LOCUS       NM_012950               3442 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus coagulation factor II (thrombin) receptor (F2r),
            mRNA.
ACCESSION   NM_012950
VERSION     NM_012950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3442)
  AUTHORS   El-Gazar,A.A., Soubh,A.A., Abdallah,D.M., Ragab,G.M. and
            El-Abhar,H.S.
  TITLE     Elucidating PAR1 as a therapeutic target for delayed traumatic
            brain injury: Unveiling the PPAR-gamma/Nrf2/HO-1/GPX4 axis to
            suppress ferroptosis and alleviate NLRP3 inflammasome activation in
            rats
  JOURNAL   Int Immunopharmacol 139, 112774 (2024)
   PUBMED   39067398
  REMARK    GeneRIF: Elucidating PAR1 as a therapeutic target for delayed
            traumatic brain injury: Unveiling the PPAR-gamma/Nrf2/HO-1/GPX4
            axis to suppress ferroptosis and alleviate NLRP3 inflammasome
            activation in rats.
REFERENCE   2  (bases 1 to 3442)
  AUTHORS   Bohovyk,R., Khedr,S., Levchenko,V., Stefanenko,M., Semenikhina,M.,
            Kravtsova,O., Isaeva,E., Geurts,A.M., Klemens,C.A., Palygin,O. and
            Staruschenko,A.
  TITLE     Protease-Activated Receptor 1-Mediated Damage of Podocytes in
            Diabetic Nephropathy
  JOURNAL   Diabetes 72 (12), 1795-1808 (2023)
   PUBMED   37722138
  REMARK    GeneRIF: Protease-Activated Receptor 1-Mediated Damage of Podocytes
            in Diabetic Nephropathy.
REFERENCE   3  (bases 1 to 3442)
  AUTHORS   Onimaru,H., Fukushi,I., Ikeda,K., Yazawa,I., Takeda,K., Okada,Y.
            and Izumizaki,M.
  TITLE     Cell Responses of the Ventrolateral Medulla to PAR1 Activation and
            Changes in Respiratory Rhythm in Newborn Rat En Bloc
            Brainstem-Spinal Cord Preparations
  JOURNAL   Neuroscience 528, 89-101 (2023)
   PUBMED   37557948
  REMARK    GeneRIF: Cell Responses of the Ventrolateral Medulla to PAR1
            Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc
            Brainstem-Spinal Cord Preparations.
REFERENCE   4  (bases 1 to 3442)
  AUTHORS   Xu,P., Zhan,H., Zhang,R., Xu,X.J., Zhang,Y., Le,Y. and Bi,J.G.
  TITLE     Early growth response factor 1 upregulates pro-fibrotic genes
            through activation of TGF-beta1/Smad pathway via transcriptional
            regulation of PAR1 in high-glucose treated HK-2 cells
  JOURNAL   Mol Cell Endocrinol 572, 111953 (2023)
   PUBMED   37172885
  REMARK    GeneRIF: Early growth response factor 1 upregulates pro-fibrotic
            genes through activation of TGF-beta1/Smad pathway via
            transcriptional regulation of PAR1 in high-glucose treated HK-2
            cells.
REFERENCE   5  (bases 1 to 3442)
  AUTHORS   Wang,A., Gu,X., Wang,C., Li,Y., Deng,F., Fang,J., Chen,N., Li,Q.
            and Tang,L.
  TITLE     TRAP-induced PAR1 expression with its mechanism during AMI in a rat
            model
  JOURNAL   BMC Cardiovasc Disord 23 (1), 97 (2023)
   PUBMED   36809978
  REMARK    GeneRIF: TRAP-induced PAR1 expression with its mechanism during AMI
            in a rat model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3442)
  AUTHORS   Capers,Q. 4th, Laursen,J.B., Fukui,T., Rajagopalan,S., Mori,I.,
            Lou,P., Freeman,B.A., Berrington,W.R., Griendling,K.K.,
            Harrison,D.G., Runge,M.S., Alexander,R.W. and Taylor,W.R.
  TITLE     Vascular thrombin receptor regulation in hypertensive rats
  JOURNAL   Circ Res 80 (6), 838-844 (1997)
   PUBMED   9168786
REFERENCE   7  (bases 1 to 3442)
  AUTHORS   Molino,M., Bainton,D.F., Hoxie,J.A., Coughlin,S.R. and Brass,L.F.
  TITLE     Thrombin receptors on human platelets. Initial localization and
            subsequent redistribution during platelet activation
  JOURNAL   J Biol Chem 272 (9), 6011-6017 (1997)
   PUBMED   9038223
REFERENCE   8  (bases 1 to 3442)
  AUTHORS   Nelken,N.A., Soifer,S.J., O'Keefe,J., Vu,T.K., Charo,I.F. and
            Coughlin,S.R.
