LOCUS       NM_053796               1895 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus F11 receptor (F11r), mRNA.
ACCESSION   NM_053796
VERSION     NM_053796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   Scott,D.W., Tolbert,C.E. and Burridge,K.
  TITLE     Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
  JOURNAL   Mol Biol Cell 27 (9), 1420-1430 (2016)
   PUBMED   26985018
REFERENCE   2  (bases 1 to 1895)
  AUTHORS   Tornavaca,O., Chia,M., Dufton,N., Almagro,L.O., Conway,D.E.,
            Randi,A.M., Schwartz,M.A., Matter,K. and Balda,M.S.
  TITLE     ZO-1 controls endothelial adherens junctions, cell-cell tension,
            angiogenesis, and barrier formation
  JOURNAL   J Cell Biol 208 (6), 821-838 (2015)
   PUBMED   25753039
REFERENCE   3  (bases 1 to 1895)
  AUTHORS   Ikeo,K., Oshima,T., Shan,J., Matsui,H., Tomita,T., Fukui,H.,
            Watari,J. and Miwa,H.
  TITLE     Junctional adhesion molecule-A promotes proliferation and inhibits
            apoptosis of gastric cancer
  JOURNAL   Hepatogastroenterology 62 (138), 540-545 (2015)
   PUBMED   25916097
  REMARK    GeneRIF: JAM-A promotes proliferation and inhibits apoptosis of
            gastric cancer, suggesting that it has a pivotal role in gastric
            cancer progression.
REFERENCE   4  (bases 1 to 1895)
  AUTHORS   Mitchell,L.A., Ward,C., Kwon,M., Mitchell,P.O., Quintero,D.A.,
            Nusrat,A., Parkos,C.A. and Koval,M.
  TITLE     Junctional adhesion molecule A promotes epithelial tight junction
            assembly to augment lung barrier function
  JOURNAL   Am J Pathol 185 (2), 372-386 (2015)
   PUBMED   25438062
  REMARK    GeneRIF: These findings support a key role of JAM-A in promoting
            tight junction homeostasis and lung barrier function by
            coordinating interactions among claudins, the tight junction
            scaffold, and the cytoskeleton.
REFERENCE   5  (bases 1 to 1895)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1895)
  AUTHORS   Mandell,K.J., McCall,I.C. and Parkos,C.A.
  TITLE     Involvement of the junctional adhesion molecule-1 (JAM1) homodimer
            interface in regulation of epithelial barrier function
  JOURNAL   J Biol Chem 279 (16), 16254-16262 (2004)
   PUBMED   14749337
REFERENCE   7  (bases 1 to 1895)
  AUTHORS   Ostermann,G., Weber,K.S., Zernecke,A., Schroder,A. and Weber,C.
  TITLE     JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in
            transendothelial migration of leukocytes
  JOURNAL   Nat Immunol 3 (2), 151-158 (2002)
   PUBMED   11812992
REFERENCE   8  (bases 1 to 1895)
  AUTHORS   Ebnet,K., Suzuki,A., Horikoshi,Y., Hirose,T., Meyer Zu
            Brickwedde,M.K., Ohno,S. and Vestweber,D.
  TITLE     The cell polarity protein ASIP/PAR-3 directly associates with
            junctional adhesion molecule (JAM)
  JOURNAL   EMBO J 20 (14), 3738-3748 (2001)
   PUBMED   11447115
REFERENCE   9  (bases 1 to 1895)
  AUTHORS   Ebnet,K., Schulz,C.U., Meyer Zu Brickwedde,M.K., Pendl,G.G. and
            Vestweber,D.
  TITLE     Junctional adhesion molecule interacts with the PDZ
            domain-containing proteins AF-6 and ZO-1
  JOURNAL   J Biol Chem 275 (36), 27979-27988 (2000)
   PUBMED   10856295
REFERENCE   10 (bases 1 to 1895)
  AUTHORS   Martin-Padura,I., Lostaglio,S., Schneemann,M., Williams,L.,
            Romano,M., Fruscella,P., Panzeri,C., Stoppacciaro,A., Ruco,L.,
            Villa,A., Simmons,D. and Dejana,E.
