LOCUS       NM_001109243            1741 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus eva-1 homolog A, regulator of programmed cell
            death (Eva1a), mRNA.
ACCESSION   NM_001109243 XM_001065585 XM_575572
VERSION     NM_001109243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Li L, Khatibi NH, Hu Q, Yan J, Chen C, Han J, Ma D, Chen Y and Zhou
            C.
  TITLE     Transmembrane protein 166 regulates autophagic and apoptotic
            activities following focal cerebral ischemic injury in rats
  JOURNAL   Exp Neurol 234 (1), 181-190 (2012)
   PUBMED   22227058
  REMARK    GeneRIF: The results of this study suggested that MEM166 induced
            autophagy and apoptosis may in fact play a significant role in the
            cell death process following MCAO injury and its mediation may be
            through the Bcl-2. By blocking the activity of TMEM166 using siRNA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001065585.1, XM_575572.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216129.1, BC166981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1741
                     /gene="Eva1a"
                     /gene_synonym="Fam176a; RGD1559797; Tmem166"
                     /note="eva-1 homolog A, regulator of programmed cell
                     death"
                     /db_xref="GeneID:500221"
                     /db_xref="RGD:1559797"
     exon            1..276
                     /gene="Eva1a"
                     /gene_synonym="Fam176a; RGD1559797; Tmem166"
                     /inference="alignment:Splign:2.1.0"
     exon            277..440
                     /gene="Eva1a"
                     /gene_synonym="Fam176a; RGD1559797; Tmem166"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..814
                     /gene="Eva1a"
                     /gene_synonym="Fam176a; RGD1559797; Tmem166"
                     /note="transmembrane protein 166; protein FAM176A; family
                     with sequence similarity 176, member A"
                     /codon_start=1
                     /product="protein eva-1 homolog A"
                     /protein_id="NP_001102713.1"
                     /db_xref="GeneID:500221"
                     /db_xref="RGD:1559797"
                     /translation="MPHEAALSPSTEPVAAQPLEMALLSSILAAWAYISENPERAALY
                     FVSGVCIGLFLTLAALVMRISCHTDCRQGPRRRCLQDHESSSDSSDSEDGSEDTASDL
                     SVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY"
     exon            441..1741
                     /gene="Eva1a"
                     /gene_synonym="Fam176a; RGD1559797; Tmem166"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcggggga gaccgaagga aatgagacaa ccttttcctc ccacggactc aggctcctct
       61 agagtgtgca aggctggagg aatcccgagg ccggttgtgc gcgtcccttg ctcagtcttg
      121 actggggagg gccgccccaa attgctctcc ggcgcgcgcc ggtgcctcag ccacagggcg
      181 cagcagcacg ttgctgtgcc cttccctagg tgatctgatc tactccaggc cccctgactc
      241 ggtccccgga agtactcgcc ggcggtccca gaaaaggaga ggagagggag gggccgtgct
      301 gagcctgaag aagtgtccag gagctcttct cccaatgcca catgaagctg ccctcagccc
      361 cagcacagag ccagtggccg cgcagccctt ggagatggct ttgctcagca gcatcctggc
      421 agcctgggcc tatatctcag aaaaccctga gcgagccgct ctgtactttg tctctggcgt
      481 gtgcatcggc ctgttcctga ccttggcagc cttggtgatg agaatctcct gccacacgga
      541 ctgccggcag ggtccccgga ggaggtgctt gcaggaccac gagagcagca gtgacagcag
      601 cgacagcgag gatggtagtg aggacacagc ctcggacctc tcggtgcgca gacaccgtcg
      661 cttcgagagg actttgaaca agaacgtgtt cacgtctgca gaggagctgg agcgcgcaca
      721 gcggttggag gagcgcgaac gaatcatcag ggagatctgg atgaacgggc agcctgaggt
      781 gccgggcacc aggagcctga accgctacta ctagggctca gtgtggacgc cagaacctct
      841 gcagacctga aaaagagagt gggttctgca ggcagggacg atgtgcacga gctgaggcca
      901 gctctgttaa tgtggccgga gagtgcagag cgccagccta cttcccaaga gcattggggt
      961 ttgctttaga ctcttgcctc tggagaaata gacaacccag gcaggggtat ctgccttttc
     1021 aggtcttgac acccacctgg acacaccagc ccaaagcttc ccggtcttgg aaaggtgcta
     1081 aggatttcct ctccaaccac gtgacagcga tgtgatgagc tgaaagtcct tccgaagtgc
     1141 tcagaagttt gggcggactt gtgctattcc tttacaaaag gaaaaaaaaa gtctcatagc
     1201 tggagagctg ggacatcagg gtgaccataa cccagaaaat gtaattttct aaaggactcc
     1261 gtgtagagga agtggttttg attgagatag catgatccat gctaattatt taaagctaat
     1321 ttttaaatga aaaaaaaaat cttggcaacc tctgcatttt aactgacacc tcagggatta
     1381 aaatcctatt ttttagtcta gttcccacct cattcatgaa gatgaataga acttactgtt
     1441 taatgagatg tgttggagac ctaggacaca tcaataacct cagaggataa agggttttat
     1501 tttttagtag tttatgaaat atatattgac atgtgtattt gaaaatgctg cataaaaaat
     1561 agaaaccatg ggtccttccc ttttggagag ataagtctca tgacttcaga gattcataat
     1621 atttaaataa tattttgttt taaaaaatag tttggatttc caagaagaga atggaaacca
     1681 gaggtgagaa ttaaagccaa aattagaatg gtgtctaaaa taaacattcc atgaaaatct
     1741 t
//
