LOCUS       NM_139043               2490 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus exocyst complex component 8 (Exoc8), mRNA.
ACCESSION   NM_139043
VERSION     NM_139043.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Monteiro,P., Rosse,C., Castro-Castro,A., Irondelle,M., Lagoutte,E.,
            Paul-Gilloteaux,P., Desnos,C., Formstecher,E., Darchen,F.,
            Perrais,D., Gautreau,A., Hertzog,M. and Chavrier,P.
  TITLE     Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP
            at invadopodia
  JOURNAL   J Cell Biol 203 (6), 1063-1079 (2013)
   PUBMED   24344185
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Parrini,M.C., Sadou-Dubourgnoux,A., Aoki,K., Kunida,K.,
            Biondini,M., Hatzoglou,A., Poullet,P., Formstecher,E., Yeaman,C.,
            Matsuda,M., Rosse,C. and Camonis,J.
  TITLE     SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front
            to drive cell motility
  JOURNAL   Mol Cell 42 (5), 650-661 (2011)
   PUBMED   21658605
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Rosse,C., Formstecher,E., Boeckeler,K., Zhao,Y., Kremerskothen,J.,
            White,M.D., Camonis,J.H. and Parker,P.J.
  TITLE     An aPKC-exocyst complex controls paxillin phosphorylation and
            migration through localised JNK1 activation
  JOURNAL   PLoS Biol 7 (11), e1000235 (2009)
   PUBMED   19885391
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Jin,R., Junutula,J.R., Matern,H.T., Ervin,K.E., Scheller,R.H. and
            Brunger,A.T.
  TITLE     Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the
            RalA GTPase
  JOURNAL   EMBO J 24 (12), 2064-2074 (2005)
   PUBMED   15920473
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Moskalenko,S., Tong,C., Rosse,C., Mirey,G., Formstecher,E.,
            Daviet,L., Camonis,J. and White,M.A.
  TITLE     Ral GTPases regulate exocyst assembly through dual subunit
            interactions
  JOURNAL   J Biol Chem 278 (51), 51743-51748 (2003)
   PUBMED   14525976
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Wang,S. and Hsu,S.C.
  TITLE     Immunological characterization of exocyst complex subunits in cell
            differentiation
  JOURNAL   Hybrid Hybridomics 22 (3), 159-164 (2003)
   PUBMED   12954101
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139043.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF032669.1, SRR22582416.1058319.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2490              JAXUCZ010000019.1  69752387-69754876   c
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2490
                     /gene="Exoc8"
                     /gene_synonym="Exo84"
                     /note="exocyst complex component 8"
                     /db_xref="GeneID:245709"
                     /db_xref="RGD:620245"
     exon            1..2490
                     /gene="Exoc8"
                     /gene_synonym="Exo84"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2305
                     /gene="Exoc8"
                     /gene_synonym="Exo84"
                     /note="exocyst complex 84 kDa subunit"
                     /codon_start=1
                     /product="exocyst complex component 8"
                     /protein_id="NP_620612.1"
                     /db_xref="GeneID:245709"
                     /db_xref="RGD:620245"
                     /translation="MSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRV
                     QALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLALL
                     PAAAAGASTGEDTAGAGPRERGAAQAGFLPGPAGVPREGPGTGEEGKQRTLTTLLEKV
                     EGCRDLLETPGQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRY
                     NALYPLDRLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEETKRALS
