LOCUS       NM_134414               4379 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus exocyst complex component 2 (Exoc2), mRNA.
ACCESSION   NM_134414 XM_003751679 XM_003752976
VERSION     NM_134414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4379)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   2  (bases 1 to 4379)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   3  (bases 1 to 4379)
  AUTHORS   Bodemann,B.O., Orvedahl,A., Cheng,T., Ram,R.R., Ou,Y.H.,
            Formstecher,E., Maiti,M., Hazelett,C.C., Wauson,E.M.,
            Balakireva,M., Camonis,J.H., Yeaman,C., Levine,B. and White,M.A.
  TITLE     RalB and the exocyst mediate the cellular starvation response by
            direct activation of autophagosome assembly
  JOURNAL   Cell 144 (2), 253-267 (2011)
   PUBMED   21241894
REFERENCE   4  (bases 1 to 4379)
  AUTHORS   Nichols,C.D. and Casanova,J.E.
  TITLE     Salmonella-directed recruitment of new membrane to invasion foci
            via the host exocyst complex
  JOURNAL   Curr Biol 20 (14), 1316-1320 (2010)
   PUBMED   20579884
REFERENCE   5  (bases 1 to 4379)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4379)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   7  (bases 1 to 4379)
  AUTHORS   Fukai,S., Matern,H.T., Jagath,J.R., Scheller,R.H. and Brunger,A.T.
  TITLE     Structural basis of the interaction between RalA and Sec5, a
            subunit of the sec6/8 complex
  JOURNAL   EMBO J 22 (13), 3267-3278 (2003)
   PUBMED   12839989
REFERENCE   8  (bases 1 to 4379)
  AUTHORS   Mott,H.R., Nietlispach,D., Hopkins,L.J., Mirey,G., Camonis,J.H. and
            Owen,D.
  TITLE     Structure of the GTPase-binding domain of Sec5 and elucidation of
            its Ral binding site
  JOURNAL   J Biol Chem 278 (19), 17053-17059 (2003)
   PUBMED   12624092
REFERENCE   9  (bases 1 to 4379)
  AUTHORS   Sugihara,K., Asano,S., Tanaka,K., Iwamatsu,A., Okawa,K. and Ohta,Y.
  TITLE     The exocyst complex binds the small GTPase RalA to mediate
            filopodia formation
  JOURNAL   Nat Cell Biol 4 (1), 73-78 (2002)
   PUBMED   11744922
REFERENCE   10 (bases 1 to 4379)
  AUTHORS   Kee,Y., Yoo,J.S., Hazuka,C.D., Peterson,K.E., Hsu,S.C. and
            Scheller,R.H.
  TITLE     Subunit structure of the mammalian exocyst complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14438-14443 (1997)
   PUBMED   9405631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB582051.1, AF032666.1, CK482593.1, CO396803.1, CO393045.1,
            DV724419.1, BP475684.1 and AA875297.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003752976.1, XM_003751679.1, NM_134414.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               CB582051.1         1-602
            603-797             AF032666.1         541-735
            798-1149            CK482593.1         247-598
            1150-1928           AF032666.1         1088-1866
            1929-2050           CO396803.1         227-348
            2051-3265           AF032666.1         1989-3203
            3266-3751           CO393045.1         86-571
            3752-4130           DV724419.1         282-660
            4131-4273           BP475684.1         93-235              c
            4274-4379           AA875297.1         1-106               c
FEATURES             Location/Qualifiers
     source          1..4379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4379
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /note="exocyst complex component 2"
                     /db_xref="GeneID:171455"
                     /db_xref="RGD:619961"
     exon            1..117
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..218
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..379
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..3036
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /note="exocyst complex component Sec5"
                     /codon_start=1
                     /product="exocyst complex component 2"
                     /protein_id="NP_599241.2"
                     /db_xref="GeneID:171455"
                     /db_xref="RGD:619961"
                     /translation="MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTIC
