LOCUS       NM_001106012            4067 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus EvC ciliary complex subunit 2 (Evc2), mRNA.
ACCESSION   NM_001106012 XM_001063003 XM_223550
VERSION     NM_001106012.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L and
            Rohatgi R.
  TITLE     EFCAB7 and IQCE regulate hedgehog signaling by tethering the
            EVC-EVC2 complex to the base of primary cilia
  JOURNAL   Dev Cell 28 (5), 483-496 (2014)
   PUBMED   24582806
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Blair HJ, Tompson S, Liu YN, Campbell J, MacArthur K, Ponting CP,
            Ruiz-Perez VL and Goodship JA.
  TITLE     Evc2 is a positive modulator of Hedgehog signalling that interacts
            with Evc at the cilia membrane and is also found in the nucleus
  JOURNAL   BMC Biol 9, 14 (2011)
   PUBMED   21356043
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Ruiz-Perez VL, Tompson SW, Blair HJ, Espinoza-Valdez C, Lapunzina
            P, Silva EO, Hamel B, Gibbs JL, Young ID, Wright MJ and Goodship
            JA.
  TITLE     Mutations in two nonhomologous genes in a head-to-head
            configuration cause Ellis-van Creveld syndrome
  JOURNAL   Am J Hum Genet 72 (3), 728-732 (2003)
   PUBMED   12571802
REFERENCE   5  (bases 1 to 4067)
  AUTHORS   Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King
            L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola
            B, Wright M, Meitinger T, Polymeropoulos MH and Goodship J.
  TITLE     Mutations in a new gene in Ellis-van Creveld syndrome and Weyers
            acrodental dysostosis
  JOURNAL   Nat Genet 24 (3), 283-286 (2000)
   PUBMED   10700184
  REMARK    Erratum:[Nat Genet 2000 May;25(1):125]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063003.1, XM_223550.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132264, SAMD00132269
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4067
                     /gene="Evc2"
                     /note="EvC ciliary complex subunit 2"
                     /db_xref="GeneID:289711"
                     /db_xref="RGD:1310417"
     exon            1..238
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3712
                     /gene="Evc2"
                     /note="Ellis van Creveld syndrome 2 homolog"
                     /codon_start=1
                     /product="limbin"
                     /protein_id="NP_001099482.1"
                     /db_xref="GeneID:289711"
                     /db_xref="RGD:1310417"
                     /translation="MGATGLTGTGGQATWVLAGNILAAALVLGVGPCALPPSFPALGP
                     GSPSPPDPVGPRASSQHSDISRDAQGPSENGVIFQKCSLVSGQSESQTMHVQLSVNNT
                     RTPMSANLSDLLVLDDITGLTVKESPGNVTQEGIQTFRKRFLQVGECYSVSYMASLDP
                     TALGPGESLDLPAQLIFQRPSQNRTQLRARFTITVEEKIMVLPNHGLHTAGFIAAFLI
                     SFLLTLAALFFLARGRCLQGSMLLRCRVQHPENKLEPSPFTSANGVSQDLSLNDQLVA
                     ILTSEEPGSMLQALEELEIATLNQADADLEACRNQISKDIIALLMKNLISGGHLSLQT
                     ERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEVRKKTENQYQREMVAMEEAEE
                     VLKRVSERSAAECSSLLRTLHGLEQEDLQRSLTLQQAEDFAQAHRQLAVFQRNELHSI
                     VYTQIQSAVAKGELRPEVAKMLLQDYSKTQESIEELMDFFQATKRYHLSKRFGHREYL
                     VQRLQAMETRVQGLLSTAATQLTSLIHKHERAGYLDEDQMEMLLERAQTETFSIKQKL
                     DNDLKQEKKRLHQKLITKRRRELLQKHKEQQKEQVSLGEASSTAEDAIQYLQQWRSVM
                     AEHTTALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMTQELLKRSAPWLF
