LOCUS       NM_001100704            2016 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus exostosin-like glycosyltransferase 2 (Extl2),
            mRNA.
ACCESSION   NM_001100704 XM_001073624 XM_227614
VERSION     NM_001100704.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Pedersen LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen
            LG, Sugahara K and Negishi M.
  TITLE     Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase
            (EXTL2), a member of the exostosin gene family involved in heparan
            sulfate biosynthesis
  JOURNAL   J Biol Chem 278 (16), 14420-14428 (2003)
   PUBMED   12562774
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   McCormick C, Duncan G, Goutsos KT and Tufaro F.
  TITLE     The putative tumor suppressors EXT1 and EXT2 form a stable complex
            that accumulates in the Golgi apparatus and catalyzes the synthesis
            of heparan sulfate
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 668-673 (2000)
   PUBMED   10639137
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Kitagawa H, Shimakawa H and Sugahara K.
  TITLE     The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,
            4-N-acetylhexosaminyltransferase that transfers
            N-acetylgalactosamine and N-acetylglucosamine to the common
            glycosaminoglycan-protein linkage region. The key enzyme for the
            chain initiation of heparan sulfate
  JOURNAL   J Biol Chem 274 (20), 13933-13937 (1999)
   PUBMED   10318803
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162014.1.
            
            On or before May 31, 2008 this sequence version replaced
            XM_001073624.1, XM_227614.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162014.1, EV776185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2016
                     /gene="Extl2"
                     /note="exostosin-like glycosyltransferase 2"
                     /db_xref="GeneID:310803"
                     /db_xref="RGD:1307684"
     exon            1..105
                     /gene="Extl2"
                     /inference="alignment:Splign:2.1.0"
     exon            106..181
                     /gene="Extl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1166
                     /gene="Extl2"
                     /EC_number="2.4.1.223"
                     /note="exotoses (multiple)-like 2; exostoses-like 2;
                     exostoses (multiple)-like 2"
                     /codon_start=1
                     /product="exostosin-like 2"
                     /protein_id="NP_001094174.1"
                     /db_xref="GeneID:310803"
                     /db_xref="RGD:1307684"
                     /translation="MRGCHICKLPGRVMGIRVLRFSLVIILVLLLVAGALTNLLPNIK
                     EDKMLTVRREIKSQSKSALDSFTLIMQTYNRTDLLLRLLNHYQAVPNLHKVIVVWNNV
                     GEKGPEELWNSLGPHPIPVLFKPQTANRMRNRLQVFPEVETNAVLMVDDDVLISAQDL
                     VFAFSIWQQFPDQIVGFVPRKHVSTSSGIYSYGGFELQTPGLGNGDQYSMVLIGASFF
                     HSKYLDLFQKQPAAVHTLIDETQNCDDIAMNFIVSKHTGKSSGIFVKPINIINLEKET
                     NGYSGMWHRAEHFLQRSYCLNKLVNIFSGMPLKYSNIMISQFGFPYANHKSKM"
     exon            182..609
                     /gene="Extl2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..680
                     /gene="Extl2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1991
                     /gene="Extl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaggatgg cttcacgagg tcaacgctaa gggagcccac gctacccgcg gaaaccgtga
       61 tgcggtacgc gatcgttgag tgccttgcaa aagaaactct taaagtacca agagagcctg
      121 ttcccatgaa gccctgaagc tgtaaggaat gctgttgtaa aaaaattaat aatacgatga
      181 ggggttgcca catctgcaaa cttccgggaa gagtcatggg gatccgtgtg ctccggttct
      241 ccctggtgat catccttgtg ttgctgctag tagctggagc tttgaccaac ttactcccca
      301 acatcaaaga agacaagatg ctcactgtgc gtagggaaat caaatcccag agcaagtcgg
      361 ccctggattc gttcactctc atcatgcaga cgtacaacag aacagacctc ttactaagac
      421 tcttaaatca ttatcaggcg gtaccgaatc tgcacaaagt gatcgtggtg tggaacaatg
      481 tgggagagaa gggaccagag gagttgtgga attctctagg gcctcacccc atccctgtcc
      541 tcttcaaacc acaaacggca aacagaatga gaaatcgact ccaggtcttc cctgaggtgg
      601 agaccaacgc ggtgttaatg gtagacgatg acgtgctcat tagcgcccag gaccttgttt
      661 ttgctttctc aatctggcag caatttccgg atcagatcgt aggatttgta cctagaaaac
      721 acgtatctac ttcctccggt atctacagtt acggaggctt tgagctgcag actcctgggc
      781 ttggaaacgg cgaccagtac tccatggtgc tcatcggagc ctccttcttc cacagcaaat
      841 acctggacct cttccagaaa cagcctgcag ccgtccacac gctgatcgac gagacccaaa
      901 actgtgacga tatcgccatg aacttcatcg tcagcaagca cactggcaag tcttcaggga
      961 tattcgtgaa acctataaac atcatcaatt tggagaaaga aaccaacggt tattcaggaa
     1021 tgtggcatcg ggcagagcac tttctgcaga gatcctactg tctgaataag cttgttaaca
     1081 tcttcagtgg catgcccttg aagtactcca acattatgat ttcccagttt ggctttccat
     1141 atgccaacca caaaagtaag atgtgaacca gaaacaaaca aacccaaaac acctcttggt
     1201 tttcagtggt ttctccatgc tgtgtgttct tttgcttttt ttttttttaa agcaacaccg
     1261 tgaactttta tctagtccac aagtctgtat aatagaaaaa aatatgcagt acttctcaag
     1321 tataaaacac atggacttca aaagccaaaa agccgacctt accagatagt atttcttgta
     1381 aagagctttt gtccaaggtt gtaattcctt ggcggtaata ttattgttta catctcgagg
     1441 ctgcttttgt ttgagccctg gcatttgcct tatggaccta cagcgagctg cttccagaga
     1501 ctcaaaagag acaattttca acttttcagt gaaggttgat tgtttttatt tgaagcctga
     1561 aatgcctgca gtatagggaa aagccatgtg aggagagttt agtctgaacc cagtgttgag
     1621 aatcaggaac attcctggtt gccagtgtcc tttctggccc ctctaagcag aattgactaa
     1681 gcccagcatg gtttggacaa agccgtcagt gctggtgttt ttgctgttat gcctgtcgtg
     1741 actgggagtg ttaagttttc atggctgact attgtttaat tgtttggggt tttgtttgtt
     1801 tgtttgtttt cgtgaaccta ctctgcatgg atcactaaaa tgtgcccgcc atgtttctta
     1861 gatgcaactt atatgcaaca aggagtcagt gtgctcctgt aacctgccac cgtgtgtgac
     1921 cttgagaatc gacattagtt cttatatttt ccagaatgtg ttgagtaaat atgtataaat
     1981 aacttctgaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