                     GHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGRGTSTVSFKLLKPEKIGILD
                     QSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKCKLPQKNLEVLFHGMSADF
                     TSENFSAAWYLIENHSNTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDA
                     LSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNV
                     LQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVEAGIED
                     LRELLLKKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWTLKLMQDCKEGH
                     MKSLKGNPGPHSPMLDLDNDARPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVA
                     FVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQIERSKNVRQRQNDFKKMIQE
                     VMHSLVKLIRGALLPFSLREGDGRQYGGWEVQAELSGQWLAHVIQTIRLTYESLTALE
                     IPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDWIVDNEGLTSLPCQFEQS
                     IVHSLQSLKGVVDCKPGEASVFQQPKTQEEVCQLCISIMQVFIYCLEQLSTKPDADID
                     TTHLSVDVSSPDLFGSIHEDFGLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQG
                     IEKITQVSMASLKELDQRLFENYIELKADPIVGSLETGIYAGYFDWKDCLPPAGVRNY
                     LKEALVNIIAVHAEVFTISKELVPRVLARVIEAVSEELSRLMQCVSSFSRNGALQARL
                     EICALRDTVAIYLTPESRSSFKQALEALPQLASGADKKLLEELLNKFKSSMHLQLTCF
                     QAASPTVMKT"
     exon            380..556
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..683
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..797
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..922
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1003
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1149
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1231
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1334
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1453
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1579
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1704
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1770
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1928
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2050
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2112
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2193
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2253
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2315
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2382
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2499
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2641
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2697
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2820
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2882
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2942
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..4363
                     /gene="Exoc2"
                     /gene_synonym="Rsec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaggcgg cggatcgacg tgctcggcgc tcgcggcgtg cggaagtgcg gccctacggc
       61 agactgctgc ggcccggagc gggttggccc ggacctgacg ccgcctgcaa gctgcaggac
      121 agagggctgg agatggcaga tcccaggagc tagcagccag cccagccgaa tggtgtctcc
      181 acctggagtg caggagagag agactgaaaa ccaaaaaggt tgcttttata actggaacag
      241 gagtttgctg ctcaaagtac aatgtctcga tcccggcagc ctccacttgt gacaggcatc
      301 tctccaaatg aagggattcc ttggaccaaa gtcacaatta gaggggagaa tctgggtact
      361 ggtcccactg accttatagg cttgacaatt tgtggacata attgcctcct cacggcagaa
      421 tggatgtctg caagtaaaat tgtctgtcga gtgggacaag ccaaaaatga caaaggagac
      481 attattgtca caaccaagtc agggggcaga ggaacctcaa ctgtctcttt taagctactc
      541 aaacctgaaa aaataggcat tttggatcag tctgcagtgt gggtggatga gatgaattat
      601 tatgatatgc ggactgacag gaataagggg attcccccct tgtcacttcg tcctgcgaat
      661 cctctcggca ttgaaattga gaagtgtaaa cttcctcaga agaacttaga agtgttattc
      721 catggcatga gtgctgattt tacgagtgag aatttttcag cagcctggta tctcatagag
      781 aaccactcca acaccagttt tgagcagctc aagatggcag ttaccaacct caaaaggcag
      841 gccaacaaga agagcgaggg tagtctagcg tatgtgaagg gcggcctcag taccttcttt
      901 gaagctcaag atgctctctc agctatccat caaaaactag aagcagacgg aacagaaaaa
      961 gtagaaggat ccatgacaca gaaattggag aatgtcctca acagagcaag taatactgct
