LOCUS       NM_001401246            3067 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus EZH inhibitory protein (Ezhip), mRNA.
ACCESSION   NM_001401246 XM_006256764
VERSION     NM_001401246.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Ragazzini,R., Perez-Palacios,R., Baymaz,I.H., Diop,S., Ancelin,K.,
            Zielinski,D., Michaud,A., Givelet,M., Borsos,M., Aflaki,S.,
            Legoix,P., Jansen,P.W.T.C., Servant,N., Torres-Padilla,M.E.,
            Bourc'his,D., Fouchet,P., Vermeulen,M. and Margueron,R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Hubner,J.M., Muller,T., Papageorgiou,D.N., Mauermann,M.,
            Krijgsveld,J., Russell,R.B., Ellison,D.W., Pfister,S.M.,
            Pajtler,K.W. and Kool,M.
  TITLE     EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an
            intrinsic inhibitor of PRC2 function in aggressive posterior fossa
            ependymoma
  JOURNAL   Neuro Oncol 21 (7), 878-889 (2019)
   PUBMED   30923826
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Pajtler,K.W., Wen,J., Sill,M., Lin,T., Orisme,W., Tang,B.,
            Hubner,J.M., Ramaswamy,V., Jia,S., Dalton,J.D., Haupfear,K.,
            Rogers,H.A., Punchihewa,C., Lee,R., Easton,J., Wu,G.,
            Ritzmann,T.A., Chapman,R., Chavez,L., Boop,F.A., Klimo,P.,
            Sabin,N.D., Ogg,R., Mack,S.C., Freibaum,B.D., Kim,H.J., Witt,H.,
            Jones,D.T.W., Vo,B., Gajjar,A., Pounds,S., Onar-Thomas,A.,
            Roussel,M.F., Zhang,J., Taylor,J.P., Merchant,T.E., Grundy,R.,
            Tatevossian,R.G., Taylor,M.D., Pfister,S.M., Korshunov,A., Kool,M.
            and Ellison,D.W.
  TITLE     Molecular heterogeneity and CXorf67 alterations in posterior fossa
            group A (PFA) ependymomas
  JOURNAL   Acta Neuropathol 136 (2), 211-226 (2018)
   PUBMED   29909548
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000021.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006256764.4.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3067              JAXUCZ010000021.1  19040397-19043463   c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3067
                     /gene="Ezhip"
                     /note="EZH inhibitory protein"
                     /db_xref="GeneID:102547118"
                     /db_xref="RGD:7681336"
     exon            1..3067
                     /gene="Ezhip"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2687
                     /gene="Ezhip"
                     /note="retinitis pigmentosa 1-like 1 protein-like;
                     uncharacterized protein CXorf67 homolog"
                     /codon_start=1
                     /product="EZH inhibitory protein"
                     /protein_id="NP_001388175.1"
                     /db_xref="GeneID:102547118"
                     /db_xref="RGD:7681336"
                     /translation="MASYSTPKKERTARRGSVRSQGKAPVTVCSDTSAAGSAFQGLEV
                     DLGEPDIFSSQGKAPVTVCSGTSAASSAFQGLEVDLGAPDIFSFQGEAPVASVLAVCS
                     DTSVAGSAFQGVEVDLGPPDTFSSQGKAPVASSVLAVCSDTSAAGSAFQGLEVDLGAP
                     DIFSFQGEAPVASVLAVCSDTSAASSAFQGLEVDLGAPDIFSFQGEAPVASVLAVCSD
                     TSAAGSAFQGVEVDLGPPDTFSTQGKAPVASSVLAVCSDTSAAGSAFQGLEVDLGPPD
                     TFSTQGKAPVASSVLTVCSGTSAAGSTFQGVEVDLGEPETFSMAIENLGTFSVPDNQP
                     FDPEGSFGPNIQLGRVRPMTRSQRELGQALRGEKDSNEPPAQTKSCRKRKQPSQNLTT
                     KSLGALQLPEALELPHRLQLPSSLSSQPSSSHHSEYAVGNLDSPGPTTLRSTTRSGPV
                     STPAPMALSQAFLTVSGPPSSASGSSSDENVQELSQQTILQAPDDGVFCREPDSRGSV
                     IPGGWVLRSRVVTFGHHSPALVSPEVQPEVHTIGWNLRPRATPRIPVLHSGPPVSSPD
                     TGSRATQSRSRSRSASRPGSDHRRRSRETKMEPEPEPEPKSESESDHELESESEAEAE
                     PESEAEAEPESEAETEAESEAEAEPESEAEPEPESEAEPESEPEVEPESEPEVEAEVE
                     PESEPEAEAEVEPESEPEVEAEAEAEPESEPESESEPELVEMEPGPRSQSQARPFTST
                     PTLPRRSSHATASSPPRRPVRMRASSPSPPGRLYPLPGQYGEGASSSSSSTSELCVSS
