LOCUS       NM_001107198            5060 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus exonuclease 1 (Exo1), mRNA.
ACCESSION   NM_001107198 XM_001059185 XM_222932
VERSION     NM_001107198.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5060)
  AUTHORS   Laulederkind,S.J., Shimoyama,M., Hayman,G.T., Lowry,T.F., Nigam,R.,
            Petri,V., Smith,J.R., Wang,S.J., de Pons,J., Kowalski,G., Liu,W.,
            Rood,W., Munzenmaier,D.H., Dwinell,M.R., Twigger,S.N. and
            Jacob,H.J.
  CONSRTM   RGD Team
  TITLE     The Rat Genome Database curation tool suite: a set of optimized
            software tools enabling efficient acquisition, organization, and
            presentation of biological data
  JOURNAL   Database (Oxford) 2011, bar002 (2011)
   PUBMED   21321022
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5060)
  AUTHORS   Heyer,W.D., Ehmsen,K.T. and Liu,J.
  TITLE     Regulation of homologous recombination in eukaryotes
  JOURNAL   Annu Rev Genet 44, 113-139 (2010)
   PUBMED   20690856
  REMARK    Review article
REFERENCE   3  (bases 1 to 5060)
  AUTHORS   Li,G.M.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   4  (bases 1 to 5060)
  AUTHORS   Nielsen,F.C., Jager,A.C., Lutzen,A., Bundgaard,J.R. and
            Rasmussen,L.J.
  TITLE     Characterization of human exonuclease 1 in complex with mismatch
            repair proteins, subcellular localization and association with PCNA
  JOURNAL   Oncogene 23 (7), 1457-1468 (2004)
   PUBMED   14676842
REFERENCE   5  (bases 1 to 5060)
  AUTHORS   Bardwell,P.D., Woo,C.J., Wei,K., Li,Z., Martin,A., Sack,S.Z.,
            Parris,T., Edelmann,W. and Scharff,M.D.
  TITLE     Altered somatic hypermutation and reduced class-switch
            recombination in exonuclease 1-mutant mice
  JOURNAL   Nat Immunol 5 (2), 224-229 (2004)
   PUBMED   14716311
REFERENCE   6  (bases 1 to 5060)
  AUTHORS   Genschel,J., Bazemore,L.R. and Modrich,P.
  TITLE     Human exonuclease I is required for 5' and 3' mismatch repair
  JOURNAL   J Biol Chem 277 (15), 13302-13311 (2002)
   PUBMED   11809771
REFERENCE   7  (bases 1 to 5060)
  AUTHORS   Jager,A.C., Rasmussen,M., Bisgaard,H.C., Singh,K.K., Nielsen,F.C.
            and Rasmussen,L.J.
  TITLE     HNPCC mutations in the human DNA mismatch repair gene hMLH1
            influence assembly of hMutLalpha and hMLH1-hEXO1 complexes
  JOURNAL   Oncogene 20 (27), 3590-3595 (2001)
   PUBMED   11429708
REFERENCE   8  (bases 1 to 5060)
  AUTHORS   Lee,B.I. and Wilson,D.M. 3rd.
  TITLE     The RAD2 domain of human exonuclease 1 exhibits 5' to 3'
            exonuclease and flap structure-specific endonuclease activities
  JOURNAL   J Biol Chem 274 (53), 37763-37769 (1999)
   PUBMED   10608837
REFERENCE   9  (bases 1 to 5060)
  AUTHORS   Qiu,J., Qian,Y., Chen,V., Guan,M.X. and Shen,B.
  TITLE     Human exonuclease 1 functionally complements its yeast homologues
            in DNA recombination, RNA primer removal, and mutation avoidance
  JOURNAL   J Biol Chem 274 (25), 17893-17900 (1999)
   PUBMED   10364235
REFERENCE   10 (bases 1 to 5060)
  AUTHORS   Schmutte,C., Marinescu,R.C., Sadoff,M.M., Guerrette,S.,
            Overhauser,J. and Fishel,R.
