LOCUS       NM_022204               2700 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus exocyst complex component 5 (Exoc5), mRNA.
ACCESSION   NM_022204
VERSION     NM_022204.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Fujimoto,B.A., Young,M., Carter,L., Pang,A.P.S., Corley,M.J.,
            Fogelgren,B. and Polgar,N.
  TITLE     The exocyst complex regulates insulin-stimulated glucose uptake of
            skeletal muscle cells
  JOURNAL   Am J Physiol Endocrinol Metab 317 (6), E957-E972 (2019)
   PUBMED   31593505
  REMARK    GeneRIF: Heterozygous knockout of Exoc5 in skeletal myoblast cells
            leads to impaired GLUT4 trafficking to the plasma membrane and
            hinders glucose uptake in response to an insulin stimulus.
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Polgar,N., Lee,A.J., Lui,V.H., Napoli,J.A. and Fogelgren,B.
  TITLE     The exocyst gene Sec10 regulates renal epithelial monolayer
            homeostasis and apoptotic sensitivity
  JOURNAL   Am J Physiol Cell Physiol 309 (3), C190-C201 (2015)
   PUBMED   26040895
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Fogelgren,B., Polgar,N., Lui,V.H., Lee,A.J., Tamashiro,K.K.,
            Napoli,J.A., Walton,C.B., Zuo,X. and Lipschutz,J.H.
  TITLE     Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in
            Mice Cause Ureteropelvic Junction Obstructions
  JOURNAL   PLoS One 10 (6), e0129346 (2015)
   PUBMED   26046524
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Hazuka,C.D., Hsu,S.C. and Scheller,R.H.
  TITLE     Characterization of a cDNA encoding a subunit of the rat brain
            rsec6/8 complex
  JOURNAL   Gene 187 (1), 67-73 (1997)
   PUBMED   9073068
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128739.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022204.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128739.1, U79417.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2700              BC128739.1         4-2703
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..2700
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /note="exocyst complex component 5"
                     /db_xref="GeneID:60627"
                     /db_xref="RGD:708408"
     exon            1..255
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2355
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /note="p71 component of rsec6/8 secretory complex; exocyst
                     complex component Sec10; 71 kDa component of rsec6/8
                     secretory complex; SEC10-like 1"
                     /codon_start=1
                     /product="exocyst complex component 5"
                     /protein_id="NP_071540.1"
                     /db_xref="GeneID:60627"
                     /db_xref="RGD:708408"
                     /translation="MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLE
                     EFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEH
                     ISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNPEKIKEAA
                     DVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEVSRMREVAAV
                     LLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGDIFSNPEAVLAKLI
                     QNVFEVKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTSLSSKLMEFNLGTDKQTFL
                     SKLIKSIFVSYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIR
                     QRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTIL
                     VEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLI
                     SSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDEN
                     NVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLTYEHLQQYSYS
                     CMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLAN
                     LDKNILHSFVQLRADYRSARLARHFS"
     exon            256..350
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..498
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..693
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..758
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..787
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..897
