LOCUS       NM_019357               2973 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ezrin (Ezr), mRNA.
ACCESSION   NM_019357
VERSION     NM_019357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2973)
  AUTHORS   Guo,T., Zhang,L., Xiao,H., Yang,Y. and Shi,Y.
  TITLE     Ezrin interacts with L-periaxin by the 'head to head and tail to
            tail' mode and influences the location of L-periaxin in Schwann
            cell RSC96
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (4), 129520 (2020)
   PUBMED   31931020
  REMARK    GeneRIF: Ezrin interacts with L-periaxin by the ''head to head and
            tail to tail'' mode and influences the location of L-periaxin in
            Schwann cell RSC96.
REFERENCE   2  (bases 1 to 2973)
  AUTHORS   Demacopulo,B. and Kreimann,E.L.
  TITLE     Bisphenol S increases EZRIN expression and the detrimental effects
            induced by dehydroepiandrosterone in rat endometrium
  JOURNAL   Mol Cell Endocrinol 483, 64-73 (2019)
   PUBMED   30654004
  REMARK    GeneRIF: In a model of a polycystic ovarian syndrome (PCOS)-like
            condition in rats through treatment with xenoestrogens (Bisphenol S
            and DHEA), Ezrin expression was found de be increased in the
            endometrium and highly located in the cytoplasm of intraepithelial
            lumina.
REFERENCE   3  (bases 1 to 2973)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2973)
  AUTHORS   Dukic,A.R., Haugen,L.H., Pidoux,G., Leithe,E., Bakke,O. and
            Tasken,K.
  TITLE     A protein kinase A-ezrin complex regulates connexin 43 gap junction
            communication in liver epithelial cells
  JOURNAL   Cell Signal 32, 1-11 (2017)
   PUBMED   28077322
  REMARK    GeneRIF: Ezrin associates with Cx43 (in complex with ZO-1) which
            places PKA in proximity to Cx43, enabling its phosphorylation and
            gap junction opening.
REFERENCE   5  (bases 1 to 2973)
  AUTHORS   Panichakul,T., Ponnikorn,S., Roytrakul,S., Paemanee,A.,
            Kittisenachai,S., Hongeng,S. and Udomsangpetch,R.
  TITLE     Plasmodium vivax inhibits erythroid cell growth through altered
            phosphorylation of the cytoskeletal protein ezrin
  JOURNAL   Malar J 14, 138 (2015)
   PUBMED   25889165
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2973)
  AUTHORS   Doi,Y., Itoh,M., Yonemura,S., Ishihara,S., Takano,H., Noda,T. and
            Tsukita,S.
  TITLE     Normal development of mice and unimpaired cell adhesion/cell
            motility/actin-based cytoskeleton without compensatory
            up-regulation of ezrin or radixin in moesin gene knockout
  JOURNAL   J Biol Chem 274 (4), 2315-2321 (1999)
   PUBMED   9890997
REFERENCE   7  (bases 1 to 2973)
  AUTHORS   Buss,F., Kendrick-Jones,J., Lionne,C., Knight,A.E., Cote,G.P. and
            Paul Luzio,J.
  TITLE     The localization of myosin VI at the golgi complex and leading edge
            of fibroblasts and its phosphorylation and recruitment into
            membrane ruffles of A431 cells after growth factor stimulation
  JOURNAL   J Cell Biol 143 (6), 1535-1545 (1998)
   PUBMED   9852149
REFERENCE   8  (bases 1 to 2973)
  AUTHORS   Yonemura,S., Hirao,M., Doi,Y., Takahashi,N., Kondo,T., Tsukita,S.
            and Tsukita,S.
  TITLE     Ezrin/radixin/moesin (ERM) proteins bind to a positively charged
            amino acid cluster in the juxta-membrane cytoplasmic domain of
            CD44, CD43, and ICAM-2
  JOURNAL   J Cell Biol 140 (4), 885-895 (1998)
   PUBMED   9472040
REFERENCE   9  (bases 1 to 2973)
  AUTHORS   Barila,D., Murgia,C., Nobili,F. and Perozzi,G.
  TITLE     Transcriptional regulation of the ezrin gene during rat intestinal
            development and epithelial differentiation
  JOURNAL   Biochim Biophys Acta 1263 (2), 133-140 (1995)
   PUBMED   7640303
REFERENCE   10 (bases 1 to 2973)
  AUTHORS   Andreoli,C., Martin,M., Le Borgne,R., Reggio,H. and Mangeat,P.
