LOCUS       NM_001399229            2779 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus exosome component 10 (Exosc10), mRNA.
ACCESSION   NM_001399229 XM_003750088
VERSION     NM_001399229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Shukla,S., Schmidt,J.C., Goldfarb,K.C., Cech,T.R. and Parker,R.
  TITLE     Inhibition of telomerase RNA decay rescues telomerase deficiency
            caused by dyskerin or PARN defects
  JOURNAL   Nat Struct Mol Biol 23 (4), 286-292 (2016)
   PUBMED   26950371
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Yoshikatsu,Y., Ishida,Y., Sudo,H., Yuasa,K., Tsuji,A. and
            Nagahama,M.
  TITLE     NVL2, a nucleolar AAA-ATPase, is associated with the nuclear
            exosome and is involved in pre-rRNA processing
  JOURNAL   Biochem Biophys Res Commun 464 (3), 780-786 (2015)
   PUBMED   26166824
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Sloan,K.E., Bohnsack,M.T., Schneider,C. and Watkins,N.J.
  TITLE     The roles of SSU processome components and surveillance factors in
            the initial processing of human ribosomal RNA
  JOURNAL   RNA 20 (4), 540-550 (2014)
   PUBMED   24550520
REFERENCE   4  (bases 1 to 2779)
  AUTHORS   Sloan,K.E., Mattijssen,S., Lebaron,S., Tollervey,D., Pruijn,G.J.
            and Watkins,N.J.
  TITLE     Both endonucleolytic and exonucleolytic cleavage mediate ITS1
            removal during human ribosomal RNA processing
  JOURNAL   J Cell Biol 200 (5), 577-588 (2013)
   PUBMED   23439679
REFERENCE   5  (bases 1 to 2779)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2779)
  AUTHORS   Schilders,G., van Dijk,E. and Pruijn,G.J.
  TITLE     C1D and hMtr4p associate with the human exosome subunit PM/Scl-100
            and are involved in pre-rRNA processing
  JOURNAL   Nucleic Acids Res 35 (8), 2564-2572 (2007)
   PUBMED   17412707
REFERENCE   7  (bases 1 to 2779)
  AUTHORS   Liu,Q., Greimann,J.C. and Lima,C.D.
  TITLE     Reconstitution, activities, and structure of the eukaryotic RNA
            exosome
  JOURNAL   Cell 127 (6), 1223-1237 (2006)
   PUBMED   17174896
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):188-9]
REFERENCE   8  (bases 1 to 2779)
  AUTHORS   Ciaudo,C., Bourdet,A., Cohen-Tannoudji,M., Dietz,H.C., Rougeulle,C.
            and Avner,P.
  TITLE     Nuclear mRNA degradation pathway(s) are implicated in Xist
            regulation and X chromosome inactivation
  JOURNAL   PLoS Genet 2 (6), e94 (2006)
   PUBMED   16789828
REFERENCE   9  (bases 1 to 2779)
  AUTHORS   West,S., Gromak,N., Norbury,C.J. and Proudfoot,N.J.
  TITLE     Adenylation and exosome-mediated degradation of cotranscriptionally
            cleaved pre-messenger RNA in human cells
  JOURNAL   Mol Cell 21 (3), 437-443 (2006)
   PUBMED   16455498
REFERENCE   10 (bases 1 to 2779)
  AUTHORS   Kho,C.J., Huggins,G.S., Endege,W.O., Patterson,C., Jain,M.K.,
            Lee,M.E. and Haber,E.