  TITLE     Junctional adhesion molecule, a novel member of the immunoglobulin
            superfamily that distributes at intercellular junctions and
            modulates monocyte transmigration
  JOURNAL   J Cell Biol 142 (1), 117-127 (1998)
   PUBMED   9660867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF276998.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276998.1, BC065309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1895
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /note="F11 receptor"
                     /db_xref="GeneID:116479"
                     /db_xref="RGD:621842"
     exon            1..133
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..975
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /note="junctional adhesion molecule A; JAM-1; JAM-A;
                     junctional adhesion molecule 1"
                     /codon_start=1
                     /product="junctional adhesion molecule A precursor"
                     /protein_id="NP_446248.1"
                     /db_xref="GeneID:116479"
                     /db_xref="RGD:621842"
                     /translation="MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDS
                     VKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKD
                     NGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPP
                     SEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGY
                     GTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPG
                     KKVIYSQPSARSEGEFKQTSSFLV"
     exon            134..202
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..310
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..457
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..663
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..766
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..874
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..887
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..939
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1881
                     /gene="F11r"
                     /gene_synonym="Jam1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagcgca gtggatagcg aagctgttcc cagcggagtt gcggcgcccg tcgcgtcggg
       61 attgaaactg taatgggcac cgaggggaaa gccgggagca aactgttgtt tctcttcacg
      121 tctatgatcc tgggctcctt ggtgcaaggc aagggttcgg tgtacagtcc tcagactgcc
      181 gtccaggttc ctgagaacga ctctgtcaag ttgccctgta tctactctgg cttctcctca
      241 ccccgcgtgg agtggaagtt cgtccaaggc agcaccactg cgcttgtgtg ctataacaac
      301 cagatcacag ttccctatgc agaccgcgtc accttctcat ccagtggcat caccttcagc
      361 tctgtgaccc ggaaagacaa tggagagtat acttgcatgg tctctgagga cgggggtcag
      421 aactacgggg aggtcagcat ccacctcact gtgcttgtgc ctccatccaa gccgacagtc
      481 agtatcccct cctctgtcac cattgggaac agggcagtgc tgacctgctc agaacacgac
      541 ggttcccctc cttctgaata ttcctggttc aaggatgggg tacctatgct tacagcagat
      601 gccaagaaaa cccgtgcctt catcaattct tcatacacca tcgatccaaa gtcaggggat
      661 ttggtctttg accctgtgtc agcctttgat agtggcgaat actactgcga ggcacagaac
      721 gggtatggga cagccatgag gtcagaggct gtacgcatgg aggctgtgga gctgaatgtg
      781 gggggcatcg tggcagctgt cctggtaaca ctgattctcc ttggactcct gatttttggc
      841 atctggtttg cctatagccg tggatacttt gaaagaacaa agaaagggac tgcaccgggt
      901 aagaaggtca tttacagcca gcccagtgct cgcagtgagg gagaattcaa acagacctcg
      961 tcattcctgg tgtgacctgc tggggctcat ctcatgtcca cttgccttac tcaggtgcta
     1021 caagttccag cccctgctgg ctgtagctgc actggatgcc ttcaatgtct tctaggtccc
     1081 ccgggacccc ttgcttttat tctagctagg atatgaattt aataacatca gctacttctc
     1141 cctcctcttt cccgccctcc ctcctttcct taccaccatt gcgtggcctg agactagtta
     1201 caaagttttc attccccatt cctatgtggg attggacaag agtcctagac taggcagtaa
     1261 taatgactgg gctgacagga gcccaaaacc actacctgcc tgtaaaggcc tctccataag
     1321 gactttgagc ctagcttccc agctttcctc cccgggcgga gtgccagttg ctctagagtg
     1381 gggactggag gaagatgggc tgaggcattt gatggtgacc tcaggtgtct agcctctgga
     1441 gcctgctctt tgtctcaaaa tgtgccactg ggattctcct ggatacaagt aaactgacac
     1501 cgtgtccgaa caaggtggga gagctcggtt aactcccaag agacttggag tgagaaagat
     1561 ttaaagcgat ctaaggagaa aaggctggaa ctggtggctg ttagtcactt catttggctg
     1621 gaactactgc acagaccctt gtaagattta tatggatcga ggagatgtgt gtgttaatag
     1681 tctcgtctct ttgatggtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ggagagagag
     1741 agagagagag agagagagag agagtgagat tgagattcta tattgaaatt gattgttata
     1801 tagaagggct ttctagctct ttggcaaggt tgtgtttata tctgacagat gttgctggaa
     1861 ataaaaactt gatttgacaa aaaaaaaaaa aaaaa
//
