LOCUS       NM_001271317            3586 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus EYA transcriptional coactivator and phosphatase 4
            (Eya4), mRNA.
ACCESSION   NM_001271317 XM_001054483 XM_003748676 XM_003753153 XM_217715
VERSION     NM_001271317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Williams,T., Hundertmark,M., Nordbeck,P., Voll,S., Arias-Loza,P.A.,
            Oppelt,D., Muhlfelder,M., Schraut,S., Elsner,I., Czolbe,M.,
            Seidlmayer,L., Heinze,B., Hahner,S., Heinze,K., Schonberger,J.,
            Jakob,P. and Ritter,O.
  TITLE     Eya4 Induces Hypertrophy via Regulation of p27kip1
  JOURNAL   Circ Cardiovasc Genet 8 (6), 752-764 (2015)
   PUBMED   26499333
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Depreux,F.F., Darrow,K., Conner,D.A., Eavey,R.D., Liberman,M.C.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Eya4-deficient mice are a model for heritable otitis media
  JOURNAL   J Clin Invest 118 (2), 651-658 (2008)
   PUBMED   18219393
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Schonberger,J., Wang,L., Shin,J.T., Kim,S.D., Depreux,F.F., Zhu,H.,
            Zon,L., Pizard,A., Kim,J.B., Macrae,C.A., Mungall,A.J.,
            Seidman,J.G. and Seidman,C.E.
  TITLE     Mutation in the transcriptional coactivator EYA4 causes dilated
            cardiomyopathy and sensorineural hearing loss
  JOURNAL   Nat Genet 37 (4), 418-422 (2005)
   PUBMED   15735644
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Wayne,S., Robertson,N.G., DeClau,F., Chen,N., Verhoeven,K.,
            Prasad,S., Tranebjarg,L., Morton,C.C., Ryan,A.F., Van Camp,G. and
            Smith,R.J.
  TITLE     Mutations in the transcriptional activator EYA4 cause late-onset
            deafness at the DFNA10 locus
  JOURNAL   Hum Mol Genet 10 (3), 195-200 (2001)
   PUBMED   11159937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 15, 2012 this sequence version replaced
            XM_217715.6, XM_003748676.1, XM_001054483.3, XM_003753153.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345238,
                              SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000001.1  23991431-23991554
            125-253             JAXUCZ010000001.1  23992336-23992464
            254-352             JAXUCZ010000001.1  24019901-24019999
            353-402             JAXUCZ010000001.1  24114473-24114522
            403-527             JAXUCZ010000001.1  24162784-24162908
            528-620             JAXUCZ010000001.1  24172144-24172236
            621-687             JAXUCZ010000001.1  24176415-24176481
            688-830             JAXUCZ010000001.1  24177942-24178084
            831-974             JAXUCZ010000001.1  24178200-24178343
            975-1054            JAXUCZ010000001.1  24179374-24179453
            1055-1220           JAXUCZ010000001.1  24183387-24183552
            1221-1357           JAXUCZ010000001.1  24192958-24193094
            1358-1441           JAXUCZ010000001.1  24194784-24194867
            1442-1531           JAXUCZ010000001.1  24210840-24210929
            1532-1590           JAXUCZ010000001.1  24221676-24221734
            1591-1751           JAXUCZ010000001.1  24221841-24222001
            1752-1866           JAXUCZ010000001.1  24224283-24224397
            1867-1988           JAXUCZ010000001.1  24226488-24226609
            1989-2089           JAXUCZ010000001.1  24228354-24228454
            2090-3586           JAXUCZ010000001.1  24231783-24233279
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..3586
                     /gene="Eya4"
                     /note="EYA transcriptional coactivator and phosphatase 4"
                     /db_xref="GeneID:292172"
                     /db_xref="RGD:1307099"
     exon            1..124
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            125..253
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            254..352
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2170
                     /gene="Eya4"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="eyes absent homolog 4"
                     /protein_id="NP_001258246.1"
                     /db_xref="GeneID:292172"
                     /db_xref="RGD:1307099"
                     /translation="MEDTQDLNEQSVKKTCPESDVSEPQNSRSMEMQDLASPHALVGG
                     SDTPGSSKLDKSGLSSTSVTTNGTGVSLLAVKTEPLHSSETTTTTGDGALDTFTGSVI
                     TSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQ
                     TGQPYSLPAYDLGVMLPAIKTESGLPQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMP
                     GSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNT
                     ADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRK
                     NNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFN
                     LADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHATASSANLCLPTGVRG
                     GVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALK
                     SLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIV
                     SRFGTNITYVVIGDGRDEEHAANQHNMPFWRISSHSDLLALHQALELEYL"
     exon            353..402
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            403..527
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..620
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            621..687
