LOCUS       NP_569111                531 aa            linear   ROD 07-MAY-2024
DEFINITION  eyes absent homolog 2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_569111 XP_008760678 XP_230860
VERSION     NP_569111.2
DBSOURCE    REFSEQ: accession NM_130427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Lee,S.H., Kim,J., Ryu,J.Y., Lee,S., Yang,D.K., Jeong,D., Kim,J.,
            Lee,S.H., Kim,J.M., Hajjar,R.J. and Park,W.J.
  TITLE     Transcription coactivator Eya2 is a critical regulator of
            physiological hypertrophy
  JOURNAL   J Mol Cell Cardiol 52 (3), 718-726 (2012)
   PUBMED   22197309
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Krishnan,N., Jeong,D.G., Jung,S.K., Ryu,S.E., Xiao,A., Allis,C.D.,
            Kim,S.J. and Tonks,N.K.
  TITLE     Dephosphorylation of the C-terminal tyrosyl residue of the DNA
            damage-related histone H2A.X is mediated by the protein phosphatase
            eyes absent
  JOURNAL   J Biol Chem 284 (24), 16066-16070 (2009)
   PUBMED   19351884
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Grifone,R., Demignon,J., Giordani,J., Niro,C., Souil,E., Bertin,F.,
            Laclef,C., Xu,P.X. and Maire,P.
  TITLE     Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis
            in the mouse embryo
  JOURNAL   Dev Biol 302 (2), 602-616 (2007)
   PUBMED   17098221
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Rayapureddi,J.P., Kattamuri,C., Steinmetz,B.D., Frankfort,B.J.,
            Ostrin,E.J., Mardon,G. and Hegde,R.S.
  TITLE     Eyes absent represents a class of protein tyrosine phosphatases
  JOURNAL   Nature 426 (6964), 295-298 (2003)
   PUBMED   14628052
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Clark,S.W., Fee,B.E. and Cleveland,J.L.
  TITLE     Misexpression of the eyes absent family triggers the apoptotic
            program
  JOURNAL   J Biol Chem 277 (5), 3560-3567 (2002)
   PUBMED   11700312
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Oct 27, 2022 this sequence version replaced
            XP_008760678.1, NP_569111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1285756.1,
                                           SRR22582416.1274500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     Protein         1..531
                     /product="eyes absent homolog 2 isoform 1"
                     /EC_number="3.1.3.48"
                     /note="Drosophila-type eyes absent 2-like protein; eyes
                     absent 2 homolog; eyes absent homolog 2"
                     /calculated_mol_wt=57906
     Region          260..531
                     /region_name="HAD_Eya"
                     /note="protein tyrosine phosphatase domain of the nuclear
                     transcription factor of Eyes absent (Eya) and related
                     phosphatase domains; cd02601"
                     /db_xref="CDD:319789"
     Site            order(262,489,491,507,509..512,518,521,524..525,528..531)
                     /site_type="other"
                     /note="SIX1 interface [polypeptide binding]"
                     /db_xref="CDD:319789"
     Site            order(267..271,361..362,470,494..495,499..500)
                     /site_type="active"
                     /db_xref="CDD:319789"
     CDS             1..531
                     /gene="Eya2"
                     /coded_by="NM_130427.2:212..1807"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:156826"
                     /db_xref="RGD:620096"
ORIGIN      
        1 mlevvispsl aassdwgehg aavgaltdre gtakaaslsv pqlfakshpr vppgqssaam
       61 aaygqtqyst giqqtppyta ypppaqaygi ppysikteds lnhspsqsgf lsygpsfsta
      121 pagqspytyp vhstaglyqg angltntagf gsvhqdypsy pnfpqnqypq yfspsynppy
      181 vpasslcssp lststyvlqe aphnvsqsse slagdynthn gpstpakegd tdrphrasdg
      241 klrgrskrss dpspagdnei ervfvwdlde tiiifhsllt gtfasrygkd tttsvriglm
      301 meemifnlad thlffndled cdqihvddvs sddngqdlst ynfstdgfhs tapgaslclg
      361 tgvhggvdwm rklafryrrv kemyntyrnn vggligapkr etwlqlrael ealtdlwlth
      421 slkalnlins rpncvnvlvt ttqlipalak vllyglgsvf pieniysatk tgkescferi
      481 mqrfgrkavy ivigdgveee qgakkhnmpf wrischadle alrhaleley l
//
