LOCUS       NM_020097               3190 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus exostosin-like glycosyltransferase 3 (Extl3),
            mRNA.
ACCESSION   NM_020097
VERSION     NM_020097.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3190)
  AUTHORS   Volpi,S., Yamazaki,Y., Brauer,P.M., van Rooijen,E., Hayashida,A.,
            Slavotinek,A., Sun Kuehn,H., Di Rocco,M., Rivolta,C.,
            Bortolomai,I., Du,L., Felgentreff,K., Ott de Bruin,L.,
            Hayashida,K., Freedman,G., Marcovecchio,G.E., Capuder,K., Rath,P.,
            Luche,N., Hagedorn,E.J., Buoncompagni,A., Royer-Bertrand,B.,
            Giliani,S., Poliani,P.L., Imberti,L., Dobbs,K., Poulain,F.E.,
            Martini,A., Manis,J., Linhardt,R.J., Bosticardo,M.,
            Rosenzweig,S.D., Lee,H., Puck,J.M., Zuniga-Pflucker,J.C., Zon,L.,
            Park,P.W., Superti-Furga,A. and Notarangelo,L.D.
  TITLE     EXTL3 mutations cause skeletal dysplasia, immune deficiency, and
            developmental delay
  JOURNAL   J Exp Med 214 (3), 623-637 (2017)
   PUBMED   28148688
REFERENCE   2  (bases 1 to 3190)
  AUTHORS   Oud,M.M., Tuijnenburg,P., Hempel,M., van Vlies,N., Ren,Z.,
            Ferdinandusse,S., Jansen,M.H., Santer,R., Johannsen,J.,
            Bacchelli,C., Alders,M., Li,R., Davies,R., Dupuis,L., Cale,C.M.,
            Wanders,R.J.A., Pals,S.T., Ocaka,L., James,C., Muller,I.,
            Lehmberg,K., Strom,T., Engels,H., Williams,H.J., Beales,P.,
            Roepman,R., Dias,P., Brunner,H.G., Cobben,J.M., Hall,C.,
            Hartley,T., Le Quesne Stabej,P., Mendoza-Londono,R., Davies,E.G.,
            de Sousa,S.B., Lessel,D., Arts,H.H. and Kuijpers,T.W.
  TITLE     Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome
  JOURNAL   Am J Hum Genet 100 (2), 281-296 (2017)
   PUBMED   28132690
REFERENCE   3  (bases 1 to 3190)
  AUTHORS   Acquatella-Tran Van Ba,I., Marchal,S., Francois,F., Silhol,M.,
            Lleres,C., Michel,B., Benyamin,Y., Verdier,J.M., Trousse,F. and
            Marcilhac,A.
  TITLE     Regenerating islet-derived 1alpha (Reg-1alpha) protein is new
            neuronal secreted factor that stimulates neurite outgrowth via
            exostosin Tumor-like 3 (EXTL3) receptor
  JOURNAL   J Biol Chem 287 (7), 4726-4739 (2012)
   PUBMED   22158612
  REMARK    GeneRIF: Regenerating islet-derived 1alpha (Reg-1alpha) protein is
            new neuronal secreted factor that stimulates neurite outgrowth via
            exostosin Tumor-like 3 (EXTL3) receptor.
REFERENCE   4  (bases 1 to 3190)
  AUTHORS   Bluth,M.H., Patel,S.A., Dieckgraefe,B.K., Okamoto,H. and
            Zenilman,M.E.
  TITLE     Pancreatic regenerating protein (reg I) and reg I receptor mRNA are
            upregulated in rat pancreas after induction of acute pancreatitis
  JOURNAL   World J Gastroenterol 12 (28), 4511-4516 (2006)
   PUBMED   16874863
  REMARK    GeneRIF: Acute pancreatitis results in increased tissue reg I
            protein levels in the pancreas, as well as a threefold induction of
            reg I receptor. Induction of reg I and its receptor may be
            important for recovery from acute pancreatitis.
REFERENCE   5  (bases 1 to 3190)
  AUTHORS   Kazumori,H., Ishihara,S., Fukuda,R. and Kinoshita,Y.
  TITLE     Localization of Reg receptor in rat fundic mucosa
  JOURNAL   J Lab Clin Med 139 (2), 101-108 (2002)
   PUBMED   11919548
  REMARK    GeneRIF: localization in fundic mucosa
REFERENCE   6  (bases 1 to 3190)
  AUTHORS   Kobayashi,S., Akiyama,T., Nata,K., Abe,M., Tajima,M.,
            Shervani,N.J., Unno,M., Matsuno,S., Sasaki,H., Takasawa,S. and
            Okamoto,H.