  TITLE     The polymyositis-scleroderma autoantigen interacts with the
            helix-loop-helix proteins E12 and E47
  JOURNAL   J Biol Chem 272 (20), 13426-13431 (1997)
   PUBMED   9148967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2022 this sequence version replaced XM_003750088.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2560240.1,
                                           SRR26360172.391333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000005.1  164278440-164278589
            151-287             JAXUCZ010000005.1  164279585-164279721
            288-411             JAXUCZ010000005.1  164280798-164280921
            412-516             JAXUCZ010000005.1  164281917-164282021
            517-682             JAXUCZ010000005.1  164282143-164282308
            683-797             JAXUCZ010000005.1  164282450-164282564
            798-873             JAXUCZ010000005.1  164283555-164283630
            874-984             JAXUCZ010000005.1  164283830-164283940
            985-1128            JAXUCZ010000005.1  164284251-164284394
            1129-1319           JAXUCZ010000005.1  164284899-164285089
            1320-1476           JAXUCZ010000005.1  164286126-164286282
            1477-1625           JAXUCZ010000005.1  164288164-164288312
            1626-1676           JAXUCZ010000005.1  164288453-164288503
            1677-1788           JAXUCZ010000005.1  164290345-164290456
            1789-1839           JAXUCZ010000005.1  164292697-164292747
            1840-1918           JAXUCZ010000005.1  164292889-164292967
            1919-2025           JAXUCZ010000005.1  164293057-164293163
            2026-2121           JAXUCZ010000005.1  164295602-164295697
            2122-2196           JAXUCZ010000005.1  164295943-164296017
            2197-2278           JAXUCZ010000005.1  164298050-164298131
            2279-2355           JAXUCZ010000005.1  164298995-164299071
            2356-2527           JAXUCZ010000005.1  164299954-164300125
            2528-2589           JAXUCZ010000005.1  164300675-164300736
            2590-2666           JAXUCZ010000005.1  164301372-164301448
            2667-2779           JAXUCZ010000005.1  164301955-164302067
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2779
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /note="exosome component 10"
                     /db_xref="GeneID:313707"
                     /db_xref="RGD:1593248"
     exon            1..150
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2697
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /codon_start=1
                     /product="exosome complex component 10"
                     /protein_id="NP_001386158.1"
                     /db_xref="GeneID:313707"
                     /db_xref="RGD:1593248"
                     /translation="MAPPSPREHQSAPATGATKPDAEMVLPGFPDADSFVKFALGSVV
                     AVTKASGGLPQVGDEYDFYRSFPAFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSK
                     VTELEDKFDLLVDTNDVILERVGILLDEASGVNKHQQPVLPAGLQVPKTIVSSWNRKA
                     GEYGKKAKAETFRLLHAKNILRPQLRFREKIDNSNTPFLPKIFVKPNARKPLPQALSK
                     ERRERPQDRPEDLDVPPALADFIHQQRAQQVEQDVFAHPYQYELDHFTPPPSVLQRPQ
                     PQLYRPVEETPCHVVSSLDELVELNEKLLGCQEFAVDLEHHSYRSFLGLTCLMQISTR
                     TEDFIVDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQA
                     ARLLNLARHSLDHLLRLYCGVESNKQYQLADWRIRPLPEEMLNYARDDTHYLLYIYDR
                     MRLELWERGNDQPVQLQVVWQRSRDICLKKFVKPIFTDESYLELYRKQKKHLNSQQLT
                     AFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQI
                     NEMHLLIQQAREMPLLKSETAAGVKKSGPLPSAERLENDLFGPHDCSHAPPDNYPVTS
                     TDGTMPLQKQPSLFDEGKEETSVDARCLLATAVITLFSEPSTEEAGKTPLTVAQKKAQ
                     SIMESFENPFRMFLPSLENKAHISQAAKFDPSSKIYEISNRWKLASQVQKEPKEAAKK
                     KVAEQTAAREETKEESTAAVLEQPIPVRQQAALENATKKRERATSDLRTIEQKQEKKR
                     LKSSKKAKDPDPPGKDFSPYDYSQSDFGAFAGDSKSKPSSQFDPNKVAPSGKKCFGAK
                     KFKQSVGNKSMSFPAGKSDRGFRHNWPKR"
     exon            151..287
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            288..411
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            412..516
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            517..682
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            683..797
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            798..873
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            874..984
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1128
