LOCUS       NP_001100521             747 aa            linear   ROD 26-FEB-2024
DEFINITION  histone-lysine N-methyltransferase EZH1 [Rattus norvegicus].
ACCESSION   NP_001100521 XP_001081456 XP_220986
VERSION     NP_001100521.1
DBSOURCE    REFSEQ: accession NM_001107051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 747)
  AUTHORS   Ragazzini R, Perez-Palacios R, Baymaz IH, Diop S, Ancelin K,
            Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P,
            Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P,
            Vermeulen M and Margueron R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 747)
  AUTHORS   Bae WK, Kang K, Yu JH, Yoo KH, Factor VM, Kaji K, Matter M,
            Thorgeirsson S and Hennighausen L.
  TITLE     The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2
            control hepatocyte homeostasis and regeneration
  JOURNAL   FASEB J 29 (5), 1653-1662 (2015)
   PUBMED   25477280
REFERENCE   3  (residues 1 to 747)
  AUTHORS   Herz HM, Garruss A and Shilatifard A.
  TITLE     SET for life: biochemical activities and biological functions of
            SET domain-containing proteins
  JOURNAL   Trends Biochem Sci 38 (12), 621-639 (2013)
   PUBMED   24148750
  REMARK    Review article
REFERENCE   4  (residues 1 to 747)
  AUTHORS   Henriquez B, Bustos FJ, Aguilar R, Becerra A, Simon F, Montecino M
            and van Zundert B.
  TITLE     Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in
            developing hippocampal neurons
  JOURNAL   Mol Cell Neurosci 57, 130-143 (2013)
   PUBMED   23932971
  REMARK    GeneRIF: knock-down of Ezh1 reduces PSD-95 transcription in
            developing hippocampal neurons
REFERENCE   5  (residues 1 to 747)
  AUTHORS   Simon JA and Kingston RE.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   6  (residues 1 to 747)
  AUTHORS   Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC,
            Lee Y and Orkin SH.
  TITLE     Jumonji modulates polycomb activity and self-renewal versus
            differentiation of stem cells
  JOURNAL   Cell 139 (7), 1303-1314 (2009)
   PUBMED   20064376
REFERENCE   7  (residues 1 to 747)
  AUTHORS   Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G,
            Tarakhovsky A and Fuchs E.
  TITLE     Ezh2 orchestrates gene expression for the stepwise differentiation
            of tissue-specific stem cells
  JOURNAL   Cell 136 (6), 1122-1135 (2009)
   PUBMED   19303854
REFERENCE   8  (residues 1 to 747)
  AUTHORS   Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL,
            Dynlacht BD and Reinberg D.
  TITLE     Ezh1 and Ezh2 maintain repressive chromatin through different
            mechanisms
  JOURNAL   Mol Cell 32 (4), 503-518 (2008)
   PUBMED   19026781
REFERENCE   9  (residues 1 to 747)
  AUTHORS   van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T and
            Wientjens E.
  TITLE     Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2
            with Eed: indication for separate Pc-G complexes
  JOURNAL   Mol Cell Biol 18 (6), 3572-3579 (1998)
   PUBMED   9584197
REFERENCE   10 (residues 1 to 747)
  AUTHORS   Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin
            D, Pillus L and Jenuwein T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_220986.4, XP_001081456.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     Protein         1..747
                     /product="histone-lysine N-methyltransferase EZH1"
                     /EC_number="2.1.1.354"
                     /note="enhancer of zeste homolog 1"
                     /calculated_mol_wt=85218
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          159..262
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          433..474
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(434,463..464,466..467,469..471,473..474)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     Region          560..591
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          608..743
                     /region_name="SET_EZH1"
                     /note="SET domain found in enhancer of zeste homolog 1
                     (EZH1) and similar proteins; cd19217"
                     /db_xref="CDD:380994"
     Site            order(622,624..625,642,649,652..653,656,660,663,665..669,
                     686..690,698,725,727..728)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380994"
     Site            order(624..625,658..659,666,679,686..690,727)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380994"
     Site            order(624..625,658..659,662,666,679,686..687,689)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:380994"
     Site            order(642,652..653,665,667..669,698,725,727,729)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380994"
     Site            727
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:380994"
     CDS             1..747
                     /gene="Ezh1"
                     /coded_by="NM_001107051.1:74..2317"
                     /db_xref="GeneID:303547"
                     /db_xref="RGD:1305028"
ORIGIN      
        1 mdiaspptsk citywkrkvk seymrlrqlk rlqanmgaka lyvanfakvq ektqilneew
       61 kklrvqpvqp mkpvsghpfl kkctiesifp gfdsqdmlmr slntvalvpi myswsplqqn
      121 fmvedetvlc nipymgdevk eedetfieel innydgkvhg eeemipgsvl isdavflelv
      181 dalnqysdee eeghndtsdg kqddskedlp vtrkrkrhai egnkksskkq fpndmifsai
      241 asmfpengvp ddmkeryrel temsdpnalp pqctpnidgp naksvqreqs lhsfhtlfcr
      301 rcfkydcflh pfhatpnvyk rknreikiep epcgadcflw legakeyaml hnprskcsgr
      361 rrrrhpvvsa scsntsasam aetkegdsdr dtgndwasss seansrcqtp tkqkaspapp
      421 qlcvveapse pvewtgaees lfrvfhgtyf nnfcsiarll gtktckqvfq favkeslilk
      481 lptdelmnps qkkkrkhrlw aahcrkiqlk kdnnstqvyn yqpcdhpdrp cdstcpcimt
      541 qnfcekfcqc spdcqnrfpg crcktqcntk qcpcylavre cdpdlcltcg asehwdckvv
      601 sckncsiqrg lkkhlllaps dvagwgtfik esvqknefis eycgelisqd eadrrgkvyd
      661 kymssflfnl nndfvvdatr kgnkirfanh svnpncyakv vmvngdhrig ifakraiqag
      721 eelffdyrys qadalkyvgi eretdvf
//
