LOCUS       NM_001414900            2172 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Enah/Vasp-like (Evl), transcript variant 1, mRNA.
ACCESSION   NM_001414900 XM_008764857
VERSION     NM_001414900.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2172)
  AUTHORS   Kumar,A., Dumasia,K., Deshpande,S. and Balasinor,N.H.
  TITLE     Direct regulation of genes involved in sperm release by estrogen
            and androgen through their receptors and coregulators
  JOURNAL   J Steroid Biochem Mol Biol 171, 66-74 (2017)
   PUBMED   28242260
  REMARK    GeneRIF: Data suggest that expression of spermiation-related genes
            is directly up-regulated by estrogen 17-beta-estradiol in testes of
            adult rats; a functional estrogen response element lies upstream of
            Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex,
            subunit 1B; Evl = enabled-VASP-like protein)
REFERENCE   2  (bases 1 to 2172)
  AUTHORS   Mouneimne,G., Hansen,S.D., Selfors,L.M., Petrak,L., Hickey,M.M.,
            Gallegos,L.L., Simpson,K.J., Lim,J., Gertler,F.B., Hartwig,J.H.,
            Mullins,R.D. and Brugge,J.S.
  TITLE     Differential remodeling of actin cytoskeleton architecture by
            profilin isoforms leads to distinct effects on cell migration and
            invasion
  JOURNAL   Cancer Cell 22 (5), 615-630 (2012)
   PUBMED   23153535
REFERENCE   3  (bases 1 to 2172)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2172)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   5  (bases 1 to 2172)
  AUTHORS   Bournier,O., Kroviarski,Y., Rotter,B., Nicolas,G., Lecomte,M.C. and
            Dhermy,D.
  TITLE     Spectrin interacts with EVL (Enabled/vasodilator-stimulated
            phosphoprotein-like protein), a protein involved in actin
            polymerization
  JOURNAL   Biol Cell 98 (5), 279-293 (2006)
   PUBMED   16336193
  REMARK    GeneRIF: The possible link between the spectrin-based skeleton and
            actin via the EVL protein suggests a new way of integrating the
            spectrin-based skeleton in areas of dynamic actin reorganization.
REFERENCE   6  (bases 1 to 2172)
  AUTHORS   Quinlan,M.P.
  TITLE     Vinculin, VASP, and profilin are coordinately regulated during
            actin remodeling in epithelial cells, which requires de novo
            protein synthesis and protein kinase signal transduction pathways
  JOURNAL   J Cell Physiol 200 (2), 277-290 (2004)
   PUBMED   15174098
  REMARK    GeneRIF: Evl is coordinately regulated during actin remodeling in
            epithelial cells.
REFERENCE   7  (bases 1 to 2172)
  AUTHORS   Lambrechts,A., Kwiatkowski,A.V., Lanier,L.M., Bear,J.E.,
            Vandekerckhove,J., Ampe,C. and Gertler,F.B.
  TITLE     cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP
            relative, regulates its interaction with actin and SH3 domains
  JOURNAL   J Biol Chem 275 (46), 36143-36151 (2000)
   PUBMED   10945997
REFERENCE   8  (bases 1 to 2172)
  AUTHORS   Ohta,S., Mineta,T., Kimoto,M. and Tabuchi,K.
  TITLE     Differential display cloning of a novel rat cDNA (RNB6) that shows
            high expression in the neonatal brain revealed a member of Ena/VASP
            family
  JOURNAL   Biochem Biophys Res Commun 237 (2), 307-312 (1997)
   PUBMED   9268706
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Dec 18;241(2):611]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced XM_008764857.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.37050.1,
                                           SRR26643297.23754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               JAXUCZ010000006.1  133238547-133239039
            494-662             JAXUCZ010000006.1  133319882-133320050
            663-840             JAXUCZ010000006.1  133324038-133324215
            841-904             JAXUCZ010000006.1  133343621-133343684
            905-963             JAXUCZ010000006.1  133344547-133344605
            964-1193            JAXUCZ010000006.1  133345611-133345840
            1194-1315           JAXUCZ010000006.1  133346387-133346508
            1316-1376           JAXUCZ010000006.1  133350637-133350697
            1377-1440           JAXUCZ010000006.1  133352151-133352214
            1441-1507           JAXUCZ010000006.1  133353705-133353771
            1508-1570           JAXUCZ010000006.1  133353859-133353921
            1571-1637           JAXUCZ010000006.1  133356404-133356470
            1638-1695           JAXUCZ010000006.1  133356744-133356801
            1696-2172           JAXUCZ010000006.1  133358252-133358728
FEATURES             Location/Qualifiers
     source          1..2172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2172
                     /gene="Evl"
                     /note="Enah/Vasp-like"
                     /db_xref="GeneID:79115"