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1319
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1476
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1625
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1676
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1788
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1839
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1918
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2025
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2121
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2196
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2278
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2355
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2527
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2589
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2666
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2779
                     /gene="Exosc10"
                     /gene_synonym="PM/Scl100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacaatct cgcgagaaga gccgccctag gacggaaaaa tggcgcctcc cagtccccgg
       61 gagcatcagt ccgcgccagc gaccggtgcg accaagcctg acgcggagat ggtactgcct
      121 ggcttcccgg atgcagacag cttcgtaaag tttgcacttg ggtcggtagt ggccgttacc
      181 aaggcatctg ggggcctgcc acaggtcggt gacgagtatg acttttaccg aagttttcct
      241 gccttccagg cattttgtga gacacaagga gacaggttgc ttcagtgcat gagtcgggtg
      301 atgcagtacc atgggtgtcg cagcaacatc aaagaccgaa gcaaagtcac tgagttggag
      361 gacaagttcg atttactcgt cgacaccaac gacgtgatat tggagagagt gggtatatta
      421 ctggatgaag cttcaggtgt caacaagcat cagcagcctg tcctccctgc ggggctgcag
      481 gtccccaaaa cgatagtgtc gagctggaac cggaaggcag gagaatatgg caaaaaagca
      541 aaggcggaga ctttccgact gctacatgca aaaaacatcc tccggcctca gctcaggttt
      601 cgagagaaga tcgacaattc caacacgcca tttctcccaa agatctttgt taaacccaat
      661 gctcggaagc cactccctca ggctctctca aaagaaaggc gggaacgccc gcaggatcgt
      721 ccagaggacc tggatgtccc tccagcgctg gcagatttca tccatcagca gagagcccag
      781 caggtggagc aggatgtgtt tgcacaccct tatcagtatg aactcgatca ctttactccg
      841 cctccctcgg tgctgcaaag gccgcagccc cagttgtaca ggcctgtgga agagacaccc
      901 tgccacgttg tgtcatccct agatgaactt gtggagctca atgaaaagct cttgggttgt
      961 caagagtttg cagtggactt agagcaccac tcatacagaa gcttcctagg actgacgtgc
     1021 ctgatgcaga tctccacgcg cacagaagac ttcattgttg acacccttga gcttcgaagt
     1081 gacatgtaca tcctcaacga gagcctcaca gacccagcca tcgttaaggt cttccatggt
     1141 gccgactctg acatcgagtg gctgcagaag gacttcgggc tctatgtggt gaacatgttt
     1201 gacacacacc aggcagcacg gcttctcaac ctggctcgcc actcacttga ccatctgctg
     1261 aggctctact gtggggtgga gtcaaacaag cagtatcagc tggcggactg gaggatacgc
     1321 cctctgccag aggagatgct gaactatgcc cgggatgaca cccattacct gctttacatc
     1381 tatgaccgaa tgaggctgga gctgtgggaa agaggcaacg accagcctgt ccagttgcag
     1441 gtggtgtggc agcggagcag ggacatctgc ctcaagaaat ttgtcaagcc tatctttacg
     1501 gatgagtcct accttgagct atatcgaaag caaaagaagc atctgaattc ccagcagctg
     1561 acagcctttc agctgctgtt tgcttggcga gataagacag cgcgcaggga ggatgagagc
     1621 tacggatatg ttctaccaaa tcacatgatg ctaaagatag ctgaggaact gcctaaggag
     1681 cctcaaggca tcatagcttg ctgtaaccca gtaccacctc ttgtccggca acagatcaat
     1741 gagatgcatc tcttaatcca gcaggcccgg gagatgcccc tgctcaagtc tgaaactgca
     1801 gctggagtga agaagagtgg acccctgcct agcgccgaga gattggagaa tgatctcttt
     1861 ggaccccatg actgctccca tgcccctcca gataactacc cggtcacctc aactgatggg
     1921 accatgccac ttcagaagca gccgagcctc ttcgatgagg gcaaagaaga gacgtctgtg
     1981 gatgccagat gcctccttgc tacagctgtc atcactctgt tcagtgaacc cagcactgag
     2041 gaagctggaa agactccatt gacggtggca cagaaaaaag cccagagcat aatggagtcc
     2101 tttgaaaacc catttaggat gttcctgcct tctctggaaa acaaggccca catctctcaa
     2161 gcagcaaagt ttgatccttc ttcgaaaatc tatgaaatca gcaaccgttg gaagctggcc
     2221 agccaggtcc agaaagaacc taaagaagca gccaagaaga aggtagctga gcaaacagct
     2281 gcccgagagg agacaaaaga ggagtccaca gctgctgtgc tcgaacagcc tatccctgtg
     2341 cggcagcaag ccgcgctaga aaatgctact aagaagagag agcgagccac cagtgacctg
     2401 aggaccatag agcaaaaaca ggagaagaaa cgactaaaaa gctccaagaa agccaaggac
     2461 cctgatcccc cagggaaaga cttcagtccg tatgactaca gccagtcaga cttcggggcc
     2521 ttcgctgggg acagtaaatc caagccttcc tcccagtttg accccaataa ggtggcacct
     2581 tctggaaaga aatgttttgg agccaaaaag tttaagcagt cggtgggaaa caaaagcatg
     2641 tcatttcctg ctgggaagtc ggacagaggc ttccggcaca actggccaaa gagatagtct
     2701 tggagagact cctggggccg tggacactgc tgctttgtac aaaacccatt ttaaaatcat
     2761 taaaaattta ttcctacca
//
