LOCUS       NM_001106866            4083 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus exo/endonuclease G (Exog), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001106866 XM_001077489 XM_236696
VERSION     NM_001106866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4083)
  AUTHORS   Xiao J, Dong X, Peng K, Ye F, Cheng J, Dan G, Zou Z, Cao J and Sai
            Y.
  TITLE     PGC-1a Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial
            DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity
            of PC12 Cells
  JOURNAL   J Mol Neurosci 71 (11), 2336-2352 (2021)
   PUBMED   33515431
  REMARK    GeneRIF: PGC-1a Mediated-EXOG, a Specific Repair Enzyme for
            Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced
            Neurotoxicity of PC12 Cells.
REFERENCE   2  (bases 1 to 4083)
  AUTHORS   Tigchelaar W, De Jong AM, van Gilst WH, De Boer RA and Sillje HH.
  TITLE     In EXOG-depleted cardiomyocytes cell death is marked by a decreased
            mitochondrial reserve capacity of the electron transport chain
  JOURNAL   Bioessays 38 Suppl 1, S136-S145 (2016)
   PUBMED   27417117
  REMARK    GeneRIF: Endo/exonuclease G-like plays an essential role in
            cardiomyocyte physiology. Loss of endo/exonuclease G-like results
            in diminished adaptation to pathological stress. The decline in
            maximal respiration and reserve capacity is the first sign of
            mitochondrial dysfunction that determines subsequent cell death.
REFERENCE   3  (bases 1 to 4083)
  AUTHORS   Szczesny B, Brunyanszki A, Olah G, Mitra S and Szabo C.
  TITLE     Opposing roles of mitochondrial and nuclear PARP1 in the regulation
            of mitochondrial and nuclear DNA integrity: implications for the
            regulation of mitochondrial function
  JOURNAL   Nucleic Acids Res 42 (21), 13161-13173 (2014)
   PUBMED   25378300
REFERENCE   4  (bases 1 to 4083)
  AUTHORS   Cymerman IA, Chung I, Beckmann BM, Bujnicki JM and Meiss G.
  TITLE     EXOG, a novel paralog of Endonuclease G in higher eukaryotes
  JOURNAL   Nucleic Acids Res 36 (4), 1369-1379 (2008)
   PUBMED   18187503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001106866.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001106866.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487230.119123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JACYVU010000200.1  22143919-22144124
            207-356             JACYVU010000200.1  22145857-22146006
            357-496             JACYVU010000200.1  22146594-22146733
            497-573             JACYVU010000200.1  22147959-22148035
            574-688             JACYVU010000200.1  22150228-22150342
            689-4083            JACYVU010000200.1  22160208-22163602
FEATURES             Location/Qualifiers
     source          1..4083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4083
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /note="exo/endonuclease G"
                     /db_xref="GeneID:301062"
                     /db_xref="RGD:1304628"
     exon            1..206
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1150
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /EC_number="3.1.30.-"
