LOCUS       NM_021698               3468 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus coagulation factor XIII A1 chain (F13a1), mRNA.
ACCESSION   NM_021698
VERSION     NM_021698.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3468)
  AUTHORS   Thomas,A., Biswas,A., Dodt,J., Philippou,H., Hethershaw,E.,
            Ensikat,H.J., Ivaskevicius,V. and Oldenburg,J.
  TITLE     Coagulation Factor XIIIA Subunit Missense Mutations Affect
            Structure and Function at the Various Steps of Factor XIII Action
  JOURNAL   Hum Mutat 37 (10), 1030-1041 (2016)
   PUBMED   27363989
REFERENCE   2  (bases 1 to 3468)
  AUTHORS   Katona,E., Muszbek,L., Devreese,K., Kovacs,K.B., Bereczky,Z.,
            Jonkers,M., Shemirani,A.H., Mondelaers,V. and Ermens,A.A.
  TITLE     Factor XIII deficiency: complete phenotypic characterization of two
            cases with novel causative mutations
  JOURNAL   Haemophilia 20 (1), 114-120 (2014)
   PUBMED   24118344
REFERENCE   3  (bases 1 to 3468)
  AUTHORS   Ivaskevicius,V., Biswas,A., Thomas,A., Lyonga,S., Rott,H.,
            Halimeh,S., Kappert,G., Klammroth,R., Scholz,U., Eberl,W.,
            Harbrecht,U., Gnida,C., Hertfelder,H.J., Marquardt,N. and
            Oldenburg,J.
  TITLE     A common F13A1 intron 1 variant IVS1+12(A) is associated with mild
            FXIII deficiency in Caucasian population
  JOURNAL   Ann Hematol 92 (7), 975-979 (2013)
   PUBMED   23508224
REFERENCE   4  (bases 1 to 3468)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 3468)
  AUTHORS   Tsujimoto,I., Moriya,K., Sakai,K., Dickneite,G. and Sakai,T.
  TITLE     Critical role of factor XIII in the initial stages of carbon
            tetrachloride-induced adult liver remodeling
  JOURNAL   Am J Pathol 179 (6), 3011-3019 (2011)
   PUBMED   22019897
REFERENCE   6  (bases 1 to 3468)
  AUTHORS   Oshitani,N., Kitano,A., Hara,J., Suzuki,N., Aoki,T., Yasuda,K.,
            Watanabe,Y., Obayashi,M., Obata,A., Nakamura,S. et al.
  TITLE     Deficiency of blood coagulation factor XIII in Crohn's disease
  JOURNAL   Am J Gastroenterol 90 (7), 1116-1118 (1995)
   PUBMED   7611208
REFERENCE   7  (bases 1 to 3468)
  AUTHORS   Mikkola,H., Syrjala,M., Rasi,V., Vahtera,E., Hamalainen,E.,
            Peltonen,L. and Palotie,A.
  TITLE     Deficiency in the A-subunit of coagulation factor XIII: two novel
            point mutations demonstrate different effects on transcript levels
  JOURNAL   Blood 84 (2), 517-525 (1994)
   PUBMED   8025280
REFERENCE   8  (bases 1 to 3468)
  AUTHORS   Board,P., Coggan,M. and Miloszewski,K.
  TITLE     Identification of a point mutation in factor XIII A subunit
            deficiency
  JOURNAL   Blood 80 (4), 937-941 (1992)
   PUBMED   1353995
REFERENCE   9  (bases 1 to 3468)
  AUTHORS   Moja,E.A., Mendelson,W.B., Stoff,D.M., Gillin,J.C. and Wyatt,R.J.
  TITLE     Reduction of REM sleep by a tryptophan-free amino acid diet
  JOURNAL   Life Sci 24 (16), 1467-1470 (1979)
   PUBMED   224277
REFERENCE   10 (bases 1 to 3468)
  AUTHORS   Pastorova,V.E., Umarova,B.A. and Sukhanova,S.A.
  TITLE     [Rat thrombocyte factor XIII and its role in platelet aggregation]
  JOURNAL   Biull Eksp Biol Med 87 (2), 99-101 (1979)
   PUBMED   420942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN931132.1, BQ207464.1, Y12502.1, JAXUCZ010000017.1, DY575207.1 and
            BF560108.1.