                     PHSLKGSSPPLSDLSSVSGPSPNTLWRALIPDLDNLHSSSERESEEETG"
ORIGIN      
        1 actgtatcct gtctctaccc agcatccttt gctgggtctt gggaagccac ttcactgggc
       61 acgaagcctt cgagaagcca cttcaccgcg cgaagccacc gagaagccat ttctctgaac
      121 tagtaagacg ctgttaagcc gatatggcct catattcaac tccaaagaag gagcggactg
      181 cacgtagagg cagtgtcagg tcccaaggta aagcccccgt cacagtctgc agtgacacct
      241 cagcggccgg cagtgctttc caggggctcg aagttgactt gggggagcct gacatcttct
      301 cgtctcaagg taaagccccc gtcacagtct gcagtggcac ctcagcggcc agcagcgctt
      361 tccagggcct cgaagttgac ttgggggcgc ctgacatctt ctcgtttcaa ggtgaagctc
      421 ccgttgcttc ggttctcgca gtctgcagtg acacctcagt ggctggcagc gctttccagg
      481 gcgtcgaagt tgacttgggg ccgcctgaca ccttctcctc tcaaggtaaa gcccccgttg
      541 cttcttcggt tctcgcagtc tgcagtgaca cctcagcggc cggcagcgct ttccagggcc
      601 tggaagttga cttgggggcg cctgacatct tctcgtttca aggtgaagct ccggttgctt
      661 cggttctcgc agtctgcagt gacacctcag cggccagcag cgctttccag ggcctcgaag
      721 ttgacttggg ggcgcctgac atcttctcgt ttcaaggtga agctcccgtt gcttcggttc
      781 tcgcagtctg cagtgacacc tcagcggctg gcagcgcttt ccagggcgtc gaagttgatt
      841 tggggccgcc tgacaccttc tcgactcaag gtaaagcccc cgttgcttct tcggttctcg
      901 cagtctgcag tgacacctca gcggctggca gcgctttcca gggcctggaa gttgacttgg
      961 ggccgcctga caccttctcg actcaaggta aagcccccgt tgcttcttcg gttctcacag
     1021 tctgcagtgg cacctcagcg gctggcagca ctttccaggg cgtcgaagtt gacttggggg
     1081 agcctgaaac cttctccatg gctattgaaa acctggggac attttctgtg cctgacaatc
     1141 agccttttga ccctgagggt agctttggcc caaacataca acttggacgt gttaggccca
     1201 tgacgagaag ccagagagag ctaggccaag ccctgagagg cgaaaaagac agcaacgagc
     1261 ccccagctca aacaaagagc tgtagaaaga ggaagcagcc cagccaaaac ctaacgacaa
     1321 aaagtctagg tgcacttcag cttccggaag ctctcgagtt gccccatagg cttcagctac
     1381 catcttcttt gagctctcag cctagcagca gccaccattc tgaatatgca gtggggaacc
     1441 tagactcccc agggcctact acccttagga gcaccaccag gtcaggccct gtgtctactc
     1501 cagcccctat ggccctcagc caagcctttc tgactgtttc tggtcctccc agcagcgcct
     1561 ctgggtccag cagtgatgag aacgtccagg aactcagtca acagaccatt ctgcaggctc
     1621 ctgatgatgg agttttctgc agggaacctg actccagagg cagtgtgatt cccggaggct
     1681 gggttctccg ctcacgtgtg gtaacatttg gtcatcatag ccctgcactg gtcagccctg
     1741 aggttcagcc cgaagtccac accataggct ggaatttacg ccctcgggcc actccacgga
     1801 ttcctgttct tcacagtggt cccccggtgt ccagtcctga tacaggcagc cgtgcaacac
     1861 agagcagaag ccgcagtcgc agtgcatcca ggcccggctc tgaccaccga cgacgaagcc
     1921 gtgaaacaaa gatggagccg gagcctgagc ctgagcccaa gtccgagtct gaatctgacc
     1981 acgagctcga gtctgagtcg gaggccgagg ccgagcctga gtcggaggcc gaggccgagc
     2041 ctgagtcgga ggccgagacc gaggccgagt cggaggccga ggctgagcct gagtcggagg
     2101 ccgagcctga gcctgagtcg gaggccgagc ctgagtcgga gccggaggtc gagcctgagt
     2161 cggagcccga ggtcgaggcc gaggtcgagc ctgagtcgga gcccgaggcc gaggccgagg
     2221 tcgagcctga gtcggagccc gaggtcgagg ccgaggccga ggccgagcct gagtcggagc
     2281 ccgagtcgga gtcagagcca gagctggtgg agatggagcc tggccctcgc agccagtcac
     2341 aagcaaggcc tttcacctct acgcctacac ttccaaggag atcttcacat gcaaccgcaa
     2401 gctctcctcc aaggcgtcca gtccgtatgc gggcctcttc cccttctcct cctggtaggc
     2461 tctatccttt gcctgggcag tatggtgaag gtgccagttc ttcctcctca tccaccagtg
     2521 agctctgtgt ttcaagcccc cattctttaa agggctcttc acctccatta agtgacttga
     2581 gttctgtctc tggtcctagt cctaataccc tttggcgtgc cttgatacct gacctggata
     2641 acctccattc ctcctcagag agggagtcag aggaagaaac aggatgaccc tcactctcct
     2701 gcagaggggg aagtgtagag gatgtccctt attccaccct tgctgttatt ctttgtgtgt
     2761 tctagcagac tgacaaaagg aataagccct tatacaaagt tggctgtgtg gttgataatc
     2821 tgaggtttct agggtttcta cctattcacc agtagtctga gcagttttga agtcccctgt
     2881 tctcctcgcc ccaactattt agcacttata agaactttgg ttccattcag tacccccatt
     2941 atctttaaaa cagcttgggt tgtttatttg ttgttgggtt tgggtggggc ttttgttgtt
     3001 ttttatcttt tgcctctgag ttgcttttct gtaattaagt atttttaata aagtgttaag
     3061 ttttatt
//