  TITLE     Identification of a receptor for reg (regenerating gene) protein, a
            pancreatic beta-cell regeneration factor
  JOURNAL   J Biol Chem 275 (15), 10723-10726 (2000)
   PUBMED   10753861
REFERENCE   7  (bases 1 to 3190)
  AUTHORS   McCormick,C., Duncan,G., Goutsos,K.T. and Tufaro,F.
  TITLE     The putative tumor suppressors EXT1 and EXT2 form a stable complex
            that accumulates in the Golgi apparatus and catalyzes the synthesis
            of heparan sulfate
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 668-673 (2000)
   PUBMED   10639137
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            [WARNING] On Jul 15, 2024 this sequence was replaced by
            NM_020097.3.
            
            On Nov 26, 2020 this sequence version replaced NM_020097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033367.1, SRR26643290.46387.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2152              JAXUCZ010000015.1  43493010-43495161   c
            2153-2280           JAXUCZ010000015.1  43483636-43483763   c
            2281-2425           JAXUCZ010000015.1  43477262-43477406   c
            2426-2554           JAXUCZ010000015.1  43473930-43474058   c
            2555-3190           JAXUCZ010000015.1  43471366-43472001   c
FEATURES             Location/Qualifiers
     source          1..3190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3190
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /note="exostosin-like glycosyltransferase 3"
                     /db_xref="GeneID:56819"
                     /db_xref="RGD:62065"
     exon            1..2152
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..2764
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /EC_number="2.4.1.223"
                     /note="exostoses-like 3; Reg receptor; exostoses
                     (multiple)-like 3; exostosin-like 3-like"
                     /codon_start=1
                     /product="exostosin-like 3"
                     /protein_id="NP_064482.1"
                     /db_xref="GeneID:56819"
                     /db_xref="RGD:62065"
                     /translation="MTGYTMLRNGGVGNGGQTCMLRWSNRIRLTWLSFTLFIILVFFP
                     LIAHYYLTTLDEADEAGKRIFGPRAGNELCEVKHVLDLCRIRESVSEELLQLEAKRQE
                     LNSEIAKLNLKIEACKKSIENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLL
                     PEKDDAGLPPPKVTRGCRLHNCFDYSRCPLTSGFPVFVYDSDQFAFGSYLDPLVKQAF
                     QATVRANVYVTENAAIACLYVVLVGEIQEPAVLQPADLEKQLHSLPHWRTDGHNHVII
                     NLSRKSDTQNLLYNVSTGRAMVAQSTFYAAQYRAGFDLVVSPLVHAMSEPNFMEIPPQ
                     VPVKRKYLFTFQGEKIESLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLD
                     QVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPSLLISSGCATR
                     LFEALEVGAVPVVLGEQVQLPYHDMLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAM
                     RRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEVAAEIPHRSGKAAGTDPN
                     MADNGDLDLGPVETEPPYASPKYLRNFTLTVTDCYRSWNSAPGPFHLFPHTPFDPVLP
                     SEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVQREQFTVVMLTYEREEVLMNSLER
                     LNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAI
                     LSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
                     LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWT
                     FRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTK
                     CFKFI"
     exon            2153..2280
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2425
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2554
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..3190
                     /gene="Extl3"
                     /gene_synonym="Regr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcatgaca ggctatacca tgttgcggaa tgggggagtg gggaacggtg gtcagacctg
