LOCUS       NM_001415864            5293 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus EYA transcriptional coactivator and phosphatase 3
            (Eya3), transcript variant 1, mRNA.
ACCESSION   NM_001415864 XM_006239024
VERSION     NM_001415864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5293)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   2  (bases 1 to 5293)
  AUTHORS   Krishnan,N., Jeong,D.G., Jung,S.K., Ryu,S.E., Xiao,A., Allis,C.D.,
            Kim,S.J. and Tonks,N.K.
  TITLE     Dephosphorylation of the C-terminal tyrosyl residue of the DNA
            damage-related histone H2A.X is mediated by the protein phosphatase
            eyes absent
  JOURNAL   J Biol Chem 284 (24), 16066-16070 (2009)
   PUBMED   19351884
REFERENCE   3  (bases 1 to 5293)
  AUTHORS   Cook,P.J., Ju,B.G., Telese,F., Wang,X., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     Tyrosine dephosphorylation of H2AX modulates apoptosis and survival
            decisions
  JOURNAL   Nature 458 (7238), 591-596 (2009)
   PUBMED   19234442
REFERENCE   4  (bases 1 to 5293)
  AUTHORS   Zhang,H. and Stavnezer,E.
  TITLE     Ski regulates muscle terminal differentiation by transcriptional
            activation of Myog in a complex with Six1 and Eya3
  JOURNAL   J Biol Chem 284 (5), 2867-2879 (2009)
   PUBMED   19008232
REFERENCE   5  (bases 1 to 5293)
  AUTHORS   Rayapureddi,J.P., Kattamuri,C., Steinmetz,B.D., Frankfort,B.J.,
            Ostrin,E.J., Mardon,G. and Hegde,R.S.
  TITLE     Eyes absent represents a class of protein tyrosine phosphatases
  JOURNAL   Nature 426 (6964), 295-298 (2003)
   PUBMED   14628052
REFERENCE   6  (bases 1 to 5293)
  AUTHORS   Li,X., Oghi,K.A., Zhang,J., Krones,A., Bush,K.T., Glass,C.K.,
            Nigam,S.K., Aggarwal,A.K., Maas,R., Rose,D.W. and Rosenfeld,M.G.
  TITLE     Eya protein phosphatase activity regulates Six1-Dach-Eya
            transcriptional effects in mammalian organogenesis
  JOURNAL   Nature 426 (6964), 247-254 (2003)
   PUBMED   14628042
  REMARK    Erratum:[Nature. 2004 Jan 15;427(6971):265]
REFERENCE   7  (bases 1 to 5293)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2023 this sequence version replaced XM_006239024.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3178222.1,
                                           SRR26643289.16397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000005.1  150137294-150137361
            69-170              JAXUCZ010000005.1  150153890-150153991
            171-214             JAXUCZ010000005.1  150158620-150158663
            215-294             JAXUCZ010000005.1  150162531-150162610
            295-361             JAXUCZ010000005.1  150165686-150165752
            362-498             JAXUCZ010000005.1  150168872-150169008
            499-636             JAXUCZ010000005.1  150176170-150176307
            637-722             JAXUCZ010000005.1  150183813-150183898
            723-906             JAXUCZ010000005.1  150185225-150185408
            907-1043            JAXUCZ010000005.1  150187578-150187714
            1044-1127           JAXUCZ010000005.1  150192851-150192934
            1128-1217           JAXUCZ010000005.1  150194836-150194925
            1218-1276           JAXUCZ010000005.1  150198989-150199047
            1277-1437           JAXUCZ010000005.1  150201915-150202075
            1438-1552           JAXUCZ010000005.1  150205040-150205154
            1553-1674           JAXUCZ010000005.1  150206393-150206514
            1675-1775           JAXUCZ010000005.1  150212068-150212168
            1776-5293           JAXUCZ010000005.1  150215002-150218519
FEATURES             Location/Qualifiers
     source          1..5293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5293
                     /gene="Eya3"
                     /note="EYA transcriptional coactivator and phosphatase 3"
                     /db_xref="GeneID:313027"
                     /db_xref="RGD:1309932"
     exon            1..68
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            69..170
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1856
                     /gene="Eya3"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; eyes
                     absent 3 homolog; eyes absent homolog 3"
                     /codon_start=1
                     /product="eyes absent homolog 3 isoform 1"
