LOCUS       NP_001386435             718 aa            linear   ROD 30-MAR-2024
DEFINITION  exostosin-2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001386435
VERSION     NP_001386435.1
DBSOURCE    REFSEQ: accession NM_001399506.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 718)
  AUTHORS   Shevelev,O.B., Rykova,V.I., Fedoseeva,L.A., Leberfarb,E.Y.,
            Dymshits,G.M. and Kolosova,N.G.
  TITLE     Expression of Ext1, Ext2, and heparanase genes in brain of
            senescence-accelerated OXYS rats in early ontogenesis and during
            development of neurodegenerative changes
  JOURNAL   Biochemistry (Mosc) 77 (1), 56-61 (2012)
   PUBMED   22339633
  REMARK    GeneRIF: Ext2 gene is involved in heparan sulfate proteoglycans
            metabolism.
REFERENCE   2  (residues 1 to 718)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (residues 1 to 718)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (residues 1 to 718)
  AUTHORS   Presto,J., Thuveson,M., Carlsson,P., Busse,M., Wilen,M.,
            Eriksson,I., Kusche-Gullberg,M. and Kjellen,L.
  TITLE     Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1
            expression and heparan sulfate sulfation
  JOURNAL   Proc Natl Acad Sci U S A 105 (12), 4751-4756 (2008)
   PUBMED   18337501
REFERENCE   5  (residues 1 to 718)
  AUTHORS   Busse,M., Feta,A., Presto,J., Wilen,M., Gronning,M., Kjellen,L. and
            Kusche-Gullberg,M.
  TITLE     Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain
            elongation
  JOURNAL   J Biol Chem 282 (45), 32802-32810 (2007)
   PUBMED   17761672
REFERENCE   6  (residues 1 to 718)
  AUTHORS   Stickens,D., Zak,B.M., Rougier,N., Esko,J.D. and Werb,Z.
  TITLE     Mice deficient in Ext2 lack heparan sulfate and develop exostoses
  JOURNAL   Development 132 (22), 5055-5068 (2005)
   PUBMED   16236767
REFERENCE   7  (residues 1 to 718)
  AUTHORS   Busse,M. and Kusche-Gullberg,M.
  TITLE     In vitro polymerization of heparan sulfate backbone by the EXT
            proteins
  JOURNAL   J Biol Chem 278 (42), 41333-41337 (2003)
   PUBMED   12907669
REFERENCE   8  (residues 1 to 718)
  AUTHORS   McCormick,C., Duncan,G., Goutsos,K.T. and Tufaro,F.
  TITLE     The putative tumor suppressors EXT1 and EXT2 form a stable complex
            that accumulates in the Golgi apparatus and catalyzes the synthesis
            of heparan sulfate
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 668-673 (2000)
   PUBMED   10639137
REFERENCE   9  (residues 1 to 718)
  AUTHORS   Philippe,C., Porter,D.E., Emerton,M.E., Wells,D.E., Simpson,A.H.
            and Monaco,A.P.
  TITLE     Mutation screening of the EXT1 and EXT2 genes in patients with
            hereditary multiple exostoses
  JOURNAL   Am J Hum Genet 61 (3), 520-528 (1997)
   PUBMED   9326317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166748.1, SRR26643291.9520.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     Protein         1..718
                     /product="exostosin-2 isoform 1"
                     /EC_number="2.4.1.224"
                     /note="exostoses (multiple) 2; exostosin 2"
                     /calculated_mol_wt=81889
     Region          100..380
                     /region_name="Exostosin"
                     /note="Exostosin family; pfam03016"
                     /db_xref="CDD:397245"
     Region          456..697
                     /region_name="Glyco_transf_64"
                     /note="Glycosyl transferase family 64 domain; pfam09258"
                     /db_xref="CDD:430488"
     CDS             1..718
                     /gene="Ext2"
                     /coded_by="NM_001399506.1:214..2370"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:311215"
                     /db_xref="RGD:1307707"
ORIGIN      
        1 mcasvksnir gpaliprmkt khriyyvtlf sivllgliat gmfqfwphsi esssdggvek
       61 rsirevpvvr ltadspiper gdlscrmhtc fdvyrcgfnp knkikvyiyp lkkyvddagv
      121 pvssaisrey nelltaisds dyytddisra clfvpsidvl nqnplriket aqalaqlprw
      181 drgtnhllfn mlpggppdyn taldvprdra llagggfstw tyrqgydvsi pvfsplsaev
      241 alpekapgsr ryfllssqma ihpeyreele alqakhresv lvldkctnls egvlsirkrc
      301 hqhqvfdypq vlqeatfctv lrgarlgqav lsdvlqagcv pvviadsyil pfsevldwkr
      361 asvvipeekm sdvysilqni pqrqieemqr qarwfweayf rsikaialat lqiindriyp
      421 yaaisyeewn dppavkwasv snplflplip pqsqgftaiv ltydrveslf rvitevskvp
      481 slskllvvwn nqnknppees lwpkirvplk vvrtaenkls nrffpydeie teavlaiddd
      541 iimltsdelq fgyevwrefp drlvgypgrl hlwdhemnkw kyesewtnev smvltgaafy
      601 hkyfnylyty kmpgdiknwv dahmncedia mnflvanvtg kavikvtprk kfkcpectai
      661 dglsldqthm versecinkf asvfgtmplk vvehradpvl ykddfpeklk sfpnigsl
//
