LOCUS       NM_053875               3509 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus exocyst complex component 4 (Exoc4), mRNA.
ACCESSION   NM_053875 XM_001063828 XM_001063871 XM_342655
VERSION     NM_053875.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Gainey,M.A., Tatavarty,V., Nahmani,M., Lin,H. and Turrigiano,G.G.
  TITLE     Activity-dependent synaptic GRIP1 accumulation drives synaptic
            scaling up in response to action potential blockade
  JOURNAL   Proc Natl Acad Sci U S A 112 (27), E3590-E3599 (2015)
   PUBMED   26109571
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Parrini,M.C., Sadou-Dubourgnoux,A., Aoki,K., Kunida,K.,
            Biondini,M., Hatzoglou,A., Poullet,P., Formstecher,E., Yeaman,C.,
            Matsuda,M., Rosse,C. and Camonis,J.
  TITLE     SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front
            to drive cell motility
  JOURNAL   Mol Cell 42 (5), 650-661 (2011)
   PUBMED   21658605
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Chernyshova,Y., Leshchyns'ka,I., Hsu,S.C., Schachner,M. and
            Sytnyk,V.
  TITLE     The neural cell adhesion molecule promotes FGFR-dependent
            phosphorylation and membrane targeting of the exocyst complex to
            induce exocytosis in growth cones
  JOURNAL   J Neurosci 31 (10), 3522-3535 (2011)
   PUBMED   21389209
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Riefler,G.M., Balasingam,G., Lucas,K.G., Wang,S., Hsu,S.C. and
            Firestein,B.L.
  TITLE     Exocyst complex subunit sec8 binds to postsynaptic density
            protein-95 (PSD-95): a novel interaction regulated by cypin
            (cytosolic PSD-95 interactor)
  JOURNAL   Biochem J 373 (Pt 1), 49-55 (2003)
   PUBMED   12675619
  REMARK    GeneRIF: cytosolic PSD-95 interactor may function to regulate the
            ability of sec8 to bind to PSD-95
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Brymora,A., Valova,V.A., Larsen,M.R., Roufogalis,B.D. and
            Robinson,P.J.
  TITLE     The brain exocyst complex interacts with RalA in a GTP-dependent
            manner: identification of a novel mammalian Sec3 gene and a second
            Sec15 gene
  JOURNAL   J Biol Chem 276 (32), 29792-29797 (2001)
   PUBMED   11406615
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Shin,D.M., Zhao,X.S., Zeng,W., Mozhayeva,M. and Muallem,S.
  TITLE     The mammalian Sec6/8 complex interacts with Ca(2+) signaling
            complexes and regulates their activity
  JOURNAL   J Cell Biol 150 (5), 1101-1112 (2000)
   PUBMED   10973998
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Friedrich,G.A., Hildebrand,J.D. and Soriano,P.
  TITLE     The secretory protein Sec8 is required for paraxial mesoderm
            formation in the mouse
  JOURNAL   Dev Biol 192 (2), 364-374 (1997)
   PUBMED   9441674
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Ting,A.E., Hazuka,C.D., Hsu,S.C., Kirk,M.D., Bean,A.J. and
            Scheller,R.H.