                     /protein_id="NP_001402793.1"
                     /db_xref="GeneID:313027"
                     /db_xref="RGD:1309932"
                     /translation="MEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLA
                     SNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQS
                     QPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAH
                     YSYPIPASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFG
                     VTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQ
                     ARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTV
                     VIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGS
                     GGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAE
                     IEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYS
                     ATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQA
                     LELDFL"
     exon            171..214
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            215..294
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..361
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..498
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..636
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..722
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..906
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1043
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1127
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1217
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1276
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1437
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1552
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1674
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1775
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..5293
                     /gene="Eya3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctgttgg tgccagagtg ggtccgaagt ggtcccatgt tgtgctttgg agtatctgca
       61 gccgtctgac agtttgtgaa gaccgcagag acttgcagtc cagtcacata agtgtgtgta
      121 aagagacagc ggtcctcatg gaagaagagc aagacctacc agagcgaccg gtgaaaaagg
      181 ccaagatgca ggaaccagga gaacaaactt taagtcaagt aaacaaccca gacaccagtg
      241 atcagaagcc tgagaccgcc agccttgcgt caaaccttag catgtcagag gaaattatga
      301 catgcaccga ttacatccct cgctcatcca atgattatac ctcacaaatg tattctgcaa
      361 aaccttatgc acacatcctc tcggttcctg tttcggaaac cacttatcct gggcagactc
      421 agtaccagac actgcagcag tctcaaccct acgctgtcta ccctcaggca acccaaactt
      481 atggactacc tcctttcggt gcactgtggc caggtatgaa acctgaaagt ggtttaattc
      541 agactccatc tccaagtcaa cacagtgttc ttacctgcac tacaggctta accacaagcc
      601 agccaagccc agcacattat tcttacccca ttccagcttc aagcacaaat gccagcctga
      661 tatccacttc atctgcaatt gccaatattc cagcagcagc cgtggccagc atctcaaacc
      721 aggactatcc cacctatact attcttggac agaatcagta ccaggcctgc taccccagtt
      781 ccagctttgg agtcacaggt cagactaaca gtgatactga gaatacagca ttagcagcta
      841 caacgtacca gacggagaag cctggtgcta tgggacctgc accagccaca cagaggcttc
      901 cttccgactc gtccacaagc ccacctttgt cccagacaac accaaataaa gatgctgatg
      961 atcaggccag gaaaaacatg actgtcaaga accgaggcaa gaggaaagct gacgccagct
     1021 cttcccagga cagcgaatta gaacgggtat ttctctggga cttggatgaa accatcatca
     1081 tatttcattc ccttcttacc ggatcctatg ctcagaagta tggaaaggac ccaacagtcg
     1141 taattggctc aggtttaaca atggaagaaa tgatttttga agtggctgat acacatctat
     1201 ttttcaatga cttagaagag tgtgaccagg tgcatgtgga agatgtggct tctgatgaca
     1261 atggccagga tttgagcaac tacagtttct caacagatgg tttcagtggt tcaggaggca
     1321 gcgggagcca cggatcctct gtgggagttc agggaggtgt ggactggatg aggaaactgg
     1381 cctttcgcta ccgaaaagtg agggaaatct atgataagca taaaagcaac gttggtggcc
     1441 ttctcagccc ccagaggaag gaggctctgc agcggctcag agcagagatc gaagtgctga
     1501 cggactcctg gctaggaacc gcgctgaagt ccttgcttct catccagtct cgaaagaatt
     1561 gtgtgaatgt tctgatcact accacccagt tggttccagc cctggccaag gttctcctgt
     1621 atggactagg agaaatattt cctattgaga acatctacag tgctaccaaa atcggtaagg
     1681 agagctgctt tgagagaatc gtttcgagat ttgggaaaaa agtcacatat gtagtaattg
     1741 gagatggacg agatgaagaa attgcagcca agcagcacaa catgcccttc tggaggatca
     1801 caaaccatgg agatctggtg tccctgcacc aggctttaga gctcgacttc ctctaagaac