     1021 gacacattgt ttcaagaagt gttaggtcgg aaagacaagg cagattccac taggaatgca
     1081 ctcaacgtgc ttcagcggtt taaatttctc ttcaaccttc ctctcaatat caaacggaac
     1141 attcaaaagg gggattatga tgtggttatt aatgattatg aaaaagccaa atcgctcttt
     1201 gggaaaacgg aggtgcaagt tttcaagaaa tattatgctg aagtagaggc aggaattgaa
     1261 gatctaagag agttacttct aaagaaactg ctcgagactc cgtcaacctt acatgaccag
     1321 aagcgttaca taaggtatct ttctgacctc catgctcctg gtgatcctgc ttggcagtgt
     1381 atcggagctc agcacaagtg gaccctcaaa ctcatgcaag actgcaaaga aggccacatg
     1441 aagagcctga aaggtaaccc aggcccacac agccccatgc ttgacctaga taatgatgcc
     1501 cgcccctctg tgttgggcca tctcagtcag acagcatcac tgaagagagg cagcagcttc
     1561 cagtctggtc gagatgacac atggaggtac aagacgcccc acagagtggc atttgttgaa
     1621 aaattaacga agcttgtgtt aagtcagctg cctaacttct ggaaactctg gatttcatat
     1681 gttaatggaa gtctgttcag tgagacagct gagaagtcag gccagattga aagatcaaag
     1741 aatgtgaggc aaagacaaaa tgatttcaag aaaatgattc aagaagtaat gcactccctg
     1801 gtgaagttga tccggggagc cctgctccca ttcagcctcc gagaagggga tgggagacag
     1861 tatggcggct gggaggtgca ggcagagctc tcggggcagt ggctcgcaca cgttatccag
     1921 accataaggc tgacatatga atcactgacc gctctggaga ttcccaatga catgttacag
     1981 attatccagg acctgatttt ggatctccgt atacgttgca taatggtgac gttgcaacat
     2041 acagctgaag agataaagag attagctgaa aaagaagatt ggattgttga taacgaagga
     2101 ctgacttccc taccatgtca gtttgaacag agcattgttc actccctgca gtcgttgaag
     2161 ggtgttgtgg attgcaaacc tggagaagcc agtgtctttc agcagcctaa aacccaggag
     2221 gaggtttgcc agttgtgcat cagtatcatg caggttttta tatactgcct ggaacaactg
     2281 agcaccaagc ctgatgcgga catagatact actcatcttt ctgttgatgt ttcttctcct
     2341 gatttgtttg gaagcatcca tgaagacttc ggtttgactt cagagcagag gcttttgata
     2401 gtcctgagta attgctgcta tttagaacgt cacaccttcc taaacatagc agaacatttt
     2461 gaaaagcaca acttccaggg aatagaaaaa ataacacagg ttagtatggc atcactgaaa
     2521 gaactggatc aacgactctt tgaaaattac attgagctaa aagcagatcc tattgttgga
     2581 tccttggaaa ctgggatata tgcaggctat tttgattgga aagactgtct gcctccagca
     2641 ggtgtcagaa actatttaaa agaagcactg gtgaatataa ttgctgtgca tgcagaggtg
     2701 ttcactattt ccaaagaact ggtgccccgg gtcctggcca gagtgataga agcagtctct
     2761 gaagagctga gccggctgat gcagtgtgtc tcatccttca gcagaaatgg agcgctgcag
     2821 gccagacttg aaatctgtgc tctgagggac actgtagcca tttacctgac cccggagagc
     2881 aggtctagtt ttaaacaggc cctggaggcc ctgcctcagc ttgcaagtgg tgcagacaaa
     2941 aagctactgg aagagctgct caacaagttc aagagcagta tgcacttgca gctcacctgc
     3001 ttccaagctg cgtctccaac agtgatgaag acatagacac agacagagat cccagtccaa
     3061 gcactgcatt taccttctct cttttcccca gcatggtggt gcagaaagat gttgatgggt
     3121 atttaatttc agccgattta gactaccata caattttgtt attactagct ttggtcctgt
     3181 agcatactct tcaaaatgtt ttttcttagc tctatgtttc ttggtgtgag ttttgagagc
     3241 ttctccagca tggcccaaag cggcccatgg tgtgtgtgaa tgtgcttcgc agtggcgctc
     3301 tacctggcct cagtgttggc agtttccagc ccaggggagg atatgaagtc acagcttttg
     3361 gagctgtcat aaactttaaa cccaccattt caaacaagtg gttctaggtg cgctctctct
     3421 ctctctctct ctctctctct ctctctctct ctctctctct ctctgtaaag aaaaatataa
     3481 aaatgttaaa atctgtgatg cagaagtccc tggatgaact ctgaatttca tagtctggct
     3541 ttcatttttc ccagtgttca acacggaagc ttctggttct cacccttaag ttgatgcatc
     3601 gttgtgggga gggtttacaa ggacctgaat gtggaggccc tgtcacaccc gcaagccctg
     3661 tggcaggctt gtggtcttca atgcaaccta aagattaagc caggctcctc ccctcccgca
     3721 ggttactccc ctctgctact ttccacactt cgaaatgtct tgctccatag ctggaaagat
     3781 ggtgccctgg cacaggctgt gttttgtaaa gattagaggt gcctcggtga ccaggcattg
     3841 agcagtgact cactgctcac tggctggcac agtagaatcc ggtcactgcg acctgcaagc
     3901 agcttttacc tcactgcatc tgaccctagc ttcagctctg gttcactcca gacagatctg
     3961 tggcgccttt ctttcagttg acaaaattcc tgtcactttt agttcaggta attcaagagc
     4021 acagcatatg cacactatgg attatttgag gttaataaca gtgtgtttat ttatcacagt
     4081 aactggaagt acaaatttaa tcctttgttt gcaaagtatg tatgtacagc attgtctcct
     4141 cagtgcactg gtattacatc tggcatagcc aaactgaatt ccaaggcaga agtacacaac
     4201 cattggttgt ttaaacacct aacaaataca ctacacaaag ccagtagtct tccttctctg
     4261 taaaacctct aagtgtcttt atttcaccat tttttattag ctctgtaatt gtttatattc
     4321 ctagttttaa aatccaaaat aaatagtggt gttctctctt ttaaaaaaaa aaaaaaaaa
//
