LOCUS       NM_001134979            2794 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus enhancer of zeste 2 polycomb repressive complex 2
            subunit (Ezh2), mRNA.
ACCESSION   NM_001134979 XM_001073768 XM_231705
VERSION     NM_001134979.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2794)
  AUTHORS   Wang,Q., Sun,J., Wang,R. and Sun,J.
  TITLE     Inhibition of EZH2 mitigates peritoneal fibrosis and lipid
            precipitation in peritoneal mesothelial cells mediated by klotho
  JOURNAL   Ren Fail 45 (1), 2149411 (2023)
   PUBMED   36724065
  REMARK    GeneRIF: Inhibition of EZH2 mitigates peritoneal fibrosis and lipid
            precipitation in peritoneal mesothelial cells mediated by klotho.
REFERENCE   2  (bases 1 to 2794)
  AUTHORS   Huang,X., Yang,C. and Huang,M.
  TITLE     Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in
            rats with depressive-like behaviors
  JOURNAL   J Chem Neuroanat 132, 102283 (2023)
   PUBMED   37146769
  REMARK    GeneRIF: Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10
            axis in rats with depressive-like behaviors.
REFERENCE   3  (bases 1 to 2794)
  AUTHORS   Zhang,L., Liu,H.H., Yang,F., Zhang,Z.Y., Wu,Y., Li,F., Dang,S.P.,
            Zhang,Z.Y., Qian,L.L. and Wang,R.X.
  TITLE     Calcineurin/NFATc3 pathway mediates myocardial fibrosis in diabetes
            by impairing enhancer of zeste homolog 2 of cardiac fibroblasts
  JOURNAL   BMC Cardiovasc Disord 23 (1), 474 (2023)
   PUBMED   37735624
  REMARK    GeneRIF: Calcineurin/NFATc3 pathway mediates myocardial fibrosis in
            diabetes by impairing enhancer of zeste homolog 2 of cardiac
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2794)
  AUTHORS   Chen,M., Fan,L., Wu,G., Wang,H. and Gu,S.
  TITLE     Histone methyltransferase enzyme enhancer of zeste homolog 2
            counteracts ischemic brain injury via H3K27me3-mediated regulation
            of PI3K/AKT/mTOR signaling pathway
  JOURNAL   Environ Toxicol 38 (9), 2240-2255 (2023)
   PUBMED   37334851
  REMARK    GeneRIF: Histone methyltransferase enzyme enhancer of zeste homolog
            2 counteracts ischemic brain injury via H3K27me3-mediated
            regulation of PI3K/AKT/mTOR signaling pathway.
REFERENCE   5  (bases 1 to 2794)
  AUTHORS   Zhu,N., Guan,H., Wang,X., Zhang,Y., Gu,L., Jia,J., Wang,L. and
            Yuan,W.
  TITLE     EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically
            activating SP4 expression in the IL-6/sIL-6R signalling pathway
  JOURNAL   Int J Med Sci 20 (1), 114-124 (2023)
   PUBMED   36619221
  REMARK    GeneRIF: EZH2 promotes angiogenesis in peritoneal dialysis by
            epigenetically activating SP4 expression in the IL-6/sIL-6R
            signalling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2794)
  AUTHORS   Pasini,D., Bracken,A.P., Jensen,M.R., Lazzerini Denchi,E. and
            Helin,K.
  TITLE     Suz12 is essential for mouse development and for EZH2 histone
            methyltransferase activity
  JOURNAL   EMBO J 23 (20), 4061-4071 (2004)
   PUBMED   15385962
REFERENCE   7  (bases 1 to 2794)
  AUTHORS   Bracken,A.P., Pasini,D., Capra,M., Prosperini,E., Colli,E. and
            Helin,K.
  TITLE     EZH2 is downstream of the pRB-E2F pathway, essential for
            proliferation and amplified in cancer
  JOURNAL   EMBO J 22 (20), 5323-5335 (2003)
   PUBMED   14532106
  REMARK    Erratum:[EMBO J. 2024 Mar;43(5):886. doi:
            10.1038/s44318-024-00033-4. PMID: 38347304]
REFERENCE   8  (bases 1 to 2794)
  AUTHORS   Erhardt,S., Su,I.H., Schneider,R., Barton,S., Bannister,A.J.,
            Perez-Burgos,L., Jenuwein,T., Kouzarides,T., Tarakhovsky,A. and
            Surani,M.A.
  TITLE     Consequences of the depletion of zygotic and embryonic enhancer of
            zeste 2 during preimplantation mouse development
  JOURNAL   Development 130 (18), 4235-4248 (2003)
   PUBMED   12900441
REFERENCE   9  (bases 1 to 2794)
  AUTHORS   van Lohuizen,M., Tijms,M., Voncken,J.W., Schumacher,A., Magnuson,T.
