LOCUS       XM_006236402            2662 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus enhancer of zeste 2 polycomb
            repressive complex 2 subunit (Ezh2), transcript variant X3, mRNA.
ACCESSION   XM_006236402
VERSION     XM_006236402.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051339.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006236402.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006236402.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..2662
                     /gene="Ezh2"
                     /note="enhancer of zeste 2 polycomb repressive complex 2
                     subunit; Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 26 ESTs, 4 long SRA reads, 2
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 81 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:312299"
                     /db_xref="RGD:1595860"
     CDS             141..2396
                     /gene="Ezh2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     X1"
                     /protein_id="XP_006236464.1"
                     /db_xref="GeneID:312299"
                     /db_xref="RGD:1595860"
                     /translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSS
                     NRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLN
                     AVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGD
                     RECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLDDSRDDKETCPPRKF
                     PADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQ
                     SLHSFHTLFCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLE
                     GAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTE
                     TGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIG
                     TYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHC
                     RKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCR
                     CKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPS
                     DVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDA
                     TRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALK
                     YVGIEREMEIP"
ORIGIN      
        1 gcgtttggcg ctcggtccgg tcgcgtccga cacccagtgg gacatcgaag gcagtggagt
       61 cccggcggcg gcggcggcgg cggcgcgttg gggcggcgcg cgggagaagc gcgggctggc
      121 gcgcgggacg aagaataatc atgggccaga ctgggaagaa atctgagaag ggaccggttt
      181 gttggcggaa gcgtgtaaag tcagagtaca tgagactgag acagctcaag aggttcagaa
      241 gagctgacga agtaaagact atgtttagtt ccaatcgtca gaaaattttg gaaagaactg
      301 aaaccttaaa tcaagaatgg aagcagcgaa ggatacagcc tgtgcacatc atgacttctg
      361 tgagctcatt acgcgggact agggagtgtt cagtgaccag tgacttggat tttccagcac
      421 aagtcatccc gttaaagacc ctaaatgctg tcgcatcggt gcccataatg tattcttggt
      481 ctcccttaca acagaatttt atggtggaag atgaaactgt tttacataac attccttata
      541 tgggggatga agttctggat caggatggca ctttcattga agaattaata aaaaattatg
      601 atggaaaagt gcatggagac agagaatgtg gatttataaa tgatgaaatt tttgtggagt
      661 tggtaaatgc tcttggtcaa tataatgatg atgacgatga tgatgatgga gacgatcctg
      721 atgaaagaga agaaaaacag aaagatctag acgatagtcg agatgataaa gaaacttgcc
      781 cacctcggaa atttcctgct gataaaatat ttgaagccat ttcctcaatg tttccagata
      841 agggcacagc agaagaactg aaagaaaagt ataaagaact cacggagcag cagctccccg
      901 gtgctctacc tcctgaatgt accccaaaca tcgatggacc aaatgccaaa tctgttcaga
      961 gggagcaaag tttacattca tttcatacgc tcttttgtcg acgatgtttt aagtatgact
     1021 gcttcctaca tcgtaagtgc aattattcct ttcatgcaac acccaacaca tataagagga
     1081 agaacacaga aacagctctg gacaacaagc cttgtggacc acagtgttat cagcatctgg
     1141 agggagctaa ggagtttgct gctgccctta ctgctgagcg gataaagaca ccacctaaac
     1201 gtccaggggg ccgcagaaga ggaagacttc cgaataacag tagcagaccc agcaccccca
     1261 ccatcagtgt gctggagtca aaggatacag acagtgacag agaagcaggg actgaaaccg
     1321 ggggagagaa caacgataaa gaagaagaag agaaaaaaga tgagacttcc agttcctctg
     1381 aagcaaattc tcggtgtcaa acaccaataa agatgaagcc aaatattgaa cctcctgaga
     1441 atgtggagtg gagtggtgct gaagcctcca tgtttagagt cctcattggt acttactacg
     1501 ataacttttg tgccattgct aggctaattg ggaccaaaac atgtagacag gtgtatgagt
     1561 ttagagtcaa agagtccagt atcatagcac ctgttcccac tgaggatgtg gacactcctc
     1621 caagaaagaa gaaaagaaaa catcggttgt gggctgcaca ctgcagaaag atccaactga
     1681 aaaaggacgg ctcctctaac catgtttaca actatcaacc ctgtgaccat ccacggcagc
     1741 cttgtgacag ttcgtgccct tgtgtgatag cacaaaattt ttgtgaaaag ttttgtcaat
     1801 gtagttcaga gtgtcaaaac cgctttcctg gatgccggtg caaagcacaa tgcaacacca
     1861 agcagtgtcc gtgctacctg gctgtccgag agtgtgatcc tgacctctgt ctcacttgtg
     1921 gagctgctga ccactgggac agtaaaaatg tgtcctgcaa gaactgtagc attcagcggg
     1981 gctctaaaaa gcacttactg ctggcaccgt ctgatgtggc aggctggggc atctttatca
     2041 aagatccagt acagaaaaat gaattcatct cagaatactg tggagagatt atttctcagg
     2101 atgaagcaga cagaagaggg aaagtgtatg acaaatacat gtgcagcttt ctgttcaact
     2161 tgaacaatga ttttgtggtg gatgcaaccc gcaagggcaa caaaattcgt tttgctaatc
     2221 attcagtaaa tccaaactgc tatgcaaaag ttatgatggt taatggtgac cacaggatag
     2281 gcatctttgc taagagagct atccagactg gtgaagagtt gttctttgat tacagataca
     2341 gccaggctga tgccctgaag tatgtgggca tcgaacgaga aatggaaatc ccttgaaatc
     2401 tactacctct tcccctcctc tcaaacagct gccttagctt caggaacctt gagtactgtg
     2461 ggcaatttag aaaaaggaaa tgcagtttga aattttgaat ttgcaaagta ctgtaacagt
     2521 aatttatagt aatgagtttt aaaatcaact ttttattgcc ttctcaccag ctgcaaagtg
     2581 ttttgtacca gtgaattttt gcaataatgc agtatggtac atttttcaaa tttgaataaa
     2641 gaatacttga acttgttgtt ga
//