  TITLE     rSec6 and rSec8, mammalian homologs of yeast proteins essential for
            secretion
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9613-9617 (1995)
   PUBMED   7568183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U32498.1 and FM107548.1.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by NM_053875.2.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_342655.3, XM_001063871.1, XM_001063828.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2925              U32498.1           1-2925
            2926-3509           FM107548.1         9-592
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3509
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /note="exocyst complex component 4"
                     /db_xref="GeneID:116654"
                     /db_xref="RGD:621791"
     CDS             1..2928
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /note="rSec8; exocyst complex component Sec8; SEC8-like 1;
                     secretory protein SEC8; augmenter of liver regeneration
                     (ALR) pseudogene"
                     /codon_start=1
                     /product="exocyst complex component 4"
                     /protein_id="NP_446327.1"
                     /db_xref="GeneID:116654"
                     /db_xref="RGD:621791"
                     /translation="MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEK
                     GRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKM
                     LLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSA
                     VESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIEELHRHLYIKSTSRVVQRNKEKGKM
                     SSHGKDASPGPLIDVSNISTPRKFLDATQYSAAGSSSVREMNLQDIKEDLDCDPEENS
                     TLFMGILIQGLARLKKIPETVKAIKERLEQELKQIVKRSTTQVADSAYQRGESLTVDN
                     QPRLLLELLELLFDKFNAVASAHSIVLGYLQDSVGTQPTQQEEIKLYDMADVWVKIQD
                     VLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSH
                     AISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFI
                     QEIEHALGLGPAKQCLLREFLTIYIKNIFLNQVLTEINKEIEGVTKTSDPLKILANAD
                     TMKVLGVQRPLLQSTIIVEKTVQDLMNLMHDLSAYSDQFLNMVCVKLQEYKDTCSTAY
                     RGIVQSEEKLVISASWAKDDDISRLLKSLPNWTNMAQPKQLRPKREEEEDFIRAAFGK
                     ESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLAGRTKSAFSSLSASQMLSP
                     AQESHVNMDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEG
                     NYAIVANVESMDYDPLVVKLNKDISAMEEAMSASLQQHKFQYIFEGLGHLISCILING
                     AQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLV
                     VDQGVKYTELEYIHALTLLHRSQTGVGDQTTQNTRLQRLKEIICEQAAIKQATKDKKI
                     TTV"
     exon            1..86
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..276
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..471
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..656
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..766
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1010
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1185
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1331
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1420
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1517
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1737
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1874
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2030
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2209
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2351
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2530
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2690
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..3509
                     /gene="Exoc4"
                     /gene_synonym="ALR; Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcag aagcagctgg tgggaaatac aggagcacag tcagcaaaag caaagacccc
       61 tcggggctgc tcatctcggt gatcaggact ctgtctacca gtgatgatgt tgaagaccga
      121 gaaaatgaga aaggtcgcct tgaagaagcc tatgagaagt gtgaccgtga cctggatgaa
      181 ttgatcgttc agcactacac agaattgaca acagccattc gcacatacca gagcatcaca
