LOCUS       NM_001025406            1647 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus exosome component 9 (Exosc9), mRNA.
ACCESSION   NM_001025406 XM_215550
VERSION     NM_001025406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Richard,P., Feng,S. and Manley,J.L.
  TITLE     A SUMO-dependent interaction between Senataxin and the exosome,
            disrupted in the neurodegenerative disease AOA2, targets the
            exosome to sites of transcription-induced DNA damage
  JOURNAL   Genes Dev 27 (20), 2227-2232 (2013)
   PUBMED   24105744
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Dong,Y., Zhang,L., Zhang,S., Bai,Y., Chen,H., Sun,X., Yong,W.,
            Li,W., Colvin,S.C., Rhodes,S.J., Shou,W. and Zhang,Z.Y.
  TITLE     Phosphatase of regenerating liver 2 (PRL2) is essential for
            placental development by down-regulating PTEN (Phosphatase and
            Tensin Homologue Deleted on Chromosome 10) and activating Akt
            protein
  JOURNAL   J Biol Chem 287 (38), 32172-32179 (2012)
   PUBMED   22791713
REFERENCE   3  (bases 1 to 1647)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1647)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   5  (bases 1 to 1647)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   6  (bases 1 to 1647)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   7  (bases 1 to 1647)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   8  (bases 1 to 1647)
  AUTHORS   West,S., Gromak,N., Norbury,C.J. and Proudfoot,N.J.
  TITLE     Adenylation and exosome-mediated degradation of cotranscriptionally
            cleaved pre-messenger RNA in human cells
  JOURNAL   Mol Cell 21 (3), 437-443 (2006)
   PUBMED   16455498
REFERENCE   9  (bases 1 to 1647)
  AUTHORS   Mukherjee,D., Gao,M., O'Connor,J.P., Raijmakers,R., Pruijn,G.,
            Lutz,C.S. and Wilusz,J.
  TITLE     The mammalian exosome mediates the efficient degradation of mRNAs
            that contain AU-rich elements
  JOURNAL   EMBO J 21 (1-2), 165-174 (2002)
   PUBMED   11782436
REFERENCE   10 (bases 1 to 1647)
  AUTHORS   Kho,C.J., Huggins,G.S., Endege,W.O., Patterson,C., Jain,M.K.,
            Lee,M.E. and Haber,E.
  TITLE     The polymyositis-scleroderma autoantigen interacts with the
            helix-loop-helix proteins E12 and E47
  JOURNAL   J Biol Chem 272 (20), 13426-13431 (1997)
   PUBMED   9148967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097413.1.
            
            On Jul 15, 2005 this sequence version replaced XM_215550.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1647
                     /gene="Exosc9"
                     /note="exosome component 9"
                     /db_xref="GeneID:294975"
                     /db_xref="RGD:1307888"
     exon            1..111
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1359
                     /gene="Exosc9"
                     /note="exosome complex exonuclease RRP45"
                     /codon_start=1
                     /product="exosome complex component RRP45"
                     /protein_id="NP_001020577.1"
                     /db_xref="GeneID:294975"
                     /db_xref="RGD:1307888"
                     /translation="MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYG
                     CCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKL
                     NRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHF
                     RRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMD
                     GLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVR
                     KEGGKFGFAESIANQRITAFKMEKAPIDTSNIEEKAEEIIAEAEPPPEVVSKPVLWTP
                     GTAQIGEGIENSWGDLEDSEKEEEEEGGIDETVILDDTKMDTGEVSDIGSQGAPIVLS
                     DSEEEEMIILEPEKSPKKIRAQTSANQKAPSKSQGKRRKKKRTAN"
     exon            112..206
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            207..326
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            327..429
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            430..567
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            568..650
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            651..783
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            784..872
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1019
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1201
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1280
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1623
                     /gene="Exosc9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggatttgt ctcggtgcgg ttcttcctct gcgtgtcccg ccactatgaa ggaaacgccg
       61 ctttccaact gcgagcgccg cttcctgctc cgtgcaattg aggagaagaa gcggctggat
      121 ggcagacaaa cctatgatta caggaacatc aggatctcat tcggaacgga ttatggatgc
      181 tgtattgtag aactggggaa aacaagagtc ctcggacagg tttcctgtga acttgtttct
      241 ccaaagctca atagggcaac agaaggtatt ctctttttta accttgagct ttctcagatg
      301 gctgctccag cttttgaacc tggcaggcag tcagatctct tggtgaagct gaatcggctc
      361 ttggaaaggt gtctaagaaa ttcaaagtgc atagacactg aatctctctg tgttgtcgct
      421 ggtgaaaagg tttggcagat acgtgtagac ctacatttat taaatcatga tggaaatatt
      481 attgatgctg ctagcattgc tgcaatcgtg gccttgtgtc acttccgaag acccgatgtc
      541 tctgtccaag gagaagaagt aacattgtat acccctgagg agcgtgatcc tgtgcctttg
      601 agcatacacc atatgcccat ctgtgtcagt tttgctttct tccagcaagg aacatactta
      661 ttggtggacc ccaatgagcg tgaagagcga gtgatggatg gcctgctggt gatcgccatg
      721 aacaagcatc gagaaatctg tacgattcag tctagtggtg ggataatgct gctcaaagac
      781 caggttttca ggtgcagtaa aatagctggt gtgaaagtag cagaaatcac agagctaata
      841 cagaaagctt tggaaaatga ccagagagtt aggaaagaag gtggaaaatt tggctttgca
      901 gagtctatag caaatcagag aatcacagca tttaaaatgg agaaggcccc tattgatacc
      961 tccaacatag aagagaaagc agaagaaatt attgcggaag ccgaacctcc tccagaggtt
     1021 gtttctaaac ctgtgctgtg gactcctgga actgcccaga ttggagaggg aatagaaaac
     1081 tcctggggtg accttgaaga ttctgagaag gaagaggagg aggaaggtgg cattgatgaa
     1141 actgtcattc ttgatgatac aaagatggac acgggagaag tttctgatat tgggagccaa
     1201 ggtgccccta tagtgctatc agatagtgaa gaagaagaaa tgattatttt ggagccagag
     1261 aagagtccaa aaaaaataag agctcagacc agtgcaaacc agaaggcacc aagtaaaagt
     1321 caagggaaaa ggaggaaaaa gaagagaact gctaattaag ctaaagtggt gtggatgtgt
     1381 atgtatatat atatataaaa tatatatata tataactaat aagagggtat ttgctcagtg
     1441 ctaacagctc tggatatttt ttatttgaaa atctattatg agctgaactt aataaactgt
     1501 tttgtcttta acattatgct tcgaataaac tttctggaaa acttttctgt tgcataaaag
     1561 cttcccaatt catgtaaaac cttatttgta aaagttggta aataaaatgt ctccataaac
     1621 tacaaaaaaa aaaaaaaaaa aaaaaaa
//
