LOCUS       NM_001107936            1085 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus exosome component 3 (Exosc3), mRNA.
ACCESSION   NM_001107936 XM_001071395 XM_006238067 XM_233001
VERSION     NM_001107936.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Bauer,L., Hapfelmeier,A., Blank,S., Reiche,M., Slotta-Huspenina,J.,
            Jesinghaus,M., Novotny,A., Schmidt,T., Grosser,B., Kohlruss,M.,
            Weichert,W., Ott,K. and Keller,G.
  TITLE     A novel pretherapeutic gene expression-based risk score for
            treatment guidance in gastric cancer
  JOURNAL   Ann Oncol 29 (1), 127-132 (2018)
   PUBMED   29069277
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Basu,U., Meng,F.L., Keim,C., Grinstein,V., Pefanis,E.,
            Eccleston,J., Zhang,T., Myers,D., Wasserman,C.R., Wesemann,D.R.,
            Januszyk,K., Gregory,R.I., Deng,H., Lima,C.D. and Alt,F.W.
  TITLE     The RNA exosome targets the AID cytidine deaminase to both strands
            of transcribed duplex DNA substrates
  JOURNAL   Cell 144 (3), 353-363 (2011)
   PUBMED   21255825
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   de Almeida,S.F., Garcia-Sacristan,A., Custodio,N. and
            Carmo-Fonseca,M.
  TITLE     A link between nuclear RNA surveillance, the human exosome and RNA
            polymerase II transcriptional termination
  JOURNAL   Nucleic Acids Res 38 (22), 8015-8026 (2010)
   PUBMED   20699273
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Preker,P., Nielsen,J., Kammler,S., Lykke-Andersen,S.,
            Christensen,M.S., Mapendano,C.K., Schierup,M.H. and Jensen,T.H.
  TITLE     RNA exosome depletion reveals transcription upstream of active
            human promoters
  JOURNAL   Science 322 (5909), 1851-1854 (2008)
   PUBMED   19056938
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   8  (bases 1 to 1085)
  AUTHORS   Mukherjee,D., Gao,M., O'Connor,J.P., Raijmakers,R., Pruijn,G.,
            Lutz,C.S. and Wilusz,J.
  TITLE     The mammalian exosome mediates the efficient degradation of mRNAs
            that contain AU-rich elements
  JOURNAL   EMBO J 21 (1-2), 165-174 (2002)
   PUBMED   11782436
REFERENCE   9  (bases 1 to 1085)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 8, 2020 this sequence version replaced
            XM_006238067.3, NM_001107936.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.16297.1, BP500942.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               JAXUCZ010000005.1  64374344-64374711   c
            369-518             JAXUCZ010000005.1  64373619-64373768   c
            519-670             JAXUCZ010000005.1  64371700-64371851   c
            671-1085            JAXUCZ010000005.1  64369495-64369909   c
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1085
                     /gene="Exosc3"
                     /note="exosome component 3"
                     /db_xref="GeneID:313243"
                     /db_xref="RGD:1304739"
     exon            1..368
                     /gene="Exosc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..872
                     /gene="Exosc3"
                     /note="exosome complex exonuclease RRP40"
                     /codon_start=1
                     /product="exosome complex component RRP40"
                     /protein_id="NP_001101406.2"
                     /db_xref="GeneID:313243"
                     /db_xref="RGD:1304739"
                     /translation="MAEVSAGAESVAGCRARAVHKVLNQVVLPGEELVLPDHEDADGL
                     GGPGEQPLRLNAGARPRLRIVCGPGLRRCGDRLLVTKCGRLRHKEPSGGGGGGGGGGG
                     GGGVYWVDSQQKRYVPVKGDHVIGIVVAKSGDIFKVDVGGSEPASLSYLAFEGATKRN
                     RPNVQVGDLIYGQCVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLL
                     APDCEIVQELGKLYPLEIVFGMNGRIWVKAKTIQQTLILANVLEACEHMTTEQRKQIF
                     ARLAES"
     exon            369..518
                     /gene="Exosc3"
                     /inference="alignment:Splign:2.1.0"
     exon            519..670
                     /gene="Exosc3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1085
                     /gene="Exosc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttgcaat ggtgatgcct gccatggctg aagtgtccgc tggggctgag tctgtggcgg
       61 gctgccgagc acgggcagtg cacaaggtgc taaatcaggt ggttctccct ggggaggagc
      121 tggtgctgcc ggaccacgag gacgcagacg gccttggggg ccccggggag cagccgttac
      181 gcctgaatgc gggagcgcgc ccgaggctgc gcatagtatg cggcccgggt ttgcgacgct
      241 gcggggaccg tctgctggtc actaagtgtg gccgcctgcg tcacaaggag cccagcggcg
      301 gcggcggcgg cggcggcggc ggcggcggcg gcggcggcgt ttattgggtg gactcgcagc
      361 agaagcggta tgtaccagtg aaaggagacc acgtgattgg catagtagtc gctaagtctg
      421 gcgatatatt caaagttgat gttggaggga gtgagccagc ttctttgtcc tacctggcat
      481 ttgaaggggc aactaaaaga aacagaccaa atgtacaggt tggagatctc atctatggcc
      541 agtgtgtggt tgctaataaa gacatggaac cagaaatggt ctgtattgac agctgcggac
      601 gcgccaatgg gatgggtgtg attggacagg atgggctgct cttcaaagtg accttgggct
      661 taattagaaa gctattggct ccagattgtg aaatcgtgca agagctggga aaactctatc
      721 cgctggagat tgtgtttgga atgaatggga gaatatgggt caaggcaaaa accatccagc
      781 agacgttaat tttggcaaat gtcttagaag cttgtgaaca catgacaaca gagcagagga
      841 aacagatctt tgccagactg gcagagagct gacgtgtcca tttcctcagt ggatttgtta
      901 gccaagactg agtttcctgg ggaaatcttt tttttttcag gtgaatttct tcctggcaga
      961 tcttcagaag atgcatattg tcttactaga atccaataaa atatttttgt aagagttgct
     1021 ggtcaccaat catgtataga tgagaaatta taaaaatttt tatataataa attttgctgg
     1081 aagta
//
