LOCUS       NM_022924               2005 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus coagulation factor II, thrombin (F2), mRNA.
ACCESSION   NM_022924
VERSION     NM_022924.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Zou,Y., Guo,H., Zhang,Y., Zhang,Z., Liu,Y., Wang,J., Lu,H. and
            Qian,Z.
  TITLE     Analysis of coagulation parameters in patients with COVID-19 in
            Shanghai, China
  JOURNAL   Biosci Trends 14 (4), 285-289 (2020)
   PUBMED   32350161
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Wan,S., Xiang,Y., Fang,W., Zheng,Y., Li,B., Hu,Y., Lang,C.,
            Huang,D., Sun,Q., Xiong,Y., Huang,X., Lv,J., Luo,Y., Shen,L.,
            Yang,H., Huang,G. and Yang,R.
  TITLE     Clinical features and treatment of COVID-19 patients in northeast
            Chongqing
  JOURNAL   J Med Virol 92 (7), 797-806 (2020)
   PUBMED   32198776
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Zheng,Y., Xu,H., Yang,M., Zeng,Y., Chen,H., Liu,R., Li,Q., Zhang,N.
            and Wang,D.
  TITLE     Epidemiological characteristics and clinical features of 32
            critical and 67 noncritical cases of COVID-19 in Chengdu
  JOURNAL   J Clin Virol 127, 104366 (2020)
   PUBMED   32302954
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Yan,Y., Yang,Y., Wang,F., Ren,H., Zhang,S., Shi,X., Yu,X. and
            Dong,K.
  TITLE     Clinical characteristics and outcomes of patients with severe
            covid-19 with diabetes
  JOURNAL   BMJ Open Diabetes Res Care 8 (1) (2020)
   PUBMED   32345579
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Lisman,T., Kleiss,S., Patel,V.C., Fisher,C., Adelmeijer,J., Bos,S.,
            Singanayagam,A., Stoy,S.H., Shawcross,D.L. and Bernal,W.
  TITLE     In vitro efficacy of pro- and anticoagulant strategies in
            compensated and acutely ill patients with cirrhosis
  JOURNAL   Liver Int 38 (11), 1988-1996 (2018)
   PUBMED   29768734
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Takahashi,H., Wada,K., Niwano,H. and Shibata,A.
  TITLE     Comparison of prothrombin fragment 1 + 2 with thrombin-antithrombin
            III complex in plasma of patients with disseminated intravascular
            coagulation
  JOURNAL   Blood Coagul Fibrinolysis 3 (6), 813-818 (1992)
   PUBMED   1336986
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Banfield,D.K. and MacGillivray,R.T.
  TITLE     Partial characterization of vertebrate prothrombin cDNAs:
            amplification and sequence analysis of the B chain of thrombin from
            nine different species
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2779-2783 (1992)
   PUBMED   1557383
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Iwahana,H., Yoshimoto,K., Shigekiyo,T., Shirakami,A., Saito,S. and
            Itakura,M.
  TITLE     Detection of a single base substitution of the gene for prothrombin
            Tokushima. The application of PCR-SSCP for the genetic and
            molecular analysis of dysprothrombinemia
  JOURNAL   Int J Hematol 55 (1), 93-100 (1992)
   PUBMED   1349838
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   Vu,T.K., Hung,D.T., Wheaton,V.I. and Coughlin,S.R.
  TITLE     Molecular cloning of a functional thrombin receptor reveals a novel
            proteolytic mechanism of receptor activation
  JOURNAL   Cell 64 (6), 1057-1068 (1991)
   PUBMED   1672265
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   Cavanaugh,K.P., Gurwitz,D., Cunningham,D.D. and Bradshaw,R.A.
  TITLE     Reciprocal modulation of astrocyte stellation by thrombin and
            protease nexin-1
  JOURNAL   J Neurochem 54 (5), 1735-1743 (1990)
   PUBMED   1691280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EX492416.1, DY318887.1, DW392486.1, DW391550.1 and CO575133.1.
