LOCUS       NM_001107493            1051 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus exosome component 5 (Exosc5), mRNA.
ACCESSION   NM_001107493 XM_218343
VERSION     NM_001107493.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Sloan,K.E., Bohnsack,M.T., Schneider,C. and Watkins,N.J.
  TITLE     The roles of SSU processome components and surveillance factors in
            the initial processing of human ribosomal RNA
  JOURNAL   RNA 20 (4), 540-550 (2014)
   PUBMED   24550520
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Flynn,R.A., Almada,A.E., Zamudio,J.R. and Sharp,P.A.
  TITLE     Antisense RNA polymerase II divergent transcripts are P-TEFb
            dependent and substrates for the RNA exosome
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10460-10465 (2011)
   PUBMED   21670248
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   de Almeida,S.F., Garcia-Sacristan,A., Custodio,N. and
            Carmo-Fonseca,M.
  TITLE     A link between nuclear RNA surveillance, the human exosome and RNA
            polymerase II transcriptional termination
  JOURNAL   Nucleic Acids Res 38 (22), 8015-8026 (2010)
   PUBMED   20699273
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Mukherjee,D., Gao,M., O'Connor,J.P., Raijmakers,R., Pruijn,G.,
            Lutz,C.S. and Wilusz,J.
  TITLE     The mammalian exosome mediates the efficient degradation of mRNAs
            that contain AU-rich elements
  JOURNAL   EMBO J 21 (1-2), 165-174 (2002)
   PUBMED   11782436
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A.,
            Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D.,
            Kerlavage,A.R. et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            H31667.1 and BC167023.1.
            
            On Nov 24, 2010 this sequence version replaced NM_001107493.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225297.1, EV776639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               H31667.1           1-101
            102-1051            BC167023.1         14-963
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1051
                     /gene="Exosc5"
                     /note="exosome component 5"
                     /db_xref="GeneID:308441"
                     /db_xref="RGD:1307861"
     exon            1..231
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..791
                     /gene="Exosc5"
                     /note="exosome complex exonuclease RRP46"
                     /codon_start=1
                     /product="exosome complex component RRP46"
                     /protein_id="NP_001100963.2"
                     /db_xref="GeneID:308441"
                     /db_xref="RGD:1307861"
                     /translation="MEGAKRADAKVLTDTGTESSPRSPVCSLRHFACEQNLLSRPDGS
                     ASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTC
                     EAVVLGALHPRTSITVVLQVVSDTGSLLACCLNAACMALVDAGVPMRALFCGVTCALD
                     PDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSATKGLYSDAELQQCLAAAQAASQ
                     HIFRFYRESLQRRYSKS"
     exon            232..345
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
     exon            346..467
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
     exon            468..608
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..698
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1026
                     /gene="Exosc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtaggta cacggccggt agaactgcgc gtgcggctga gcggaagcta cggtaggagc
       61 cccagcgcgc gtggtcagcg gctatggagg gagcaaagcg tgcagacgcc aaggtactca
      121 ctgacaccgg aacagagtcc agccctcgaa gtccagtctg cagcctccgg cactttgctt
      181 gtgagcaaaa cctgctgtcc cggccggatg gatctgcttc ttttctgcaa ggtgatacct
      241 ctgtcctggc tggagtctac gggccggccg aggtgaaggt cagcaaagaa atcttcaaca
      301 aagccaccct tgaagtgatc ctgaggccga agatcggcct gcccggcgtg gctgagaaga
      361 gccgggagcg actgatcagg aacacgtgtg aggcagtggt tctaggggcc ctgcaccccc
      421 ggacctcaat caccgtggtg ctgcaggtgg tgagcgacac tggctctctc ttggcctgtt
      481 gcctgaatgc agcctgcatg gcattggtgg atgcaggcgt gcccatgcga gccctcttct
      541 gtggggtcac ctgtgccctg gaccctgatg gcaatcttgt gctggacccc acaaccaaac
      601 aagaaaagga ggcccgggcc attctgacct ttgctctgga tagtgcggag cagaagctgc
      661 tcatgtccgc caccaagggg ctctattctg atgcagagct ccagcagtgt ctggccgccg
      721 cccaagctgc ctcacagcac atcttccgct tctaccgaga atccctgcag aggcgctact
      781 ccaagagctg aggcccgcca gggcagggcg ccctccacca cgcccaccgc ctacccgcca
      841 gcagccagca ctccactgtg cctctgtctg tgcccaggta gcctctggtc ctgtcgcagc
      901 aggggctgct gaggcaggct agggaggggc ttagggacat tctaggcctg ggtacaaccc
      961 tctcttcacc aggacaccat taaaaagggc tcacctgtgt tgagcgagtg agtcggtagc
     1021 cactgaaaaa aaaaaaaaaa aaaaaaaaaa a
//