                     DKRRREQEEAAALRAPPPVTSKGSNPFEDEAEEELATPEAEEEKVDLSMEWIQELPED
                     LDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPSVKELRAKVDERVRQLTEVLVFELSPD
                     RSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKL
                     CHVFFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLST
                     AAECVKVAKEHCQQLGEIGLDLTFIIHALLVKDIQGALLSYKEIIIEATKHRNSEEMW
                     RRMNLMTPEALGKLKEEMRSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALK
                     LYFPELHMVLLESLVEVILVAVQHVDYSLRCEQDPEKKTFIRQNASFLYDTVLPVVER
                     RFEEGVGKPAKQLQDLRNASRLLRVNPESTTSVV"
ORIGIN      
        1 ggcacaggcg caatgcagcg ctcggccccg gcgcaggcgt ttgggtgttg ctcccgcccc
       61 gcttcctcta ccgcttctcc accgggctcg ggtggggccg ggaggcggcg agtgacagcc
      121 actgcgggcc gcgggagcag ggcgggtggc agccatgtcg gacagcgggg cgagccgcct
      181 gcggaggcag ctggagtcgg ggggcttcga ggcgcggctg tacgtgaagc aactgtcgca
      241 gcagtcggac ggcgaccgcg acctgcagga gcaccgacag cgggtgcagg cgctggcgga
      301 ggagacggcg cagaacctga agcgcaacgt ctaccagaac taccggcagt tcatcgagac
      361 ggcgcgcgag atctcctacc tggagagcga gatgtaccag ctgagccacc tgctgacgga
      421 gcagaagagc agtctggaga gcatcccgct ggcactgctg cccgccgctg ccgcgggcgc
      481 atccacgggt gaggacacgg cgggcgcggg accgcgggag cgcggggcgg cccaggcggg
      541 ctttcttccg gggccggccg gagtccctcg cgagggcccc gggacgggag aggagggcaa
      601 gcagcgaacg ctcaccacgc tgctggagaa ggtggagggc tgcagggacc tgctggagac
      661 accaggtcag taccttgtgt acaacgggga cctggtggaa tacgaggcag accatatggc
      721 ccagctgcag cgagtgcatg gcttcctcat gaacgactgt ctgctggtgg ccacttggct
      781 accacaacgg cgaggcatgt accgctacaa cgcactctac ccactggacc gcctggctgt
      841 ggtcaacgtc aaagacaatc cacctatgaa agacatgttc aagctgctca tgttccctga
      901 gagccgaatc tttcaagcgg aaaatgccaa gattaaacgc gagtggctgg aagtgctgga
      961 ggaaaccaag agggcgctca gcgacaagag gagacgggag caggaggagg cagccgcctt
     1021 gcgtgcgcca ccaccggtca cttccaaggg cagcaacccg tttgaggatg aggccgagga
     1081 ggaactggcc accccggagg cagaggagga aaaggttgac ctttccatgg agtggatcca
     1141 ggagttgccg gaagacctgg atgtttgtat tgcgcagagg gactttgagg gtgccgtgga
     1201 cttgctggac aaattaaatc actatcttga agataagccc agcccacctt ctgtgaaaga
     1261 gctgagggcc aaagtggatg aacgagtgcg acagctcacc gaggtgcttg tgtttgagct
     1321 ctccccggat cgctctctga gaggtggccc taaggctact cgaagggcag tgtctcaact
     1381 gatccgtctc ggccagtgca ctaaggcttg tgagctgttt ctgaggaaca gggcggcagc
     1441 tgtgcatact gccatccgcc agcttcgaat tgagggcgcc actctgctct atattcacaa
     1501 gctgtgccat gtcttcttta ccagcctcct agagactgca cgggagtttg agacagactt
     1561 tgcaggcacg gacagtggct gctactctgc ctttgtggtc tgggcaaggt ctgccatggg
     1621 catgttcgtg gatgctttca gcaagcaggt ttttgacagc aaggagagcc tgtccactgc
     1681 tgccgagtgt gtgaaggtag ccaaggagca ctgccagcag ctgggagaga ttgggctgga
     1741 tctcaccttc atcatccatg ccctcctggt gaaggacatc cagggggcct tgctcagtta
     1801 caaggagatt atcattgaag ccaccaagca ccgaaactcg gaggagatgt ggcgtcggat
     1861 gaacctgatg actcctgagg ccctgggcaa gctcaaggag gagatgagaa gttgcggggt
     1921 cagtaacttt gagcagtata cgggggatga ctgctgggtg aacctgagct acactgtggt
     1981 agccttcacc aagcagacca tgggcttcct ggaggaggca ctgaaactgt acttcccaga
     2041 gctacacatg gtgctcctgg agagtctggt ggaagtcata ctggttgctg tgcagcatgt
     2101 ggactacagc ctgcgctgtg agcaggaccc agagaagaag actttcatcc ggcagaacgc
     2161 atccttcctt tacgacactg tcctcccagt ggtggagagg aggtttgagg aaggtgtggg
     2221 gaagcctgcc aagcagctgc aggaccttcg gaatgcatcg agactcctgc gggtgaatcc
     2281 tgagagcacc acgtctgtgg tctgaggctc tggttcgatg ctgtgtgtgc gtctgtctgt
     2341 ctgtctgtct gtctgtctgt atgtatgtat gtatgtctgt acacacacat gtactacaga
     2401 tgcattgttt gtattcacat tacacaatat caacacattc ctcagacaca aacagcatat
     2461 aaaagtgccc tcttaaaaat gcagtcaaaa
//
