LOCUS       NM_022691               2105 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus exocyst complex component 7 (Exoc7), mRNA.
ACCESSION   NM_022691
VERSION     NM_022691.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Lira,M., Arancibia,D., Orrego,P.R., Montenegro-Venegas,C., Cruz,Y.,
            Garcia,J., Leal-Ortiz,S., Godoy,J.A., Gundelfinger,E.D.,
            Inestrosa,N.C., Garner,C.C., Zamorano,P. and Torres,V.I.
  TITLE     The Exocyst Component Exo70 Modulates Dendrite Arbor Formation,
            Synapse Density, and Spine Maturation in Primary Hippocampal
            Neurons
  JOURNAL   Mol Neurobiol 56 (7), 4620-4638 (2019)
   PUBMED   30374940
  REMARK    GeneRIF: Exo70 is essentially involved in the formation of synapses
            and neuronal dendritic morphology.
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Ma,W., Wang,Y., Yao,X., Xu,Z., An,L. and Yin,M.
  TITLE     The role of Exo70 in vascular smooth muscle cell migration
  JOURNAL   Cell Mol Biol Lett 21, 20 (2016)
   PUBMED   28536622
  REMARK    GeneRIF: Exo70 in vascular smooth muscle cell migration. Exo70 and
            alpha-actin were co-localized at the leading edge of migrating
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Fujita,A., Koinuma,S., Yasuda,S., Nagai,H., Kamiguchi,H., Wada,N.
            and Nakamura,T.
  TITLE     GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic
            fusion of Rab11- and L1-containing vesicles by releasing exocyst
            component Exo70
  JOURNAL   PLoS One 8 (11), e79689 (2013)
   PUBMED   24223996
  REMARK    GeneRIF: Exocytosis of Rab11- and L1-positive vesicles may play a
            central role in TC10-mediated neurite outgrowth
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Liu,J., Zhao,Y., Sun,Y., He,B., Yang,C., Svitkina,T., Goldman,Y.E.
            and Guo,W.
  TITLE     Exo70 stimulates the Arp2/3 complex for lamellipodia formation and
            directional cell migration
  JOURNAL   Curr Biol 22 (16), 1510-1515 (2012)
   PUBMED   22748316
  REMARK    GeneRIF: functions as a kinetic activator of the Arp2/3 complex
            that promotes actin filament nucleation and branching
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Lizunov,V.A., Lisinski,I., Stenkula,K., Zimmerberg,J. and
            Cushman,S.W.
  TITLE     Insulin regulates fusion of GLUT4 vesicles independent of
            Exo70-mediated tethering
  JOURNAL   J Biol Chem 284 (12), 7914-7919 (2009)
   PUBMED   19155211
  REMARK    GeneRIF: fusion of GLUT4 vesicles is the rate-limiting step
            regulated by insulin downstream of Exo70-mediated tethering
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Oeffner,F., Moch,C., Neundorf,A., Hofmann,J., Koch,M. and
            Grzeschik,K.H.
  TITLE     Novel interaction partners of Bardet-Biedl syndrome proteins
  JOURNAL   Cell Motil Cytoskeleton 65 (2), 143-155 (2008)
   PUBMED   18000879
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Liu,J., Zuo,X., Yue,P. and Guo,W.
  TITLE     Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the
            exocyst to the plasma membrane for exocytosis in mammalian cells
  JOURNAL   Mol Biol Cell 18 (11), 4483-4492 (2007)
   PUBMED   17761530
  REMARK    GeneRIF: Exo70-phosphatidylinositol 4,5-bisphosphate interaction is
            critical for the docking and fusion of post-Golgi secretory
            vesicles, but not for their transport to the plasma membrane
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Zuo,X., Zhang,J., Zhang,Y., Hsu,S.C., Zhou,D. and Guo,W.