  TITLE     Ezrin has properties to self-associate at the plasma membrane
  JOURNAL   J Cell Sci 107 (Pt 9), 2509-2521 (1994)
   PUBMED   7844168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081958.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081958.1, AY428869.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2973
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2973
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /note="ezrin"
                     /db_xref="GeneID:54319"
                     /db_xref="RGD:621161"
     exon            1..494
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..2243
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /note="p81; villin-2; cytovillin"
                     /codon_start=1
                     /product="ezrin"
                     /protein_id="NP_062230.1"
                     /db_xref="GeneID:54319"
                     /db_xref="RGD:621161"
                     /translation="MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWY
                     FGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVADELIQDITQKLF
                     FLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQ
                     HKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWL
                     GVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVE
                     REKEQMLREKEELMLRLQDFEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEAD
                     RMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAK
                     EAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGI
                     LDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYK
                     TLRQIRQGNTKQRIDEFEAM"
     exon            495..578
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..674
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..949
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1033
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1180
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1277
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1441
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1572
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1733
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1826
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2078
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2947
                     /gene="Ezr"
                     /gene_synonym="Vil2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgatggagg ggacgactgc ctgtgcgcgg acttgggagt ccccacgcct gagggacagt
       61 ggagctgagc ccccagtgca gctcgagccg ctgcgcgacc ctccgtccac ccctcctgcg
      121 ggggagcgtg gatcccttcc cgaagccaag cggagcgcgg gctgcacaga cacgcgcccc
      181 cctcccggcc gatcccaatt tgtgaagaaa aagaaaaaag aagtgttaaa agatcccgcg
      241 gttgcggttt cggctctggg gcaacggttg cttcacgaag tgaaacctgc ggagcgctcg
      301 ggcgcgcgcg cccggccccg ccccgtctgg gcgtgacagc ctgggactgc cgggccagtt
      361 cttaagctcc ggactgcgga gcgcgcgtag ggcttccctc cgcctgccgg tcccgacgtg
      421 tctccgccgt cgccgcacag ccgacttacc gaggacccac gcagagccac cagccagcca
      481 agatgcccaa gccaatcaac gtccgcgtga ccaccatgga tgcagagctg gagtttgcca
      541 tccagccaaa caccaccggg aagcagctct ttgatcaggt ggtaaagacc attggcctcc
      601 gggaagtgtg gtacttcggc ctccagtatg tagacaataa aggatttcct acctggctga
      661 aacttgataa aaaggtctct gcacaggagg ttcgaaagga gaaccctgtc cagttcaaat
      721 tccgggccaa gttctacccc gaggatgtgg ctgatgagct catccaggac atcacacaga
      781 agctcttctt cctgcaagtc aaggaaggga tcctcagcga tgagatctac tgccccccag
      841 agacagccgt gctcctgggg tcctatgccg ttcaggccaa gttcggagat tataacaagg
      901 aaatgcacaa gtctgggtac ctcagctccg agagacttat ccctcagaga gtcatggacc
      961 agcacaagct cagcagggac cagtgggagg accggatcca ggtgtggcac gcagaacacc
     1021 gagggatgct caaggacagt gctatgctcg aatacctgaa gattgcccag gacctggaaa
     1081 tgtatgggat caactatttc gagatcaaaa acaagaaagg aacagatctt tggcttggag
     1141 tggatgccct tggacttaac atttatgaga aagatgacaa gttgaccccg aagatcggct
     1201 tcccttggag tgaaatcagg aacatctctt tcaacgacaa gaagtttgtc atcaagccca
     1261 tcgacaagaa ggctcctgac ttcgtgttct acgctccccg cctgagaatt aacaagcgga
     1321 ttctgcagct ctgcatgggg aaccacgagc tgtacatgcg ccgcaggaag cccgacacca
     1381 tcgaggtgca gcagatgaag gcccaggctc gggaggagaa gcaccagaag cagctggagc
     1441 gacaacagtt ggaaaccgag aagaagagga gagaaactgt agagagagaa aaggaacaga
     1501 tgctccggga gaaggaagag ctgatgcttc ggctgcagga ctttgagcag aagaccaaga
     1561 gggcagagaa agagctctcc gagcagattg agaaggccct ccagctggag gaagagagga
     1621 ggcgagccca ggaggaggct gaacgtctgg aggccgaccg catggccgcc ctgcgggcca
     1681 aggaagaact ggagagacag gcacaggatc agataaagag ccaggagcag ctggctgcag
     1741 agctggcaga gtatactgcc aagattgccc tgctggagga ggcacggagg cgcaaggagg
     1801 acgaggtgga ggagtggcag caccgggcta aagaggccca ggacgacctg gtgaagacca
     1861 aagaggagct gcacctggtg atgacggctc ccccgccccc acccccgccc gtgtacgagc
     1921 ccgtgaatta ccacgtgcag gaggggctgc aggatgaggg agcagagccc atgggctaca
     1981 gtgccgagct ctccagcgag ggcatcctgg acgaccgtaa cgaggagaag cggatcaccg
     2041 aggcagagaa gaacgagcgc gtgcagcggc agctgctgac tctgagcaat gagttgtccc
     2101 aggcccggga tgagaataag aggacccaca atgacatcat ccacaatgag aacatgcggc
     2161 aaggccggga caagtataag acgctgcggc agatcaggca gggcaacacc aagcagcgca
     2221 tcgacgagtt tgaggccatg tagaggccag gccgggacca agggcggagg gcacctcaca
     2281 gcaggcaggt gtcactcttg gctctttagt actctataag tctagaaacc cccttgccgt
     2341 gttccagtcc cttaaagagc aggtaccggg cgatgttctg ccccaagacc cagtggaatc
     2401 ctccctggtt gcttccaata gtatcacata gtgccaaaca ggccagattt ttatgacagt
     2461 tgccgaatca cttcccgttc ggagcaggga ttcggagggc tggcccgaat gacgcgattc
     2521 agtgtcactg gggataataa tagcactgtg gctcacacac gggtgccata ctttctctag
     2581 ttttacaatg agctcaaatc gattttgttc ttgatttcta tgaaggatcc atctctgtgt
     2641 gttgaggggt gaaaatgatt ttgaaatttg agtcttaaag gacgccccca cacagtctcc
     2701 ttcctccaga ccgctggcag agtctcctgc ggtccctcag agtgtacggt acaggactct
     2761 ccgatacaaa attctcatgc ttaccctgtt agcattcatt gttggactga tacacctaat
     2821 gatcttctat agagaatagt atttatatat aagcgataat atgggtttgt aacattagtt
     2881 ttaaaaaggg aaagttttgt tctgtatatt ttgttacctt ttacagaata aaagaattca
     2941 acattaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