            
            On Nov 29, 2007 this sequence version replaced NM_022924.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               EX492416.1         22-697
            677-1239            DY318887.1         206-768
            1240-1541           DW392486.1         82-383
            1542-1748           DW391550.1         25-231              c
            1749-2005           CO575133.1         65-321
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2005
                     /gene="F2"
                     /note="coagulation factor II, thrombin"
                     /db_xref="GeneID:29251"
                     /db_xref="RGD:61996"
     exon            1..94
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1869
                     /gene="F2"
                     /EC_number="3.4.21.5"
                     /note="prothrombin; coagulation factor 2; thrombin"
                     /codon_start=1
                     /product="prothrombin precursor"
                     /protein_id="NP_075213.2"
                     /db_xref="GeneID:29251"
                     /db_xref="RGD:61996"
                     /translation="MSHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRA
                     NSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFM
                     DCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLKENFCRN
                     PDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSPPLGECLLE
                     RGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWC
                     FVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGL
                     RPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLI
                     SDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYN
                     WRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWT
                     TNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGG
                     PFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR"
     exon            95..258
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..283
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..334
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..440
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..577
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..892
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1006
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1133
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1301
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1475
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1657
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1728
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1983
                     /gene="F2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagctgac acactatgtc gcacgtccgc ggcctgggcc tacctggctg cctggctctg
       61 gctgccctgg ctagcctggt acacagtcag catgtgttcc tggcccctca gcaagcactg
      121 tcgctgctcc agcgggtccg cagagccaac agcggcttcc tggaggagct ccgaaagggc
      181 aacctggagc gtgagtgcgt ggaagagcag tgcagctatg aggaggcttt tgaggccctg
      241 gagtctcccc aagacacgga tgtgttctgg gccaagtaca cagtgtgtga ttcagtgagg
      301 aaacctcgag agaccttcat ggactgtcta gaaggtcgct gtgctatgga tctgggtctg
      361 aactaccatg ggaatgtgag tgtcacccat accggcatcg agtgtcagct gtggcgaagc
      421 cgctacccac acaggcctga catcaactcc accacccatc ctggggctga cctgaaggag
      481 aacttctgcc gaaatccaga cagcagcacc tcagggccct ggtgctacac cacagaccct
      541 actgtgcgca gagaggaatg cagtatccct gtctgtggtc aggagggccg taccactgtg
      601 aaaatgactc ctcgctcaag aggttccaag gagaatctgt cgcctccatt gggagagtgc
      661 ctcctcgagc gtggccggct gtaccagggg aacttagctg tgacaacact tgggtccccc
      721 tgcctggcct gggacagttt gccaaccaag accctgagca agtaccagaa cttcgaccct
      781 gaggtgaaac tcgtgcaaaa cttctgccgc aatccagacc gggatgagga gggcgcgtgg
      841 tgctttgttg cgcagcagcc tggttttgaa tactgcagcc tcaactactg tgatgaagcg
      901 gtgggagagg agaaccatga cggggacgag tccatcgcag gacgcaccac cgacgcggag
      961 ttccacacct tcttcgatga gaggactttc ggccttgggg aggcagactg tggcctgcgg
     1021 cctttgttcg agaagaagtc cttgacagac aaaacggaaa aggagcttct tgattcttac
     1081 atagatgggc gcatcgtgga gggctgggac gctgagaagg gtatcgcccc atggcaggtg
     1141 atgctttttc ggaagagtcc ccaagagctg ctgtgtggag ccagccttat cagtgatcga
     1201 tgggtcctca ctgctgccca ctgcattctg tacccaccct gggacaagaa cttcactgag
     1261 aatgacctcc tggtgcgcat tggcaagcac tccagaacca gatatgagcg gaatgttgaa
     1321 aagatctcca tgctggaaaa gatctacatc caccccagat ataactggcg ggaaaaccta
     1381 gaccgtgaca ttgctctgct caagctaaag aagccagtgc ccttcagtga ctacattcac
     1441 cccgtgtgct tgccagacaa gcagacagta accagtttgc tccaggctgg ttataaaggg
     1501 cgggtgacag gctggggcaa ccttcgggag acgtggacaa ctaacatcaa cgagatacag
     1561 cccagcgtcc tgcaggtggt gaacctgccc attgtagagc gaccagtgtg caaggcctct
     1621 acccggatac gcattactga caacatgttc tgtgctggct tcaaggtgaa tgacaccaag
     1681 cgaggagatg cttgtgaagg tgacagtggg ggaccttttg tcatgaagag cccctacaac
     1741 caccgctggt accaaatggg tattgtctcc tggggtgaag gctgtgaccg gaatgggaaa
     1801 tatggcttct acacgcacgt gttccgtctg aaaaggtgga tgcagaaagt cattgatcag
     1861 catagatagg tttgtgggtg ggtgagagac ccacagtatg ggatcctcat tgcaaaatca
     1921 cagaaaccag tcaaaatatt tttgtggttt gtttctgttc tcaataaaag tgattgtcag
     1981 taaaaaaaaa aaaaaaaaaa aaaaa
//
