LOCUS       NM_017143               1618 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus coagulation factor X (F10), mRNA.
ACCESSION   NM_017143
VERSION     NM_017143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Foley,J.H. and Conway,E.M.
  TITLE     Cross Talk Pathways Between Coagulation and Inflammation
  JOURNAL   Circ Res 118 (9), 1392-1408 (2016)
   PUBMED   27126649
  REMARK    Review article
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Tinholt,M., Viken,M.K., Dahm,A.E., Vollan,H.K., Sahlberg,K.K.,
            Garred,O., Borresen-Dale,A.L., Jacobsen,A.F., Kristensen,V.,
            Bukholm,I., Karesen,R., Schlichting,E., Skretting,G., Lie,B.A.,
            Sandset,P.M. and Iversen,N.
  TITLE     Increased coagulation activity and genetic polymorphisms in the F5,
            F10 and EPCR genes are associated with breast cancer: a
            case-control study
  JOURNAL   BMC Cancer 14, 845 (2014)
   PUBMED   25407022
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Morishima,Y., Kamisato,C., Honda,Y., Furugohri,T. and Shibano,T.
  TITLE     The effects of warfarin and edoxaban, an oral direct factor Xa
            inhibitor, on gammacarboxylated (Gla-osteocalcin) and
            undercarboxylated osteocalcin (uc-osteocalcin) in rats
  JOURNAL   Thromb Res 131 (1), 59-63 (2013)
   PUBMED   22999414
  REMARK    GeneRIF: Factor Xa inhibitor edoxaban at or higher doses than
            needed for an antithrombotic effect sustained the circulating
            Gla-osteocalcin level.
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Takahashi,R., Ono,K., Ikeda,T., Akagi,A., Noto,D., Nozaki,I.,
            Sakai,K., Asakura,H., Iwasa,K. and Yamada,M.
  TITLE     Coagulation and fibrinolysis abnormalities in familial amyloid
            polyneuropathy
  JOURNAL   Amyloid 19 (3), 129-132 (2012)
   PUBMED   22624582
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Nobukata,H., Katsuki,Y., Ishikawa,T., Inokuma,M. and Shibutani,Y.
  TITLE     Effect of dienogest on bleeding time, coagulation, fibrinolysis,
            and platelet aggregation in female rats
  JOURNAL   Toxicol Lett 104 (1-2), 93-101 (1999)
   PUBMED   10048754
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Stanton,C., Ross,P., Hutson,S. and Wallin,R.
  TITLE     Evidence for competition between vitamin K-dependent clotting
            factors for intracellular processing by the vitamin K-dependent
            gamma-carboxylase
  JOURNAL   Thromb Res 80 (1), 63-73 (1995)
   PUBMED   8578539
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Wallin,R., Stanton,C. and Ross,R.P.
  TITLE     Intracellular proteolytic processing of the two-chain vitamin
            K-dependent coagulation factor X
  JOURNAL   Thromb Res 73 (6), 395-403 (1994)
   PUBMED   8073392
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Murakawa,M., Okamura,T., Kamura,T., Kuroiwa,M., Harada,M. and
            Niho,Y.
  TITLE     Analysis of the partial nucleotide sequences and deduced primary
            structures of the protease domains of mammalian blood coagulation
            factors VII and X
  JOURNAL   Eur J Haematol 52 (3), 162-168 (1994)
   PUBMED   8168596
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Reddy,S.V., Zhou,Z.Q., Rao,K.J., Scott,J.P., Watzke,H., High,K.A.
            and Jagadeeswaran,P.
  TITLE     Molecular characterization of human factor XSan Antonio
  JOURNAL   Blood 74 (5), 1486-1490 (1989)
   PUBMED   2790181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088151.1.
            
            On Jan 2, 2005 this sequence version replaced NM_017143.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088151.1, X79807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1618
                     /gene="F10"
                     /note="coagulation factor X"
                     /db_xref="GeneID:29243"
                     /db_xref="RGD:61850"
     exon            1..173
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1552
                     /gene="F10"
                     /EC_number="3.4.21.6"
                     /note="stuart factor; coagulation factor 10"
                     /codon_start=1
                     /product="coagulation factor X precursor"
                     /protein_id="NP_058839.1"
                     /db_xref="GeneID:29243"
                     /db_xref="RGD:61850"
                     /translation="MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSF
                     FEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECR
                     DGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGND
                     GKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLN
                     KTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCL
                     HQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRE
                     NVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLST
                     SFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIY
                     TKVTAFLKWIDRSMKARVGPTSETPRLTHPPY"
     exon            174..334
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            335..359
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            360..473
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            474..605
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            606..841
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            842..962
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1570
                     /gene="F10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagaaggc tgagataagc agactgacca tggccacctg gggcctaggg tgagtgaacc
       61 ttgccccatg cctgtcacag cagctgctgt ccttgaccac atcatggaga gcccggtgcg
      121 actcagcctt ctctatgttg tcctggccag cctcctgctc ccggggagaa gtgtgtttat
      181 taaccgggaa cgagccaaca acgtcctgca gaggattcgg agagcaaact cattttttga
      241 ggagataaag aaaggaaatc tggaaaggga gtgtgtggaa gaaatttgtt cttttgaaga
      301 ggcccgcgaa gtctttgagg acaatgagaa gacgacagaa ttctggaaca aatatgaaga
      361 tggtgaccag tgtgagagca gtccttgcca gaaccaaggc gagtgtcgag atggccttgg
      421 gagttataca tgcacctgca cggagggatt cgaaggcaaa aactgtgaac tctttgttcg
      481 gaaactctgc agcctagaca acggagactg cgaccagttc tgccgtgagg agcagaactc
      541 agtggtgtgc tcctgtgcca agggttactt cctgggtaat gacggcaagt cctgcctctc
      601 cacagctccc ttcccctgtg gaaaaaccaa taaaggacgc gcgaagaggt ctgtggccct
      661 aaataccagc aacagtgaac ctgaccctga agacctcatg cctgatgcag atattctata
      721 tcctactgag agtccttctg aactgctcaa tctcaacaag acagagcctg aagcaaacag
      781 tgatgacgtt attcggattg tgggtggcca agaatgcaag agaggagaat gtccttggca
      841 ggctctgctc tttagcgacg aagagactga tgggttctgt gggggcacca tcttgaatga
      901 gttctacatc ctcactgccg cccattgtct ccatcaagcc aagcgattca aggtgagggt
      961 aggggacctg aacacggaac aggaagacgg cggcgagatg gtgcacgagg tggatatgat
     1021 catcaagcac aacaagtttc agagggacac ctacgacttc gacattgcca tgctgaggct
     1081 gaagaccccc atcacgttcc gcgagaacgt ggcccctgcc tgcttgcctc agaaagactg
     1141 ggccgaggcc acactgatga cgcaaaagac aggcatcgtg agcgggtttg gacgcacgca
     1201 cgagaagggc cgccagtcca aagtcctgaa gatgatggag gtgccctatg tggaccgcaa
     1261 cacctgcagg ctctccacca gcttcagcat tacgcagaat atgttctgcg caggctatga
     1321 cgccaagcaa gaggacgcct gccaggggga cagcggtggc cctcacgtca cacgattcaa
     1381 agacacctac tttgtgaccg gcatcgtcag ctggggagag gggtgtgcaa ggaaagggaa
     1441 atacggcatc tacacgaagg tcacggcctt cctcaaatgg attgacaggt ccatgaaagc
     1501 cagggtgggg cccacctctg agaccccaag gttaacccat ccaccctatt aaagcagtcc
     1561 ttctccagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