                     /note="endonuclease G-like 1; endo/exonuclease (5'-3'),
                     endonuclease G-like"
                     /codon_start=1
                     /product="nuclease EXOG, mitochondrial"
                     /protein_id="NP_001100336.1"
                     /db_xref="GeneID:301062"
                     /db_xref="RGD:1304628"
                     /translation="MAAKGFASRLRDSRRFLNGFLAGAVVGAAGAGLTALQFLQRRDA
                     GSARPARQPHESVEKVVLEQFGFPLTGTETRRYTNHALSYDQAKRVPRWVLEHISKDK
                     IIGDADRKHCKFKPDPTVPSAFSALNEDYIGSGWSRGHMAPAGNNKFSSEAMAETFYL
                     SNIVPQNFENNSGYWNRIEMYCRELTERFEDVWIVSGPLTLPHTRNDGTKTVSYQVIG
                     EDNVAVPSHLYKVILARRSPESTEPLALGAFVVPNKAIGFQSQLSEFQVSLHDLEKMS
                     GLVFFPHLDRTRDIRNICSVDTCKLLGFQEFTLYLSTRKIDGARSVARLEKVLEALKS
                     SGVEPDDYFLSRYGKKLEELKAKEQKDAQLEKQS"
     exon            207..356
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..496
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..573
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..688
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..4083
                     /gene="Exog"
                     /gene_synonym="Endogl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcatgc gcggcagaga caaagtgctg gcggcccaga atcatggctg caaagggctt
       61 cgcttcgcgt ctcagggact cgcggaggtt tctgaatggc ttcttggccg gggctgtagt
      121 gggcgccgca ggagcagggc tgacggcgct gcagttcctc cagcgtcggg acgcggggtc
      181 cgcgaggccg gcgaggcagc cgcacgaatc tgtagaaaaa gttgtcttgg aacagtttgg
      241 atttccttta actggaacag agaccaggcg ttacactaac catgccttgt cgtatgatca
      301 ggcaaagcgg gtgcccagat gggttcttga acatatatcc aaggacaaga tcatcggtga
      361 cgcggacaga aagcattgta aattcaagcc ggatcctact gtcccttcag ccttcagcgc
      421 cctcaatgaa gactatattg gaagtggctg gtcacgaggc cacatggccc cagcaggaaa
      481 taacaagttt tccagtgaag ccatggcaga aaccttttac ctttctaaca tcgtgcctca
      541 gaattttgag aataattccg gctactggaa taggatagaa atgtactgcc gtgagctgac
      601 ggagagattt gaagatgttt ggatagtatc gggaccttta accttacctc atactagaaa
      661 cgatggaacg aagacagtta gttaccaggt gatcggtgag gacaatgtgg cagtcccctc
      721 acacctttac aaggtaatcc tggctcgcag aagcccagaa tctaccgaac cactggcact
      781 gggggccttt gtggtaccaa ataaagccat cgggttccag tcccagttaa gcgagttcca
      841 ggtgagcctc catgacctgg agaagatgtc aggcctggtg tttttccccc atctggatag
      901 aaccagggac atccggaaca tttgctctgt ggacacctgc aaactcctgg ggttccagga
      961 gttcactctg tacctgagca caaggaagat cgacggagcc cggtctgtgg ccagactgga
     1021 gaaggttctg gaagctttga agagctctgg ggtggaacct gacgattact tcctgagtcg
     1081 ctatgggaaa aagctggagg aactgaaggc taaggagcag aaggacgccc agctggaaaa
     1141 gcagtcctag cgtctgtctg ggtatgcgct cagcatctga gatgaacagc caagccctct
     1201 ctgggcagag gcattttcaa gaaatgatgg aatcctgacc aaaacccact ggctcaaaac
     1261 tcagtgttgt tttcctcccc taggaccgga gttggctgag gtggttttaa aactctcttc
     1321 tctccgattt gcatttgcat gcttcttctc tcatggcctt gagatcctgc aaccgagcat
     1381 cagatgactg ctcctcccct gtgcaaaccc tgctgttccc atcttatctg tggggaagac
     1441 gaggctcagg gaactgtgtc ccccattggt gttctacagc agtctcccgg gtgcctcaga
     1501 gttaagacaa agtagatggg ggtttgaagg ctgtttctgg tgccaagacc ctcctggtga
