LOCUS       NM_001411666            2192 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus coagulation factor XI (F11), mRNA.
ACCESSION   NM_001411666 XM_006253144
VERSION     NM_001411666.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   2  (bases 1 to 2192)
  AUTHORS   Sokol,J., Biringer,K., Skerenova,M., Stasko,J. and Kubisz,P.
  TITLE     Activity of coagulation factor XI in patients with spontaneous
            miscarriage: the presence of risk alleles
  JOURNAL   J Obstet Gynaecol 35 (6), 621-624 (2015)
   PUBMED   25517908
REFERENCE   3  (bases 1 to 2192)
  AUTHORS   Lunghi,B., Cini,M., Legnani,C., Bernardi,F. and Marchetti,G.
  TITLE     The F11 rs2289252 polymorphism is associated with FXI activity
            levels and APTT ratio in women with thrombosis
  JOURNAL   Thromb Res 130 (3), 563-564 (2012)
   PUBMED   22633531
REFERENCE   4  (bases 1 to 2192)
  AUTHORS   Li,Y., Bezemer,I.D., Rowland,C.M., Tong,C.H., Arellano,A.R.,
            Catanese,J.J., Devlin,J.J., Reitsma,P.H., Bare,L.A. and
            Rosendaal,F.R.
  TITLE     Genetic variants associated with deep vein thrombosis: the F11
            locus
  JOURNAL   J Thromb Haemost 7 (11), 1802-1808 (2009)
   PUBMED   19583818
REFERENCE   5  (bases 1 to 2192)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2192)
  AUTHORS   Nobukata,H., Katsuki,Y., Ishikawa,T., Inokuma,M. and Shibutani,Y.
  TITLE     Effect of dienogest on bleeding time, coagulation, fibrinolysis,
            and platelet aggregation in female rats
  JOURNAL   Toxicol Lett 104 (1-2), 93-101 (1999)
   PUBMED   10048754
REFERENCE   7  (bases 1 to 2192)
  AUTHORS   Wojcik,E.G., Van Den Berg,M., Poort,S.R. and Bertina,R.M.
  TITLE     Modification of the N-terminus of human factor IX by defective
            propeptide cleavage or acetylation results in a destabilized
            calcium-induced conformation: effects on phospholipid binding and
            activation by factor XIa
  JOURNAL   Biochem J 323 (Pt 3) (Pt 3), 629-636 (1997)
   PUBMED   9169594
REFERENCE   8  (bases 1 to 2192)
  AUTHORS   Asakai,R., Chung,D.W., Ratnoff,O.D. and Davie,E.W.
  TITLE     Factor XI (plasma thromboplastin antecedent) deficiency in
            Ashkenazi Jews is a bleeding disorder that can result from three
            types of point mutations
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7667-7671 (1989)
   PUBMED   2813350
REFERENCE   9  (bases 1 to 2192)
  AUTHORS   de Haan,M., vd Kamp,J.J., Briet,E. and Dubbeldam,J.
  TITLE     Noonan syndrome: partial factor XI deficiency
  JOURNAL   Am J Med Genet 29 (2), 277-282 (1988)
   PUBMED   3354599
REFERENCE   10 (bases 1 to 2192)
  AUTHORS   Mandle,R.J. Jr. and Kaplan,A.P.
  TITLE     Hageman-factor-dependent fibrinolysis: generation of fibrinolytic
            activity by the interaction of human activated factor XI and
            plasminogen
  JOURNAL   Blood 54 (4), 850-862 (1979)
   PUBMED   89876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 31, 2022 this sequence version replaced XM_006253144.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.41721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000016.1  53720502-53720547
            47-102              JAXUCZ010000016.1  53721459-53721514
            103-265             JAXUCZ010000016.1  53728389-53728551
            266-372             JAXUCZ010000016.1  53730525-53730631
            373-532             JAXUCZ010000016.1  53731602-53731761
            533-642             JAXUCZ010000016.1  53733539-53733648
            643-802             JAXUCZ010000016.1  53733969-53734128
            803-912             JAXUCZ010000016.1  53734515-53734624
            913-1075            JAXUCZ010000016.1  53734729-53734891
            1076-1182           JAXUCZ010000016.1  53734979-53735085
            1183-1342           JAXUCZ010000016.1  53736605-53736764
            1343-1518           JAXUCZ010000016.1  53737681-53737856
            1519-1614           JAXUCZ010000016.1  53738767-53738862
            1615-1754           JAXUCZ010000016.1  53739361-53739500
            1755-2192           JAXUCZ010000016.1  53740512-53740949
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2192
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /note="coagulation factor XI"
                     /db_xref="GeneID:290757"
                     /db_xref="RGD:1309364"
     exon            1..46
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            47..102
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1916
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /EC_number="3.4.21.27"
                     /codon_start=1
                     /product="coagulation factor XI precursor"