  TITLE     Thrombin receptor expression in normal and atherosclerotic human
            arteries
  JOURNAL   J Clin Invest 90 (4), 1614-1621 (1992)
   PUBMED   1328304
REFERENCE   9  (bases 1 to 3442)
  AUTHORS   Zhong,C., Hayzer,D.J., Corson,M.A. and Runge,M.S.
  TITLE     Molecular cloning of the rat vascular smooth muscle thrombin
            receptor. Evidence for in vitro regulation by basic fibroblast
            growth factor
  JOURNAL   J Biol Chem 267 (24), 16975-16979 (1992)
   PUBMED   1324917
REFERENCE   10 (bases 1 to 3442)
  AUTHORS   Vu,T.K., Hung,D.T., Wheaton,V.I. and Coughlin,S.R.
  TITLE     Molecular cloning of a functional thrombin receptor reveals a novel
            proteolytic mechanism of receptor activation
  JOURNAL   Cell 64 (6), 1057-1068 (1991)
   PUBMED   1672265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085759.1 and CV116337.1.
            
            On Nov 23, 2005 this sequence version replaced NM_012950.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC085759.1 [ECO:0000345]
            RNAseq introns           :: single sample supports all introns
                                        SAMN12840105, SAMN12840110
                                        [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2790              BC085759.1         1-2790
            2791-2943           CV116337.1         590-742
            2944-3442           BC085759.1         2943-3441
FEATURES             Location/Qualifiers
     source          1..3442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3442
                     /gene="F2r"
                     /gene_synonym="Par1; TRGPC"
                     /note="coagulation factor II (thrombin) receptor"
                     /db_xref="GeneID:25439"
                     /db_xref="RGD:2586"
     exon            1..153
                     /gene="F2r"
                     /gene_synonym="Par1; TRGPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1364
                     /gene="F2r"
                     /gene_synonym="Par1; TRGPC"
                     /note="proteinase-activated receptor 1; PAR-1; Thrombin
                     receptor; protease-activated receptor 1; coagulation
                     factor II receptor"
                     /codon_start=1
                     /product="proteinase-activated receptor 1 precursor"
                     /protein_id="NP_037082.2"
                     /db_xref="GeneID:25439"
                     /db_xref="RGD:2586"
                     /translation="MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNP
                     RSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGY
                     LTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVS
                     VLPFKISYYFSGTDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPIQSL
                     SWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSY
                     YFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFG
                     PTNVLLIVHYLLLSDSPGTETAYFAYLLCVCVSSVSCCIDPLIYYYASSECQKHLYSI
                     LCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA"
     exon            154..3423
                     /gene="F2r"
                     /gene_synonym="Par1; TRGPC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgagctg ctcctaagaa agtaggcgac cgcggtcgcc gggccgcgcg ggcagcctcg
       61 ggacaatggg gccccggcgc ttgctgctcg tcgcggtcgg cctcagcctg tgcggtcctt
      121 tgctgtcttc ccgcgttcct atgagacagc cagaatctga gaggatgtat gctacgccgt
      181 atgctacgcc aaacccccgc tcattttttc tcaggaatcc cagtgaagat acatttgaac
      241 agttccccct aggggatgag gaggagaaaa atgaaagcat accgctcgag ggcagggcag
      301 tctacttaaa taaaagccgt tttcctccca tgccgcctcc tcccttcatc tccgaggacg
      361 cctccggata tctgaccagc ccctggctga cgctcttcat accctccgtg tacacgtttg