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..830
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..974
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1054
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1220
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1357
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1441
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1531
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1590
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1751
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1866
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1988
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2089
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..3586
                     /gene="Eya4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgttgct tacttcccca gaaaaaagct ctttcctcag cccagagcaa gctccaggct
       61 ggtgtccatt ggtgtttaac tttgttacaa gtggacaaga gtcccttctg cctcctctct
      121 tgggagacac agcgcgaagg gaaaacttag acactggaag gaaagcgagt aaatacacag
      181 atcggacccg cagatcactg gctgggacag acaattgaac ttcgggagcc cgaggcggtc
      241 cgggccgcca gagatagtca attttgaatc ccaggaagct gcttctgcgt gggagtggca
      301 gaagaagtta gagaaccaca tggaagatac ccaggaccta aatgagcagt ccgtaaagaa
      361 aacgtgccca gaatcagatg tttcagaacc tcagaattcc aggtctatgg aaatgcaaga
      421 cctagcaagt ccccatgcct tggttggagg cagtgacaca cctgggagct ccaagctgga
      481 taaatccggt ctcagcagca cttcggtcac aacaaatggg acaggagtgt ctcttcttgc
      541 agtcaaaaca gagcccttgc acagcagtga gaccactacc acgactggag atggagcgct
      601 tgacactttt actgggtcag taataaccag cagtggctac agccccagat cggcacacca
      661 gtactcccca cagctgtacc cctccaagcc ctatccacac attctttcta caccagcagc
      721 tcaaacaatg tcggcctacg caggccagac tcagtactct gggatgcagc agccagcggt
      781 ctacacagcc tactcgcaga cagggcagcc ctacagcctg cccgcctacg atcttggtgt
      841 gatgttgcca gccatcaaga cggaaagtgg gcttccccaa actcagtccc ctttacagag
      901 tggctgcctc agctacagcc ctgggttttc taccccacag ccaggccaga caccttactc
      961 ttaccaaatg ccaggctcca gttttgcacc atcatccact atttatgcaa ataattccgt
     1021 ctctaattca acaaatttca gcggctcaca acaggattac ccatcgtaca cagcctttgg
     1081 ccaaaaccag tatgctcagt attactcagc atcaacctat ggggcataca tgacttcaaa
     1141 caacacagcc gatggcacat cgtcatccac ctcgacttac cagctacagg aatctctcca
     1201 aggactgact agccaaccag gagagtttga tacagtgcag agcccatcca caccaatcaa
     1261 agatcttgat gacagaacat gtagaagttc tgggtcaaag tctcgaggaa gaggccggaa
     1321 aaataatccc tccccacctc cggacagtga cctggagcgt gtgtttgtct gggacttgga
     1381 tgaaaccatc atcgtcttcc actctctcct cacgggctct tacgcacaga agtacggcaa
     1441 ggatcccccg atggctgtaa cccttgggct ccgaatggaa gaaatgatct ttaatcttgc
     1501 ggatacacat ttgtttttta acgacttaga ggagtgtgat caagttcata tagatgatgt
     1561 ttcctccgat gacaatggtc aggacttaag tacctacagt tttgcaactg atggcttcca
     1621 tgcaactgca agtagtgcga acctttgttt gccaacaggt gtgagaggag gggtggactg
     1681 gatgaggaag ctggcttttc gttacagaag agtaaaggaa ttatataaca cctacaagaa
     1741 caatgtcgga ggtctccttg gccctgccaa gagggatgca tggctgcagt taagggcaga
     1801 gatcgaaggc ctaacagatt cctggctaac aaatgcactt aagtctttat caattattag
     1861 tactaggagt aactgtgtaa atgtcttggt aacgacaacc cagctgattc ctgctcttgc
     1921 aaaagtcctg ctttacagcc taggaggtgc tttccccatt gagaatattt acagcgcaac
     1981 taaaataggc aaggaaagct gttttgagcg tatagtgtcc agatttggca ctaacataac
     2041 ttatgttgtg attggagatg gccgagacga ggagcacgcg gctaaccagc acaacatgcc
     2101 cttttggagg atatcaagcc actcggacct cttggctcta catcaagcac tggaattaga
     2161 gtatttgtaa ctgtattctc tagctgagga tccatttttt tttatatttc aagtacactg
     2221 aatttttatg tgtgatccaa tgccgctggc ttcttctaca catataaatg gtcttaacgg
     2281 atgaaatcat acttggaagg aaaactccag agtgaagaat tcgggttgct gaatggaatt
     2341 aaactttagt gctacagaaa ggaagctcta tggtcttatt atctttacaa tactttcatg
     2401 gtttaaaaaa aaatcagtgg cagttgctga cacgtatcaa gtgagtccta agagggatta
     2461 acagctttag taaagaactg gaaccctccg agccacagca cctgctctgc ctctgacaag
     2521 gtggttgaaa acattcctca aaatgggagc tcttctcaac cctgaggttt gaatctgact
     2581 tatagcctac ctagcccaga aaatctgaat cggaatgcac tcagactgta taacgacagt
     2641 cctatctaga catgtaattt gtgtaaatta ttgatggaaa taatttactg tgactttatt
     2701 agcagctgac tctgaaagtg gatgcaattt ttcttttatt tgttggggtg ggaaagggct
     2761 ggggaaatgg gaatataata ttgtctcttt tttaaggttg gcaaagagaa tgttcatact
     2821 gatgtgttgt gccttaaaga caagacagca tttgtgtgtt acaatgtaac tttggttaca
     2881 actctctata gataatcaaa gacaaaaaaa actttaaaaa aatcaagcaa acaaacaaat
     2941 acctttgtga taattcttca catgaccaaa tttaaaattc aacctatcag tttaatatgg
     3001 agtcattgac aaactgagta tttgttaaaa tgagaaacca gtaacacaga actattgggt
     3061 tctaaatgat ttcagtaatc agtatatgtc agttatctga acacccaatc acaagcaggt
     3121 ttgggagact ataggttctt tatttagaga gtgaaatata tagatattaa agtttcaagt
     3181 atcctttctt acagttttct ggatggaaat taagagctct attcatgtca acatacccaa
     3241 ttttagttta agactggata tgtgccagtt tctaagagga caatatcatg gtgcaaattt
     3301 agcaaatatt accaaagtca tttttagaac atgctatgga tgtagcttaa aacacacatt
     3361 gagtaggcac agcagagtgc atttgtcttc catgctgtta caaaagcaag tgtcatcaat
     3421 ggtagaaggc aggtatacca gatagctctc aaggaaacaa ctctgaatct gtgaattttt
     3481 tatataatat tattataagt aaattatcga acaagctata tcttgacatc accaccagat
     3541 cacaacagta aaagggtatt cactctcctt ggaacacatc agtcca
//
