LOCUS       NM_001108715            3197 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2),
            mRNA.
ACCESSION   NM_001108715 XM_001053206 XM_343086
VERSION     NM_001108715.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Nieminuszczy,J., Broderick,R., Bellani,M.A., Smethurst,E.,
            Schwab,R.A., Cherdyntseva,V., Evmorfopoulou,T., Lin,Y.L.,
            Minczuk,M., Pasero,P., Gagos,S., Seidman,M.M. and Niedzwiedz,W.
  TITLE     EXD2 Protects Stressed Replication Forks and Is Required for Cell
            Viability in the Absence of BRCA1/2
  JOURNAL   Mol Cell 75 (3), 605-619 (2019)
   PUBMED   31255466
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Park,J., Lee,S.Y., Jeong,H., Kang,M.G., Van Haute,L., Minczuk,M.,
            Seo,J.K., Jun,Y., Myung,K., Rhee,H.W. and Lee,C.
  TITLE     The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease
            domain that discriminates substrates via metal coordination
  JOURNAL   Nucleic Acids Res 47 (13), 7078-7093 (2019)
   PUBMED   31127291
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Hensen,F., Moretton,A., van Esveld,S., Farge,G. and Spelbrink,J.N.
  TITLE     The mitochondrial outer-membrane location of the EXD2 exonuclease
            contradicts its direct role in nuclear DNA repair
  JOURNAL   Sci Rep 8 (1), 5368 (2018)
   PUBMED   29599527
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Broderick,R., Nieminuszczy,J., Baddock,H.T., Deshpande,R.,
            Gileadi,O., Paull,T.T., McHugh,P.J. and Niedzwiedz,W.
  TITLE     EXD2 promotes homologous recombination by facilitating DNA end
            resection
  JOURNAL   Nat Cell Biol 18 (3), 271-280 (2016)
   PUBMED   26807646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343086.3, XM_001053206.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC166432.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3197
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /note="exonuclease 3'-5' domain containing 2"
                     /db_xref="GeneID:362759"
                     /db_xref="RGD:1311087"
     exon            1..93
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            94..552
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2085
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /EC_number="3.1.11.1"
                     /note="exonuclease 3''-5'' domain-like 2"
                     /codon_start=1
                     /product="exonuclease 3'-5' domain-containing protein 2"
                     /protein_id="NP_001102185.1"
                     /db_xref="GeneID:362759"
                     /db_xref="RGD:1311087"
                     /translation="MSRQNLLALTVTTLLGVAMGGFVLWKGIQRKWSKTSRVMQPQLQ
                     PQPQQQQQPQPQQQQQPPQQEQQKQQVPGAREWPPPEDDQLPFGALRTPRASWEERIL
                     QAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFC
                     ALVRLPRLIYGGKTLPRTLLDILADGTILKVGVGCSEDANKLLQDYGLIVRGCLDLRY
                     LAMKQGNSVLCNGLSLKSLAETLLNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQI
                     SVALFLHLLGYPFSRNSYEEENNGQINWQKVLEKCRDMVDIPFRSKGLARLGEEINGE
                     ALESQQKPRNRKARTDGMVPGSNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDG
                     QPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVC
                     GKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEF
                     QAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIVTEE
                     MLQEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQ
                     QWSVDHNHQKLLRKYGDDLPIKLS"
     exon            553..809
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            810..936
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1268
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1375
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1511
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1868
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..3197
                     /gene="Exd2"