     1561 gaagggtctg tctcctcaga agagtgagca cgtcatctct gtgggaagaa acagcgggtc
     1621 tttgaaagat ggagatacct cgtgggttta accagagcct gtggttccct ccagggatca
     1681 cgtggtgcca gataagtgcg tttcttgctt catgggggcc tttctaaggg agcgcaagaa
     1741 aggtgtgtcc cgagagtctt cgggtacctc tgttctttcc tgctatctgc tgggccagca
     1801 caccacaggt aggtctagcc tgggccctag ctccaaagca gttcattccc aggggaaaga
     1861 gcagctgctc tctgtgctga cttctgcaat gctgtataca gatcttgagc tgtcctgagt
     1921 atgctcggcc caatagcttc cgggcagaag gacttgtctg aatctgccac tctgcctctg
     1981 tcttctgagc agtacgagag tgatctttgt ggcgttgtgt ttgcctctga tggaaatgcc
     2041 atggctttac aataaagaca agaaggcagt ggctggccct gttctgctcc ttcatttgga
     2101 taaaaagaaa caatcgggtg taggacacag tggctgatta atgccattct gttttatctt
     2161 cctgttcccc actaacttgt gccagtcctt ctgaggatag aaagccaaaa tgtcactgtg
     2221 accaaaaaaa cctgttactt tctctcctca aaaaagaggt gatggtgggg cctgagcgct
     2281 tctccaggag ccctgggaag gaagctgggg ctcctcctga ctgtgtccca ggttcccacc
     2341 atgtatccat gcagccgagc ccctctctcg tggccgtgct cccctctgct gacctgactt
     2401 gccagtggcc ttggacttac ttcccatgct ttccccgctc aggaagaatc ttgtctgact
     2461 tcatcagtaa gttttagaag cttgggattt gatttcctat gaaagatgct acctggtcat
     2521 tgtgagacag agatcagaac aaaccaaaaa gacagtgtgc ctgaccattt tttattttat
     2581 tttttatttg aatctgtgtc tttatgagtg ttttgcctgt ttgcatctat gcataccaag
     2641 tacccgatgc ccacagaaga gctcattgaa tatcctggaa atgattccca gatggttctg
     2701 agccaccatg tgaatgccgg gttctctaca gcgagtcggg gtcctctgcg agagcagcca
     2761 gtgctctgaa gccccgccct cggtgtttag gtgtgaaatg tagtgcattg gtaacaacac
     2821 tgatgcttga attgtctgtg aacatttcca ttaaaagtgc ccagcacaaa cacttggaat
     2881 ttcctctagc tcgggtcact gtggcccctt tggtgtggct gtcctttaag agccctgggc
     2941 cagtaccaga tgtgtcagag acaaacgccg taacctgcca aacctgaatg gggtcactac
     3001 ccgtttgcta cctcagtggg ttcccctcag gttcttgggc cgagcctgga tcactgcctt
     3061 ctgggtcatt tacccttcca gttcctggtc tggagaaatg gccatgctgg gtgggctccg
     3121 ctgtgggaag tccctggctg tgggtagggg atttaatcct taatctttct ttttttttaa
     3181 aaagatttat ttatttattt atttatttat ttatttattt atttatttat tatatgtgaa
     3241 tacactgtag ctgtcttcag acacaccaga agagggcatc aggtctcatt acaggtggtt
     3301 gtgagccacc atgtggttgc tgggaattga actcaggacc tctggaagag cagtcagtgc
     3361 tcttaaccgc tgagccatct ctccagcccc agtctttttt ctagtgacat cttcaaattc
     3421 tttgatctct ggactaaggc tgttggctaa agttgaatac agcaaaggaa ggccttacta
     3481 aaagttagag agctcagggg tagcacccca ctccactccc accccaagct atgcgctacc
     3541 atttctgcac ttaacttcta aacagcagaa acctgtcttc tttggccttt gattagtgcc
     3601 cagcaggaga ggcagtctgc tcttgaggga atggcttcct gcagagctgc gctcagtttg
     3661 cagcccaaca ctggcatgat cctctgtgtt gccatgtcac ctgtgtgccc tgccccatct
     3721 ctgagggtat tgttgagctt cctccgttca tggcagactt cctgttaaca gctggtggat
     3781 gggtaggatg taacgtgtgc ctcaccaaca cattcccagc ctgtgcagct ttgaaagctg
     3841 tgagttcttg ggaggggagg cctgactggt ggaagtaggt caggagaagc aggctttgaa
     3901 ggtcaactcc cccccccccc ccccctggtt ctggcctgtg tgctttgcct cctgtctgcc
     3961 actgtgtaaa caccttccac ctcactgctc aaacctcggg agacagccat tcctgttgtg
     4021 gtgcctccca cgccatggtg aactggagtc ccagcaccat cagctcaaat aaacccttcc
     4081 tgc
//