            
            On Oct 12, 2007 this sequence version replaced NM_021698.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12502.1, SRR26643284.18998.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               DN931132.1         407-682
            277-434             BQ207464.1         252-409             c
            435-449             Y12502.1           402-416
            450-672             BQ207464.1         14-236              c
            673-706             Y12502.1           640-673
            707-708             JAXUCZ010000017.1  28097454-28097455
            709-793             Y12502.1           676-760
            794-923             JAXUCZ010000017.1  28123045-28123174
            924-1025            Y12502.1           762-863
            1026-1155           JAXUCZ010000017.1  28123045-28123174
            1156-1219           Y12502.1           994-1057
            1220-1289           JAXUCZ010000017.1  28125653-28125722
            1290-1376           Y12502.1           1128-1214
            1377-2574           JAXUCZ010000017.1  28196763-28197960
            2575-2655           Y12502.1           1216-1296
            2656-3293           DY575207.1         1-638
            3294-3596           BF560108.1         46-348
            3597-4794           JAXUCZ010000017.1  28196763-28197960
FEATURES             Location/Qualifiers
     source          1..3468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3468
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /note="coagulation factor XIII A1 chain"
                     /db_xref="GeneID:60327"
                     /db_xref="RGD:621495"
     exon            1..54
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            55..202
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2271
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /EC_number="2.3.2.13"
                     /note="transglutaminase A chain; protein-glutamine
                     gamma-glutamyltransferase A chain; coagulation factor
                     XIIIa; coagulation factor XIII, A1 subunit; coagulation
                     factor XIII, A1 polypeptide"
                     /codon_start=1
                     /product="coagulation factor XIII A chain"
                     /protein_id="NP_067730.2"
                     /db_xref="GeneID:60327"
                     /db_xref="RGD:621495"
                     /translation="MSDTPATTFGGRRAIPPNNSNAAEVDLPTEDLQGLVPRGVSLKD
                     YLNVTAVHLFKERWDSNKIDHHTDKYDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRV
                     EYVIGRYPQENKGTYIPVPVVTELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRM
                     YVAVWTPYGILRTQRDPETDTYILFNPWCEEDAVYLDDEKEREEYVLNDIGVIFHGDF
                     NDIKSRSWSYGQFEDGILDACLYVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVL
                     VGSWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVFAGVFNTFLRCLGIPAR
                     VITNYFSAHDNDANLQMDIFLEEDGSVSSKLTKDSVWNYHCWNEAWMTRPDLPVGFGG
                     WQAVDSTPQENSDGMYRCGPASVQAVKHGHVCFQFDAPFVFAEVNSDLVYITAKKDGT
                     HVVENVDATHIGKLIVTKEIGGDGMQDITDTYKFQEGQEEERLALETALMYGAKKTLN
                     TEGVVKSRSDVDMNFDVENAVLGKDFRVTITFQNNSSNLYTILAYLSGNITFYTGVSK
                     KEFKTESFEVTLDPLSLEKKEVLIRAGEYMSYLLEQGLLHFFVTARINETRVVLAKQK
                     SIVLTIPKVTIKVRGTAMVGSDMVVTVEFTNPLKETLKNVWLHLEGPGVMRPKRKMFR
                     EIRPNATVQWEEVCQPWVSGHRKLIASMTSDSLRHVYGELDLQIRRRPTV"
     exon            203..391
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            392..643
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            644..762
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            763..870
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1045
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1184
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1288
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1377
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1531
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1819
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1980
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2117
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..3468
                     /gene="F13a1"
