LOCUS       NM_001134860            1106 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus exosome component 4 (Exosc4), mRNA.
ACCESSION   NM_001134860 XM_216949
VERSION     NM_001134860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1106)
  AUTHORS   Miyashita,M., Oshiumi,H., Matsumoto,M. and Seya,T.
  TITLE     DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting
            RIG-I-like receptor-mediated signaling
  JOURNAL   Mol Cell Biol 31 (18), 3802-3819 (2011)
   PUBMED   21791617
REFERENCE   2  (bases 1 to 1106)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   3  (bases 1 to 1106)
  AUTHORS   de Almeida,S.F., Garcia-Sacristan,A., Custodio,N. and
            Carmo-Fonseca,M.
  TITLE     A link between nuclear RNA surveillance, the human exosome and RNA
            polymerase II transcriptional termination
  JOURNAL   Nucleic Acids Res 38 (22), 8015-8026 (2010)
   PUBMED   20699273
REFERENCE   4  (bases 1 to 1106)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   5  (bases 1 to 1106)
  AUTHORS   Slomovic,S., Fremder,E., Staals,R.H., Pruijn,G.J. and Schuster,G.
  TITLE     Addition of poly(A) and poly(A)-rich tails during RNA degradation
            in the cytoplasm of human cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7407-7412 (2010)
   PUBMED   20368444
REFERENCE   6  (bases 1 to 1106)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   7  (bases 1 to 1106)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   8  (bases 1 to 1106)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   9  (bases 1 to 1106)
  AUTHORS   Anderson,J.R., Mukherjee,D., Muthukumaraswamy,K., Moraes,K.C.,
            Wilusz,C.J. and Wilusz,J.
  TITLE     Sequence-specific RNA binding mediated by the RNase PH domain of
            components of the exosome
  JOURNAL   RNA 12 (10), 1810-1816 (2006)
   PUBMED   16912217
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Sep 10, 2008 this sequence version replaced XM_216949.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK845408.1, CB580651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000007.1  109928491-109928699
            210-416             JAXUCZ010000007.1  109930237-109930443
            417-1106            JAXUCZ010000007.1  109930544-109931233
FEATURES             Location/Qualifiers
     source          1..1106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1106
                     /gene="Exosc4"
                     /note="exosome component 4"
                     /db_xref="GeneID:300045"
                     /db_xref="RGD:1310986"
     exon            1..209
                     /gene="Exosc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..776
                     /gene="Exosc4"
                     /note="exosome complex exonuclease RRP41"
                     /codon_start=1
                     /product="exosome complex component RRP41"
                     /protein_id="NP_001128332.1"
                     /db_xref="GeneID:300045"
                     /db_xref="RGD:1310986"
                     /translation="MAGLELLSDQGYRIDGRRAGELRKIQARMGVFAQADGSAYIEQG
                     NTKALAVVYGPHEIRGSRSRALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQ
                     LRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVMDAGIPMRDFVCAC
                     SAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDSRLHEDHLEQVLEAAA
                     QAARDVHTLLDRVVRQHVQEASILLGD"
     exon            210..416
                     /gene="Exosc4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1106
                     /gene="Exosc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtcgtgct ctcggaggcg gagcgaggac tgcgcaacat ggccgggctg gagctcctgt
       61 ccgatcaggg ttaccggata gacggtcgcc gcgcggggga gctgcgcaag attcaggcgc
      121 ggatgggcgt gtttgcgcag gccgatggct cggcttatat cgagcagggc aacaccaagg
      181 cactggcggt ggtctacggg cctcacgaga tccggggctc ccggtcacgg gctctgcctg
      241 accgggctct agtgaactgt cagtacagtt cagcaacctt cagcacaggt gagcgcaagc
      301 gaaggcctca tggagaccgg aagtcttgtg agatggggct gcagctacgc cagaccttcg
      361 aggcagctat cctcacacag ctgcacccac gttctcagat agacatttat gtgcaggtgc
      421 tacaagcaga cggtgggacc tatgcagcat gtgtgaatgc agccacgcta gcagtgatgg
      481 atgctgggat acccatgcgg gactttgtgt gtgcatgttc ggctggtttt gtggatggca
      541 cagcactagc ggacctcagt cacgtggagg aagcagctgg cgggccccag ctagccctgg
      601 ccctgctgcc agcctctggc cagattgcac tgcttgagat ggattcgagg ttgcatgaag
      661 accacttgga gcaggtgctc gaggctgctg cccaggcagc ccgggatgtg cacactctgc
      721 tggatcgtgt tgtccggcag catgtgcagg aggcctctat cttactgggg gactgaggcc
      781 aaccccccat atccagaata aaggcctgtt cctctcctga acacactgta atgtacagca
      841 cttcaaagca gctcagggcc ctacatagca gtttgtactg cagtccctaa gtggagagaa
      901 cacttgtgct aggaagagca agagtgctca tgctgtgcct gcccagatat cagggtccac
      961 aaagaccacc aggggtctgg atttgtatgc aaaagcaaag cctttattca cacttaagct
     1021 tggaccctca gaatcctcca agcatcagat ttgtgctgag accttgaacc tcatttaggc
     1081 aaggttttta tactagtttg agcagg
//
