LOCUS       NP_001020803             655 aa            linear   ROD 28-APR-2025
DEFINITION  RNA-binding protein EWS isoform 2 [Rattus norvegicus].
ACCESSION   NP_001020803 XP_237930
VERSION     NP_001020803.2
DBSOURCE    REFSEQ: accession NM_001025632.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 655)
  AUTHORS   Parvanov,E.D., Tian,H., Billings,T., Saxl,R.L., Spruce,C.,
            Aithal,R., Krejci,L., Paigen,K. and Petkov,P.M.
  TITLE     PRDM9 interactions with other proteins provide a link between
            recombination hotspots and the chromosomal axis in meiosis
  JOURNAL   Mol Biol Cell 28 (3), 488-499 (2017)
   PUBMED   27932493
REFERENCE   2  (residues 1 to 655)
  AUTHORS   Thomsen,C., Grundevik,P., Elias,P., Stahlberg,A. and Aman,P.
  TITLE     A conserved N-terminal motif is required for complex formation
            between FUS, EWSR1, TAF15 and their oncogenic fusion proteins
  JOURNAL   FASEB J 27 (12), 4965-4974 (2013)
   PUBMED   23975937
REFERENCE   3  (residues 1 to 655)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 655)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 655)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 655)
  AUTHORS   Young,P.J., Francis,J.W., Lince,D., Coon,K., Androphy,E.J. and
            Lorson,C.L.
  TITLE     The Ewing's sarcoma protein interacts with the Tudor domain of the
            survival motor neuron protein
  JOURNAL   Brain Res Mol Brain Res 119 (1), 37-49 (2003)
   PUBMED   14597228
REFERENCE   7  (residues 1 to 655)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   8  (residues 1 to 655)
  AUTHORS   Delattre,O., Zucman,J., Plougastel,B., Desmaze,C., Melot,T.,
            Peter,M., Kovar,H., Joubert,I., de Jong,P., Rouleau,G. et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 3, 2008 this sequence version replaced NP_001020803.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162004.1, SRR26360194.155858.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..655
                     /product="RNA-binding protein EWS isoform 2"
                     /note="RNA-binding protein EWS; Ewing sarcoma breakpoint
                     region 1; RNA-binding protein EWS-like"
                     /calculated_mol_wt=68200
     Region          360..443
                     /region_name="RRM_EWS"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     Ewing Sarcoma Protein (EWS); cd12533"
                     /db_xref="CDD:409950"
     Region          517..546
                     /region_name="zf-RanBP"
                     /note="Zn-finger in Ran binding protein and others;
                     pfam00641"
                     /db_xref="CDD:395516"
     Region          521..542
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275375"
     CDS             1..655
                     /gene="Ewsr1"
                     /coded_by="NM_001025632.3:47..2014"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:289752"
                     /db_xref="RGD:1307258"
ORIGIN      
        1 mastdystys qaaaqqgysa ytaqptqgya qttqaygqqs ygtygqptdv sytqaqstat
       61 ygqtayatsy gqpptgyttp tapqaysqpv qgygtgaydt ttatvtttqa syaaqsaygt
      121 qpaypaygqq paataptrpq dgnkpaetsq pqsstggynq pslgygqsny sypqvpgsyp
      181 mqpvtappsy pptsysssqp tsydqssysq qntygqpssy gqqssygqqs sygqqpptsy
      241 ppqtgsysqa psqysqqsss ygqqssfrqd hpssmgvygq esggfsgpge nrslsgpdnr
      301 grgrggfdrg gmsrggrggg rggmgagerg gfnkpggpmd egpdldlglp idpdedsdns
      361 avyvqglnds vtlddladff kqcgvvkmnk rtgqpmihiy ldketgkpkg datvsyedpp
      421 takaavewfd gkdfqgsklk vslarkkppl nsmrggmppr egrgmppplr ggpggpggpg
      481 gpmgrmggrg gdrggfpprg prgsrgnpsg ggnvqhragd wqcpnpgcgn qnfawrtecn
      541 qckapkpegf lpppfpppgg drgrggpggm rggrgglmdr ggpggmfrgg rggdrggfrg
      601 grgmdrggfg ggrrggpggp pgplmeqmgg rrggrggpgk mdkgehrqer rdrpy
//
