LOCUS       NM_130427               2381 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus EYA transcriptional coactivator and phosphatase 2
            (Eya2), transcript variant 1, mRNA.
ACCESSION   NM_130427 XM_008762456 XM_230860
VERSION     NM_130427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Lee,S.H., Kim,J., Ryu,J.Y., Lee,S., Yang,D.K., Jeong,D., Kim,J.,
            Lee,S.H., Kim,J.M., Hajjar,R.J. and Park,W.J.
  TITLE     Transcription coactivator Eya2 is a critical regulator of
            physiological hypertrophy
  JOURNAL   J Mol Cell Cardiol 52 (3), 718-726 (2012)
   PUBMED   22197309
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Krishnan,N., Jeong,D.G., Jung,S.K., Ryu,S.E., Xiao,A., Allis,C.D.,
            Kim,S.J. and Tonks,N.K.
  TITLE     Dephosphorylation of the C-terminal tyrosyl residue of the DNA
            damage-related histone H2A.X is mediated by the protein phosphatase
            eyes absent
  JOURNAL   J Biol Chem 284 (24), 16066-16070 (2009)
   PUBMED   19351884
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Grifone,R., Demignon,J., Giordani,J., Niro,C., Souil,E., Bertin,F.,
            Laclef,C., Xu,P.X. and Maire,P.
  TITLE     Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis
            in the mouse embryo
  JOURNAL   Dev Biol 302 (2), 602-616 (2007)
   PUBMED   17098221
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   Rayapureddi,J.P., Kattamuri,C., Steinmetz,B.D., Frankfort,B.J.,
            Ostrin,E.J., Mardon,G. and Hegde,R.S.
  TITLE     Eyes absent represents a class of protein tyrosine phosphatases
  JOURNAL   Nature 426 (6964), 295-298 (2003)
   PUBMED   14628052
REFERENCE   5  (bases 1 to 2381)
  AUTHORS   Clark,S.W., Fee,B.E. and Cleveland,J.L.
  TITLE     Misexpression of the eyes absent family triggers the apoptotic
            program
  JOURNAL   J Biol Chem 277 (5), 3560-3567 (2002)
   PUBMED   11700312
REFERENCE   6  (bases 1 to 2381)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Oct 27, 2022 this sequence version replaced
            XM_008762456.3, NM_130427.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1285756.1,
                                           SRR22582416.1274500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000003.1  174754876-174755076
            202-302             JAXUCZ010000003.1  174829065-174829165
            303-348             JAXUCZ010000003.1  174840164-174840209
            349-491             JAXUCZ010000003.1  174842897-174843039
            492-608             JAXUCZ010000003.1  174845034-174845150
            609-676             JAXUCZ010000003.1  174874147-174874214
            677-851             JAXUCZ010000003.1  174877420-174877594
            852-994             JAXUCZ010000003.1  174886803-174886945
            995-1078            JAXUCZ010000003.1  174894188-174894271
            1079-1168           JAXUCZ010000003.1  174917424-174917513
            1169-1227           JAXUCZ010000003.1  174927204-174927262
            1228-1388           JAXUCZ010000003.1  174929107-174929267
            1389-1503           JAXUCZ010000003.1  174932326-174932440
            1504-1625           JAXUCZ010000003.1  174933042-174933163
            1626-1726           JAXUCZ010000003.1  174935063-174935163
            1727-2381           JAXUCZ010000003.1  174937381-174938035
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2381
                     /gene="Eya2"
                     /note="EYA transcriptional coactivator and phosphatase 2"
                     /db_xref="GeneID:156826"
                     /db_xref="RGD:620096"
     exon            1..201
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..302
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1807
                     /gene="Eya2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Drosophila-type eyes absent 2-like protein; eyes absent 2
                     homolog; eyes absent homolog 2"
                     /codon_start=1
                     /product="eyes absent homolog 2 isoform 1"
                     /protein_id="NP_569111.2"
                     /db_xref="GeneID:156826"
                     /db_xref="RGD:620096"
                     /translation="MLEVVISPSLAASSDWGEHGAAVGALTDREGTAKAASLSVPQLF
                     AKSHPRVPPGQSSAAMAAYGQTQYSTGIQQTPPYTAYPPPAQAYGIPPYSIKTEDSLN
                     HSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSY
