LOCUS       NP_001258246             616 aa            linear   ROD 31-MAR-2024
DEFINITION  eyes absent homolog 4 [Rattus norvegicus].
ACCESSION   NP_001258246 XP_001054483 XP_003748724 XP_003753201 XP_217715
VERSION     NP_001258246.1
DBSOURCE    REFSEQ: accession NM_001271317.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 616)
  AUTHORS   Williams,T., Hundertmark,M., Nordbeck,P., Voll,S., Arias-Loza,P.A.,
            Oppelt,D., Muhlfelder,M., Schraut,S., Elsner,I., Czolbe,M.,
            Seidlmayer,L., Heinze,B., Hahner,S., Heinze,K., Schonberger,J.,
            Jakob,P. and Ritter,O.
  TITLE     Eya4 Induces Hypertrophy via Regulation of p27kip1
  JOURNAL   Circ Cardiovasc Genet 8 (6), 752-764 (2015)
   PUBMED   26499333
REFERENCE   2  (residues 1 to 616)
  AUTHORS   Depreux,F.F., Darrow,K., Conner,D.A., Eavey,R.D., Liberman,M.C.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Eya4-deficient mice are a model for heritable otitis media
  JOURNAL   J Clin Invest 118 (2), 651-658 (2008)
   PUBMED   18219393
REFERENCE   3  (residues 1 to 616)
  AUTHORS   Schonberger,J., Wang,L., Shin,J.T., Kim,S.D., Depreux,F.F., Zhu,H.,
            Zon,L., Pizard,A., Kim,J.B., Macrae,C.A., Mungall,A.J.,
            Seidman,J.G. and Seidman,C.E.
  TITLE     Mutation in the transcriptional coactivator EYA4 causes dilated
            cardiomyopathy and sensorineural hearing loss
  JOURNAL   Nat Genet 37 (4), 418-422 (2005)
   PUBMED   15735644
REFERENCE   4  (residues 1 to 616)
  AUTHORS   Wayne,S., Robertson,N.G., DeClau,F., Chen,N., Verhoeven,K.,
            Prasad,S., Tranebjarg,L., Morton,C.C., Ryan,A.F., Van Camp,G. and
            Smith,R.J.
  TITLE     Mutations in the transcriptional activator EYA4 cause late-onset
            deafness at the DFNA10 locus
  JOURNAL   Hum Mol Genet 10 (3), 195-200 (2001)
   PUBMED   11159937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 15, 2012 this sequence version replaced
            XP_217715.6, XP_003748724.1, XP_001054483.3, XP_003753201.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345238,
                              SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     Protein         1..616
                     /product="eyes absent homolog 4"
                     /EC_number="3.1.3.48"
                     /calculated_mol_wt=66793
     Region          12..>328
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          345..616
                     /region_name="HAD_Eya"
                     /note="protein tyrosine phosphatase domain of the nuclear
                     transcription factor of Eyes absent (Eya) and related
                     phosphatase domains; cd02601"
                     /db_xref="CDD:319789"
     Site            order(347,574,576,592,594..597,603,606,609..610,613..616)
                     /site_type="other"
                     /note="SIX1 interface [polypeptide binding]"
                     /db_xref="CDD:319789"
     Site            order(352..356,446..447,555,579..580,584..585)
                     /site_type="active"
                     /db_xref="CDD:319789"
     CDS             1..616
                     /gene="Eya4"
                     /coded_by="NM_001271317.1:320..2170"
                     /db_xref="GeneID:292172"
                     /db_xref="RGD:1307099"
ORIGIN      
        1 medtqdlneq svkktcpesd vsepqnsrsm emqdlaspha lvggsdtpgs skldksglss
       61 tsvttngtgv sllavktepl hssetttttg dgaldtftgs vitssgyspr sahqyspqly
      121 pskpyphils tpaaqtmsay agqtqysgmq qpavytaysq tgqpyslpay dlgvmlpaik
      181 tesglpqtqs plqsgclsys pgfstpqpgq tpysyqmpgs sfapsstiya nnsvsnstnf
      241 sgsqqdypsy tafgqnqyaq yysastygay mtsnntadgt ssststyqlq eslqgltsqp
      301 gefdtvqsps tpikdlddrt crssgsksrg rgrknnpspp pdsdlervfv wdldetiivf
      361 hslltgsyaq kygkdppmav tlglrmeemi fnladthlff ndleecdqvh iddvssddng
      421 qdlstysfat dgfhatassa nlclptgvrg gvdwmrklaf ryrrvkelyn tyknnvggll
      481 gpakrdawlq lraeiegltd swltnalksl siistrsncv nvlvtttqli palakvllys
      541 lggafpieni ysatkigkes cferivsrfg tnityvvigd grdeehaanq hnmpfwriss
      601 hsdllalhqa leleyl
//