     1861 tggaatgtgg gaccttcctt ccttgtgagc ttctttttac ctccgacagg agccagaagc
     1921 cagaaccctc tgagcccctt ctctcctgtc tgtctctcca tgtctcagcg cccctccccc
     1981 tctcctgctc tctctccatg gaatgctggc gagcacacaa tcagaaccaa cagctgcagc
     2041 ccacgtccac tgtacagcag gaggcgcctg gataaagctg cagaccggct gcagccactg
     2101 tgctttaatt tttcagtttc ctttgggaaa ggaagaacaa ggaaagctga tgctcagggc
     2161 acagctgtgc tcacacggac agactgggag ctgctcctga gcgtggggat ggaacgtgcg
     2221 tccccttgag atcttctgtt ctcttagtgt agactgtctc ccagtgatgg gtatgttgtt
     2281 tttataggtg agggtctggt ctctcaagca gccttcccca cttctctatg aagaaagcag
     2341 tgtgtaaagt ttccgtgaca gtagtaatgg aaatatctaa aatacctccg tgacaggacc
     2401 tcttctggac aggaccgagg ctccagtgct ctgctctcta gcgaggctcc ttgccatcta
     2461 cagggccctg gtcacttact ttagactttg gcatctccca tcttgtaagc ctcggtctcc
     2521 ttggcaatcc tacttcacct gtaagcaaat ggcacaaccc tggaaacaac ttccacagac
     2581 aataaatcta agcctttagc ttgtaattca gaagctctgt cccaggaagc taccctgcaa
     2641 actggagaga aggggcttgg acttcttagg aattccatcc ttagttcctg aggtaagact
     2701 tcaccccgtg cacctgcaga tgcttcttct gcggtcagct tagttgtcag atgctgggca
     2761 cacttctgcc ctcacaaccg cccctctcca tgcagctctg gccagcccct acccactcca
     2821 ttcaagtcag aaaggccagg ggcgggctct agctgcttcc ttcacctgca cttgcatgcg
     2881 gtgatcccac cttgtattta cacagatctg tgcctaggag tggagagcag agaactagaa
     2941 tcaaaaccca gtttcacatg aaatatccca ctgctcaaat tccatgctga agtgggaaac
     3001 ccgaccagaa agactttctt gacttaaaca cttgaaaata gaatcctgag cttaggtgta
     3061 agagcacttc tcaagcctgc tcccctgccc ctgcaccctg gacagttagg aggggaactg
     3121 gtccgaagtc ccagccctca agcccagctg tgttttttgg ttttattttg gtttttgttt
     3181 gggtattttg ttttggtttg atttagtttg gttttgtttt ttaaggcact atcccttcag
     3241 gaccaatgtc ggtgcctgct taattgggtt aaacttccct gaagttgaga atgtgcagcc
     3301 ttggtcttca gggggtcttg aaccaacccc tagctacaat cactgtcccc aaagatactg
     3361 cagcccagag gcaaagttcc tcttcatgcc aggctaccag acagtggcag aaaggctgac
     3421 acaccatctt cagagctgtt ggacacttct gagtgcttct gagaccagca gttgaggaag
     3481 gagctcagga ggcgaggttg gtgtcttggc cacgcctttg gctttgtttt gaggtatggg
     3541 gttggagtaa ggagctggag tctaagccag accttccgaa gctgtatttg gcaccactat
     3601 cctagtcctg gccatccgtg cttcctggtc caatagagaa aactccaggg taagttttac
     3661 tttaagtctc caaccctccc cccgttgcca gtgtagtttc ttgtcctgga caatggccac
     3721 ctattggtgc tgtgcttcag gcttaccaga ctgccaagtg gtgacacacc cctctgcaca
     3781 caggtaccac cacaaaccct tcaggggaga ctctgttctt agaacaggga atccctttcc
     3841 tcttgccctg actggagtgg caaggaggtg ttctgagctg agtggctgtt ccagcaccag
     3901 cagccactct gacagggcag acagagcagg agtgcattgg tgtctctagg gactgctggc
     3961 ctttgagctg ctgaccttcc ctccctccca tagaggcttg ggaaggaaaa tgagcgggca
     4021 gcattaagag ctgctagtaa cagaagcagg cttggtggag gatagcgcct gcagcctgtg
     4081 cagaggtcca aggtttgagt gcccacagga ctcctcacga cctctcactg cagctccaga
     4141 gggtttggtg ccctcctttg gcctcttcag gcaccaagca cttacatgta agaaagcact
     4201 caagtataca ataaaatttc ttttaatatt aaaagctgtt ggaggttaga cctgaaggaa
     4261 actgggtcct ttcatcaaca tcagaaggca gtccttaccg gaaggacccc ttgaagaaat
     4321 tagctggtga gtcctttccc tgccggatcc tgtgttctgg aagattagtt tggacatctc
     4381 atggtgacag ctagttctag gagagtctgt ggagttgcag gaaggtcctg ggatacaagg
     4441 tggcttgact tcgaatgtaa cagtgactgt gccttagcat caccctgtcc agtgcccctg
     4501 gggcagctgg tgatgtccgt ccgagagagt ggatacctgc tccacagttt aggtgcctat
     4561 ttgggctttt gatttggggg tgttctcttc tctgctagtt gggtgtcaga gctagtgtcc
     4621 caagagactt ggcacagctg gcacagcttg tcttatgttt gcccaaactc agccttcaca
     4681 gctccaagta gaatctgatt ggcaaactgc aactggaagc ccgcggcgct tctagaccct
     4741 gctttgaatg ggcgtcacac gaccgacagg agcaccaggc aaagccgggt gctgtcctgg
     4801 aagagtacag gctagcctcc aagtgccaag cttgggcctc attgttcatc ttccccaggt
     4861 tgtagctgag ggcccctcga gtaagcttgt gctccttgct gctcacctgg tcagcagcta
     4921 gaatgaccca gttcactgga gacgctaagt tggaattctg agcttcccaa atatcttaac
     4981 cacaagaggg aaaactccgc ttgtacccca ggctttccgg ggccgcttgc cctcctcttc
     5041 cgtgagtgga ttctagtgag catggcccct ggctgcctcc ttactgagca gaaccctccc
     5101 agttaaggac catttctact tggatcacca ctctccctct ggactctgcc tctagcaggg
     5161 aaaggcaaca gttgggttgg atgtatttat gtgactgcgg gcatttgtgg ctatagagtc
     5221 cttgaccata atgttatatg taatgggaac tatcttataa acttgaaaaa ataaagtttt
     5281 tattttctat aca
//