                     /db_xref="RGD:621150"
     exon            1..493
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..1733
                     /gene="Evl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ena/VASP-like protein; ena/vasodilator-stimulated
                     phosphoprotein-like; RNB6; Ena-vasodilator stimulated
                     phosphoprotein"
                     /codon_start=1
                     /product="ena/VASP-like protein isoform 1"
                     /protein_id="NP_001401829.1"
                     /db_xref="GeneID:79115"
                     /db_xref="RGD:621150"
                     /translation="MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTAS
                     NTFRVVGVKLQDQQVVINYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFS
                     NAMLFALNIMNSQEGGPSTQRQVQNGPSPEEMDIQRRQVMEQQHRQESLERRISATGP
                     ILPPGHPSSAASATFSCSGPPPPPPPPVPPPPTGSTPPPPPPLPAGGAQGTNHDESSA
                     SGLAAALAGAKLRRVQRPEDASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKR
                     RKAASQTDKPADRKEDENQTEDPSTSPSPGSRATSQPPNSSEAGRKPWERSNSVEKPV
                     SSLLSRTPSVAKSPEAKSPLQSQPHSRVKPAGSVNDVGLDALDLDRMKQEILEEVVRE
                     LHKVKEEIIDAIRQELSGISTT"
     exon            494..662
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            663..840
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            841..904
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            905..963
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1193
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1315
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1376
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1440
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1507
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1570
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1637
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1695
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2172
                     /gene="Evl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttttgtg tggagcttct ctgcggcgcg cacccattcc ctccgcggcc gcggaccgag
       61 ggccgtcggc gcgcgcagtc ccctctgcgg gcggagggtc cctccgcccc gcgtgcaccc
      121 cgcaccccat cctcccgccg ccgccccgag tttcaaggcg gacgcgcgct ctcgctcccg
      181 ccctcgagac cccgccgctc gccccctccc ccggcccgtc ggctggcggg cggcacgcgc
      241 acgcgccggc ccgggcacgc gcgcccgcca agatggcagg ggccggggcc cagctgtcag
      301 tcgccgccgc cgccgcggcc gcgctgcctc gcagctagcg gcccggacgc ccgccggaga
      361 agatgagccc ccgccgccgc ctgcagccca gccagacgcg gagccgccgc gcccggggcc
      421 ggctgccccg ctagcgcccc gtcgcgccgc gccttcatcc ccggccccgt gcccgcccgg
      481 cagccacgat gagcgaacag agtatctgcc aagcacgggc ctccgtgatg gtctacgatg
      541 acaccagtaa gaaatgggta ccaatcaagc ctggccagca gggattcagc cggatcaaca
      601 tctaccacaa cactgccagc aacactttca gggttgtagg ggtcaagcta caggatcagc
      661 aggttgtgat caattattca attgtgaaag ggctgaagta caatcaggca acacccacct
      721 tccatcagtg gcgagacgcc cgtcaggtct atggcttaaa ctttgcgagt aaggaagaag
      781 caaccacatt ctccaacgcg atgctctttg ccctgaacat catgaactcc caagaaggag
      841 gcccctccac acagcgtcag gtgcagaatg gcccctctcc tgaggagatg gacatccaga
      901 gaagacaagt aatggagcag cagcaccgcc aggagtctct ggagagaaga atctccgcca
      961 cagggcccat tctcccccct gggcatccgt catcggcagc cagcgccacc ttctcctgta
     1021 gtggacctcc acctccacct ccacctccag ttccacctcc acccacaggg tctactcccc
     1081 cgcccccgcc cccgctgcct gctggaggag cccaggggac caaccacgat gagagctctg
     1141 catcaggact ggctgctgct ctggcaggag ccaagctaag gagggtgcag cggccagagg
     1201 atgcatctgg aggctccagt cctagcggga cttcaaagtc cgatgccaac cgggcaagca
     1261 gtgggggagg aggaggaggc ctcatggaag aaatgaacaa gctgctggct aagaggagaa
     1321 aggcagcctc ccagacagac aagcccgctg acagaaagga agatgagaac caaacggaag
     1381 atcctagcac ctccccatcc ccagggagcc gagccaccag ccagccacct aattcctcag
     1441 aggctggccg aaagccctgg gaacggagca actcggtgga gaaacctgtg tcctcgttgc
     1501 tgtccagaac cccgtctgtg gcaaagagcc ccgaagctaa gagccccctt cagtcgcagc
     1561 ctcactctag ggtgaagcct gctgggagtg tgaatgacgt gggcctggat gccttagatt
     1621 tggaccggat gaaacaggag attctggagg aggtggtccg agagctccac aaggtgaagg
     1681 aggagatcat agatgccatc aggcaggaac taagtgggat cagcaccaca taagatggcg
     1741 ccagccctgg aggatcttga ggagctgtgc tagccccagc gaacatcgag cctgcggaag
     1801 ctgggatata cttaagtctc aacctgtgat acaatattaa aatgaggaaa caaacttcaa
     1861 ctcctggatt ttttagtgta tctgacacag aacaccgggt ctattctttt ttgtatttta
     1921 tatttgctta tttaagtgta cattcctttg gtttatagag aacaccccca aatcacctgc
     1981 tttattagat ggcttccaag ttttctccta ggtgacactg ttggcacctc agctggcagg
     2041 gagcagctgg gtgcagcgtg acctttccgt gccacagagc tgtcaggatg cagcacagct
     2101 ccagcagcca cagtgtccca gtttgtccac gcagtgcgtg ttatgtccac agaataaact
     2161 gttcactgtc ca
//
