LOCUS       NM_001399221             957 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus exosome component 8 (Exosc8), mRNA.
ACCESSION   NM_001399221 XM_006232332
VERSION     NM_001399221.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   2  (bases 1 to 957)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   3  (bases 1 to 957)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   4  (bases 1 to 957)
  AUTHORS   Anderson,J.R., Mukherjee,D., Muthukumaraswamy,K., Moraes,K.C.,
            Wilusz,C.J. and Wilusz,J.
  TITLE     Sequence-specific RNA binding mediated by the RNase PH domain of
            components of the exosome
  JOURNAL   RNA 12 (10), 1810-1816 (2006)
   PUBMED   16912217
REFERENCE   5  (bases 1 to 957)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006232332.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233209.1, SRR26360172.2168996.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000002.1  141087057-141087097 c
            42-78               JAXUCZ010000002.1  141086354-141086390 c
            79-142              JAXUCZ010000002.1  141086182-141086245 c
            143-216             JAXUCZ010000002.1  141085776-141085849 c
            217-262             JAXUCZ010000002.1  141084786-141084831 c
            263-368             JAXUCZ010000002.1  141084060-141084165 c
            369-414             JAXUCZ010000002.1  141083924-141083969 c
            415-511             JAXUCZ010000002.1  141083043-141083139 c
            512-632             JAXUCZ010000002.1  141081636-141081756 c
            633-739             JAXUCZ010000002.1  141081066-141081172 c
            740-957             JAXUCZ010000002.1  141080568-141080785 c
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..957
                     /gene="Exosc8"
                     /note="exosome component 8"
                     /db_xref="GeneID:295050"
                     /db_xref="RGD:1306169"
     exon            1..41
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..855
                     /gene="Exosc8"
                     /note="exosome complex exonuclease RRP43"
                     /codon_start=1
                     /product="exosome complex component RRP43"
                     /protein_id="NP_001386150.1"
                     /db_xref="GeneID:295050"
                     /db_xref="RGD:1306169"
                     /translation="MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSIST
                     ADGSALVKLGNTTVICGVKAEFAAPPVDAPDRGYVVPNVDLPPLCSSRFRTGPPGEEA
                     QVTSQFIADVIENSQIIKKEDLCISPGKLAWVLYCDLICLDYDGNILDACTFALLAAL
                     KNVQLPEVTINEETALAEVNLKKKSYLNVRANPVATSFAVFDDTLLIVDPTGEEEHLS
                     TGTLTVVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVSKLLDEVIQSMKHK
                     "
     exon            42..78
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            79..142
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            143..216
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            217..262
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            263..368
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            369..414
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            415..511
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            512..632
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            633..739
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
     exon            740..957
                     /gene="Exosc8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcgcag tgcgagcagg aaaaatggcg gccgggttca aaactgtgga accgctggag
       61 tattacagga gatttctgaa agaaaactgc cgtccagatg gaagagaact tggtgaattc
      121 agaaccacaa ctgtcaacat aggttcgatc agtacagcgg atggctctgc tctagtgaag
      181 ctggggaaca ccacagtcat ttgtggagtt aaagcagaat ttgcagcacc accagtagat
      241 gcccctgata gaggatatgt cgtccctaat gtggacctac caccgctgtg ttcatcgagg
      301 tttcggactg gacctcctgg agaagaggct caagtaacca gccagttcat tgcagatgtc
      361 attgagaact cacagataat taagaaagag gacttatgca tttctccagg gaagcttgct
      421 tgggttctat actgtgacct tatttgccta gactacgatg ggaacatttt ggatgcctgc
      481 acatttgctt tgttagcagc tttaaagaat gtacagttgc ctgaagttac tataaatgaa
      541 gaaactgctt tagcggaagt caatttaaag aagaaaagtt atttgaatgt tagagcaaac
      601 ccagttgcta cttcatttgc tgtgtttgat gacactttgc tgatagtcga tcctaccggg
      661 gaggaggagc acctgtccac aggaacctta accgtagtaa tggacgagga aggcaagctg
      721 tgctgtcttc acaagccagg tgggagtggg ctgactggag ctaaacttca ggactgcatg
      781 agtcgagcag taacgagaca caaagaagtg agcaaactac tggatgaagt aattcagagc
      841 atgaaacaca aatgaacaga cgccacgatt gtaaaacagc tgtaaaaatt gtatttgtta
      901 cactgtgcac aggcctttta tactaaataa atacctaatt acattctttg aaagata
//