                     /protein_id="NP_001398595.1"
                     /db_xref="GeneID:290757"
                     /db_xref="RGD:1309364"
                     /translation="MTSLQQVLYFIFFASVSSECITKVFKDISFQGGDLSTVFTPSAT
                     YCQLVCTHHPRCLLFTFMAESSSDDPTKWFACILKDSLTETLPMVHMTGAVSGYSFKQ
                     CPQQLSACSKNVYVNLDMKGMNYNSSAVKNARECQERCTNDAHCQFFTYATGHFPSVD
                     HRKMCLLKYTQMGTPTSITKLDSVVSGFSLKSCGLSNLACIRDIFPNTVLADLNIDSV
                     LAPDAFVCRRICTHHPTCLFFTFFTQAWPKESQRHLCLLKTSESGFPSTRITKSNALS
                     GFSLQHCRHSIPVFCHPNFYNDTDFLGEELDIVDVKGKESCQKMCSDNVRCQFFTYYP
                     SRGSCSERKGRCYLKLSSNGSPTRILHGRGGISGYTLRLCKMDNVCTTKIRPRVFGGA
                     ASVHGEWPWQVTLHTTQGHLCGGSIIGNRWILTAAHCFSGTETPKTLRVYGGIVNQSE
                     INEDTTFFRVQEMIIHDQYTSAESGFDIALLKLEPAMNYTDFQRPICLPSKGDRNVVH
                     TECWVTGWGYTKSRDEVQSTLQKAKVPLVSNEECQTRYRKHKITNKVICAGYKEGGKD
                     TCKGDSGGPLSCKHNGVWHLVGITSWGEGCGQKERPGVYTNVAKYVDWILEKTQSE"
     exon            103..265
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            266..372
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            373..532
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            533..642
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            643..802
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            803..912
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1075
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1182
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1342
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1518
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1614
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1754
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2192
                     /gene="F11"
                     /gene_synonym="LRRGT00086"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacactcct ccgaggaccg cagcaaaggc agagaaagat ctgcaggatg acctcattac
       61 agcaggtgtt atattttatc ttttttgcct ccgtttctag tgaatgtatc actaaggtct
      121 tcaaagacat cagctttcaa ggaggtgacc taagtactgt tttcacaccg agtgccacgt
      181 actgccagct ggtctgcaca caccacccac gttgcttgct cttcacgttc atggctgagt
      241 catcttctga cgatcccacc aaatggtttg cctgcatcct gaaggacagt ctcacagaaa
      301 cattgccgat ggtacacatg acaggagcgg tttctggata ttccttcaag caatgccctc
      361 agcaattaag tgcttgcagc aaaaacgtgt acgtgaacct ggacatgaag ggcatgaact
      421 ataacagttc tgccgtgaag aatgctcgag aatgtcagga gagatgcacc aacgatgccc
      481 actgccagtt tttcacatac gcaacggggc attttcccag tgtggaccat cgtaaaatgt
      541 gtcttttgaa gtacacccaa atggggacgc caacttcaat aacaaagctc gacagtgtgg
      601 tatctggatt ttcactgaag tcctgtgggc tttcgaacct ggcttgtatc agggacattt
      661 tcccgaacac cgtgcttgca gaccttaaca ttgacagcgt gttggcccca gatgcttttg
      721 tctgtcgtcg catttgcacg catcacccca cgtgcctgtt ttttacattc tttacccaag
      781 cgtggccaaa agaatcccag agacatcttt gcctccttaa aacatctgaa agcggatttc
      841 caagcacacg catcacaaag agcaacgccc tttccgggtt cagtctccag cactgcaggc
      901 acagcatccc agtattctgt catccgaact tttacaacga cactgatttc ttgggagaag
      961 aactggacat cgtcgatgtg aaaggcaaag aatcctgcca gaaaatgtgc tctgacaacg
     1021 tccgctgcca gttctttacc tattatccct ctcgaggatc ttgcagtgag aggaagggca
     1081 gatgttactt aaagctttct tcaaacggat ctccaactag aatacttcat gggaggggag
     1141 gcatctctgg atacacgctg aggctgtgca aaatggataa tgtatgcaca accaaaatca
     1201 ggcccagggt gttcggagga gctgcgtctg ttcacggcga gtggccatgg caggtgaccc
     1261 tgcacaccac ccagggacac ctgtgtggag gctccatcat tggaaaccgg tggatattga
     1321 cagcggctca ttgtttctct gggacagaga cacctaaaac tctgcgtgtc tacggtggta
     1381 ttgtaaatca atcagaaata aatgaagata ccactttctt cagggttcaa gaaatgataa
     1441 ttcatgatca atatacatcg gcagaaagtg ggtttgacat tgccctctta aaactggaac
     1501 cggccatgaa ttacacagat tttcagcggc caatatgcct gccttccaaa ggagacagaa
     1561 acgtagttca cacagaatgc tgggtgactg gatggggata cacaaaatca agagatgaag
     1621 tacaaagtac tctccagaaa gccaaggtac cattggtgtc gaatgaagaa tgtcaaacaa
     1681 gatacagaaa acataaaata accaacaagg tgatctgtgc aggatataag gaaggaggga
     1741 aggatacgtg taagggagat tctggagggc ccctgtcctg caaacacaat ggggtctggc
     1801 acttggtggg catcacaagc tggggtgaag gctgcggcca gaaagagagg ccgggtgtct
     1861 acaccaacgt ggccaagtat gtggactgga ttttggagaa aactcagtcg gaatgaaaga
     1921 gttcaacagg tgtcatttcg tggccctgga agactattcc acagaagaga gcatgatgtg
     1981 tctcatgaag acacggggaa gctgtatctt cactgtcagg aactggaggg gcttgatgta
     2041 tgtaagaacg cacagaaaga aaactattat tttcagaatt cccgatctgt gagaatcaca
     2101 ggttgctttc tgtatccagc tactctcaag gaaaccaaca caacgaggag atttttaaaa
     2161 taaaaacaca gcagataaac taggaaagta tc
//