  TITLE     Human exonuclease I interacts with the mismatch repair protein
            hMSH2
  JOURNAL   Cancer Res 58 (20), 4537-4542 (1998)
   PUBMED   9788596
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222932.4, XM_001059185.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..5060
                     /gene="Exo1"
                     /note="exonuclease 1"
                     /db_xref="GeneID:305000"
                     /db_xref="RGD:1309465"
     exon            1..64
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            65..126
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..303
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2653
                     /gene="Exo1"
                     /codon_start=1
                     /product="exonuclease 1"
                     /protein_id="NP_001100668.1"
                     /db_xref="GeneID:305000"
                     /db_xref="RGD:1309465"
                     /translation="MGIQGLLQFIKEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAE
                     KLAKGEPTDRYVGFCMKFVNMLLSYGVKPILVFDGCTLPSKKEVERSRRERRQSNLLK
                     GKQLLREGKVSEARECFTRSVNITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNK
                     AGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYM
                     CILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYITGFI
                     RANNTFLYQLVFDPIQRKLIPLNAYGDDVNPETLTYAGQYVDDSVALQIALGNRDINT
                     FEQIDDYSPDTMPAHSRSHSWNDKACQKSPVASSIWHKNYCPRLEVNSVSHAPQLKEK
                     PSTVGLKQVISTKGLNLPRKPCVLKRPRNEALSEDDLLSQYSSLTKKIRENSCGNGTS
                     PNSSEMSVPCPDGGTAHKTDAHTPSRTRNKFATFLQRRNEECGAIVVPGTKSRFFCSS
                     PDFDNFIPKKGSNQPPNETVATGKATTSLLGALDCPDTGGQKPVVTNGTHSPNTHIPG
                     DATGSPKDEAQSSETSKFLGTMSPPTLGTLRSCFSWSGTLGEFSRTPSPSTRSTLQQF
                     RRKSEPPACLPEACAVTDVCDSKSGTLGDKSQSLHELDWSSRSQESIDSTCSLNTSSL
                     SQPSSKDSDSEESDCNNKSLDNQGSQNSKQHLPHFPKKDILGRNKVPGLCRSSSMDSL
                     SATKIKPLVPARVSGLSKKPGSIQKRKHHDAENKPGLQIKISELWKNFGFKKDSEKLP
                     SCKKPLSPVKDNIQLTPETEDEIFNKPECARAQRAIFH"
     exon            304..423
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..547
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..685
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..898
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1086
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1180
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1406
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1650
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2221
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2323
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2517
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..5060
                     /gene="Exo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaattgaa aggtccatgg ctgcgcttgc agctacagca gctcgctggt gttctgaacc
       61 ccaggtttga ggagccacgg cgcttggaat gggcttgcgg gccatgcctg tttattcgga
      121 agacaattaa cctggcggaa ccatggggat tcaaggatta cttcagttca tcaaagaagc