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..942
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1083
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1166
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1376
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1524
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1633
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1754
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1841
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1950
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2166
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2677
                     /gene="Exoc5"
                     /gene_synonym="Sec10l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggcgcg ggcggcgctg ggaggcagct gacaggcgtc tgcggctccg cttcatggcc
       61 gctctcttgc gctgtcttcg ctgtgtgagg acccgggcaa cccgcagcgg tgcgcagccg
      121 gggccggagg cggtaggccg agttgggact ggtgagccgc gcctctgagg cgcagcatgt
      181 gaagcggaga cggcctcgag cgcggggcga gcctctcagc cggccggcat ggccacgacg
      241 gccgagctct tcgaggagcc ttttgtggcc gatgaataca ttgaacgtct cgtgtggaga
      301 accccgggag gtggttctag gggtggacct gaagcttttg atcctaaaag gttattagaa
      361 gaatttgtga atcatattca agaactacag ataatggatg aaaggattca aaggaaagta
      421 gagaagttag aacagcagtg tcagaaggag gcaaaggagt ttgctaagaa ggtacaagag
      481 ctgcagaaaa gcaaccaggt tgctttccaa catttccaag aactagatga acacattagc
      541 tatgtagcta ccaaagtgtg tcaccttgga gaccagttgg aaggggtaaa cacacctaga
      601 cagcgtgcag tggaggcgca gaaattgatg aaatacttta atgagtttct agatggagaa
      661 ttgaaatctg atgtttttac aaatcctgaa aagatcaagg aagcagcaga cgtcattcag
      721 aaactgcatc tgatcgccca ggagttacct ttcgataggt tttcagaagt aaaatccaaa
      781 attgcaagta aataccacga cttagaatgc cagctgattc aggagtttac cagtgcacaa
      841 cgaagaggtg aggtctcccg gatgagggag gtggcagctg tcctgcttca ttttaagggt
      901 tattcccact gtattgatgt ttatataaag cagtgccagg agggtgctta cttgagaaat
      961 gatatattcg aagacgcagc aattctctgt cagcgagtga acaagcaagt tggagatatc
     1021 tttagtaatc cagaagcagt actggctaag cttattcaga atgtgtttga agtcaaacta
     1081 cagagttttg tgaaagatca gttagaagaa tgtaggaaat cggatgctga gcagtatctt
     1141 aaaagtctgt atgatctgta cacaagaacc accagtcttt ccagcaaatt gatggagttt
     1201 aacttaggta ctgataaaca gactttcttg tctaagctta tcaaatccat tttcgtttcc
     1261 tatctggaga actatattga agtggagatt ggatatttga aaagcagaag tgctatgatc
     1321 ctacagcgct attatgattc aaaaaaccac caaaagagat ccattggcac aggaggtatt
     1381 caagatttga aagaaaggat tagacaacgt accaacttac cactggggcc aagtattgac
     1441 acacatgggg agactttcct atctcaagaa gtggtagtta atcttttaca agaaaccaaa
     1501 caagcctttg aaagatgtca taggctttct gatccttctg atttaccaag gaatgccttt
     1561 agaattttta ccattcttgt ggaattttta tgtattgagc atattgatta tgctttagaa
     1621 acggggcttg ctggaattcc atcatcagat tctaggaacg caaatctcta ttttttggat
     1681 gttgtacaac aggccaatac tatttttcat ctttttgaca aacagtttaa tgatcaccta
     1741 atgccactaa taagctcttc tcctaagttg tctgaatgcc tccagaagaa gaaggagata
     1801 attgagcaga tggagatgaa gttggacact ggcatcgata ggacgttaaa ttgtatgatt
     1861 ggacagatga agcacatctt ggctgcagaa caaaagaaaa cagattttaa gccagaagat
     1921 gaaaacaatg ttttgattca gtatactaat gcatgtgtaa aggtttgtgc ttatgtaaga
     1981 aaacaagttg agaagattaa gaattccatg gatgggaaga atgtggacac ggttctgatg
     2041 gagctcggag tacgtttcca ccggcttact tatgagcatc ttcaacaata ttcctacagt
     2101 tgtatgggcg gcatgcttgc aatttgcgac gttgctgaat atagaaaatg tgccaaagac
     2161 ttcaagattc caatggtatt acatcttttt gatactctgc atgcactttg caatctccta
     2221 gtcgttgctc cagataattt aaagcaagtc tgctcaggag aacaactggc caatctggac
     2281 aagaacatac tccactcctt cgtccagctt cgagctgact atagatccgc ccgcctggct
     2341 cggcacttca gctgagctta gtttacagag gcaatgggtt gctcttcaga aggcctcggg
     2401 tgacagaaag cacaggagag tccttcagac accgccaata tttgaaggga aaaaatgact
     2461 ggaagaaaac agcagccata cttacccagg aattttattt gaaaattgga cacttctagc
     2521 tgtgttttgc tttatatttt ttccctgtta tattgaattc catactttaa tttataaatt
     2581 tcaaattcta ttaacctaca tgactgttaa aatcctgaaa aatgttggtg tcagaagatg
     2641 aatgaaattc accagtgttc tggttcttgg tctttaaaaa aaaaaaaaaa aaaaaaaaaa
//
