LOCUS       NM_001025632            2199 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus EWS RNA-binding protein 1 (Ewsr1), mRNA.
ACCESSION   NM_001025632 XM_237930
VERSION     NM_001025632.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2199)
  AUTHORS   Parvanov,E.D., Tian,H., Billings,T., Saxl,R.L., Spruce,C.,
            Aithal,R., Krejci,L., Paigen,K. and Petkov,P.M.
  TITLE     PRDM9 interactions with other proteins provide a link between
            recombination hotspots and the chromosomal axis in meiosis
  JOURNAL   Mol Biol Cell 28 (3), 488-499 (2017)
   PUBMED   27932493
REFERENCE   2  (bases 1 to 2199)
  AUTHORS   Thomsen,C., Grundevik,P., Elias,P., Stahlberg,A. and Aman,P.
  TITLE     A conserved N-terminal motif is required for complex formation
            between FUS, EWSR1, TAF15 and their oncogenic fusion proteins
  JOURNAL   FASEB J 27 (12), 4965-4974 (2013)
   PUBMED   23975937
REFERENCE   3  (bases 1 to 2199)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2199)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2199)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2199)
  AUTHORS   Young,P.J., Francis,J.W., Lince,D., Coon,K., Androphy,E.J. and
            Lorson,C.L.
  TITLE     The Ewing's sarcoma protein interacts with the Tudor domain of the
            survival motor neuron protein
  JOURNAL   Brain Res Mol Brain Res 119 (1), 37-49 (2003)
   PUBMED   14597228
REFERENCE   7  (bases 1 to 2199)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   8  (bases 1 to 2199)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162004.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001025632.3.
            
            On Jun 3, 2008 this sequence version replaced NM_001025632.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2199
                     /gene="Ewsr1"
                     /note="EWS RNA-binding protein 1"
                     /db_xref="GeneID:289752"
                     /db_xref="RGD:1307258"
     exon            1..49
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2004
                     /gene="Ewsr1"
                     /note="Ewing sarcoma breakpoint region 1; RNA-binding
                     protein EWS-like"
                     /codon_start=1
                     /product="RNA-binding protein EWS"
                     /protein_id="NP_001020803.2"
                     /db_xref="GeneID:289752"
                     /db_xref="RGD:1307258"
                     /translation="MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTY
                     GQPTDVSYTQAQSTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPVQGYGTGAYDTTT
                     ATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPAETSQPQSSTGGYNQ
                     PSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSSQPTSYDQSSYSQQNTYGQPS
                     SYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMG
                     VYGQESGGFSGPGENRSLSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNK
                     PGGPMDEGPDLDLGLPIDPDEDSDNSAVYVQGLNDSVTLDDLADFFKQCGVVKMNKRT
                     GQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPL
                     NSMRGGMPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNP
                     SGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGG
                     PGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPL
                     MEQMGGRRGGRGGPGKMDKGEHRQERRDRPY"
     exon            50..86
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..138
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..262
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..449
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..617
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..829
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1010
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1045
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1078
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1197
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1327
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1450
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1613
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1711
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1964
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2171
                     /gene="Ewsr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggacgtt gagagaacga ggaggaagga gagaaaatgg cgtccacgga ttatagtacc
       61 tatagccaag ctgcagccca gcagggctac agtgcttaca ccgcccagcc aactcaagga
      121 tatgcacaga ccacccaggc atatgggcaa caaagctatg gaacctatgg acagcctact
      181 gatgtcagct atacccaggc tcagagcact gccacctacg ggcagactgc atatgcaact
      241 tcttatggac agcctcccac tggttatacc actccaactg ccccccaggc gtacagccag
      301 cctgtccaag gatatggcac tggggcttat gacaccacca ctgctaccgt caccacaacg
      361 caggcctctt atgcagctca gtctgcatac ggcacccagc ctgcctaccc agcctatggc
      421 cagcagccag cagccactgc acccacaaga ccacaggatg gtaacaagcc tgctgagact
      481 agtcaacctc aatctagcac agggggttat aatcaaccca gcctaggata tggacagagt
      541 aactacagtt atccccaggt tcctgggagc tacccgatgc agccagtcac cgcacctcca
      601 tcttatcctc ctaccagcta ctcctcttca cagccaacta gttacgatca gagcagttac
      661 tctcagcaga acacctacgg gcagccgagc agctatggac agcagagtag ctatggtcaa
      721 caaagcagct atgggcagca gcctcccact agttaccccc ctcagactgg atcctacagc
      781 caggctccaa gtcaatatag ccaacagagc agcagctacg ggcagcagag ttcattccga
      841 caggaccacc ccagtagcat gggtgtttat gggcaggagt ctggaggatt ttccggacca
      901 ggagagaacc ggagcttgag tggccctgat aaccggggca ggggaagagg gggatttgat
      961 cgtggaggca tgagcagagg tgggcgggga ggaggacgcg gtggaatggg cgctggagag
     1021 cgaggtggct tcaataagcc tggtggaccc atggatgaag gaccagatct cgatctaggc
     1081 cttcctatag atcccgatga agactctgac aacagtgcag tttatgtgca aggattaaat
     1141 gacagtgtga ctctggatga tctggcagac ttctttaagc agtgtggggt tgtcaagatg
     1201 aacaagagaa ctggacaacc catgatccat atctacctgg ataaggagac aggaaagcct
     1261 aaaggtgatg ccacagtgtc ctatgaagat ccaccaactg ccaaggctgc cgtggaatgg
     1321 tttgatggga aagactttca aggaagcaaa cttaaagttt ctcttgcccg aaagaagcct
     1381 ccactgaaca gcatgcgggg tggcatgcca cctcgtgagg gcagagggat gccaccgccg
     1441 cttcgtggag gtcctggtgg cccaggaggt cctgggggac ccatgggtcg catgggaggc
     1501 cgtggaggag acagaggagg cttccctcca agagggcccc gaggctccag agggaacccc
     1561 tctggaggag gaaatgtcca gcaccgagct ggagactggc agtgtcccaa tccgggctgt
     1621 ggaaatcaga acttcgcctg gagaacagaa tgcaaccagt gtaaggcccc taagcccgag
     1681 ggcttcctcc cgccaccctt tccacctccg ggtggtgatc gtggccgagg cggccctggt
     1741 ggcatgcgag gaggaagagg tggactcatg gaccgtggtg gtcctggagg aatgttcaga
     1801 ggtggcagag gtggagaccg agggggcttc cgaggtggcc gtggcatgga ccgaggtggc
     1861 tttggtggag gaagacgagg tggtcctggg gggcctcctg gacctttaat ggaacagatg
     1921 ggaggaagaa gaggcggacg tggaggacct gggaaaatgg ataaaggcga gcaccgtcag
     1981 gaacgcagag accggcccta ctagagacct gcagagctgc attgacgacc agatttattt
     2041 tttaaaccag aaaatgtttt aaatttataa ttccatattt ataatgttgg cgacaacatt
     2101 atgattattc cttgtctgta ctttagtatt ttcaccattt gtgaagaaac attaaaacaa
     2161 gttaaatagt aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