      421 tgttcatagt cagccttccc ctgaacatcc tggccatcgc tgtgtttgtc tttcggatga
      481 aggtcaagaa gccggccgtg gtgtacatgc tgcacctggc catggccgat gtcctcttcg
      541 tgtccgtgct ccccttcaag atcagctact acttctccgg caccgattgg cagttcgggt
      601 ccggaatgtg tcgcttcgcc accgcagcgt tttattgtaa catgtacgcc tccatcatgc
      661 tcatgacagt cataagcatt gaccggttcc tggcagtggt gtaccccatc cagtccctgt
      721 cctggcgcac tctgggccga gccaacttca cctgcgtggt catctgggtg atggccatca
      781 tgggggtggt gcccctcctc ctcaaagagc agaccaccca ggttccgggg ctcaacatca
      841 ccacctgcca cgacgtcctc aacgagaccc tgctgcatgg cttttactcg tactatttct
      901 ccgccttctc cgccatcttc tttcttgtgc cgttgatcat ttccacagtc tgctacacgt
      961 ccatcatccg atgcctcagc tcctccgcgg tggcgaaccg gagcaagaag tcgcgggctt
     1021 tgttcctgtc cgccgccgtg ttctgcatct tcatcgtctg ctttgggccc accaacgtcc
     1081 tcctgattgt gcactacctg ctcctctccg acagtcctgg cacagagacg gcctattttg
     1141 cttacctcct ctgcgtctgc gtgagcagcg tgagctgctg catcgacccc ttgatttact
     1201 actatgcctc ctccgagtgc cagaagcacc tttacagcat tttgtgctgc agagaaagct
     1261 ctgattccaa cagttgcaac agcaccggcc agctgatgcc cagtaagatg gatacctgct
     1321 ctagccacct gaataatagc atatacaaaa agctactagc ttagggaaag ggtggctgga
     1381 aggttccatg aagaaaaggt tggaaagtga acagctgggg aacccccatc agtccctggc
     1441 aagaactgta ttgacttcaa cgccttaaga aaaccgccaa cgtctgattt gcatgcatac
     1501 ttcttacaag tgctatcaag tgtatagatt ggataatcac cagcaaggtg atgggaacgg
     1561 agtcaaggtt tccagtgttg cttagtgctg ggatagtagt tgagcgtcac ctcttctata
     1621 tctaggtgac tttaacatac aggtggtgtg cacacacaca gtggcagtgc agggtggatt
     1681 ctgcgctttg acgctttctt gtttattccc tggcagttgc tatagaaata atctgattct
     1741 ctgacttaat aaagtctggg ttggtggatg ctagccctgg gcagctgaag accccagtga
     1801 tagggaagaa gcccatagtt tagacttaag acagcttttg cctatgtgtc tatatttata
     1861 tattttcaaa ttatttgata gtaatgttta gtgatggaag gatgagacag tattacctgt
     1921 gtaggggaag gtcttgaaca accacagttt aagaattatc aaagcagttg aaaagccccg
     1981 ttttgatacg caatttactt acaaaatacg tggaccaaga ctgagcataa gactcgccag
     2041 gaatgtaaga aacctttcaa agcagccaag cctgataact agacacagcc atctgcatgg
     2101 aggcctctga gcatgaggta tatcataccc cttcagctat gcctcccaga gagcagagat
     2161 gaggaccacc aggcccactc caccctgcta ggggtctcat ttgctgtgaa ctgattatgt
     2221 caattagaaa ttggcaaggg aggggatgcc atcttgggag gcaataacac ctgcacatct
     2281 gacaatcgga gaaaggtgtg tttacatcca gcagctgtcc cgcaaggctg gcccttgcac
     2341 agacagacac acccatgtgc cctggtcaca ctgttggata gtgggccgta gactgactga
     2401 ctgtcggaga atagctgagt cctgccctta ctcaggcagc gcagagagct ggcacacggt
     2461 cagctgtgac gtatgcgctg caaaccatcg cacatagaag ttgtcattag ctggatgtca
     2521 ccaagcatat gtcacacaag cacggcctat cagctaaacc gctttggata tctgagtctc
     2581 tgcttccggt aactatagat tgggataaag acacaataca agatgtatat ttttaataca
     2641 taagcccttc agtctacaat aattagatgc tatttattta caaatgtttt gttaaaaatt
     2701 actcagatca gcctggcatt ttgtcgcatg cctttaagcc cagtaggtgg gaggcagagg
     2761 cagtcagatg gtaaacaact tttttttttt tgttcttttt ttcagagctg gggaccgaac
     2821 ccaggacctt gtgcttgctc ggcaagtgct ctaccactga gctaaatccc caaccccggt
     2881 aaacaacttt tttaagaagc aagcaaacac actgaagtcc agttttaaga aatatatagg
     2941 tcagtttggt taaaaataat aataatgaaa ggaaatttca ttgattgaaa ttgattgcaa
     3001 tgtaggaaaa ttagcctgta tttctctcaa gagttactga agttgttttt aaagtctttt
     3061 aatgccacag tgactaacaa gcatataaaa atcttcatgc ctttgacaaa ttaatttaga
     3121 agttaattta aaacatatcc ttttcctggt taaaaaaata tgttggcatt ttaagcagat
     3181 aagactagaa agtatttaag aaaacaaagt atttcccaat actgtagaat agcttccatg
     3241 aaactcccct agttgtctgg ttaactctgt tcctgtgttg atttatctaa atcattgact
     3301 ccctgtcctg tgctctgtga cttaacgtaa ctgttaccac tgcacttgtg aactttcgtg
     3361 tcattgtttt gtgttcaccc tcttttttta aaaaatatat taataaacta aaaacctgct
     3421 tggaaaaaaa aaaaaaaaaa aa
//
