggcc gctctacaaa cttcagtgat gtctgcatac acagaaccgc
     1981 agaggcgagc cccgttccgc ttgccagggc accgtagtga cgttggcaaa gaaaaaccaa
     2041 cagcagtgtt tgagcctcct tttggtcagt ttatgatgaa tttccctatg ggttaactgg
     2101 gatttctggt tcctttatta cccctttgta gttttatatg tctgtaagtc aacaaaatga
     2161 ggctcctaaa catgtaaata aaaattttgt ttattttttt taattttaca taagtcagtg
     2221 tgggtaatag agtattaggc cgactgcaaa tactgcttag tttttttcta agttaatttt
     2281 taaatacatc atgcaaactt aagacatttt catgataaag cactattaca gtgtcagttc
     2341 ccttctccct cagtcatatg ccttcccggg atgctggccc ttcccctcct ctccttcccc
     2401 ccttgccttc cccctccccc cagatagcca gtgtgccttc atgtaccatt tagtatttta
     2461 taaaaaccgt cgttgaaata tttattatca gttttgttca ccttttaccg tccattgaat
     2521 gaacgtcttc tcgtctgttt gggcaagagc aggaacaaga ggctacggcc attgcagggg
     2581 tacgtggttc cagacttact ttatataccg cctggatctg cggcttgaga aattaccttg
     2641 tacgaaggct ttctaaataa tgtataaccc ttgacctttt tttttttaaa caacttcttt
     2701 ccagctgtgt gttcttttgt agaaggagga ggagaaggga atccccctgt tgtagataca
     2761 gtgatctgat caccctatcc tgttctgttc tttcttcctt tcttctttaa cacagtgcga
     2821 tgcccacccc accactttcc agtccttcct tcttccttct ttccttcctt tcttctcttt
     2881 ccacaacact agggatctaa acctagcctt gtgaatttac actttttccc ccacactagt
     2941 ttttctaata aacaaaatgt agttcacgtt gctccacaa
//