                     /gene_synonym="F13a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacccagagg cacacgggga gactaccaga gcaccctctc aggagcacaa gcaggatcca
       61 gtaaagctga aaatgtcgga tactccagca actacctttg ggggacggcg agcaatccca
      121 cccaacaact ctaatgcagc agaagtggac ctcccgactg aggatctgca gggcctggtg
      181 cccaggggtg tcagcctgaa agattacttg aatgtcacag ctgttcacct gttcaaggag
      241 agatgggaca gcaacaagat tgatcaccac acagacaaat atgacaacaa taagttgatt
      301 gtccgcagag gacagacttt ctacatccag attgacttca atcgcccata tgaccccagg
      361 aaggatctct tcagagtgga atatgtcatt ggtcgctacc ctcaggagaa taagggcacc
      421 tacatcccag tgccggtagt gacggagctg caaagcggaa agtggggggc caaggttatc
      481 atgaatgagg acaggtctgt gcggctttcc gttcagtctt cccccgaatg catcgtgggg
      541 aaattccgca tgtatgttgc cgtctggact ccctatggca tcctgcgtac tcagagagac
      601 ccggaaacag acacatacat tctcttcaat ccttggtgcg aagaagacgc tgtgtatctg
      661 gatgatgaga aagaaagaga agagtacgtc ctaaatgaca tcggagtgat atttcatggg
      721 gacttcaatg acatcaagag cagaagctgg agctatggcc agtttgaaga tggcatcctg
      781 gacgcttgct tgtatgtgat ggacaaagct gagatggacc tttctggcag agggaacccc
      841 atcaaagtca gccgagttgg atcagcaatg gtgaatgcca aggatgacga aggtgttctt
      901 gttggatcat gggacaatgt ctatgcctac ggcatccctc catcagcctg gacaggaagt
      961 gttgacattc tactagaata cagaagctca gaaacaccag tccgatatgg ccagtgctgg
     1021 gtttttgctg gtgtctttaa cacattttta aggtgccttg gaatccctgc gagagtcatt
     1081 accaattact tctcagccca cgacaatgat gccaatttgc aaatggacat cttcctggaa
     1141 gaagatggga gtgtgagctc caaactcacc aaggattcag tgtggaacta ccactgctgg
     1201 aatgaagcat ggatgacgag gcctgatctc cctgttggat ttggaggatg gcaagctgtg
     1261 gacagcacac cccaagaaaa cagcgatggc atgtaccgct gtggccctgc ctctgttcaa
     1321 gccgttaagc acggccatgt ctgcttccaa tttgatgccc catttgtttt tgcagaggtc
     1381 aacagtgatc ttgtttacat cacagctaag aaagatggca cccacgtggt agagaacgtg
     1441 gatgccaccc acatcgggaa gctaattgtg accaaagaaa ttggaggaga tgggatgcag
     1501 gatatcacgg atacttacaa atttcaggaa ggccaagaag aagagagact agcccttgaa
     1561 actgccctga tgtatggagc caagaagacc ctcaatactg aaggcgtggt caaatccaga
     1621 tctgatgtgg acatgaactt tgatgtggaa aatgctgtgc tgggaaaaga cttcagagtg
     1681 actatcacct tccagaacaa tagctccaat ctgtacacca tcctggccta tctttccggc
     1741 aacatcacct tctacactgg ggtatccaag aaagagttca agacagagtc ctttgaagtg
     1801 acgctggatc ccttgtcctt agagaaaaag gaggtgctga tcagagcagg cgagtatatg
     1861 agctaccttc tggaacaggg cctcctgcac ttcttcgtca ctgcacgcat caacgagacc
     1921 agggtcgtcc tggccaagca gaagtccata gtgctgacta tccccaaggt caccatcaag
     1981 gtccgaggca ctgccatggt tggctctgat atggttgtga ctgttgagtt cacaaatcct
     2041 ttgaaagaaa cgctaaaaaa tgtctggctt cacttggaag gtcctggagt gatgagaccc
     2101 aagaggaaga tgttccgtga aatccggccc aacgccactg tgcagtggga agaagtctgt
     2161 cagccttggg tctctggtca tcggaagctg attgccagca tgaccagtga ctccctgaga
     2221 catgtgtatg gagagctgga cctgcagatt cgaagacgac ctactgtata aatgcccagg
     2281 aggctcgaat gggctggggc acatggccta ttgcagtctt ggttatggcc attctaacgc
     2341 aaaacatagc tagctcttgc tttaatttgg atgtgaagac taagacagat tccagcatag
     2401 agatgctatg tatttcatag acacgccttt ccaaacaggc tattggacaa gggagttaga
     2461 tttgaattgt tccacctcca aagggtctga gcattagctt aattaagcta taattaagcc
     2521 ttcatagctc ataagaatga aagccatcat ttatcactgc aaatggctac agctccacag
     2581 atcagaggtc tgcccatgag cagggaggat gtgcccaata cctggcctca attaagaatt
     2641 ctgattcccc actcagtctt ttaggggtaa catactcccc aaaggaaagg gtgtccacaa
     2701 tcagatccta aaaattctat tcccctttct tggaatcagg ttgaaccctc cgtattaaaa
     2761 tatttttttc caggaattaa gcccaacatc atttttcttc ctggcaaagc cagagaaagg
     2821 tctttcatct tgcacctgca gccaaggagc tgcctgccaa atttcacaga ttaccttgtg
     2881 agaagatgtg gccccacatt aacaaattgc atttgtgggg aacttaatca cctaagagga
     2941 gataaggaag caggtgcggt gctcagatct attaaataat gcagtttatg gtgcacttta
     3001 taggtgtcac actgtgtctg atcagcaaga atgaataacc ttactttaac cctttctcgg
     3061 gcagagaact agaaagtaag ggaactgatt taggattgga gaactgaggg attagcatcc
     3121 atggttggtg agtagacatc acctgtctct atgagatcat cacattcaca caatgacact
     3181 ggcaaaaaca gaaacagctt gaggaactag cagatttggt aggcacctgg aagaccaaac
     3241 agactttgag cacccccttt cttcgtgttt cctatatcaa gcccttgcct aaacccttga
     3301 gtgctcagag ctaagacact caggcttgca aatggccagc attacccttg acccaaggac
     3361 agaggacacc ttatgtgcca aggccccaac attggcactt atagttaaaa tttcccattg
     3421 aaatgccttg agtgtgattt aagtcaggag actatgaaaa aaaaagaa
//
