LOCUS       NM_001014006            2128 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus coagulation factor XII (F12), mRNA.
ACCESSION   NM_001014006 XM_225172
VERSION     NM_001014006.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Papageorgiou,P.C., Chan,C.T., Yeo,E.L., Backx,P.H. and Floras,J.S.
  TITLE     Coagulation factor XIIa-kinin-mediated contribution to hypertension
            of chronic kidney disease
  JOURNAL   J Hypertens 32 (7), 1523-33 (2014)
   PUBMED   24733030
  REMARK    GeneRIF: FXIIa-kininogen mediated vasoconstriction contributes
            significantly to CKD hypertension in Brown Norway rats.
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Dendrinos,S., Deliveliotou,A., Anastasiou,A. and Creatsas,G.K.
  TITLE     Role of coagulation factor XII in unexplained recurrent abortions
            in the Greek population
  JOURNAL   J Reprod Med 59 (1-2), 56-62 (2014)
   PUBMED   24597288
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Papageorgiou,P.C., Yeo,E.L., Backx,P.H. and Floras,J.S.
  TITLE     Activated plasma coagulation beta-Factor XII-induced
            vasoconstriction in rats
  JOURNAL   Clin Sci (Lond) 122 (12), 581-590 (2012)
   PUBMED   22216926
  REMARK    GeneRIF: beta-FXIIa infusion induces both adrenal
            catecholamine-mediated and adrenally independent increases in
            peripheral resistance
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Bork,K., Wulff,K., Meinke,P., Wagner,N., Hardt,J. and Witzke,G.
  TITLE     A novel mutation in the coagulation factor 12 gene in subjects with
            hereditary angioedema and normal C1-inhibitor
  JOURNAL   Clin Immunol 141 (1), 31-35 (2011)
   PUBMED   21849258
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Gordon,E.M., Gallagher,C.A., Johnson,T.R., Blossey,B.K. and Ilan,J.
  TITLE     Hepatocytes express blood coagulation factor XII (Hageman factor)
  JOURNAL   J Lab Clin Med 115 (4), 463-469 (1990)
   PUBMED   2324612
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Miyata,T., Kawabata,S., Iwanaga,S., Takahashi,I., Alving,B. and
            Saito,H.
  TITLE     Coagulation factor XII (Hageman factor) Washington D.C.: inactive
            factor XIIa results from Cys-571----Ser substitution
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8319-8322 (1989)
   PUBMED   2510163
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Chung,D.W., Fujikawa,K., McMullen,B.A. and Davie,E.W.
  TITLE     Human plasma prekallikrein, a zymogen to a serine protease that
            contains four tandem repeats
  JOURNAL   Biochemistry 25 (9), 2410-2417 (1986)
   PUBMED   3521732
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Saito,H. and Scialla,S.J.
  TITLE     Isolation and properties of an abnormal Hageman factor (Factor XII)
            molecule in a cross-reacting material-positive hageman trait plasma
  JOURNAL   J Clin Invest 68 (4), 1028-1035 (1981)
   PUBMED   6793628
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Mandle,R.J. Jr. and Kaplan,A.P.
  TITLE     Hageman-factor-dependent fibrinolysis: generation of fibrinolytic
            activity by the interaction of human activated factor XI and
            plasminogen
  JOURNAL   Blood 54 (4), 850-862 (1979)
   PUBMED   89876
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088187.1.
            
            On Apr 20, 2005 this sequence version replaced XM_225172.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2128
                     /gene="F12"
                     /gene_synonym="HAF"
                     /note="coagulation factor XII"
                     /db_xref="GeneID:306761"
                     /db_xref="RGD:1359175"
     exon            1..266
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2021
                     /gene="F12"
                     /gene_synonym="HAF"
                     /EC_number="3.4.21.38"
                     /note="hageman factor; factor XII"
                     /codon_start=1
                     /product="coagulation factor XII precursor"
                     /protein_id="NP_001014028.1"
                     /db_xref="GeneID:306761"
                     /db_xref="RGD:1359175"
                     /translation="MTALLFLGSLLMSLDLTLSAPPWKSKEFKDGAGDPSVVLTVDGK
                     LCHFPFQYHRRLYHKCIHKGQPGSRPWCATTPNFDEDQQWGYCLEPKKVKDHCSKHSP