                     LQQILEEHSRESAARTAQLEAEERERGQELVQGVRQRLQQDAPEACTEEQAELRHWEH
                     LVFTKLCSAAISLSEEDLLRVRQEAQGCFTQLDRSLALPRVRARVLQQQMQMTWREAE
                     FRKLDQALAVPELQSKSRKLRSKGRGKADLLKKNLEDKIRLFEERAPEDLADQVRGEL
                     LQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLT
                     KSACVQILESHRPELLELERMLEDRLVQQEEAEQRRVLESRQRWAADGPALGEPEEID
                     PERQVSAVLRQALNKGQKLLEQYQQRVREEQQNGAVLEDSLESMETDTMASLCSQGLR
                     LVSYLSRMTMVPGGTLLRLLSVVLPAASQPQLLALLDAVSEKHSDHTAENESGGEQAQ
                     AEQGKRRKHQSWWKALDSRFRADLVSQGLERMLWARRKKESILKKRYVPVQERVVFPG
                     KGSWPHLSLEPIGELAPIPITGLDTMDILNTGEKIFVFRSPKEPEISLRVPPRRKKNF
                     LNAKAASRALGLD"
     exon            239..307
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..494
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            495..604
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..658
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..793
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..933
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1258
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1498
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1674
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1834
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2289
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2494
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2611
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2839
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3051
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3139
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3342
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3444
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..4067
                     /gene="Evc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggtccg gaagctccgc gacactccgg gggcctgtgt ggggtctgca gccaccagat
       61 gggggcgacc ggtctcacgg gcactggggg acaagccacg tgggtgctgg ctggaaatat
      121 cctggccgcg gccttggtac tgggtgtggg tccgtgtgcg cttccaccct ccttccctgc
      181 cctgggccca gggtcgccat ccccacccga ccctgtagga ccccgggcaa gctcacagca
      241 cagcgatatt tcaagagatg cccaaggtcc ctcagagaac ggagtgatat ttcaaaaatg
      301 ctcgctggtg tctgggcaga gcgaatcgca gaccatgcat gtgcagctgt cagtgaacaa
      361 caccaggacg cccatgtcag ccaacctttc ggacctgctt gtgctggatg acatcactgg
      421 cctcactgtg aaggagtcac ctggaaatgt gactcaggaa ggaatccaga cttttagaaa
      481 gcggtttctg caagtgggag agtgctactc cgtcagctac atggcctcgc tggaccccac
      541 agcccttggg cctggagaga gcctggatct tcccgcccag ctcatctttc agagaccctc
      601 acagaacaga actcagctaa gagcccgctt taccatcacc gtggaagaaa agataatggt
      661 tctgcctaac catggtctcc acacagcagg cttcatcgca gccttcctca tctccttcct
      721 cctgaccttg gcagccctgt tcttcctggc tcggggtcgg tgtctgcagg gaagcatgct
      781 gttgagatgc cgggttcagc atcctgagaa caagctggag ccctcaccct tcacctctgc
      841 taatggtgtg agccaggacc tttccctcaa tgaccaactg gttgccatcc tgacttctga
      901 ggagcctggg agcatgcttc aagccctaga agagttggag atcgcaaccc tgaatcaggc
      961 agatgcggat ctggaggctt gtcgaaacca gattagtaag gacatcattg cccttctgat
     1021 gaagaatctg atcagtggtg gtcacctctc tctgcaaaca gaaaggaaga tggctgctgc
     1081 ttttaaaaag cagtttctgc tgctggaaaa cgaaatccag gaggagtatg agcggaagat
     1141 gttggcactc acggcagagt gtgacctaga agtgaggaag aagacagaaa accagtacca
     1201 gagggagatg gtggccatgg aggaagcaga agaggtgtta aagcgagtta gtgagaggtc
