LOCUS       NM_001107051            4245 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus enhancer of zeste 1 polycomb repressive complex 2
            subunit (Ezh1), mRNA.
ACCESSION   NM_001107051 XM_001081456 XM_220986
VERSION     NM_001107051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4245)
  AUTHORS   Ragazzini R, Perez-Palacios R, Baymaz IH, Diop S, Ancelin K,
            Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P,
            Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P,
            Vermeulen M and Margueron R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4245)
  AUTHORS   Bae WK, Kang K, Yu JH, Yoo KH, Factor VM, Kaji K, Matter M,
            Thorgeirsson S and Hennighausen L.
  TITLE     The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2
            control hepatocyte homeostasis and regeneration
  JOURNAL   FASEB J 29 (5), 1653-1662 (2015)
   PUBMED   25477280
REFERENCE   3  (bases 1 to 4245)
  AUTHORS   Herz HM, Garruss A and Shilatifard A.
  TITLE     SET for life: biochemical activities and biological functions of
            SET domain-containing proteins
  JOURNAL   Trends Biochem Sci 38 (12), 621-639 (2013)
   PUBMED   24148750
  REMARK    Review article
REFERENCE   4  (bases 1 to 4245)
  AUTHORS   Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M
            and van Zundert B.
  TITLE     Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in
            developing hippocampal neurons
  JOURNAL   Mol Cell Neurosci 57, 130-143 (2013)
   PUBMED   23932971
  REMARK    GeneRIF: knock-down of Ezh1 reduces PSD-95 transcription in
            developing hippocampal neurons
REFERENCE   5  (bases 1 to 4245)
  AUTHORS   Simon JA and Kingston RE.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   6  (bases 1 to 4245)
  AUTHORS   Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC,
            Lee Y and Orkin SH.
  TITLE     Jumonji modulates polycomb activity and self-renewal versus
            differentiation of stem cells
  JOURNAL   Cell 139 (7), 1303-1314 (2009)
   PUBMED   20064376
REFERENCE   7  (bases 1 to 4245)
  AUTHORS   Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G,
            Tarakhovsky A and Fuchs E.
  TITLE     Ezh2 orchestrates gene expression for the stepwise differentiation
            of tissue-specific stem cells
  JOURNAL   Cell 136 (6), 1122-1135 (2009)
   PUBMED   19303854
REFERENCE   8  (bases 1 to 4245)
  AUTHORS   Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL,
            Dynlacht BD and Reinberg D.
  TITLE     Ezh1 and Ezh2 maintain repressive chromatin through different
            mechanisms
  JOURNAL   Mol Cell 32 (4), 503-518 (2008)
   PUBMED   19026781
REFERENCE   9  (bases 1 to 4245)
  AUTHORS   van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T and
            Wientjens E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
REFERENCE   10 (bases 1 to 4245)
  AUTHORS   Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin
            D, Pillus L and Jenuwein T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220986.4, XM_001081456.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4245
                     /gene="Ezh1"
                     /note="enhancer of zeste 1 polycomb repressive complex 2
                     subunit"
                     /db_xref="GeneID:303547"
                     /db_xref="RGD:1305028"
     exon            1..69
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..190
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2317
                     /gene="Ezh1"
                     /EC_number="2.1.1.354"
                     /note="enhancer of zeste homolog 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EZH1"
                     /protein_id="NP_001100521.1"
                     /db_xref="GeneID:303547"