            and Wientjens,E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
REFERENCE   10 (bases 1 to 2794)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Sep 16, 2008 this sequence version replaced
            XM_001073768.1, XM_231705.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2794
                     /gene="Ezh2"
                     /note="enhancer of zeste 2 polycomb repressive complex 2
                     subunit"
                     /db_xref="GeneID:312299"
                     /db_xref="RGD:1595860"
     exon            1..139
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..263
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2387
                     /gene="Ezh2"
                     /EC_number="2.1.1.354"
                     /note="enhancer of zeste homolog 2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH2"
                     /protein_id="NP_001128451.1"
                     /db_xref="GeneID:312299"
                     /db_xref="RGD:1595860"
                     /translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSS
                     NRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLN
                     AVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGD
                     RECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLDDSRDDKETCPPRKF
                     PADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQ
                     SLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEF
                     AAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGEN
                     NDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDN
                     FCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQL
                     KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQC
                     NTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGW
                     GIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGN
                     KIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIE
                     REMEIP"
     exon            264..392
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..509
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..630
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..771
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..874
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1038
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1130
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1371
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1541
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1636
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1677
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1803
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1982
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2078
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2160
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2241
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2326
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2794
                     /gene="Ezh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctgcgt ttggcgctcg gtccggtcgc gtccgacacc cagtgggaca tcgaaggcag
       61 tggagtcccg gcggcggcgg cggcggcggc gcgttggggc ggcgcgcggg agaagcgcgg
      121 gctggcgcgc gggacgaaga ataatcatgg gccagactgg gaagaaatct gagaagggac
      181 cggtttgttg gcggaagcgt gtaaagtcag agtacatgag actgagacag ctcaagaggt
      241 tcagaagagc tgacgaagta aagactatgt ttagttccaa tcgtcagaaa attttggaaa
      301 gaactgaaac cttaaatcaa gaatggaagc agcgaaggat acagcctgtg cacatcatga
      361 cttctgtgag ctcattacgc gggactaggg agtgttcagt gaccagtgac ttggattttc
      421 cagcacaagt catcccgtta aagaccctaa atgctgtcgc atcggtgccc ataatgtatt
      481 cttggtctcc cttacaacag aattttatgg tggaagatga aactgtttta cataacattc
      541 cttatatggg ggatgaagtt ctggatcagg atggcacttt cattgaagaa ttaataaaaa
      601 attatgatgg aaaagtgcat ggagacagag aatgtggatt tataaatgat gaaatttttg
      661 tggagttggt aaatgctctt ggtcaatata atgatgatga cgatgatgat gatggagacg
      721 atcctgatga aagagaagaa aaacagaaag atctagacga tagtcgagat gataaagaaa
      781 cttgcccacc tcggaaattt cctgctgata aaatatttga agccatttcc tcaatgtttc
      841 cagataaggg cacagcagaa gaactgaaag aaaagtataa agaactcacg gagcagcagc
      901 tccccggtgc tctacctcct gaatgtaccc caaacatcga tggaccaaat gccaaatctg
      961 ttcagaggga gcaaagttta cattcatttc atacgctctt ttgtcgacga tgttttaagt
     1021 atgactgctt cctacatccc tttcatgcaa cacccaacac atataagagg aagaacacag
     1081 aaacagctct ggacaacaag ccttgtggac cacagtgtta tcagcatctg gagggagcta
     1141 aggagtttgc tgctgccctt actgctgagc ggataaagac accacctaaa cgtccagggg
     1201 gccgcagaag aggaagactt ccgaataaca gtagcagacc cagcaccccc accatcagtg
     1261 tgctggagtc aaaggataca gacagtgaca gagaagcagg gactgaaacc gggggagaga
     1321 acaacgataa agaagaagaa gagaaaaaag atgagacttc cagttcctct gaagcaaatt
     1381 ctcggtgtca aacaccaata aagatgaagc caaatattga acctcctgag aatgtggagt
     1441 ggagtggtgc tgaagcctcc atgtttagag tcctcattgg tacttactac gataactttt
     1501 gtgccattgc taggctaatt gggaccaaaa catgtagaca ggtgtatgag tttagagtca
     1561 aagagtccag tatcatagca cctgttccca ctgaggatgt ggacactcct ccaagaaaga
     1621 agaaaagaaa acatcggttg tgggctgcac actgcagaaa gatccaactg aaaaaggacg
     1681 gctcctctaa ccatgtttac aactatcaac cctgtgacca tccacggcag ccttgtgaca
     1741 gttcgtgccc ttgtgtgata gcacaaaatt tttgtgaaaa gttttgtcaa tgtagttcag
     1801 agtgtcaaaa ccgctttcct ggatgccggt gcaaagcaca atgcaacacc aagcagtgtc
     1861 cgtgctacct ggctgtccga gagtgtgatc ctgacctctg tctcacttgt ggagctgctg
     1921 accactggga cagtaaaaat gtgtcctgca agaactgtag cattcagcgg ggctctaaaa
     1981 agcacttact gctggcaccg tctgatgtgg caggctgggg catctttatc aaagatccag
     2041 tacagaaaaa tgaattcatc tcagaatact gtggagagat tatttctcag gatgaagcag
     2101 acagaagagg gaaagtgtat gacaaataca tgtgcagctt tctgttcaac ttgaacaatg
     2161 attttgtggt ggatgcaacc cgcaagggca acaaaattcg ttttgctaat cattcagtaa
     2221 atccaaactg ctatgcaaaa gttatgatgg ttaatggtga ccacaggata ggcatctttg
     2281 ctaagagagc tatccagact ggtgaagagt tgttctttga ttacagatac agccaggctg
     2341 atgccctgaa gtatgtgggc atcgaacgag aaatggaaat cccttgaaat ctactacctc
     2401 ttcccctcct ctcaaacagc tgccttagct tcaggaacct tgagtactgt gggcaattta
     2461 gaaaaaggaa atgcagtttg aaattttgaa tttgcaaagt actgtaacag taatttatag
     2521 taatgagttt taaaatcaac tttttattgc cttctcacca gctgcaaagt gttttgtacc
     2581 agtgaatttt tgcaataatg cagtatggta catttttcaa atttgaataa agaatacttg
     2641 aacttgttgt tgagtcactt gttacagaac atcaccaact gattctagaa agactatatc
     2701 cagtgggaaa acacaactcc tctttgtttt tccagctgtc tgtgaatatt taataactaa
     2761 taaacatact ggcatagtgt ttacctagat ccag
//