     1261 tgctgcagag tgcagcagcc ttttgcggac cctccatggg ctggagcagg aggacctgca
     1321 gaggtccctc actctgcagc aagcagagga ctttgcccaa gcacacaggc agctggctgt
     1381 tttccagaga aacgaattac acagcatcgt ctatacccag atacagagtg ctgttgccaa
     1441 aggagaactg aggcccgagg tggctaaaat gctgctgcaa gactattcta aaacacagga
     1501 gagtatagaa gagctgatgg acttcttcca ggccaccaag cgataccatc tcagcaagag
     1561 gtttggccac agagagtacc tggtccagag actgcaggcc atggagaccc gcgtgcaagg
     1621 gctgctgagc actgcagcta cccagctaac aagtctcatt cataaacatg agagggctgg
     1681 ttacttggat gaagatcaga tggaaatgct attggagcgt gcacagacag aaaccttttc
     1741 tataaaacag aagctggaca atgacttaaa gcaagaaaag aaaaggctcc accaaaaatt
     1801 aataaccaag agacggcgag aacttctgca aaagcacaag gagcagcaga aagagcaggt
     1861 gtcccttggc gaggcctcca gcactgcgga ggatgccatt cagtacctgc agcagtggag
     1921 gagcgtgatg gccgagcaca ccactgccct ggaggagctg caggagcggc tggaccaggc
     1981 tgccctggat gacctccggg tcctgactgt gtcactgtct gagaaagcca cagaggagct
     2041 gaggcgcctg cagagcacgg ccatgacaca ggagctgctg aagcgcagtg ctccctggct
     2101 cttcctgcag cagatcctag aggagcatag ccgggagtct gcggcccgta ccgcgcagct
     2161 ggaggcagag gagagagagc gtggccagga gctggtgcag ggcgtgagac agaggctaca
     2221 acaggatgca ccggaggctt gcacagaaga gcaggcagag ctgaggcatt gggagcactt
     2281 ggtattcacg aagctctgct ctgcggccat ctcactgtct gaagaagacc tgctccgggt
     2341 gaggcaggag gcacagggct gcttcaccca gctggaccgg agcttggccc tccccagagt
     2401 ccgtgcacgg gtgctgcagc agcagatgca gatgacctgg cgggaagcag agttccggaa
     2461 actggaccag gctctggctg tgcctgagct gcagtccaag tcaagaaagc tgcgttccaa
     2521 gggcagaggc aaggcggacc ttctgaagaa gaacctggag gataagatcc gcctgttcga
     2581 ggagcgggcc cctgaagacc tggctgacca ggtacgaggg gaattgctcc aggagagggt
     2641 ccagaggctg gaggcccagg aggcacactt tgccgagtca cttgtggctc tgcagttcca
     2701 gaaggtggcc cgggctgctg agaccctctc cgtctacacc gccctgctta gcatccaaga
     2761 cctgctgctg ggggagctga gtgagtcgga gacactgacc aagtcagcct gcgtgcagat
     2821 cctggagtcc cacaggccgg agctgctgga gctggagagg atgctggagg accggctggt
     2881 gcagcaggaa gaggctgagc agcggcgggt cctggagagc aggcagcggt gggcggctga
     2941 cggacctgcg ctgggcgagc ctgaggagat agatcccgag aggcaggtct ctgccgtcct
     3001 gcggcaggct ctgaacaagg gccagaagct actggaacag tatcagcaga gggtgagaga
     3061 ggagcagcag aacggtgcag tgctggaaga ttctctggaa agcatggaga ccgacaccat
     3121 ggccagcctc tgcagccagg gactgaggct ggtgtcctac ctctccagga tgacaatggt
     3181 gccggggggc accctactga gactcctgag tgtggtgctt cccgcagctt cacagcctca
     3241 gctactggcc ttgctggatg cagtcagcga gaagcactca gaccacacag cagagaatga
     3301 gagtggtggt gagcaggcac aggcggagca gggcaagagg agaaaacacc agagctggtg
     3361 gaaagctttg gacagcaggt tcagagcaga tctggtgagt caaggactgg agaggatgct
     3421 ctgggcccgc cggaagaagg agagcatatt gaagaagaga tatgttcctg tccaggagag
     3481 ggtggtgttc cccgggaaag gaagctggcc gcacctgtcc ctagagccca tcggagaact
     3541 ggcgcccatc cccatcacag ggctagacac tatggacata ttaaacacag gagaaaagat
     3601 ctttgtattc agaagcccaa aggagcctga gatctctttg cgtgttcctc ccagaaggaa
     3661 gaagaatttc ctgaatgcca aggcagccag cagggccttg ggcttggact gacccaagag
     3721 gaagcaccaa gaagtgtctc aagacaggca catcattcct ctggcccact gggttggtct
     3781 gtctgtctgt atcatacagc ttgcagtata cacatgcttg cagcattgac acagagccat
     3841 acaaattggc tctctcaggt ccagtctttt gtgccacagg acaccttcct tctctgtcca
     3901 tattaccaag agctagaggg gtcccacctt accccacgtt cctcacacag cctattgctg
     3961 ggatgtgtcc ccacccagtt tatgtgagga atgtgcagct ctctgttttt acgatgtgtg
     4021 ttacatgctc tgtttttttt tttttcataa agggaacttt aaaaatt
//