                     /db_xref="RGD:1305028"
                     /translation="MDIASPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVA
                     NFAKVQEKTQILNEEWKKLRVQPVQPMKPVSGHPFLKKCTIESIFPGFDSQDMLMRSL
                     NTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHG
                     EEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRH
                     AIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPN
                     IDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNREIKIEPEPCG
                     ADCFLWLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNTSASAMAETKEGDSDRDT
                     GNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYF
                     NNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQ
                     LKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRCKTQ
                     CNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAG
                     WGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKG
                     NKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGI
                     ERETDVF"
     exon            191..319
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..439
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..560
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..737
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..840
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1004
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1096
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1277
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1474
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1566
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1607
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1733
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1912
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2008
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2090
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2171
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2256
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..4245
                     /gene="Ezh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctcgcca ttcttctgaa gaacagaggt acagtataaa gtccaacatt tcctgctgca
       61 ttccgtgagg aaaatggata tagcaagtcc cccaacttcc aaatgcatca catactggaa
      121 aagaaaggtg aaatctgaat acatgcggct gcggcagctc aaacggcttc aggcaaatat
      181 gggggcaaag gctctgtatg tggcaaattt tgcaaaagtt caagaaaaaa cccaaatcct
      241 caatgaagag tggaagaaac ttcgcgtcca gcctgttcag ccaatgaagc ctgtgagtgg
      301 gcaccctttt ctgaaaaagt gtaccataga gagcattttc ccaggttttg acagccagga
      361 tatgttgatg aggtctctga acacagttgc attggttcca atcatgtatt cctggtcccc
      421 tctccagcag aacttcatgg tggaggatga gacggttttg tgcaatattc cctacatggg
      481 tgatgaggtg aaggaggaag acgaaacttt catcgaggag ctgatcaaca actatgacgg
      541 caaagtccat ggtgaagaag agatgatccc tgggtctgtg ctgatcagcg atgctgtgtt
      601 tctggagttg gtagatgccc tcaatcagta ctcggatgag gaggaggaag ggcacaatga
      661 cacctccgat ggaaagcagg atgacagcaa agaggacctg ccagtgacaa gaaagcggaa
      721 acgccatgct attgaaggca acaaaaagag ctccaagaaa cagtttccaa atgacatgat
      781 cttcagcgcc attgcttcca tgttccccga gaatggtgtc cctgacgaca tgaaggagag
      841 gtatcgagag ctgacagaga tgtcggaccc caatgcactt ccccctcagt gcacacccaa
      901 catcgatggc cccaatgcta agtcagtgca gcgggagcag tctctgcact ctttccacac
      961 cctgttctgt cggcgctgtt ttaaatacga ctgcttcctt caccctttcc acgccacccc
     1021 taatgtgtac aaaaggaaga acagagaaat caagattgag ccagaaccat gtggtgcaga
     1081 ctgcttcctt tggctggaag gagcaaagga gtacgccatg ctgcataacc ctcggtccaa
     1141 gtgctctggg cgccgccgcc gaaggcaccc agtggtcagt gcttcctgtt ccaatacatc
     1201 cgcctctgct atggccgaga ctaaagaagg agacagtgac agagacactg gcaatgactg