                     /gene_synonym="Exdl2; RGD1311087"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgcggc ccacaggcac acaccacggg ggttatatcc tcctggccag ccactgggcc
       61 ggaagtggct acggctttta tgcatccggg tggattgtgg gtcagtgaaa tgcattccta
      121 aacagtgaaa ggctaaagat gtctagacag aatttactgg ctttgacagt gaccaccctt
      181 ttgggtgtgg ccatgggggg atttgtcctg tggaaaggca tccagcgtaa atggagtaag
      241 acaagcagag tgatgcagcc acagctgcag ccacaaccac agcagcagca gcagccgcag
      301 ccacagcagc aacagcagcc gccacagcag gagcagcaga agcagcaagt gcccggtgcg
      361 agggagtggc cccctccaga agatgaccag ttaccctttg gtgccctgag aacacccaga
      421 gcttcatggg aggagaggat actccaggca gaggtggtga cagtttctca ggaggcagag
      481 tggaatcaaa tccagccctt tcttaaaaga gagttggaag attttccagt acttggaatt
      541 gactgtgaat gggtgaattt ggaaggcaaa gccagtcctt tgtcactcct acagatggct
      601 tccccaagtg gcttctgtgc attggttcgc ttgcccaggc tgatatatgg aggcaaaaca
      661 ctacccagaa cacttttgga catattggca gatggcacta tcttgaaagt aggagtggga
      721 tgctcagaag atgccaacaa acttctacag gattatggcc tcattgttag gggatgtctg
      781 gacctccgct acctagccat gaagcaggga aacagtgtac tctgtaatgg gcttagcctg
      841 aaatcacttg ctgagactct tttgaacttc ccacttgaca agtcccttct acttcgttgc
      901 agcaactggg atgctgagaa tcttactgaa gaccaggtaa cttatgctgc cagggatgca
      961 cagatttcag tggctctctt tctccatctt cttggatacc ctttctctag aaattcctat
     1021 gaagaggaaa acaatggcca aatcaactgg caaaaagtct tggagaaatg cagggatatg
     1081 gtagacatcc cattccgaag caaaggactt gcccggctgg gtgaagagat taatggggaa
     1141 gcactggaat cgcagcagaa gccaagaaat aggaaggcta ggactgatgg aatggtgcca
     1201 ggcagcaacc aagggagaga ccccaggaag cataagagga agcccctggg ggtgggctat
     1261 tctgccagaa agtcacctct ctatgataac tgctttctcc aagctcctga tggacagccc
     1321 ttgtgcacct gtgaccggag gaaagctcag tggtacctgg acaaaggcat tggagagctg
     1381 gtgagtaaag aaccctttgt ggtcaggcta cagtttgaac ctgcaggaag acctgaatcc
     1441 ccgggagatt attacttgat ggttaaagag aacctgtgtg ttgtctgtgg caagacagat
     1501 acctacatcc ggaaaaacat aattccacat gagtaccgca agcacttccc cattgagatg
     1561 aaggaccaca actcccatga tgtgctgctg ctctgcacct cctgccatgc catctctaac
     1621 tactatgaca accatctgaa gcagcagctg gccaaggagt tccaggcccc cattggctca
     1681 gaggagggcc tgcgcctgct ggaagaccta gagcgtaggc aggtgcgttc cggagccaga
     1741 gccctgctca atgcggagag cctacctgcc catcggaaag aagagttgct gcatgcactc
     1801 agggagtttt acaacacaga cattgttaca gaggagatgc tccaagaggc ggccagcctg
     1861 gagaccagga tatacaatga aagttatatt cctcatgggc taaaggtggt acagcggcac
     1921 acggagggtg ggctgcgctc cctcatgcag ctggagagcc gctggcgtca gcacttcctg
     1981 gactccatgc agcctaagca cctgccccag cagtggtcag tggaccataa ccatcagaag
     2041 ctgctccgaa agtatgggga cgaccttccc atcaagctgt catgagtact gcttcctgca
     2101 gatcaggaca ggcgggaagc aggggcctcc tgctgttaat gttcttaacg gtcgaagccc
     2161 tggtaactca gctcagaatg ctaacctaca ctgatcccca ggtccttctg atggagcaag
     2221 gctgttgttt aaaggggagc ttatggtttt gaattttagt tgaggagtct attcttttct
     2281 cctcctctct ctcctatttt tctgtgcaaa agaagcttgg ccttcatttt cacactccct
     2341 ctctgcttgt cctgttaaga gggagaagtc ttctctaaaa taacttgtcg ggccctggga
     2401 agatgtttat aattctcttt gctgccttgg tttttccagg cctgagagaa aactttctcc
     2461 acagttgaag aagtgaccca caagtcacag tcatattccc agctcagcct cacactttta
     2521 atcttccttg ctctcccata tgcatttgtt tggggcccat tccaactgta ttacttggat
     2581 ttattttaca tgcttgaaaa tgttaccact taacacatac aggaccaaag tccagcttgc
     2641 tatgggctcc ttaacatcac aggggaagtc cttttctgga aatgagtact cagctggctg
     2701 tgctgacaag cactgaccct ttcccaggag agctgtggta cattgttcag cctctcctct
     2761 gcttgcatgt ctcttgtcct gctctgagga ccatcatctc tccgcacccg ctcccttcag
     2821 tgttcatgtt ccattgcgtt tgcagtactg atctctcctt agtatttaag tcactcccat
     2881 agccctttgg ccaggtttca gagtgaggac ttcacctccc ctaaagcctg agacactgaa
     2941 attaactgat acaatagaag tttaaaaggg taatgcttca cctttcaaaa tgttagacta
     3001 ctactttgag tatgaaatca atttattagc aattagtatt ttttctaaac tattaggaaa
     3061 actttcttat tttataagat cttaacaagc ttgaaaagaa ttttatggcc agaatccaac
     3121 aagagttcta ttttggaatt gtacccaagt tggttataac tgatctgaca ttgataaata
     3181 aaacaacttc aaagcac
//