  TITLE     Exo70 interacts with the Arp2/3 complex and regulates cell
            migration
  JOURNAL   Nat Cell Biol 8 (12), 1383-1388 (2006)
   PUBMED   17086175
  REMARK    GeneRIF: Exo70, in addition to functioning in exocytosis, also
            regulates actin at the leading edges of migrating cells, therefore
            coordinating cytoskeleton and membrane traffic during cell
            migration.
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jul 20, 2021 this sequence version replaced NM_022691.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231273.1, SRR26360181.216637.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000010.1  102039178-102039301 c
            125-190             JAXUCZ010000010.1  102038955-102039020 c
            191-375             JAXUCZ010000010.1  102037450-102037634 c
            376-481             JAXUCZ010000010.1  102037147-102037252 c
            482-704             JAXUCZ010000010.1  102033735-102033957 c
            705-872             JAXUCZ010000010.1  102031542-102031709 c
            873-1018            JAXUCZ010000010.1  102026859-102027004 c
            1019-1171           JAXUCZ010000010.1  102026498-102026650 c
            1172-1270           JAXUCZ010000010.1  102026000-102026098 c
            1271-1333           JAXUCZ010000010.1  102025623-102025685 c
            1334-1400           JAXUCZ010000010.1  102025245-102025311 c
            1401-1466           JAXUCZ010000010.1  102023847-102023912 c
            1467-1587           JAXUCZ010000010.1  102022754-102022874 c
            1588-1683           JAXUCZ010000010.1  102022434-102022529 c
            1684-1747           JAXUCZ010000010.1  102021584-102021647 c
            1748-1789           JAXUCZ010000010.1  102021327-102021368 c
            1790-1923           JAXUCZ010000010.1  102020923-102021056 c
            1924-2105           JAXUCZ010000010.1  102020508-102020689 c
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2105
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /note="exocyst complex component 7"
                     /db_xref="GeneID:64632"
                     /db_xref="RGD:620236"
     exon            1..124
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2026
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /note="exocyst complex component Exo70; rexo70"
                     /codon_start=1
                     /product="exocyst complex component 7"
                     /protein_id="NP_073182.1"
                     /db_xref="GeneID:64632"
                     /db_xref="RGD:620236"
                     /translation="MIPPQEASARRREIEDKLKQEEETLSFIRDSLEKSDQLTKNMVS
                     ILSSFESRLMKLENSIIPVHKQTENLQRLQENVEKTLSCLDHVISYYHVASDTEKIIR
                     EGPTGRLEEYLGSMAKIQKAVEYFQDNSPDSPELNKVKLLFERGKESLESEFRSLMTR
                     HSKVISPVLVLDLISADDELEVQEDVVLEHLPESVLQDVIRISRWLVEYGRNQDFMNV
                     YYQIRSSQLDRSIKGLKEHFRKSSSSSGVPYSPAIPNKRKDTPTKKPIKRPGRDDMLD
                     VETDAYIHCVSAFVRLAQSEYQLLMGIIPEHHQKKTFDSLIQDALDGLMLEGENIVSA
                     ARKAIIRHDFSTVLTVFPILRHLKQTKPEFDQVLQGTAASTKNKLPGLITSMETIGAK
                     ALEDFADNIKNDPDKEYNMPKDGTVHELTSNAILFLQQLLDFQETAGAMLASQETSSS
                     ATSYNSEFSKRLLSTYICKVLGNLQLNLLSKSKVYEDPALSAIFLHNNYNYILKSLEK
                     SELIQLVAVTQKTAERSYREHIEQQIQTYQRSWLKVTDYIAEKNLPVFQPGVKLRDKE
                     RQMIKERFKGFNDGLEELCKIQKAWAIPDTEQRDKIRQAQKSIVKETYGAFLHRYSSV
                     PFTKNPEKYIKYRVEQVGDMIDRLFDTSA"
     exon            125..190
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            191..375
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            376..481