     1261 ggcctccagt tcttcagagg ctaactctcg ctgtcagacc cccacgaaac agaaagctag
     1321 tccagcccca cctcagctct gtgttgtgga agctccctca gagcccgtgg aatggactgg
     1381 agctgaagaa tctcttttcc gagtcttcca tggcacctac ttcaacaact tctgctcaat
     1441 agccaggctt ctggggacaa agacatgcaa acaggtcttt cagtttgcag tcaaagaatc
     1501 acttatcctg aagctgccaa cagatgagct catgaaccct tcacagaaga agaaaagaaa
     1561 acacaggttg tgggctgcgc actgcaggaa aattcagctg aagaaagaca acaattctac
     1621 acaagtgtat aactaccaac cctgtgacca cccggaccgt ccctgtgaca gcacatgccc
     1681 ctgcatcatg acccagaact tttgtgaaaa gttctgccag tgcagcccag actgccagaa
     1741 ccgcttccct ggttgtcgct gtaagactca gtgcaatacc aagcagtgtc cttgctactt
     1801 ggccgttcgt gagtgtgacc ctgacttgtg cctcacctgc ggggcctcag agcactggga
     1861 ctgtaaggtg gtgtcttgca aaaactgcag catccagcgt ggcctcaaaa agcacctgct
     1921 gctggcccct tccgatgtgg ccggatgggg caccttcatc aaggagtctg tgcagaagaa
     1981 cgaattcatt tctgaatact gtggtgagct catctctcag gatgaggctg atcgacgagg
     2041 gaaggtctat gataaatata tgtccagctt cctcttcaac ctcaacaatg attttgtagt
     2101 ggatgctacc cggaaaggaa acaaaattcg ctttgcaaac cattcagtga accccaactg
     2161 ttatgccaaa gtggtcatgg tgaatggaga tcaccgcatt gggatctttg ccaagagagc
     2221 aattcaggct ggcgaagagc tcttctttga ttataggtac agccaagctg atgccctcaa
     2281 gtatgtgggc atcgaaaggg aaacggacgt cttctagccc tctgggccct gtgccagtgc
     2341 tgtggtagct gcactgtcat ggcttcaggc atacaccact gctgctccag ctcctgcaat
     2401 gtcttccatg ctgaaaaccc acccactcct gcataactag gcctccactt tattccaagg
     2461 ggatgacact ctgcctcagt gagaagggga acaggcggtg aagacctgct ctcccaggag
     2521 ggttcagatg tgagaagctg cacctctgtg ttagaggaga ggagatggtg ggcttgggat
     2581 gatatcagtg cttgactttt cctcagctcc caagctgtgg gccctcagga atcaaccagt
     2641 gctaccattt cggctttcta aattgagaat tcttatgtca ctagctgtca tgcattgcta
     2701 agtgaaacca ggtgcctgga gcctgcaggt gctcggggtc aaaggtgagc ctggcaggca
     2761 atgcagacag aactcaaagg gagatgtgtc tggtgacacc aaagcaggaa tttaaggata
     2821 caggagggaa ggctacatcc ctgtcctgta gacataggaa gagccagcta gaccctggca
     2881 aaggcctatc ctatagattc tgggggccgt agggcgtttt gaggctccta ggagcatgtg
     2941 ccagtgaccc aaccccttcc gaagtcctgg ctcaatggcc gcatgcctag gccgctgctg
     3001 agcacggggc agtgcctggc tggagcgtgt actccaggtc agtgaagctg cagttggcgt
     3061 caggccctcc attcctcaga ggcttatcca gggagcagct tggcttcttc agggtagctg
     3121 ggtctatcta gacagagcga ggtgttgcgg gtctgggttc tcctatctgc agtacctgct
     3181 gttggctgtt tgcgggtggg gcatgtcaca gtgcagggta gagtggcagg cggaccaccg
     3241 tcctctggga ctcctacaga accccgcact ttaactctct tgtagaaggg ttagagcata
     3301 gagtgcagct tgagccaagg tctctggggc tcctacccaa atcccacctc tgtaggagga
     3361 agagagtaga agattcccca gttctatctc atcttctgag aggcaggagg agctggcttg
     3421 acacaagaac aaaaaccagt cagccttgaa tctgatgtgc tgagaacaca gggctatgtt
     3481 ctggaaaggg cttgggcaga tagactgccc taggcagtgt tggaatgggg acaggcttct
     3541 tgttcctgga gaaccagagc tcctcccgtg gtccttgcta actgttccct tctccaccaa
     3601 agaaaccagg ctcccttcca ccacactgcc tcttagagat ttgcatgggt catgcatgct
     3661 tgtgcacata cacactcctt cactgcactg gtaggtacat gtgtacctca cactcacact
     3721 cagcacatac cccacagctc ctgacagtag cctcacccac ctcccaatca ggctagtccc
     3781 taccacagtt ctgaaattga catctgccaa tggtttgtgt ctgttgtgtg tatcagggat
     3841 accctcaagc ctagctacag gctctgaatt actcatgaat tctctgggaa acagagacag
     3901 gtggaggagg gactggtcat gaggaatgct ttaaaacatg tcggctctag actgacctca
     3961 gccttccctc agcaagcatc actggcagcc cctccttcca ccacagttca ggccaataat
     4021 actcatcctc ctccagacgc ccattcttgg ttcctgctgt cctctatttt taatgacggg
     4081 tttcacccct cctctccact tgtgccccac gtcatggaaa atgataacgt gaggtgctgt
     4141 ggactggtgg ggaactggcg tacatgcggc tttgctgcca gtgagtttct tgcactttaa
     4201 agccctgtgg cttgtgacct cttatctaat aaagtgttag agtcc
//
