LOCUS       NP_001402793             572 aa            linear   ROD 30-MAR-2024
DEFINITION  eyes absent homolog 3 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001402793 XP_006239086
VERSION     NP_001402793.1
DBSOURCE    REFSEQ: accession NM_001415864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 572)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   2  (residues 1 to 572)
  AUTHORS   Krishnan,N., Jeong,D.G., Jung,S.K., Ryu,S.E., Xiao,A., Allis,C.D.,
            Kim,S.J. and Tonks,N.K.
  TITLE     Dephosphorylation of the C-terminal tyrosyl residue of the DNA
            damage-related histone H2A.X is mediated by the protein phosphatase
            eyes absent
  JOURNAL   J Biol Chem 284 (24), 16066-16070 (2009)
   PUBMED   19351884
REFERENCE   3  (residues 1 to 572)
  AUTHORS   Cook,P.J., Ju,B.G., Telese,F., Wang,X., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     Tyrosine dephosphorylation of H2AX modulates apoptosis and survival
            decisions
  JOURNAL   Nature 458 (7238), 591-596 (2009)
   PUBMED   19234442
REFERENCE   4  (residues 1 to 572)
  AUTHORS   Zhang,H. and Stavnezer,E.
  TITLE     Ski regulates muscle terminal differentiation by transcriptional
            activation of Myog in a complex with Six1 and Eya3
  JOURNAL   J Biol Chem 284 (5), 2867-2879 (2009)
   PUBMED   19008232
REFERENCE   5  (residues 1 to 572)
  AUTHORS   Rayapureddi,J.P., Kattamuri,C., Steinmetz,B.D., Frankfort,B.J.,
            Ostrin,E.J., Mardon,G. and Hegde,R.S.
  TITLE     Eyes absent represents a class of protein tyrosine phosphatases
  JOURNAL   Nature 426 (6964), 295-298 (2003)
   PUBMED   14628052
REFERENCE   6  (residues 1 to 572)
  AUTHORS   Li,X., Oghi,K.A., Zhang,J., Krones,A., Bush,K.T., Glass,C.K.,
            Nigam,S.K., Aggarwal,A.K., Maas,R., Rose,D.W. and Rosenfeld,M.G.
  TITLE     Eya protein phosphatase activity regulates Six1-Dach-Eya
            transcriptional effects in mammalian organogenesis
  JOURNAL   Nature 426 (6964), 247-254 (2003)
   PUBMED   14628042
  REMARK    Erratum:[Nature. 2004 Jan 15;427(6971):265]
REFERENCE   7  (residues 1 to 572)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2023 this sequence version replaced XP_006239086.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3178222.1,
                                           SRR26643289.16397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..572
                     /product="eyes absent homolog 3 isoform 1"
                     /EC_number="3.1.3.48"
                     /note="eyes absent 3 homolog; eyes absent homolog 3"
                     /calculated_mol_wt=62459
     Region          <4..>192
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          <129..>269
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          301..572
                     /region_name="EYA-cons_domain"
                     /note="eyes absent protein conserved domain; TIGR01658"
                     /db_xref="CDD:273739"
     CDS             1..572
                     /gene="Eya3"
                     /coded_by="NM_001415864.1:138..1856"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:313027"
                     /db_xref="RGD:1309932"
ORIGIN      
        1 meeeqdlper pvkkakmqep geqtlsqvnn pdtsdqkpet aslasnlsms eeimtctdyi
       61 prssndytsq mysakpyahi lsvpvsetty pgqtqyqtlq qsqpyavypq atqtyglppf
      121 galwpgmkpe sgliqtpsps qhsvltcttg lttsqpspah ysypipasst naslistssa
      181 ianipaaava sisnqdypty tilgqnqyqa cypsssfgvt gqtnsdtent alaattyqte
      241 kpgamgpapa tqrlpsdsst spplsqttpn kdaddqarkn mtvknrgkrk adasssqdse
      301 lervflwdld etiiifhsll tgsyaqkygk dptvvigsgl tmeemifeva dthlffndle
      361 ecdqvhvedv asddngqdls nysfstdgfs gsggsgshgs svgvqggvdw mrklafryrk
      421 vreiydkhks nvggllspqr kealqrlrae ievltdswlg talksllliq srkncvnvli
      481 tttqlvpala kvllyglgei fpieniysat kigkescfer ivsrfgkkvt yvvigdgrde
      541 eiaakqhnmp fwritnhgdl vslhqaleld fl
//