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            482..704
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            705..872
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1018
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1171
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1270
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1333
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1400
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1466
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1587
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1683
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1747
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1789
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1923
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2105
                     /gene="Exoc7"
                     /gene_synonym="Exo70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggaagcc gagcagggtt tggagctaag acatagggga gtgggaacag cgctgtccgc
       61 tgcgatgatt cccccgcagg aggcttccgc tcggcggcgg gagatcgagg acaagctgaa
      121 gcaggaggag gagacgctgt cctttattcg agacagcctg gagaagagcg accagctcac
      181 taagaacatg gtgtctatcc tgtcgtcctt tgagagccga ctcatgaagc tggagaactc
      241 catcatccct gtgcacaagc agacagagaa cctacagagg ctgcaggaga atgtcgaaaa
      301 gaccttatcc tgcctggacc atgttatcag ctattaccac gtagccagcg acacggagaa
      361 gatcatcaga gagggcccca caggtaggct ggaagaatac ctgggaagca tggccaaaat
      421 ccagaaggct gtggagtact ttcaggacaa cagcccagat agcccagagc tcaacaaagt
      481 gaagctgctg tttgagcggg ggaaggagtc cctggaatcg gagttccgca gtctgatgac
      541 caggcacagc aaggtcatct cccctgtgct cgtcctggac ctcatcagtg cggatgacga
      601 gctggaggtc caggaggacg tggtcctgga gcacctgcct gagagcgtgc tccaggatgt
      661 gatccgcatc tcccgctggc tggtggaata tggtcggaac caagatttca tgaatgtcta
      721 ctatcagatc cgctctagcc agctggaccg ctccatcaag ggtctgaagg agcattttcg
      781 caaaagcagt tcttcctctg gggttcccta ctcccccgcc atccccaaca agaggaaaga
      841 cacgcctacc aagaagccca tcaagcggcc agggagagat gacatgctgg acgtggagac
      901 agatgcctac attcactgcg ttagtgcctt tgtcaggctg gcacagagtg aataccagct
      961 gctgatgggc atcattcccg agcatcacca gaagaaaacc ttcgactcct tgatacagga
     1021 tgccctagat gggctgatgc ttgaagggga gaacatagtg tccgcggcca ggaaagccat
     1081 catccgccat gacttctcca ccgtgctcac cgtcttcccc atcctgcgac acctcaagca
     1141 gaccaagcct gagtttgacc aggtgctcca gggcacagca gccagcacga agaacaagct
     1201 gccaggcctc atcacctcca tggagaccat tggggccaaa gctctagaag actttgcgga
     1261 taacatcaag aatgatccag acaaggagta caacatgcct aaagatggca ccgttcatga
     1321 gctcacaagc aatgccatcc tgttcctaca gcagcttctg gacttccagg agacagcagg
     1381 cgccatgctg gcctcccaag aaaccagctc ttcggccacc agctacaact ccgagttcag
     1441 caagcgactg ctgagtacct acatttgcaa agtcctgggt aacctgcagc tgaacttgct
     1501 aagcaagtcc aaggtgtatg aggatccagc tctgagcgcc atcttcctac acaacaacta
     1561 caactacatc ctcaagtccc tggagaagtc tgagctgatc cagcttgtgg ctgtgaccca
     1621 gaagactgct gagcgctcct accgggagca cattgagcag cagatccaga cctaccagcg
     1681 cagctggcta aaggtgactg actacatcgc agagaagaat ctacctgtgt tccagcctgg
     1741 agtcaagctc cgggacaagg agcggcaaat gattaaggaa cgtttcaagg gattcaatga
     1801 tgggctcgaa gaactgtgca agattcagaa ggcctgggcc atcccagaca cggagcagag
     1861 ggacaagatc cgacaggctc agaaaagcat cgtcaaggag acctatgggg cctttctgca
     1921 caggtatagc agcgtgccct tcaccaaaaa cccggagaag tacatcaagt accgtgtgga
     1981 gcaggtgggc gacatgatcg accgcctctt cgacacctct gcttaagtcg gccagcgctt
     2041 ccgcccagtg ccactggcgt gcctagcatg tcatcggact cataaaccag tggtaacaca
     2101 ctcca
//