       61 tatgctgcgc tggtccaacc gcatccggct gacctggctg agtttcacgc tgttcatcat
      121 cctggtcttc ttccccctca ttgcccacta ttacctcacc actctggatg aggcagatga
      181 ggccggcaag cgcatctttg gcccccgggc tggcaacgag ctctgtgagg taaagcacgt
      241 cctagatctt tgtcggatcc gcgagtctgt gagcgaagag cttctacagc tagaagccaa
      301 gcggcaggag ctgaacagcg agattgccaa gctaaacctc aagattgaag cctgtaagaa
      361 gagtatagag aacgccaagc aggacctgct gcagctcaag aatgtcatta gccagacaga
      421 gcactcctac aaggagctga tggcccagaa ccagcccaaa ctgtcactgc ccatccggct
      481 gctccctgag aaggatgacg ctggccttcc accccccaag gtcactcggg gttgccggct
      541 acacaactgc ttcgattact ctcgttgccc tctgacgtct ggctttcctg tcttcgtcta
      601 tgacagtgac cagtttgcct ttgggagcta cctggaccct ttggtcaagc aggcttttca
      661 ggctacagtg agagccaacg tttatgttac agaaaatgca gccatcgcct gcctgtatgt
      721 ggtgttagtg ggagagatac aagagcccgc tgtgctgcag cctgccgacc ttgagaagca
      781 gctgcattct ctgccacact ggaggacaga cggacacaac catgtcatca tcaatctgtc
      841 ccggaagtca gacacacaaa atttactgta caatgtcagt acaggtcggg ccatggtggc
      901 ccagtctacc ttctatgctg cccagtacag agctggcttt gacttggttg tgtcaccact
      961 tgtccatgcc atgtctgaac ccaacttcat ggaaatccca ccgcaggtgc cagttaagcg
     1021 gaaatatctc ttcactttcc agggtgagaa gattgagtct ctaagatcta gccttcagga
     1081 ggcccgttcc tttgaggaag aaatggaggg tgaccctccg gccgactatg atgatcgaat
     1141 cattgccacc ctcaaggccg tacaggacag caagctagat caggtgctgg tagaatttac
     1201 ttgcaaaaac cagccaaagc ccagtctgcc tactgagtgg gcactgtgtg gggagcggga
     1261 agaccggcta gagttactga agctctccac cttcgccctc atcatcactc ccggggaccc
     1321 gagcctgctt atctcatctg gctgtgcaac acggctcttt gaagccttgg aggtgggagc
     1381 tgtgcctgtt gtccttgggg agcaggtgca gcttccgtac cacgacatgc tacaatggaa
     1441 tgaggccgcc ctagtggtgc ccaagcctcg tgttacagag gttcacttcc tgttacgaag
     1501 tctgtcagac agtgatctgt tggctatgag gcggcaaggc cgctttctct gggagaccta
     1561 cttctccacc gctgacagta tttttaatac cgtgctggcc atgattagga ctcgaattca
     1621 gatcccagct gctcccatcc gggaagaggt agcagctgag atcccccatc gttcaggcaa
     1681 ggcagctggt actgacccca acatggctga caatggggac ctggacctgg ggccggtaga
     1741 gacagagccg ccctatgcct cacctaaata cctccgtaat ttcactctga ctgtcactga
     1801 ctgttaccgc agctggaact ccgcacccgg acctttccat ctttttccac acacaccctt
     1861 tgaccctgtg ctgccctctg aggccaaatt cctgggctca gggactggat ttcggcccat
     1921 cggtggtggg gctgggggct ctggcaagga gttccaggca gcgcttggag gcaatgtcca
     1981 gcgggagcag ttcacagttg tgatgctgac ctacgagcgg gaggaagtgc tcatgaactc
     2041 cctggagagg ctcaatggcc tcccctacct gaacaaggta gtggtggtgt ggaactctcc
     2101 caagctgccc tcggaggacc ttttgtggcc agacattggt gtccccatca tggttgtccg
     2161 tactgagaag aacagtttga acaatcggtt cttgccctgg aatgagatag agacagaggc
     2221 aatattgtcc atcgatgacg atgcccacct ccgccatgat gaaatcatgt tcgggtttcg
     2281 ggtgtggaga gaggcgcgtg atcgcattgt ggggttccct ggccggtacc atgcgtggga
     2341 catccctcac cagtcctggc tctacaactc caactactcc tgtgagctgt ccatggtgct
     2401 gacgggtgct gccttctttc acaagtatta cgcctacctg tattcttatg tgatgcccca
     2461 ggccatccga gacatggtgg atgagtatat caactgtgag gatatcgcca tgaacttcct
     2521 tgtctcccac atcacacgga agccccccat caaggtgaca tcgaggtgga cttttcgatg
     2581 cccggggtgc cctcaggccc tgtcccacga tgactctcac tttcatgagc ggcacaagtg
     2641 tatcaacttt tttgtcaagg tgtacggcta tatgcctctc ctgtacacac agtttagggt
     2701 ggactctgtg ctcttcaaga cccgcctgcc ccatgacaag accaagtgct tcaagttcat
     2761 ctagggcctt gccagttctg aggagaagac agtgagcaga gtgaggggag tcacccccaa
     2821 ggttcccaag gtgttgaagg tccttgggga catcgtgggg cagggcccag gccctttgct
     2881 tggagaagag cagggagagt agaaagggat ggctgtcttt attttgaagt cagccgcact
     2941 gggcctggaa tcctggtcag cagactcagg gcaccgacta atggcgaaca ctgaggactg
     3001 ttcatgagcc cgggacagct ggttcccggt ttttaaattc agaacagcat ttactattta
     3061 aagagagagt ttcacatctg ccatccaagg cttatttata tgtgcgtata tgtacacaca
     3121 tatgtgtata tacatgtata tgcacgcaca cacacacaca cacacacaca cacacacaca
     3181 cacacacaca
//