                     PNFPQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVSQSSESLAGDYNT
                     HNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFH
                     SLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDN
                     GQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVG
                     GLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAK
                     VLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNM
                     PFWRISCHADLEALRHALELEYL"
     exon            303..348
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..491
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..608
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..676
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..851
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..994
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1078
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1168
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1227
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1388
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1503
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1625
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1726
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2381
                     /gene="Eya2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcagggc cgagtccccg cccggagcca gcgccgcgcc ccgcggcccc cacgcacggc
       61 gcggcccggc gggggcgcag gagacccgcg gcccggacag ggggccggtc cccgggacag
      121 gaggctgccg caaccctgcg acattcgctc cgcgtgccat ccccgggccc ggcccgctcg
      181 ggacgcctct gcactgagcg ggtacaaggc aatgttagaa gtggtgatct cacccagcct
      241 cgcagcaagc agtgactggg gcgagcacgg tgcggccgtg ggggcgctga ctgacagaga
      301 aggcaccgcc aaagcagcct ctctgagtgt ccctcagctc tttgcgaagt ctcacccacg
      361 tgtccctccg ggtcagtcct ctgcagccat ggcagcctat ggccagacac agtacagcac
      421 aggcatccag cagacgccac cctatacagc gtacccacct ccggcgcaag cctatggaat
      481 ccccccttac agtatcaaga cagaagacag tttgaatcac tcgcccagcc agagtgggtt
      541 cctgagctac ggaccgagct tcagcaccgc gcctgctgga cagagcccct acacctaccc
      601 agtgcacagc accgcagggc tctatcaagg cgccaacgga ttgaccaaca cggccggatt
      661 tgggagcgtg caccaggatt acccctccta ccccaacttc ccacagaacc agtaccccca
      721 gtatttcagc ccatcataca acccgcccta tgtcccagcc agcagcctct gctcctcgcc
      781 cctctccacg tccacctacg tcctccagga ggctcctcac aatgtcagcc agagttctga
      841 gtcactggcc ggagactaca acacacacaa cggaccctcc acgccagcaa aggagggtga
      901 cacagacagg ccacatcggg cctcggatgg gaaactacgg ggccggtcaa agaggagtag
      961 tgacccctcc ccagcaggag acaatgaaat tgagcgcgtg ttcgtctggg acctggacga
     1021 gacaatcatc attttccact ccctgctcac aggaacgttc gcatccagat atgggaagga
     1081 caccacgacg tcagtgcgca tcggcctgat gatggaggag atgatcttca acctcgctga
     1141 cacacacctg ttcttcaatg acctggagga ctgtgaccaa atccacgtgg atgatgtctc
     1201 atccgatgac aatggccagg acttaagcac atacaacttc tccactgatg gtttccacag
     1261 cacggcgcca ggggccagct tgtgcctggg tacaggtgtt cacggcggtg tggattggat
     1321 gaggaaacta gccttccgct accgtcgggt gaaggagatg tacaatacct accgcaacaa
     1381 cgtgggcggc ttgataggcg ctcccaaaag agagacatgg ctgcagctgc gcgctgagct
     1441 ggaggccctg actgacctct ggctcaccca ctccctgaag gccctcaacc tcatcaactc
     1501 tcgacccaac tgtgtcaatg tgttggtcac caccacacaa ctgatccctg cattggccaa
     1561 ggtcctgctg tatggtctgg gctccgtgtt ccccatcgag aacatctaca gcgcgaccaa
     1621 gacaggcaag gagagctgct tcgagaggat catgcagagg ttcggtcgca aagctgtcta
     1681 catcgtgata ggcgacgggg tggaggaaga gcaaggagcc aaaaagcaca acatgccgtt
     1741 ctggaggata tcctgccacg ctgacctgga ggctctgagg catgccctgg aactggagta
     1801 tctatagcgt gagggttgca gccaccacct gccacccacc agccaggccc ttgtcatctc
     1861 acaccatgag ggccccagac accagaaact aggtagtggc cctataccta ggggacacgt
     1921 tccacggcca tttcggaagt gtcctcttcc cttggggaca gagagtcaga ctctgctatg
     1981 aattccagag acccacgtga gggcacgcca gttcgtcttg ttctccctct taatttatgg
     2041 actgctccca acactcccat tacccactgg tccctgtgtt gtggtttctt ggctgttggt
     2101 gtggtttggg gttctaaact gcctgtgggg tagtgaatgc ccagttttgt gtttcaggga
     2161 caatcattct ctaggcgttg gttggtgagt gaggcggtgt ggggctatgg ggaagcctgt
     2221 tgcttacctt ttctcttcca agcccctctc tgatgtcatg cggacagtgt gggtgcctta
     2281 tgccgccatc ttgtgttgta ggagaggggg ggaccctggg aagggaaggg tgctcggcaa
     2341 caatggataa aggcattaaa taaaaccacg tttacatttt a
//