                     CHKGGTCVNTPNGPHCLCPEHLTGKHCQREKCFESQLLKFFHENEIWFRTGPGGVARC
                     QCKGPQAVCKLLTSQVCRVNPCLNGGTCLLVEDHRLCHCPAGYAGPFCDLDLKATCYE
                     DRGLSYRGQAKTTLSGAPCQRWASEATYRNMTETQALSWGLGHHAFCRNPDNDTRPWC
                     YVWSGDRLSWDYCDLEQCQMPTLTSPVSPESHDMLKPRPPILQMPQFPSLSDALDNST
                     RNQNVVSRTSTVVCGQRFRKRLSSLRRVVGGLVALPGSHPYIAALYWGDSFCAGSLID
                     PCWVLTAAHCLQKRPAPEELTVVLGQDRHNQSCERCQTLAVHSYRLHEGFSSKTYQHD
                     LALLRLRGRKNSCAILSPHVQPVCLPSSAAPPSETVLCEVAGWGHQFEGAEEYATFLQ
                     EAQVPFISLDRCSSSNVHGDAILPGMLCAGFLEGGADACQGDSGGPLVCDEGVTERQL
                     TLRGVISWGSGCGDRNKPGVYTDVANYLDWIQEHTAF"
     exon            267..321
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            322..421
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            422..492
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            493..603
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            604..735
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            736..840
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1006
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1203
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1426
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1563
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1704
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1853
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2100
                     /gene="F12"
                     /gene_synonym="HAF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaaccca tctcggtact ctgcttccac cagccttgcc ctgctcacga gggttcgacg
       61 gcgctgttct tctgggcttt ctgtgaagtc tgtgctcctc aggcccagga gggagcttaa
      121 ccaatctcca cctctgaggt ttctgagacc tttgcccaca tctattgatc cttactctgg
      181 ggcaggcagc tgggccattg gcggacgcca tgacggctct gttgttcctg gggtctctgc
      241 tgatgagtct ggacttgaca ctttcggcgc caccgtggaa gtccaaggag ttcaaggacg
      301 gagctggcga tccctctgtg gttctcactg tggacgggaa gctctgccac tttccctttc
      361 agtaccaccg tcgcctgtac cacaaatgca tccacaaagg acagccaggc tccaggccct
      421 ggtgtgctac cacccccaac tttgacgagg accagcaatg gggatactgc ttggagccca
      481 agaaagtgaa agaccattgc agcaaacaca gcccctgcca caaaggaggg acgtgtgtca
      541 acacccccaa cggcccgcac tgtctctgcc ctgaacacct caccgggaaa cattgccaga
      601 gagagaaatg ctttgagtct cagctcctca agttcttcca tgagaatgag atatggttta
      661 gaactgggcc aggaggtgtg gccaggtgcc agtgcaaagg tcctcaggct gtttgcaagc
      721 tgctgaccag tcaggtttgc agggtcaatc cgtgccttaa tggaggcacc tgcctcctcg
      781 tggaggacca ccgactgtgc cactgccctg caggctatgc cggacctttt tgcgacttag
      841 accttaaggc gacttgctac gaagacaggg gtctcagcta ccggggccag gctaaaacta
      901 ctctgtcggg tgcaccatgt cagcggtggg cctcggaggc cacctaccgg aacatgactg
      961 agacgcaagc tctaagctgg ggcctgggcc accacgcatt ctgccggaac ccagataatg
     1021 acacacgtcc atggtgctac gtctggagtg gcgacaggct gagctgggac tactgcgacc
     1081 tggaacagtg ccagatgcca acgctcacat ctccggtttc ccctgagagt cacgacatgc
     1141 tgaagccccg gcctcccata ttgcagatgc ctcagttccc gtctctgtcc gatgcactag
     1201 acaactcgac ccgtaatcag aatgttgtgt ccaggaccag tacggtggtc tgcggacaga
     1261 ggtttcgcaa gcgactgtcc tcgctcaggc gcgtggtggg cggactagtg gctctgcctg
     1321 gatcgcatcc ctacatcgct gcactgtact ggggcgacag cttctgcgca ggcagtctca
     1381 tcgacccctg ctgggtgctg accgctgctc actgcttgca gaaacggcca gcgcccgagg
     1441 aactgacagt ggtacttggt caagatcgcc ataaccagag ctgcgagagg tgccagactc
     1501 tggctgtgca ctcctaccgc cttcacgagg gcttctcttc caaaacctac cagcatgatt
     1561 tggctctgct gcgcctgcgg gggaggaaaa acagctgcgc gatcttgtcg cctcatgtcc
     1621 agccggtgtg tctgcccagc agcgcggccc caccctctga gacagtgctc tgcgaggtgg
     1681 ccggctgggg tcatcagttc gagggggctg aagaatacgc cacctttctg caggaggcac
     1741 aggtaccctt catctccctg gatcgctgct ccagctctaa cgtgcacgga gacgccatcc
     1801 tgcctgggat gctttgtgct ggcttcttgg agggaggcgc cgatgcctgt cagggtgact
     1861 ccgggggtcc tctggtatgt gatgaaggag ttacagagcg tcagctcacc ctgcgaggag
     1921 tcatcagctg gggctccggc tgtggtgacc ggaacaagcc cggggtctac actgacgtgg
     1981 ccaattacct ggattggatc caggagcata ctgctttcta agtaaccagg gtcggtcctt
     2041 gcgaagctag tggctgggcc ccagggacac agaaactcaa taaagtgctt tgaaaacgtt
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
