LOCUS       NM_001108952            1460 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus exosome component 2 (Exosc2), mRNA.
ACCESSION   NM_001108952 XM_001077923 XM_345336
VERSION     NM_001108952.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Yoshikatsu,Y., Ishida,Y., Sudo,H., Yuasa,K., Tsuji,A. and
            Nagahama,M.
  TITLE     NVL2, a nucleolar AAA-ATPase, is associated with the nuclear
            exosome and is involved in pre-rRNA processing
  JOURNAL   Biochem Biophys Res Commun 464 (3), 780-786 (2015)
   PUBMED   26166824
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   van Dijk,E.L., Schilders,G. and Pruijn,G.J.
  TITLE     Human cell growth requires a functional cytoplasmic exosome, which
            is involved in various mRNA decay pathways
  JOURNAL   RNA 13 (7), 1027-1035 (2007)
   PUBMED   17545563
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Raijmakers,R., Egberts,W.V., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions between human exosome components
            support the assembly of RNase PH-type subunits into a six-membered
            PNPase-like ring
  JOURNAL   J Mol Biol 323 (4), 653-663 (2002)
   PUBMED   12419256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345336.2, XM_001077923.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1460
                     /gene="Exosc2"
                     /note="exosome component 2"
                     /db_xref="GeneID:366017"
                     /db_xref="RGD:1306573"
     exon            1..142
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..902
                     /gene="Exosc2"
                     /note="exosome complex exonuclease RRP4"
                     /codon_start=1
                     /product="exosome complex component RRP4"
                     /protein_id="NP_001102422.1"
                     /db_xref="GeneID:366017"
                     /db_xref="RGD:1306573"
                     /translation="MALEMRLPRARKPLSESLGRDSKKHLVVPGDTITTDTGFMRGHG
                     TYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNS
                     RLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRS
                     LKYGKLGQGALVQVSPALVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKDEEAGG
                     FIANLEPVSLSDREVISRLRNCIVLLVTQRMMLYDTSILYCYEASLAHQIKDILKPEV
                     MEEIMLETRQRLLEQEG"
     exon            143..244
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..290
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..380
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            381..446
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..515
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..692
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..821
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1460
                     /gene="Exosc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaagtcat tggcgccaag atggcgttgg agatgaggct ccctagggct cgcaaacctc
       61 tcagtgagag cttgggccgc gattctaaaa aacatttggt agtgccaggg gacacgatca
      121 ccacggatac aggcttcatg cggggccatg gaacatacat gggggaggaa aagctcattg
      181 cgtcagtggc cggctctgtg gagagagtga acaagctgat ctgtgtcaaa gccttgaaaa
      241 ccagatacaa tggagaagtc ggagacattg tggtggggag gattactgag gtccaacaga
      301 agaggtggaa ggtggagacc aactccaggc tggactccgt cctgctcctc tcatccatga
      361 acctacctgg gggagagctg aggagaaggt cggcggagga tgagctggcc atgagaggct
      421 tcttacaaga aggcgacctc atcagtgcgg aagtccaggc tgtgttctcc gatggagctg
      481 tttctctgca cacgaggagc ctgaagtacg gaaagctagg tcagggggct ttagtccagg
      541 tctctcctgc cctggtgaaa agacagaaga cccatttcca tgacttgcca tgcggtgcct
      601 cagtgattct gggtaacaat ggtttcatct ggatctaccc gacacccgag cacaaggacg
      661 aggaggcagg gggcttcatt gccaacctgg agccggtatc ccttagtgat cgagaggtga
      721 tctcccggct ccggaactgt atagtcttgc tggtaactca gagaatgatg ctgtacgaca
      781 ccagcatcct gtactgctac gaggcctccc ttgcacatca gatcaaagat atcttaaaac
      841 cagaagtaat ggaggagatc atgctagaaa cacgccagag gcttttggag caggagggat
      901 gaggacgaga gctgaaggat gggactgtgc acctctctgg accagttttg ggaatgaaaa
      961 gtctgccatg tggtccccag ggaggatctg acaaatagtt actcacctgc agcggtctac
     1021 agagccagcc ctgtccactc ctgttctgag acagagctgg gggaagtaaa tgatgtgttt
     1081 gggcgcttgg gtcccagtac aagggggagt tttaggtctt tcagagcaca gtgtcccaac
     1141 ctgatgactt accttggact aacttggaga gtttgtcatc caatcacacc acacaatggc
     1201 cccatgaaac tgtcctggtg aaaaatatgg taggtgggga tctatctcag gggtggatca
     1261 cttcctaaca tgtgcaagtc cccaggttca atttccggca ctaccccaac ccagaacaca
     1321 gaaaaccaag acaaaaaggc ctgcagcgcc agcgcggatg gagtctctcc acttccactg
     1381 ccttccttaa cgcacaagtg tgcggctgga gaaggtggta gagtagggcc aggagcaaat
     1441 ggatctgaga ataaagggag
//