      181 ttctgaaccc gttaatgtga agaagtacaa aggacaggca gtggcggtgg acacctactg
      241 ctggcttcac aaaggagcta ttgcttgtgc tgaaaagcta gccaaagggg aacctacgga
      301 taggtatgta ggattttgta tgaagtttgt taatatgctg ctttcttatg gggtcaagcc
      361 gattctcgta tttgacggat gtactctacc ttctaaaaag gaagtagagc ggtctcgaag
      421 agagagacga caaagcaacc ttcttaaagg gaagcagctt cttcgagagg ggaaagtgtc
      481 agaagcccga gagtgcttca ctcgctctgt caacattacg cacgccatgg cccacaaagt
      541 aataaaagct gctcgggccc tgggagtgga ctgcctcgtg gctccctatg aagctgacgc
      601 tcagttggcc tacctcaaca aagctggcat tgtgcaagcc gtcatcacag aggactctga
      661 cctcctcgca tttggctgta agaaggtgat tttaaaaatg gatcagtttg gaaatggact
      721 ggaagtggac caggcacggc taggcatgtg caagcagctg ggggatgtgt tcacggagga
      781 gaagttccgg tacatgtgca ttctgtcggg ctgtgactac ctggcctccc tgcgtgggat
      841 cggcttggca aaggcctgca aagtcctgag actggccaac aaccccgaca ttgtgaaggt
      901 tatcaagaaa attgggcatt atctcaagat gaacataacg gtgccagagg actacatcac
      961 agggtttatt cgcgccaaca acactttcct ctaccagcta gtgttcgacc ccatccaaag
     1021 gaagcttatc cctctgaacg cctatggaga cgacgttaat cccgaaacac tcacgtacgc
     1081 tgggcagtat gtcgatgatt ccgtagctct tcaaatagca cttggaaata gagatataaa
     1141 tacttttgag cagattgatg actacagtcc ggacactatg ccagcccact caagaagcca
     1201 tagctggaat gacaaagcat gtcagaagtc acctgtcgcc agtagcattt ggcacaagaa
     1261 ttattgtcct agacttgagg tgaatagtgt ttcccatgct cctcagttga aggaaaagcc
     1321 aagtactgtg ggccttaaac aagtgattag tactaaaggg ttaaatcttc ccaggaagcc
     1381 ttgcgtgttg aagagaccaa gaaatgaagc gctgtctgaa gatgacctgt tgagccagta
     1441 ttcgtcactt acaaagaaga tcagggaaaa tagctgtggg aatggcacct cacccaactc
     1501 ttctgaaatg tccgtaccct gcccggatgg tgggactgct cacaagacag atgcacatac
     1561 cccgtctaga acgaggaata aattcgcaac attcttacag aggaggaatg aagaatgtgg
     1621 tgccatcgtg gttcccggga ccaaaagcag gtttttttgc agttctccag attttgacaa
     1681 cttcatacca aaaaaaggaa gcaaccagcc tccaaatgaa actgttgcca ctggcaaagc
     1741 caccaccagc ctccttggag cattggactg tccagacaca ggaggacaaa agccagttgt
     1801 cacaaatggg acgcacagtc caaacactca cattccaggc gatgcaactg ggtctcctaa
     1861 ggatgaggct cagtcttctg agaccagcaa attcttggga accatgtccc cacccactct
     1921 ggggacacta agaagttgtt tcagttggtc tggaactctc ggggaatttt caaggactcc
     1981 aagtccctca acgagaagta cattgcagca gttccggaga aagagtgagc cccccgcctg
     2041 tcttcctgag gcctgtgcag tcactgacgt atgtgattca aagagtggga cactgggtga
     2101 caagtctcag tccttgcatg agctggactg gtcctcacgg tctcaggaaa gcatagactc
     2161 cacatgcagc ttaaacacat caagcctctc gcagccttcc agtaaggact cagactcaga
     2221 ggaatcggat tgtaacaata agtcacttga taatcaagga agtcagaatt ccaagcaaca
     2281 cttacctcac tttccaaaga aagacatact tgggcggaac aaggttcctg gactctgtcg
     2341 gtctagttct atggactctt tgtctgcaac caagatcaag ccgttggtgc ctgccagagt
     2401 cagtggcctg agcaagaagc caggaagcat ccagaagaga aaacaccatg atgccgagaa
     2461 caagccagga ctgcagataa agatcagcga gctctggaaa aactttgggt ttaaaaaaga
     2521 ttctgaaaag cttccttctt gtaagaagcc cctgtctcca gtcaaggaca atatccaact
     2581 cactccagag acagaagatg agatctttaa caagcccgag tgtgcacgtg ctcagagagc