      241 gaacgcatca ctaactccag gaataaaatc aagcaggtaa aagagaacct gctttcctgc
      301 aagatgctgt tgcattgcaa acgggatgag cttcgtaaac tatggattga aggaattgag
      361 cataagcatg tcctgaacct tctggatgag attgaaaaca tcaagcaagt gcctcaaaag
      421 ctggaacagt gcatggccag caagcactac ctcagcgcca cggacatgct ggtgtcagca
      481 gtggagtctc tggagggtcc gctgctccag gtggaaggac tcagtgacct caggctggaa
      541 cttcacagca agaagatgaa cctgcacttg gttctcatag aggaactgca ccgacatctg
      601 tacatcaaat ccactagccg ggttgtacag cgtaacaagg aaaaagggaa gatgagttct
      661 catggcaaag atgcttctcc tggtcctctg attgatgttt caaacatctc tactccacgc
      721 aaattccttg atgccactca atattctgct gctggaagct caagtgtgag ggagatgaac
      781 ctgcaggaca tcaaagagga cttggactgt gatcctgagg agaacagcac tcttttcatg
      841 ggaattctta ttcaggggct ggccagactg aagaagatcc ctgagaccgt taaagccatt
      901 aaagagcgtt tggagcagga gctaaagcag attgtgaaga ggtcaaccac ccaggtggca
      961 gacagtgcct atcagagggg agagagcctc actgtggaca accagccaag gttacttcta
     1021 gaactgctgg aactgttgtt tgataagttt aatgctgtag ccagtgcaca ttctatagtc
     1081 ctggggtacc ttcaggactc tgtggggacc cagccaacac agcaggaaga gatcaaatta
     1141 tacgatatgg cagatgtgtg ggtgaagatc caggatgtgc tgcagatgct gttgactgaa
     1201 tacttggata tgaagaacac acgtactgcg tcagagccgt cagctcaact aagctatgcc
     1261 agtactggac gagagttcgc agcctttttt gccaagaaga aaccacaaag gccaaagaat
     1321 tctcttttca agtttgaatc atcctcccat gctatcagta tgagcgccta tctccgagaa
     1381 cagagaaggg agctgtacag tcggagtgga gaacttcaag gaggtcctga tgacaactta
     1441 attgaaggtg gaggaacaaa atttgtctgc aaacctggag ccagaaatat taccgtcata
     1501 ttccatccac tgctgagatt tattcaggag attgagcatg ccctgggact tggccctgcc
     1561 aaacagtgtc tccttcgaga gtttctcact atatatatca agaacatctt ccttaatcag
     1621 gtcttgactg agatcaacaa ggagatcgaa ggtgtcacca aaacctcaga ccccttgaag
     1681 atcctagcta atgcagacac catgaaggtt ctgggcgtgc agaggcctct tctacagagc
     1741 accatcatcg tggagaagac agtacaagac ctcatgaacc tgatgcatga cttgagtgca
     1801 tattcagatc agttcctcaa catggtgtgt gtgaagctac aggaatacaa ggacacatgc
     1861 tccacagcct acagaggcat tgtccaatca gaagagaaac ttgtcatcag tgcatcttgg
     1921 gcaaaagatg atgatatcag cagactcttg aaatcactgc cgaactggac taacatggct
     1981 cagcccaaac agctaaggcc taagagagag gaggaggaag acttcataag ggcagccttt
     2041 ggcaaggagt ctgaggttct gattggaaac cttggtgaca aactcattcc tccacaagat
     2101 attctccgtg acgtcagtga cctcaaagcc ttggccaaca tgcatgaaag cctggaatgg
     2161 ctggcaggcc gaacaaagtc agctttctcc agcctttctg catcccagat gctttcccct
     2221 gctcaagaga gccacgtaaa catggacctt cctccagtgt ctgaacagat catgcagacg
     2281 ctgagtgaac ttgccaagtc cttccaggac atggctgacc gctgcttgct cgtcttgcat
     2341 ctggaagtga gagttcattg tttccactat ctcatccctc tggcaaagga ggggaactat
     2401 gccattgtgg ccaatgtgga aagcatggat tatgaccctt tagtggtcaa gctcaacaaa
     2461 gacatcagtg ccatggaaga ggccatgagc gccagcctcc agcaacacaa gttccagtac
     2521 atcttcgaag gtctgggaca cctcatctcc tgtatcctca ttaatggggc tcagtacttc
     2581 cggcgcatca gtgagtctgg catcaagaaa atgtgtagaa acatttttgt tcttcagcag
     2641 aatttgacca acatcaccat gtcacgggag gcagacttgg actttgcaag acagtactac
     2701 gagatgctgt acaacactgc tgatgagctc ctgaacctgg tggtggacca gggtgtgaaa
     2761 tacacagagc tagagtacat ccatgccctg accctgctgc accgaagcca gactggcgtg
     2821 ggggaccaga ccacccagaa caccaggctg cagagactca aggagatcat ctgtgagcag
     2881 gctgccatca agcaagccac caaggacaag aaaataacca ctgtgtgatg gggtgtgggt
     2941 gggttcacgg tgtgcacaga cacaggctct agctcctcag cctgagctgg ctgtgctttg
     3001 tccaccctga tgcttagtgg gtagatggtg gattattttc tcttagtttt gcttttctat
     3061 atgaatgcta agaaagtttg caggacagaa tgttttgcct aataactact ttagtctatt
     3121 cccaagggat gagggtggaa cagggaggag accatgtcaa gttgctggac tcagaaagga
     3181 atgaaggaaa gccaactgcc acttaagttt tagaaccatc ctgaaatgcc aagtaaggcc
     3241 tgtggcatga gcagtgggct ttctcttgtc ttagccttgt cagtttataa ttcagtgtaa
     3301 taagtatgtg cacattgctt tgtctgcatt gccaaaatca aagcgcttct cagctggctt
     3361 cccaatccaa aacagatctc tttaaggctg gggatagcag tcctttatcc caaccctggg
     3421 acagattgca cctataccag gactgctcgc aggctgctga ttggttttac aaccttttta
     3481 ttttattcct tctgtattaa aaccagtta
//