     2641 aatatttcac taactgccgg ccgctgccta caggaaaatc ttatcaactg gagagatgta
     2701 ttactctcag tgccattttt taaatgggat acattttgta tattaacttt atgacttttc
     2761 ttttgctcag ctttttatat tttcatagaa agctaaatag aagaataaat ctgtctttga
     2821 catttctggg aagttgaaat gctaattggg caaatctcct ggcatcgata ccaatctaaa
     2881 ggactctccc ttgtagtata acatctatta tattgtaact cgaaagccac agatgtctac
     2941 agccacttag acccaagaac agatgactca ccagcttcca gtccctccag ctgccttttc
     3001 tgtctgccct ttaagagaaa cattgaaatc acattgttgc tgggatagaa gggcagtagg
     3061 aggggctctg tctgcttacg actggtaaca cactggtaac acacttaggt ctcgaagctc
     3121 tcagtgtacc tctgaagtac ggcccagaag ttccttagca tttactcaac cctgtgcaag
     3181 atgctgaagc tgcagagcct gtggtcagtg cattctgcaa agatacagcc gcacccgggc
     3241 caatccagta caaccagaag gagaggcata gtgaaggcat ctgtggtaca gagcagagac
     3301 aagacttaga atgtttaaag gggggatgat ttggaaagtc ctaatctgaa gctcaggttt
     3361 gagccccacc atgagcagtc ctgtcagaca gatgccatct acaggcgttc atctctgcaa
     3421 tgtcaggaaa ccaggaaaat gttctataga gcatggaaaa ggaaccatca aggaaggatg
     3481 acgagtgtca gtcaaggaag ggcaggttct ctactggcag cagccaagca ggcagttgta
     3541 gatggctccc atccgtggac agacaggtga gctctgtccc tgagggtaga gggaaaggct
     3601 ggaaacaggc atttaaaaaa aatctttaaa aaatagcaag atggtagtgg cgatgccacc
     3661 ttttccagtc tccaagtcac tgcacaagtc aagccccatt aacagctccc atgacagtct
     3721 tcatagtccc caaatagaaa ttgttccata gttactgacc acaggccata ggataggcca
     3781 cagcaggaga caggacggac tgaggccagc cagagtccct ctgaatgtgg cttcttgtgg
     3841 cttattctgg accactggtg tccatgtttg gttcctgctc acaagaacag gtgtggggat
     3901 tgggccacac tgagcaaggg acatgagcag gttgatggaa cagtaaggtt tgccacccct
     3961 gttttgagac ggactcactt gtccttacca acctctcaga cttgctgtgt ggctcaggtc
     4021 ttttctgatc tccgtcctcc ctagtctagt gagcattccc agcaagtctg cataagtcct
     4081 ctgataataa aaaggaaagt tctggtttgg gttattatcc aggttttcct taaattttat
     4141 atatttttaa ttttataaac cattatttaa agaaactttg tgaataaaag tgtcactgtg
     4201 aagagacaag aaaaaggctg aaaattcagg taggtcagat tttaaagttc aggcaccgga
     4261 gtatagactc aagatgagtc catgagagaa agtttcacat ggccagtatc tccccatctc
     4321 cattcttaat tctgaagttt cattgagcca ttgtatgcgt gggcagaaga gggtagacat
     4381 gggtaaggcc aggcgtttct ggcttggccg gattgtattc cactgtgagg atacccaacc
     4441 ctcatccatc tcatcccagg ttacacctaa agctttgcct tgggttttgt ttggctgtat
     4501 tttctctctc cctttctccc taggaagcta taagtgctta taaagatgga gagagagtgg
     4561 caaaatcagt ccttggcacc tctcagtgct tgcagtcatg aatgtagcac ctaagtctct
     4621 cgtgaataac tattgtcctg aattaaaata actttctcca caccaagcct ggtggtgcat
     4681 gctttaaatc ccagcaaaca ggaggcagaa gcaggtggat ctctgtgttg agccagcctg
     4741 ggctacagag tgagttccaa gacagccaga gctaaacaga aaacctgtct ccaaacccca
     4801 ataaataata ataacaataa taatatccat cttgtcccac acagagggga cacactcgtt
     4861 atccccacct gggaggcaga ggcaggatta ttagttcaag gtcatttctt ggctacatgc
     4921 tgagtttaga gccagttttt gagatcctgc tattaattca gggagaatat atttttaaaa
     4981 tgcattacca aaagaggaag gcttcaaggg gggtcactgc tggggttcac taattaaata
     5041 tggttctctc atctactgca
//
